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Frontiers of Architectural Research 2014年第2期3卷 199-212页

作者： Xinyu Zhuan Shichen Zhao department of urban Design Planning and Disaster Management Graduate School of Human-Environment Studies Kyushu University Fukuoka 812-8581 Japan department of Architecture and urban Design Faculty of Human-Environment Studies Kyushu University Fukuoka 812-8581 Japan

This study uses multiple regression to investigate the effects of Land and building use on popuLation, Land price, and passengers. Initialty, we abstract annuat data on Land and buildings usage within a radius of 0 m-400 m for railway stations and 400 m-800 m for subway stations in Fukuoka, Japan by using the GIS. We then analyze the relationships between 13 factors of rand use and 8 factors of building usage, as well as the related poputation, Land price, and passengers using the quantitative expression method. Using several categories of land use and building usage as explanatory variables, we anatyze the degree to which the selected categories affect population, Land price, and passengers by using the muttiple regression method. This research can aid the further development of land and buitding usage in the future.

关键词： Railway and subwaystations Multiple regressionmethod Population Land price Passengers

Microglia:a promising therapeutic target in spinal cord injury

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Neural Regeneration Research 2025年第2期20卷 454-463页

作者： Xiaowei Zha Guoli Zheng Thomas Skutella Karl Kiening Andreas Unterberg Alexander Younsi department of Neurosurgery Heidelberg University HospitalHeidelbergGermany department of Neuroanatomy Institute for Anatomy and Cell BiologyHeidelberg UniversityHeidelbergGermany

Microglia are present throughout the central nervous system and are vital in neural repair,nutrition,phagocytosis,immunological regulation,and maintaining neuronal *** a healthy spinal cord,microglia are accountable for immune surveillance,however,when a spinal cord injury occurs,the microenvironment drastically changes,leading to glial scars and failed axonal *** this context,microglia vary their gene and protein expression during activation,and proliferation in reaction to the injury,influencing injury responses both favorably and unfavorably.A dynamic and multifaceted injury response is mediated by microglia,which interact directly with neurons,astrocytes,oligodendrocytes,and neural stem/progenitor *** a clear understanding of their essential nature and origin,the mechanisms of action and new functions of microglia in spinal cord injury require extensive *** review summarizes current studies on microglial genesis,physiological function,and pathological state,highlights their crucial roles in spinal cord injury,and proposes microglia as a therapeutic target.

关键词： astrocytes cytokines functional recovery immune regulation M1/M2 activation macrophages microglia neuroinflammation spinal cord injury therapy

Quantifying the relationship between visitor satisfaction and perceived accessibility to pedestrian spaces on festival days

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Frontiers of Architectural Research 2015年第4期4卷 285-295页

作者： Andini Radisya Pratiwi Shichen Zhao Xiaoyan Mi Graduate Student Department of Urban Design Planning and Disaster Management Graduate School ofHuman-Environment Studies Kyushu University Fukuoka 812-8581 Japan department of Architecture and urban Design Faculty of Human-Environment Studies KyushuUniversity Fukuoka 812-8581 Japan

Many cities organize cultural festivals to promote their distinctiveness, boost the local economy, and enhance quality of life. However, urban spaces are packed with visitors on festival days, thus affecting accessibility to pedestrian spaces. This research examined visitor satisfaction with accessibility to pedestrian spaces during special events such as festivals. We particularly focused on the Hakata Dontaku festival, which is celebrated in Fukuoka, Japan. We studied three main elements that affect pedestrian satisfaction and perceived accessibility through walking, namely, safety, mobility, and amenities. We first analyzed previous studies and employed analytical hierarchy process to setup indicators for satisfaction measurement. Second, we determined visitor satisfaction through a survey questionnaire, which was conducted during the Hakata Dontaku festival. Third, we assessed the normality of the data set that was obtained from the questionnaire. Finally, we applied structural equation modeling. Results showed that the proposed model was a good fit, as indicated by the goodness of fit test, and the majority of indicators loaded significant values that supported their constructs. Satisfaction with amenities was found to be the most statistically significant variable that influences visitors＇ perceived accessibility during the Hukata Dontaku festival

关键词： Festivat Pedestrian Accessibitity SEM Watkabitity

Shanghai and New York:Mid-Century urban Avant-Gardes

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Built Heritage 2019年第3期3卷 49-61页

作者： Rosemary Wakeman History department&urban studies Program Fordham UniversityNew YorkUnited States

This article examines the cultural and architectural exchanges between Shanghai and New York in the mid-20^(th) century and their iconic roles as avant-garde global *** considers the cultural and architectural free-thinkers and the groundbreaking movements they led,as well as their influence on the character and identity of both *** Deco was the emblematic symbol of these modern *** article analyses the new technologies and theatrical perspective,the performative and spectacular qualities of Art Deco as the signature styles and cultural heritage of both cities.

关键词： Art Deco New York avant-garde Radio City Music Hall Park Hotel lighting design technology Cathay Cinema cityscape film

A Synergistic Multi-Attribute Decision-Making Method for Educational Institutions Evaluation Using Similarity Measures of Possibility Pythagorean Fuzzy Hypersoft Sets

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Computer Modeling in Engineering & Sciences 2025年第1期142卷 501-530页

作者： Khuram Ali Khan Saba Mubeen Ishfaq Atiqe Ur Rahman Salwa El-Morsy department of Mathematics University of SargodhaSargodha40100Pakistan department of Mathematics University of Management and TechnologyLahore54000Pakistan department of Mathematics College of ScienceQassim UniversityBuraydah51452Saudi Arabia

Due to the numerous variables to take into account as well as the inherent ambiguity and uncertainty,evaluating educational institutions can be *** concept of a possibility Pythagorean fuzzy hypersoft set(pPyFHSS)is more flexible in this regard than other theoretical fuzzy set-like models,even though some attempts have been made in the literature to address such *** study investigates the elementary notions of pPyFHSS including its set-theoretic operations union,intersection,complement,OR-and *** results related to these operations are also modified for ***,the similarity measures between pPyFHSSs are formulated with the assistance of numerical examples and ***,an intelligent decision-assisted mechanism is developed with the proposal of a robust algorithm based on similarity measures for solving multi-attribute decision-making(MADM)problems.A case study that helps the decision-makers assess the best educational institution is discussed to validate the suggested *** algorithmic results are compared with the most pertinent model to evaluate the adaptability of pPyFHSS,as it generalizes the classical possibility fuzzy set-like theoretical ***,while considering significant evaluating factors,the flexibility of pPyFHSS is observed through structural comparison.

关键词： Hypersoft set Pythagorean fuzzy hypersoft set computational complexity multi-attribute decision-making optimization similarity measures uncertainty

Does mesenchymal stem cell’s secretome affect spinal sensory circuits?Implication for pain therapies

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Neural Regeneration Research 2025年第1期20卷 181-183页

作者： Francesco Ferrini Esri H.Juárez Adalberto Merighi department of Veterinary Sciences University of TurinGrugliascoTOItaly department of Psychiatry and Neuroscience UniversitéLavalQuébec CityQCCanada

Mesenchymal stem cells(MSCs)are multipotent adult stem cells of mesodermal origin that can be isolated from various tissues,including bone marrow,tooth pulp,adipose tissue,and umbilical *** have gained significant attention in regenerative medicine due to their ability to modulate the immune system and favor tissue *** enrich the medium in which they are cultivated with a broad range of bioactive molecules,including growth factors,cytokines,chemokines,enzymes,nucleic acids,and extracellular vesicles that collectively compose the MSC *** increasing number of pre-clinical studies suggest that delivering in vivo an MSC-conditioned medium(i.e.,the medium collected from MSC cultures after at least 3 days of exposure)exerts neuroprotective and anti-inflammatory effects in a variety of neurological conditions.

关键词： protective clinical collective

Pro-resolving lipid mediator reduces amyloid-β42–induced gene expression in human monocyte–derived microglia

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Neural Regeneration Research 2025年第3期20卷 873-886页

作者： Ying Wang Xiang Zhang Henrik Biverstål Nicolas GBazan Shuai Tan Nailin Li Makiko Ohshima Marianne Schultzberg Xiaofei Li department of Neurobiology Care Sciences&SocietyDivision of NeurogeriatricsKarolinska InstitutetStockholmSweden department of Neurology Neuroscience CenterThe First Hospital of Jilin UniversityChangchunJilin ProvinceChina department of Physiology and Pharmacology Karolinska InstitutetStockholmSweden department of Biosciences and Nutrition Karolinska InstitutetHuddingeSweden Neuroscience Center of Excellence Louisiana State UniversityNew OrleansLAUSA department of Medicine SolnaClinical Pharmacology GroupKarolinska University HospitalStockholmSweden

Specialized pro-resolving lipid mediators including maresin 1 mediate resolution but the levels of these are reduced in Alzheimer's disease brain, suggesting that they constitute a novel target for the treatment of Alzheimer's disease to prevent/stop inflammation and combat disease pathology. Therefore, it is important to clarify whether they counteract the expression of genes and proteins induced by amyloid-β. With this objective, we analyzed the relevance of human monocyte–derived microglia for in vitro modeling of neuroinflammation and its resolution in the context of Alzheimer's disease and investigated the pro-resolving bioactivity of maresin 1 on amyloid-β42–induced Alzheimer's disease–like inflammation. Analysis of RNA-sequencing data and secreted proteins in supernatants from the monocyte-derived microglia showed that the monocyte-derived microglia resembled Alzheimer's disease–like neuroinflammation in human brain microglia after incubation with amyloid-β42. Maresin 1 restored homeostasis by down-regulating inflammatory pathway related gene expression induced by amyloid-β42 in monocyte-derived microglia, protection of maresin 1 against the effects of amyloid-β42 is mediated by a re-balancing of inflammatory transcriptional networks in which modulation of gene transcription in the nuclear factor-kappa B pathway plays a major part. We pinpointed molecular targets that are associated with both neuroinflammation in Alzheimer's disease and therapeutic targets by maresin 1. In conclusion, monocyte-derived microglia represent a relevant in vitro microglial model for studies on Alzheimer's disease-like inflammation and drug response for individual patients. Maresin 1 ameliorates amyloid-β42–induced changes in several genes of importance in Alzheimer's disease, highlighting its potential as a therapeutic target for Alzheimer's disease.

关键词： Alzheimer's disease amyloid-β maresin microglia monocyte neuroinflammation resolution RNA-sequencing specialized pro-resolving lipid mediator

Market Drivers in India’s Smart Grid:Responsibilities and Roles of Stakeholders

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Energy Engineering 2025年第1期122卷 101-128页

作者： Abhay Sanatan Satapathy Suresh Kumar Sahoo Asit Mohanty Yasser Fouad Manzoore ElahiMohammad Soudagar Erdem Cuce Faculty of Management studies Sri Sri UniversityCuttack754006India Institute of Power Engineering National Energy UniversityJalan Ikram-UnitenKajangSelangor43000Malaysia Centre of Research Impact and Outcome Chitkara UniversityRajpura140417PunjabIndia department of Applied Mechanical Engineering College of Applied EngineeringMuzahimiyah BranchKing Saud UniversityRiyadh11421Saudi Arabia College of Engineering Lishui UniversityLishui323000China department of Mechanical Engineering Graphic Era(Deemed to be University)Dehradun248002UttarakhandIndia department of Mechanical Engineering Faculty of EngineeringUniversity of MalayaKuala Lumpur50603Malaysia department of Mechanical Engineering Faculty of Engineering and ArchitectureRecep Tayyip Erdogan UniversityZihni Derin CampusRize53100Turkey Center for Research Impact&Outcome Chitkara UniversityRajpura140401PunjabIndia University Centre for Research and Development Chandigarh UniversityMohali140413PunjabIndia

The emergence of smart grids in India is propelled by an intricate interaction of market dynamics,regulatory structures,and stakeholder *** study analyzes the primary factors that are driving the widespread use of smart grid technologies and outlines the specific roles and obligations of different stakeholders,such as government entities,utility companies,technology suppliers,and *** activities and regulations are crucial in facilitating the implementation of smart grid technology by offering financial incentives,regulatory assistance,and strategic *** firms have the responsibility of implementing and integrating smart grid infrastructure,with an emphasis on improving the dependability of the grid,minimizing losses in transmission and distribution,and integrating renewable energy *** companies offer the essential hardware and software solutions,which stimulate creativity and enhance *** actively engage in the energy ecosystem by participating in demand response,implementing energy saving measures,and adopting distributed energy resources like solar panels and electric *** study examines the difficulties and possibilities in India’s smart grid industry,highlighting the importance of cooperation among stakeholders to build a strong,effective,and environmentally friendly energy future.

关键词： Smart grid stakeholders smart grid technology market drivers

A Latency-Aware and Fault-Tolerant Framework for Resource Scheduling and Data Management in Fog-Enabled Smart City Transportation Systems

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Computers, Materials & Continua 2025年第1期82卷 1377-1399页

作者： Ibrar Afzal Noor ul Amin Zulfiqar Ahmad Abdulmohsen Algarni department of Computer Science and Information Technology Hazara UniversityMansehra21300Pakistan department of Computer Science King Khalid UniversityAbha61421Saudi Arabia

Thedeployment of the Internet of Things(IoT)with smart sensors has facilitated the emergence of fog computing as an important technology for delivering services to smart environments such as campuses,smart cities,and smart transportation *** computing tackles a range of challenges,including processing,storage,bandwidth,latency,and reliability,by locally distributing secure information through end *** of endpoints,fog nodes,and back-end cloud infrastructure,it provides advanced capabilities beyond traditional cloud *** smart environments,particularly within smart city transportation systems,the abundance of devices and nodes poses significant challenges related to power consumption and system *** address the challenges of latency,energy consumption,and fault tolerance in these environments,this paper proposes a latency-aware,faulttolerant framework for resource scheduling and data management,referred to as the FORD framework,for smart cities in fog *** framework is designed to meet the demands of time-sensitive applications,such as those in smart transportation *** FORD framework incorporates latency-aware resource scheduling to optimize task execution in smart city environments,leveraging resources from both fog and cloud *** simulation-based executions,tasks are allocated to the nearest available nodes with minimum *** the event of execution failure,a fault-tolerantmechanism is employed to ensure the successful completion of *** successful execution,data is efficiently stored in the cloud data center,ensuring data integrity and reliability within the smart city ecosystem.

关键词： Fog computing smart cities smart transportation data management fault tolerance resource scheduling

Crosstalk between degradation and bioenergetics: how autophagy and endolysosomal processes regulate energy production

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Neural Regeneration Research 2025年第3期20卷 671-681页

作者： Angelid Pabon Jagannatham Naidu Bhupana Ching-On Wong department of Biological Sciences Rutgers UniversityNewarkNJUSA

Cells undergo metabolic reprogramming to adapt to changes in nutrient availability, cellular activity, and transitions in cell states. The balance between glycolysis and mitochondrial respiration is crucial for energy production, and metabolic reprogramming stipulates a shift in such balance to optimize both bioenergetic efficiency and anabolic requirements. Failure in switching bioenergetic dependence can lead to maladaptation and pathogenesis. While cellular degradation is known to recycle precursor molecules for anabolism, its potential role in regulating energy production remains less explored. The bioenergetic switch between glycolysis and mitochondrial respiration involves transcription factors and organelle homeostasis, which are both regulated by the cellular degradation pathways. A growing body of studies has demonstrated that both stem cells and differentiated cells exhibit bioenergetic switch upon perturbations of autophagic activity or endolysosomal processes. Here, we highlighted the current understanding of the interplay between degradation processes, specifically autophagy and endolysosomes, transcription factors, endolysosomal signaling, and mitochondrial homeostasis in shaping cellular bioenergetics. This review aims to summarize the relationship between degradation processes and bioenergetics, providing a foundation for future research to unveil deeper mechanistic insights into bioenergetic regulation.

关键词： autophagy bioenergetics endolysosome energy production glycolysis metabolic reprogramming mitochondria