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Mid-term survival of the Optimys short stem: A prospective case series of 500 patients

World Journal of orthopedics 2024年第3期15卷 257-265页

作者： Bryan Hamans Sheryl de Waard Sjoerd Kaarsemaker Esther R C Janssen Inger N Sierevelt Gino M M J Kerkhoffs Daniël Haverkamp department of Orthopaedic Surgery Xpert ClinicAmsterdam 1101EANetherlands department of Orthopedic Surgery Amsterdam University Medical CenterAmsterdam 1105 AZNetherlands Esther R C Janssen Department of Orthopaedic SurgeryViecuri Medisch CentrumVenlo 5912 BLNetherlands Centre for Orthopaedic Research Spaarne ZiekenhuisHoofddorp 2134 TMNetherlands department of Orthopaedic Surgery and sports medicine Amsterdam UMC-Location AMCAmsterdam 1105 AZNetherlands department of Orthopedic Surgery Xpert Orthopedic Surgery ClinicAmsterdam 1101 EANetherlands

BACKGROUND In recent years,there has been an increase in the number of total hip arthroplasty procedures in the younger patient *** active group has higher expectations of their prosthesis in comparison to the older population,and there is a greater physical demand for the *** femoral stems were in-troduced to retain proximal bone stock and joint biomechanics and became more common to implant in this specific ***,the long-term survival and functional outcomes of various short stems are still being investigated in different *** To determine the 5-year survival of the Optimys hip *** This was a prospective multicenter cohort study of 500 patients conducted in two hospitals in the *** patients received the Optimys short stem(Mathys Ltd,Bettlach,Switzerland).The primary outcome measure was survival of the hip stem,with revision as the *** secondary outcome measurements included patient-reported outcome measures(PROMs).Kaplan-Meier analysis was used to calculate the 5-year survival ***-minus-log transformation was performed to calculate the 95%confidence interval(95%CI).Mixed model analyses were performed to assess the course of the PROMs during the 1st 2 years after *** were modeled separately for the 1st and 2nd years to calculate the yearly change in PROMs during both follow-up periods with accompanying 95%*** The mean age of the total 500 patients was 62.3 years(standard deviation:10.6)and 202 were male(40%).At a median follow-up of 5.5 years(interquartile range:4.5-6.7),7 patients were deceased and 6 revisions were registered,for infection(n=3),subsidence(n=2)and malposition(n=1).This resulted in an overall 5-year survival of 98.8%(95%CI:97.3-99.5).If infection was left out as reason for revision,a stem survival of 99.4%(95%CI:98.1-99.8)was *** questionnaires were completed by 471 patients(94%),317 patients(63%)completed the 1-year follow-up questionna

关键词： Total hip arthroplasty Femoral stem Short stem Optimys Survival 5-year survival Revision PROMs

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Exercise promotes osteogenic differentiation by activating the long non-coding RNA H19/microRNA-149 axis

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World Journal of orthopedics 2024年第4期15卷 363-378页

作者： Xu-Chang Zhou Dong-Xue Wang Chun-Yu Zhang Ya-Jing Yang Ruo-Bing Zhao Sheng-Yao Liu Guo-Xin Ni School of Sport medicine and Rehabilitation Beijing Sport UniversityBeijing 100084China department of Acupuncture and Moxibustion Hubei University of Chinese MedicineWuhan 430065Hubei ProvinceChina department of Spinal Surgery The Second Affiliated Hospital of Guangzhou Medical UniversityGuangzhou 510260Guangdong ProvinceChina department of Rehabilitation medicine The First Affiliated Hospital of Xiamen UniversityXiamen 361003Fujian ProvinceChina

BACKGROUND Regular physical activity during childhood and adolescence is beneficial to bone development,as evidenced by the ability to increase bone density and peak bone mass by promoting bone *** To investigate the effects of exercise on bone formation in growing mice and to investigate the underlying *** 20 growing mice were randomly divided into two groups:Con group(control group,n=10)and Ex group(treadmill exercise group,n=10).Hematoxylin-eosin staining,immunohistochemistry,and micro-CT scanning were used to assess the bone formation-related indexes of the mouse *** analysis was used to find potential miRNAs targets of long non-coding RNA H19(lncRNA H19).RT-qPCR and Western Blot were used to confirm potential miRNA target genes of lncRNA H19 and the role of lncRNA H19 in promoting osteogenic *** Compared with the Con group,the expression of bone morphogenetic protein 2 was also significantly *** micro-CT results showed that 8 wk moderate-intensity treadmill exercise significantly increased bone mineral density,bone volume fraction,and the number of trabeculae,and decreased trabecular segregation in the femur of *** of lncRNA H19 significantly upregulated the expression of miR-149 and suppressed the expression of markers of osteogenic *** addition,knockdown of lncRNA H19 significantly downregulated the expression of autophagy markers,which is consistent with the results of autophagy-related protein changes detected in mouse femurs by *** Appropriate treadmill exercise can effectively stimulate bone formation and promote the increase of bone density and bone volume in growing mice,thus enhancing the peak bone mass of *** lncRNA H19/miR-149 axis plays an important regulatory role in osteogenic differentiation.

关键词： Exercise Osteogenic differentiation Bone formation Bone mesenchymal stem cells Autophagy

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Diamond-Like Carbon Depositing on the Surface of Polylactide Membrane for Prevention of Adhesion Formation During Tendon Repair

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Nano-Micro Letters 2024年第9期16卷 478-499页

作者： Yao Xiao Zaijin Tao Yufeng Ju Xiaolu Huang Xinshu Zhang Xiaonan Liu Pavel A.Volotovski Chao Huang Hongqi Chen Yaozhong Zhang Shen Liu department of Orthopaedics Shanghai Jiao Tong University School of Medicine Affiliated Sixth People’s Hospital600 Yishan RdShanghai 200233People’s Republic of China Shanghai Tongji Hospital 389 Xincun RdShanghai 200065People’s Republic of China Key Laboratory for Thin Film and Microfabrication of Ministry of Education Research Institute of Micro/Nano Science and TechnologyShanghai Jiao Tong UniversityShanghai 200240People’s Republic of China Orthopedic Trauma department Belarus Republic Scientific and Practical Center for Traumatology and OrthopedicsKizhevatova str.60/4220024 MinskBelarus Shanghai Haohai Biological Technology Limited Liability Company 1386 Hongqiao RdShanghai 200336People’s Republic of China department of General Surgery Shanghai Jiao Tong University School of Medicine Affiliated Sixth People’s Hospital600 Yishan RdShanghai 200233People’s Republic of China Shanghai Key Laboratory for High Temperature Materials and Precision Forming School of Materials Science and EngineeringShanghai Jiao Tong UniversityShanghai 200240People’s Republic of China

Post-traumatic peritendinous adhesion presents a significant challenge in clinical *** study proposes the use of diamond-like carbon(DLC)deposited on polylactic acid(PLA)membranes as a biophysical mechanism for anti-adhesion barrier to encase ruptured tendons in tendon-injured *** results indicate that PLA/DLC composite membrane exhibits more efficient anti-adhesion effect than PLA membrane,with histological score decreasing from 3.12±0.27 to 2.20±0.22 and anti-adhesion effectiveness increasing from 21.61%to 44.72%.Mechanistically,the abundant C=O bond functional groups on the surface of DLC can reduce reactive oxygen species level effectively;thus,the phosphorylation of NF-κB and M1 polarization of macrophages are ***,excessive inflammatory response augmented by M1 macrophage-originated cytokines including interleukin-6(IL-6),interleukin-1β(IL-1β),and tumor necrosis factor-α(TNF-α)is largely *** biocompatibility evaluation,PLA/DLC membrane is slowly absorbed within tissue and displays prolonged barrier effects compared to traditional PLA *** studies show the DLC depositing decelerates the release of degradation product lactic acid and its induction of macrophage M2 polarization by interfering esterase and PLA ester bonds,which further delays the fibrosis *** was found that the PLA/DLC membrane possess an efficient biophysical mechanism for treatment of peritendinous adhesion.

关键词： Diamond-like carbon Reactive oxygen species scavenging Foreign body reaction Biodegradation Antioxidant Peritendinous adhesion

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Fibula allograft transplantation combined with locking plate for treatment of recurrent monostotic fibular fibrous dysplasia:A case report

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World Journal of Clinical Cases 2023年第33期11卷 8050-8057页

作者： Lun-Li Xie Xiao Yuan Hong-Xia Zhu Lei Fu Dan Pu department of Joint and Hand orthopedics Hunan University of Medicine General HospitalHuaihua 418000Hunan ProvinceChina department of traumatic orthopedics Hunan University of Medicine General HospitalHuaihua 418000Hunan ProvinceChina department of orthopedics Hunan University of Medicine General HospitalHuaihua 418000Hunan ProvinceChina

BACKGROUND Fibrous dysplasia is a congenital disorder in which normal bone is replaced by fibro-osseous tissue or irregular trabeculae of woven bone intermixed with mature collagenous tissue.A single or multiple bones are *** rare bone disorder has three clinical patterns including monostotic,polyostotic,and that associated with McCune-Albright *** studies report primary fibrous ***,a few cases of recurrent monostotic fibular fibrous dysplasia have been ***,we report a therapeutic strategy for recurrent fibular fibrous *** SUMMARY A 4-year-old boy was admitted for persistent pain in the left lower limb and abnormal gait over the previous 9 *** had no history of present or past *** imaging data showed erosion-like changes with bone expansion of the left middle and lower fibular *** tissue in the fibular bone marrow cavity was removed by curettage,and rapid intraoperative pathological examination suggested fibular fibrous *** allograft was implanted into the fibular medullary ***,he was readmitted with clinical symptoms including persistent pain,abnormal gait,and local swelling at the age of 6 *** was diagnosed with recurrent fibular fibrous dysplasia based on the second medical *** underwent fibular bone tumor radical resection and longus fibular allograft transplantation combined with fibular bone locking plate and *** host bone to allogenic bone graft fusion was observed by the physician on postoperative regular *** Radical resection of fibrous dysplasia and longus fibula allograft combined with internal fixation for reconstruction are suitable for the treatment of recurrent monostotic fibular fibrous dysplasia.

关键词： Recurrent fibrous dysplasia Longus fibula allograft Bone fusion Case report

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Early patellar tendon rupture after total knee arthroplasty: A direct repair method

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World Journal of Clinical Cases 2022年第31期10卷 11349-11357页

作者： Tie-Jian Li Jing-Yang Sun Yin-Qiao Du Jun-Min Shen Bo-Han Zhang Yong-Gang Zhou department of orthopedics The First Medical Center of PLA General HospitalBeijing 100048China department of orthopedics The Fourth Medical Center of PLA General HospitalNational Clinical Research Center for OrthopedicsSports Medicine and RehabilitationBeijing 100853China

BACKGROUND Patellar tendon rupture after total knee arthroplasty(TKA)is a catastrophic *** the occurrence of this injury is rare,it can lead to significant dysfunction for the patient and is very tricky to deal *** has been no standard treatment for early patella tendon rupture after TKA,and long-term follow-up data are *** To introduce a direct repair method for early patella tendon rupture following TKA and determine the clinical outcomes and complications of this *** During the period of 2008 to 2021,3265 consecutive TKAs were retrospectively *** patients developed early patellar tendon rupture postoperatively and were treated by a direct repair *** follow-up was 5.7 ***,operative,and clinical data were *** clinical outcomes were assessed using the Western Ontario and McMaster Universities(WOMAC)score,the Hospital for Special Surgery(HSS)score,knee range of motion,extensor lag,and surgical *** statistics and paired t test were employed to analyze the *** For all 12 patients who underwent direct repair for early patellar tendon rupture,3 patients failed:One(8.3%)for infection and two(17.6%)for *** two patients with re-fracture both underwent reoperation to reconstruct the extensor mechanism and the patient with infection underwent revision *** range of motion was 109.2°±10.6°preoperatively to 87.9°±11°postoperatively,mean extensor lag was 21°at follow-up,and mean WOMAC and HSS scores were 65.8±30.9 and 60.3±21.7 points,*** This direct repair method of early patellar tendon rupture is not an ideal *** is actually ineffective for the recovery of knee joint function in patients,and is still associated with severe knee extension lag and high complication *** with the outcomes of other repair methods mentioned in the literature,this direct repair method shows poor clinical outcomes.

关键词： Direct repair Patellar tendon fracture Total knee arthroplasty Reconstruction High complication rates

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Vancomycin lavage for the incidence of acute surgical site infection following primary total hip arthroplasty and total knee arthroplasty

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World Journal of Clinical Cases 2022年第1期10卷 71-78页

作者： Ming-Yi Duan Hang-Zhou Zhang department of orthopedics Joint Surgery and Sports MedicineFirst Affiliated Hospital of China Medical UniversityShenyang 110001Liaoning ProvinceChina

BACKGROUND Surgical site infection is a rare but serious complication associated with total joint arthroplasty(TJA).There are limited data on the effectiveness of intrawound irrigation with vancomycin solution(1000 mg/L;2 L)before wound closure for preventing acute surgical site infection following primary total hip arthroplasty(THA)and total knee arthroplasty(TKA).AIM To investigate the effectiveness of prophylactic intraoperative application of vancomycin(1000 mg/L;2 L)solution *** irrigation in reducing the incidence of acute surgical site infection following primary THA and *** A retrospective review of 2725 consecutive patients undergoing THA or TKA from January 2012–December 2019 was *** patients received either intrawound irrigation with normal saline before wound closure between January 2012 and December 2015(group 1,1018 patients;453 undergoing THA and 565 undergoing TKA)or intrawound irrigation with vancomycin solution(1000 mg/L)before wound closure between January 2016 and December 2019(group 2,1175 patients;512 undergoing THA and 663 undergoing TKA).The outcomes were the incidences of postoperative surgical site infection and wound healing complications within 3 mo of primary *** There were no significant demographic differences between the 2 *** was a significantly higher incidence of acute infection at the surgical site in patients who received intrawound irrigation with normal saline before wound closure than in those who received intrawound irrigation with vancomycin solution(1000 mg/L;2 L)before wound closure(overall incidence of infection:group 1,2.46%vs group 2,0.09%,P<0.001).There was no significant difference in the incidence of wound healing complications between the two *** Prophylactic irrigation with vancomycin solution(1000 mg/L;2 L)significantly decreases the incidence of acute surgical site infection after primary *** strategy is a safe,efficacious,and inexpensive method for red

关键词： Total joint arthroplasty Total hip arthroplasty Total knee arthroplasty Vancomycin irrigation Postoperative acute wound infection Acute surgical site infection

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Chitin scaffold combined with autologous small nerve repairs sciatic nerve defects

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Neural Regeneration Research 2022年第5期17卷 1106-1114页

作者： Bo Wang Chang-Feng Lu Zhong-Yang Liu Shuai Han Pi Wei Dian-Ying Zhang Yu-Hui Kou Bao-Guo Jiang department of orthopedics and Trauma Key Laboratory of Trauma and Neural Regeneration(Ministry of Education/Peking University)Peking University People’s HospitalBeijingChina department of orthopedics Chinese PLA General HospitalBeijingChina National Clinical Research Center for orthopedics Sports Medicine&RehabilitationBeijingChina

Although autologous nerve transplantation is the gold standard for treating peripheral nerve defects,it has many clinical *** an alternative,various tissue-engineered nerve grafts have been developed to substitute for autologous *** this study,a novel nerve graft composed of chitin scaffolds and a small autologous nerve was used to repair sciatic nerve defects in *** novel nerve graft greatly facilitated regeneration of the sciatic nerve and myelin sheath,reduced atrophy of the target muscle,and effectively restored neurological *** the epineurium of the small autogenous nerve was removed,the degree of nerve regeneration was similar to that which occurs after autogenous nerve *** findings suggest that our novel nerve graft might eventually be a new option for the construction of tissue-engineered nerve *** study was approved by the Research Ethics Committee of Peking University People's Hospital(approval No.2019 PHE27)on October 18,2019.

关键词： autologous small nerve chitin scaffold nerve defect nervous system peripheral nerve injury peripheral nerve regeneration sciatic nerve trauma

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Surgery for fibrous dysplasia associated with aneurysmal-bone-cystlike changes in right proximal femur:A case report

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世界临床病例杂志 2023年第26期11卷 6170-6175页

作者： Lun-Li Xie Xiao Yuan Hong-Xia Zhu Dan Pu department of Joint and Hand orthopedics Hunan University of Medicine General HospitalHuaihua 418000Hunan ProvinceChina department of Joint and Hand Surgery Hunan University of Medicine General HospitalHuaihua 418000Hunan ProvinceChina department of traumatic orthopedics Hunan University of Medicine General HospitalHuaihua 418000Hunan ProvinceChina department of orthopedics Hunan University of Medicine General HospitalHuaihua 418000Hunan ProvinceChina

BACKGROUND Fibrous dysplasia associated with aneurysmal bone cyst(ABC)-like changes in the right proximal femur has a low *** is considered more difficult to make early diagnosis than for single fibrous *** SUMMARY A 14-year-old woman was admitted because of persistent pain in the right hip and abnormal gait over the previous 2 *** had no history of present or past *** photography,enhanced computed tomography,and magnetic resonance imaging showed ground-glass appearance with cortical scalloping and expansion of the right proximal femur and femoral *** examination by preoperative puncture biopsy revealed fibrous dysplasia of the right proximal *** patient was diagnosed with fibrous dysplasia based on medical history,physical examination,and results of laboratory,imaging and pathological *** to final pathological examination,the patient was diagnosed with fibrous dysplasia of the right proximal femur associated with *** and allograft along with fixation of compression screws was performed for fibrous dysplasia associated with ABClike *** obvious allograft absorption,loosening of fixation,or secondary fracture were observed during 6-months’follow-up with re-examination by plain radiography and computed *** dysplasia associated with ABClike changes in the right proximal femur has a low incidence and early diagnosis is considered more difficult than for single fibrous *** We report a cases of fibrous dysplasia associated with ABC-like changes in the right proximal femur treated with curettage and allograft along with hip compression screws.

关键词： Fibrous dysplasia Aneurysmal bone cyst Curettage Allograft Hip compression screws Case report

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Chinese expert consensus on the diagnosis and treatment of borderline developmental dysplasia of the hip (2022 Edition)

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Chinese Medical Journal 2023年第9期136卷 1012-1014页

作者： Jia Zhang Chunbao Li Mingyang An Yidong Wu Kangkang Yu Yujie Liu The Youth Group of the sports medicine Branch of the Chinese Medical Association The Hip sports Injury Working Committee of the sports medicine Branch of the Chinese Medical Association The Hip Preservation Group of the Rehabilitation Reconstruction Surgery Committee of the Chinese Association of Rehabilitation medicine The Hip Preservation Group of Orthopaedic Surgeon Branch of the Chinese Medical Doctor Association department of sports medicine Senior Department of OrthopedicsThe Fourth Medical Center of Chinese PLA General HospitalBeijing 100853China Medical School of Chinese PLA Beijing 100853China 不详

Developmental dysplasia of the hip(DDH)is one of the most common diseases causing hip pain in adults and is an important cause of osteoarthritis(OA).Borderline developmental dysplasia of the hip(BDDH)is a condition that falls between a normal hip and adult *** BDDH,the lateral center-edge angle(LCEA)of the acetabulum is usually defined between 18°and 25°or 20°and 25°;however,this definition remains controversial.

关键词： dysplasia diagnosis diseases

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Comment on “Outcomes of different minimally invasive surgical treatments for vertebral compression fractures: An observational study”

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World Journal of Clinical Cases 2022年第12期10卷 3966-3968页

作者： Long Ma Zhi-Wen Luo Ya-Ying Sun department of orthopedics The First People's Hospital of Pindingshan CityPingdingshan 467000Henan ProvinceChina department of sports medicine Huashan HospitalFudan UniversityShanghai 200040China

Recently we read the article entitled“Outcomes of different minimally invasive surgical treatments for vertebral compression fractures:An observational study”.This was an observational study that reviewed the safety and efficacy of different cement augmentation modalities for vertebral compression fractures under osteoporotic ***,this is a valuable study that can provide a reference for clinical *** the other hand,we also noticed some points in the article and are willing to share our *** studies with a higher level of evidence can add more knowledge regarding relevant concerns.

关键词： Vertebral compression fractures Osteoporosis Study design Observational study Randomize

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