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The outcomes and safety of patients undergoing endoscopic retrograde cholangiopancreatography combining a single-use cholangioscope and a single-use duodenoscope:A multicenter retrospective international study

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Hepatobiliary & Pancreatic Diseases International 2024年第1期23卷 71-76页

作者： Alessandro Fugazza Matteo Colombo Michel Kahaleh V.Raman Muthusamy Bick Benjamin Wim Laleman Carmelo Barbera Carlo Fabbri Jose Nieto Abed Al-Lehibi Mohan Ramchandani Amy Tyberg Haroon Shahid Avik Sarkar Dean Ehrlich Stuart Shermand Cecilia Binda Marco Spadaccini Andrea Iannone Kareem Khalaf Nageshwar Reddy Andrea Anderloni Alessandro Repici Division of Gastroenterology and Digestive Endoscopy Humanitas Research Hospital-IRCCSVia Manzoni 5620089RozzanoMilanoItaly Gastroenterology Rutgers Robert Wood JohnsonNew BrunswickNew JerseyUSA Vatche and Tamar Manoukian Division of Digestive Diseases University of CaliforniaLos Angeles School of Medicine at UCLALos AngelesCaliforniaUSA Division of Digestive and Liver Disorders Indiana University School of MedicineIndianapolisINUSA department of Gastroenterology and Hepatology University Hospitals LeuvenKU Leuven3000 LeuvenBelgium U.O.C.di Gastroenterologia ed Endoscopia Digestiva Ospedale Giuseppe MazziniASL TeramoItaly Gastroenterology and Digestive Endoscopy Unit Forlì-Cesena HospitalsAUSL RomagnaForlì-CesenaItaly Borland Groover Clinic JacksonvilleFloridaUSA department of Gastroenterology and Hepatology King Fahad Medical CityRiyadhSaudi Arabia Asian Institute of Gastroenterology HyderabadIndia Section of Gastroenterology Department of Emergency and Organ TransplantationUniversity of BariBari 70124Italy department of Biomedical Sciences Humanitas UniversityVia Rita Levi Montalcini 420090Pieve EmanueleMilanItaly

Background: Duodenoscope-related multidrug-resistant organism(MDRO) infections raise concerns. Disposable duodenoscopes have been recently introduced in the market and approved by regulatory agencies with the aim to reduce the risk of endoscopic retrograde cholangiopancreatography(ERCP) associated infections. The aim of this study was to evaluate the outcome of procedures performed with single-use duodenoscopes in patients with clinical indications to single-operator cholangiopancreatoscopy. Methods: This is a multicenter international, retrospective study combining all patients who underwent complex biliopancreatic interventions using the combination of a single-use duodenoscope and a single-use cholangioscope. The primary outcome was technical success defined as ERCP completion for the intended clinical indication. Secondary outcomes were procedural duration, rate of cross-over to reusable duodenoscope, operator-reported satisfaction score(1 to 10) on performance rating of the single-use duodenoscope, and adverse event(AE) rate. Results: A total of 66 patients(26, 39.4% female) were included in the study. ERCP was categorized according to ASGE ERCP grading system as 47(71.2%) grade 3 and 19(28.8%) grade 4. The technical success rate was 98.5%(65/66). Procedural duration was 64(interquartile range 15-189) min, cross-over rate to reusable duodenoscope was 1/66(1.5%). The satisfaction score of the single-use duodenoscope classified by the operators was 8.6 ± 1.3 points. Four patients(6.1%) experienced AEs not directly related to the single-use duodenoscope, namely 2 post-ERCP pancreatitis(PEP), 1 cholangitis and 1 ***: Single-use duodenoscope is effective, reliable and safe even in technically challenging procedures with a non-inferiority to reusable duodenoscope, making these devices a viable alternative to standard reusable equipment.

关键词： Single-operator cholangioscopy Single-use duodenoscope Endoscopic retrograde cholangiopancreatography Indeterminate biliary stricture Difficult biliary stones

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Challenges and advancing strategies of endoscopic submucosal dissection for early gastric cancer:The puzzle of eCura C1

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World Journal of Gastrointestinal Endoscopy 2024年第8期16卷 439-444页

作者： Giulio Calabrese Guido Manfredi Marcello F Maida Francesco V Mandarino Endrit Shahini Francesco Pugliese Paolo Cecinato Liboria Laterza Emanuele Sinagra Sandro Sferrazza department of Gastroenterology and Endoscopy ARNAS Civico–Di Cristina–BenfratelliPalermo 90127SiciliaItaly department of Gastroenterology and Digestive Endoscopy Ospedale MaggioreCrema 26013Italy department of medicine and Surgery University of Enna"Kore"Enna 94100SiciliaItaly department of Gastroenterology and Digestive Endoscopy IRCCS Ospedale San RaffaeleMilan 20132LombardyItaly department of Gastroenterology National Institute of Gastroenterology-IRCCS“Saverio de Bellis”Castellana GrotteBari 70013Italy department of Digestive and Interventional Endoscopy Niguarda HospitalASST NiguardaMilan 20162LombardyItaly department of Medical and Surgical Sciences IRCCS Azienda Ospedaliero-Universitaria di BolognaPoliclinico Sant’OrsolaBologna 40138Emilia-RomagnaItaly department of Gastroenterology and Endoscopy Fondazione Instituto San Raffaele GiglioCefalù90015PalermoItaly

In this editorial,we explore the challenges of managing noncurative resections in early gastric cancer after endoscopic submucosal dissection(ESD),starting from the consideration recently made by Zhu et ***,we evaluate the management of eCura C1 lesions,where decisions regarding further interventions are pivotal yet *** among endoscopists,surgeons,and pathologists is underscored to refine risk assessment and personalize therapeutic *** advancements in ESD techniques and interdisciplinary collaboration offer opportunities for outcome optimization in managing eCura C1 ***,despite needing further clinical validation,molecular biomarkers have emerged as promising tools for enhancing *** manuscript highlights the ongoing research attempts to define treatment paradigms effectively and evaluates the potential of emerging options,ultimately aiming to improve patient care and outcomes in this complex clinical scenario.

关键词： Early gastric cancer Endoscopic submucosal dissection eCura Non-curative resection Multidisciplinary approach

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β-Estradiol 17-acetate enhances the in vitro vitality of endothelial cells isolated from the brain of patients subjected to neurosurgery

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Neural Regeneration Research 2023年第2期18卷 389-395页

作者： Sonia Guzzo Pasquale De Bonis Barbara Pavan Luciano Fadiga department of Neuroscience and Rehabilitation Section of PhysiologyUniversity of FerraraFerraraItaly Center for Translational Neurophysiology of Speech and Communication(CTNSC) Italian Institute of Technology(IIT)FerraraItaly department of Translational medicine and for romagna University of FerraraFerraraItaly

In the current landscape of endothelial cell isolation for building in vitro models of the blood-brain barrier,our work moves towards reproducing the features of the neurovascular unit to achieve glial compliance through an innovative biomimetic coating technology for brain chronic *** hypothesized that the autologous origin of human brain mic rovascular endothelial cells(hBMECs)is the first requirement for the suitable coating to prevent the glial inflammato ry response trigge red by foreign *** re,this study established a new procedure to preserve the in vitro viability of hBMECs isolated from gray and white matter specimens taken from neurosurge ry *** adult hBMECs is generally considered a challenging task due to the difficult survival ex vivo and progressive reduction in proliferation of these *** addition of 10 nMβ-estradiol 17-acetate to the hBMEC culture medium was found to be an essential and discriminating factor promoting adhesion and proliferation both after isolation and thawing,suppo rting the well-known protective role played by estrogens on *** particular,β-estradiol 17-acetate was critical for both freshly isolated and thawed female-derived hBMECs,while it was not necessary for freshly isolated male-derived hBMECs;however,it did countera ct the decay in the viability of the latter after *** tumo r-free hBMECs were thus cultured for up to 2 months and their growth efficiency was assessed befo re and after two periods of *** pite the thermal stress,the hBMECs remained viable and suitable for re-freezing and storage for several *** approach increasing in vitro viability of hBMECs opens new perspectives for the use of cryopreserved autologous hBMECs as biomimetic therapeutic tools,offering the potential to avoid additional surgical sampling for each patient.

关键词： β-estradiol 17-acetate 17β-estradiol cryopreservation gender-specific gray matter human brain microvascular endothelial cells surgical resections vascular protection white matter

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Giant retroperitoneal liposarcoma treated with radical conservative surgery: A case report and review of literature

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World Journal of Clinical Cases 2022年第19期10卷 6636-6646页

作者： Eva Lieto Francesca Cardella Silvia Erario Giovanni Del Sorbo Alfonso Reginelli Gennaro Galizia Fabrizio Urraro Iacopo Panarese Annamaria Auricchio department of traslational Medical Sciences University of Campania"L.Vanvitelli"Naples 80128CampaniaItaly department of Precision medicine University of Campania"L.Vanvitelli"Naples 80138CampaniaItaly Depatment of Pathology Unit-Menthal Health University of Campania"L.Vanvitelli"Naples 80132CampaniaItaly

BACKGROUND Retroperitoneal liposarcoma(RLPS)is a rare malignant tumor of the connective tissue and usually grows to a large size,*** is currently based on collective findings from clinical examinations and computed tomography(CT)and magnetic resonance imaging,the latter of which show a fat density mass and possible surrounding organ *** resection is the main therapeutic *** efficacy and safety of further therapeutic choices,such as chemotherapy and radiotherapy,are still *** SUMMARY A 61-year-old man presented with complaint of a large left inguinal mass that had appeared suddenly,after a slight *** revealed an omental inguinal *** further clinical examination,an enormous palpable abdominal mass,continuing from the left inguinal location,was *** revealed a giant RLPS,with remarkable mass effect and wide visceral *** multidisciplinary consultation,surgical intervention was *** neoadjuvant chemotherapy and radiotherapy were precluded by the mass’large size and retroperitoneal localization,features typically associated with non-response to these types of ***,the patient underwent conservative treatment via radical surgical *** 1 year,his clinical condition remained good,with no radiological signs of *** Conservative treatment via surgery resulted in a successful outcome for a large RLPS.

关键词： Retroperitoneal liposarcoma Giant sarcoma Sarcoma surgical treatment Sarcoma diagnosis Differentiated liposarcoma Retroperitoneal sarcoma surgical outcome Case report

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OxInflammation in Alzheimer's disease

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Neural Regeneration Research 2023年第12期18卷 2709-2710页

作者： Carlo Cervellati Giovanni Zuliani Giuseppe Valacchi department of Translational medicine and for romagna University of FerraraFerraraItaly department of Environmental Sciences and Prevention University of FerraraFerraraItaly Plants for Human Health Institute Animal Science DepartmentNC State UniversityKannapolisNCUSA department of Food and Nutrition Kyung Hee UniversitySeoulSouth Korea

Oxlnflammation:definition and role in disease:Oxlnflammation has been introduced as a new term in the biomedical field to highlight the deep and mutual relationship between the dysregulation of redox and immune homeostasis(Valacchi et al.,2018).Regardless of which is the initial spark,inflammation cannot take place without a concomitant oxidative stress response and *** other words,they are sides of the same coin.

关键词： al. homeostasis inflammation

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Multi-disciplinary clinic models for the management of non-alcoholic fatty liver disease

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Hepatobiliary Surgery and Nutrition 2022年第4期11卷 586-591页

作者： Mirko Zoncapè Antonio Liguori Emmanuel A.Tsochatzis University College London(UCL)Institute for Liver and Digestive Health Royal Free Hospital and UCLLondonUK Liver Unit Division of General Medicine CDepartment of Internal MedicineUniversity and Azienda Ospedaliera Universitaria Integrata of VeronaVeronaItaly department of traslational medicine and Surgery Fondazione Policlinico Universitario Agostino Gemelli IRCCSUniversitàCattolica del Sacro CuoreRomeItaly

In recent years,there has been an increasing interest in the implementation of multi-disciplinary clinic(MDC)models in the medical field,in an effort to improve coordination of care due to the increasing complexity of medical *** is therefore unsurprising that there is such interest in non-alcoholic fatty liver disease(NAFLD),which is now the most prevalent liver disease worldwide.

关键词： clinic liver NAFLD

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Suggestions on gut-eye cross-talk:about the chalazion

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International Journal of Ophthalmology(English edition) 2022年第9期15卷 1566-1566页

作者： Carla Enrica Gallenga Marco Mura Pier Enrico Gallenga department of Medical Sciences University of FerraraFerrara 44124Italy Eye Unit UOC University Hospital Arcispedale Sant’AnnaFerrara 44124Italy department of traslational medicine and for romagna University of FerraraFerrara 44124Italy department of Ophthalmology Pescara 65100Italy

Dear Editor,We have studied with interest the publication"Effectiveness of oral probiotics supplementation in the treatment of adult small chalazion"by Filippelli et al[1].The conclusion of this work is exciting:the dialogue between gut and eye(brain)is now under the magnification lens and it deserves to continue the relationship studies,previously started by Filippelli et al[2]also on children.

关键词： conclusion gut exciting

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Dengue and falciparum malaria co-infection in travelers returning from Burkina Faso:Report of two cases in Northeastern Italy

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Asian Pacific Journal of Tropical medicine 2023年第3期16卷 139-142页

作者： Antonio Mastroianni Caterina Vocale Vittorio Sambri Tiziana Lazzarotto Paolo Gaibani Giada Rossini Stefania Varani Infectious&Tropical Diseases Unit Department of Specialty Medicine“Annunziata”Hub HospitalAzienda Ospedaliera di CosenzaCosenzaItaly Infectious&Tropical Diseases Unit Department of Specialty Medicine“G.B.Morgagni-L.Pierantoni”HospitalForlìItaly Microbiology Unit IRCCS Azienda Ospedaliero-Universitaria di BolognaBolognaItaly department of medicine and Surgery University of BolognaBolognaItaly Great romagna Hub Laboratory Unit of MicrobiologyPievesestinaCesenaItaly

Rationale: Malaria and dengue are the most prevalent vector-borne diseases in tropical countries. Plasmodium parasite and dengue virus(DENV) concurrent infection is possible and often under-recognized in geographical areas where these infections are both *** concern and diagnosis: We describe the first two cases of Plasmodium falciparum and DENV-3 co-infection in travelers returning to northeastern Italy from Burkina Faso during ***: Malaria infection in both patients was treated with mefloquine. Due to the persistence of symptoms despite of the antimalaria treatment, dengue was also investigated;the treatment of dengue was ***: The patients were discharged in good general ***: The need for surveillance of potential malaria and dengue co-infection in travelers returning to Europe from endemic areas is highlighted, as infection with Plasmodium does not exclude arboviral co-infection.

关键词： Dengue virus Falciparum malaria Travelers infection Co-infection Arbovirus

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BACE1 role in Alzheimer’s disease and other dementias:from the theory to the practice

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Neural Regeneration Research 2021年第12期16卷 2407-2408页

作者： Carlo Cervellati Giuseppe Valacchi Giovanni Zuliani department of Translational medicine and for romagna University of FerraraFerraraItaly department of Biomedical and Specialist Surgical Sciences University of FerraraFerraraItalyPlants for Human Health InstituteAnimal Science DepartmentNC State UniversityKannapolisNCUSA

Beta-site amyloid precursor protein(APP)cleaving enzyme-1(BACE1):brief overview on the biology and its role in Alzheimer’s disease(AD)pathogenesis:AD is a multifactorial and multifaceted disease,with a complex and still not completely understood pathogenesis(Cervellati et al.,2016;Iturria-Medina et al.,2016).Multiple hypotheses have been proposed to explain the pathobiology of the disease.

关键词： BACE1 Alzheimer al.

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A strange case of cervical pain

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Health 2012年第5期4卷 285-287页

作者： Jonathan Montomoli Davide Lazzarini Luca Morolli Giorgio Ioli Third department of medicine Santarcangelo di Romagna Italy

A 56-year-old man was admitted to hospital with fever, progressive fatigue, bilateral shoulder pain, paresthesias and stiffness after awakening. Differential diagnosis were several diseases such as rheumatoid arthritis, fibromyalgia and infectious spondylitis. Routine laboratory assays showed mild anemia and increased markers of inflammation. The worsening of clinical conditions led to performing a Computerized Tomography and a Cervical Magnetic Resonance Imaging which demonstrated an epidural liquid area in both left and anterior section of the spinal canal. Due to the high suspicious of tuberculosis we started a therapy with isoniazid, rifampicin, pyrazinamide and cyprofloxacin, even if the results of culture was negative for any kind of bacteria. This case-report underlines the difficulties of a correct diagnosis in a common symptom as back pain is.

关键词： Inflammatory Back Pain Spinal Tuberculosis Fibromyalgia

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