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A retrospective analysis of carbapenem-resistant Acinetobacter baumannii infections in critically ill patients:Experience at a tertiary-care teaching hospital ICU

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Journal of Intensive medicine 2024年第2期4卷 181-186页

作者： Leyla Ferlicolak Neriman Defne Altintas Fugen Yoruk department of Internal medicine Division of Intensive Care Unit Ankara University Faculty of MedicineAnkaraTurkey department of Infectious Diseases and clinical microbiology Ankara University Faculty of MedicineAnkaraTurkey

Background Acinetobacter baumannii is a clinically significant pathogen with a high incidence of multidrug resistance that is associated with life-threatening nosocomial ***,we aimed to provide an insight into the clinical characteristics and outcomes of a unique group of *** infections in which the isolates were resistant to carbapenems and most other antibiotic groups in a tertiary-care intensive care unit(ICU).Methods We performed a retrospective observational study in which records of patients hospitalized in the ICU between June 1,2021 and June 1,2023 were *** checked the clinical,laboratory,and microbiological records of all adult patients who had carbapenem-resistant ***(CRAB)*** antibiotic treatments and definitive antibiotic treatments after culture positivity and susceptibility test results were recorded.C-reactive protein(CRP)and procalcitonin levels and leukocyte counts were *** of ICU stay and 30-day mortality were defined as the outcome *** During the study period,57 patients were diagnosed with CRAB *** respiratory tract was the leading infection site(80.7%).In non-survivors,bloodstream infections(21.9%vs.4.0%P=0.05)and colistin-resistant(col-R)CRAB infections(43.8%vs.24.0%,P=0.12)were more common than in survivors,but these parameters were not statistically *** length of ICU stay was not different between survivors and ***,the rate of col-R among CRAB clinical isolates was 35.1%.The 30-day mortality in all patients with CRAB infection was 56.1%.Mortality in col-R CRAB and colistin-susceptible(col-S)CRAB infections was 70.0%and 48.6%,respectively(P=0.12).Prior carbapenem use was 56.1%.Prior colistin use before col-R and col-S CRAB infections was not significant(35.0%vs.27.0%,P=0.53).Conclusions Our study provides real-world data on highly resistant *** infections and shares the characteristics of infections with such resistant stra

关键词： Mortality Colistin-resi stant Gram-negative bacteria MDR Intensive care unit

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Dengue hemorrhagic fever with rectus sheath hematoma:A case report

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Asian Pacific Journal of Tropical medicine 2024年第3期17卷 136-138页

作者： Boudhayan Bhattacharjee Hardik Patel Rucha Karad Vasireddy Teja Agnibho Mondal Soumendra Nath Haldar Bibhuti Saha department of Infectious Diseases and Advanced microbiology School of Tropical MedicineKolkataIndia

Rationale:Acute pain is a medical emergency that requires prompt abdominal evaluation and ***,a mosquito-borne arboviral infection,can lead to complications such as acute abdominal *** concerns:A 72-year-old hypertensive female presented with high-grade intermittent fever with chills and rigors for four *** was diagnosed with dengue fever(NS1Ag-reactive)the day before admission.A contrast-enhanced computed tomography of the abdomen showed a hematoma along the rectus sheath which was managed conservatively as per surgical ***:Dengue hemorrhagic fever with rectus sheath ***:Blood transfusion and fluid ***:Ten days after discharge,the patient reproted no pain in the right iliac fossa and the size of the hematoma was significantly ***:Although it is rarely seen as a cause of acute abdomen,complaints of adnominal pain should never be ignored in critical or convalescent phase of dengue *** investigations should be promptly conducted as hematoma is often difficult to be diagnosed *** in diagnosis of rectus sheath hematoma can be fatal.

关键词： Dengue fever Rectus sheath hematoma Surgical emergency Acute appendicitis

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The Influence of Tartaric Acid in the Silver Nanoparticle Synthesis Using Response Surface Methodology

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Journal of Renewable Materials 2024年第2期12卷 245-258页

作者： Yatim Lailun Ni’mah Afaf Baktir Dewi Santosaningsih Suprapto Suprapto Chemistry department Faculty of Science and Data AnalyticsInstitut Teknologi Sepuluh NopemberSurabayaIndonesia Chemistry department Faculty of Science and TechnologyAirlangga UniversitySurabayaIndonesia department clinical microbiology Faculty of MedicineBrawijaya UniversityMalangIndonesia

Silver nanoparticles(AgNPs)synthesized using tartaric acid as a capping agent have a great impact on the reaction kinetics and contribute significantly to the stability of *** protective layer formed by tartaric acid is an important factor that protects the silver surface and reduces potential cytotoxicity *** attributes are critical for assessing the compatibility of AgNPs with biological systems and making them suitable for drug delivery *** aim of this research is to conduct a comprehensive study of the effect of tartaric acid concentration,sonication time and temperature on the formation of silver *** Response Surface Methodology(RSM)with Face-Centered Central Composite Design(FCCD),the optimization process identifies the most favorable synthesis ***-Vis spectrum regression analysis shows that AgNPs stabilized with tartaric acid are more stable than AgNPs without tartaric *** highlights the increased stability that tartaric acid provides in AgNP *** size distribution analysis showed a multimodal distribution for AgNPs with tartaric acid and showed the smallest size peak with an average size of 20.53 *** second peak with increasing intensity shows a dominant average size of 108.8 nm accompanied by one standard deviation of 4.225 nm and a zeta potential of−11.08 *** contrast,AgNPs synthesized with polyvinylpyrrolidone(PVP)showed a unimodal particle distribution with an average particle size of 81.62 nm and a zeta potential of−2.96 *** more negative zeta potential of AgNP-tartaric acid indicates its increased *** of antibacterial activity showed that AgNPs stabilized with tartaric acid showed better performance against *** and *** bacteria compared with *** summary,this study highlights the potential of tartaric acid in AgNP synthesis and suggests an avenue for the development of stable AgNPs with versatile applications.

关键词： Tartaric acid silver nanoparticle polyvinyl pyrrolidone response surface methodology

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Emerging role of galectin 3 in neuroinflammation and neurodegeneration

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Neural Regeneration Research 2024年第9期19卷 2004-2009页

作者： Brian M.Lozinski Khanh Ta Yifei Dong department of clinical Neuroscience University of CalgaryCalgaryABCanada Deparment of Biochemistry Microbiology&ImmunologyUniversity of SaskatchewanSaskatoonSKCanada

Neuroinflammation and neurodegeneration are key processes that mediate the development and progression of neurological ***,the mechanisms modulating these processes in different diseases remain incompletely *** in single cell based multi-omic analyses have helped to identify distinct molecular signatures such as Lgals3 that is associated with neuroinflammation and neurodegeneration in the central nervous system(CNS).Lgals3 encodes galectin-3(Gal3),aβ-galactoside and glycan binding glycoprotein that is frequently upregulated by reactive microglia/macrophages in the CNS during various neurological *** Gal3 has previously been associated with non-CNS inflammatory and fibrotic diseases,recent studies highlight Gal3 as a prominent regulator of inflammation and neuroaxonal damage in the CNS during diseases such as multiple sclerosis,Alzheimer’s disease,and Parkinson’s *** this review,we summarize the pleiotropic functions of Gal3 and discuss evidence that demonstrates its detrimental role in neuroinflammation and neurodegeneration during different neurological *** also consider the challenges of translating preclinical observations into targeting Gal3 in the human CNS.

关键词： Alzheimer’s disease Galectin 3 microglia multiple sclerosis neurodegeneration neuroinflammation Parkinson’s disease therapeutics

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Individualized anti-thrombotic therapy for acute myocardial infarction complicated with left ventricular thrombus: A case report

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World Journal of clinical Cases 2024年第4期12卷 835-841页

作者： Yan Song Hua Li Xia Zhang Lei Wang Hong-Yan Xu Zhi-Chao Lu Xiao-Gang Wang Bo Liu department of clinical Pharmacy Zibo Municipal HospitalZibo 255400Shandong ProvinceChina department of Cardiology Zibo Municipal HospitalZibo 255400Shandong ProvinceChina department of Pharmacy Zibo Municipal HospitalZibo 255400Shandong ProvinceChina department of Imaging Zibo Municipal HospitalZibo 255400Shandong ProvinceChina department of Pulmonary and Critical Care medicine Department of Clinical MicrobiologyZibo City Key Laboratory of Respiratory Infection and Clinical MicrobiologyZibo City Engineering Technology Research Center of Etiology Molecular DiagnosisZibo Municipal HospitalZibo 255400Shandong ProvinceChina

BACKGROUND Presently,there is no established standard anti-blood clot therapy for patients facing acute myocardial infarction(AMI)complicated by left ventricular thrombus(LVT).While vitamin K antagonists are the preferred choice for oral blood thinning,determining the best course of blood-thinning medication remains *** is unclear if non-vitamin K antagonist oral blood thinners have different effectiveness in treating *** study significantly contributes to the medical *** SUMMARY The blood-thinning treatment of a patient with AMI and LVT was *** blood-thinning therapy included daily enteric-coated aspirin tablets at 0.1 g,daily clopidogrel hydrogen sulfate at 75 mg,and dabigatran etexilate at 110 mg twice *** 15 d,the patient’s LVT did not decrease but instead *** pharmacists comprehensively analyzed the cases from the perspective of the patient’s disease status and drug *** drug regimen was reformulated for the patient,replacing dabigatran etexilate with warfarin,and was administered for six *** clinical pharmacist provided the patient with professional and standardized pharmaceutical *** patient’s condition was discharged after meeting the international normalized ratio value(2-3)*** patient fully complied with the follow-up,and the time in the therapeutic range was 78.57%,with no serious adverse effects during pharmaceutical *** Warfarin proves to be an effective drug for patients with AMI complicated by LVT,and its blood-thinning course lasts for six months.

关键词： Myocardial infarction Left ventricular thrombus Dabigatran etexilate Warfarin clinical pharmacist Case report

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From Entry to Evasion:A Comprehensive Analysis of Host-Virus Interactions for Monkeypox

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Infectious Microbes & Diseases 2024年第2期6卷 56-64页

作者： Vahideh Hamidi Sofiani Mohammad Rezaei Zadeh Rukerd Javad Charostad Mohammad Pardeshenas Reza Ghazi Nasir Arefinia Sara Shafieipour Faranak Salajegheh Mohsen Nakhaie department of microbiology Golestan University of Medical SciencesGorganIran Gastroenterology and Hepatology Research Center Institute of Basic and Clinical Physiology SciencesKerman University of Medical SciencesKermanIran Universal Scientific Education and Research Network(USERN) TehranIran department of microbiology Faculty of MedicineShahid Sadoughi University of Medical SciencesYazdIran department of microbiology School of MedicineKerman University of Medical SciencesKermanIran department of Biotechnology Golestan University of Medical SciencesGorganIran Student Research Committee Jiroft University of Medical SciencesJiroftIran Physiology Research Center Institute of NeuropharmacologyKerman University of Medical SciencesKermanIran clinical Research Development Unit School of MedicineAfzalipour HospitalKerman University of Medical SciencesKermanIran

Monkeypox(Mpox)has posed a novel challenge and emerged as a threat to global public health since the onset of its outbreak in *** is spreading throughout the world in both endemic and non-endemic countries,indicating that its behavior is *** prevalence of Mpox and the risk of a global pandemic necessitate a better understanding of Mpox virus replications and interactions with the ***,we attempted to provide a detailed comprehensive review of Mpox virus behavior at the molecular level from the entry level to the establishment of a successful infection,including attachment and entry,DNA replication,protein expression and viron assembly and *** review also describes its strategies to evade host immune responses and inhibit apoptosis,and uncovers underlying molecular mechanisms such as subverted signaling pathways and cellular factors behind host-viral interactions.

关键词： monkeypox immunity apoptosis virus-host interaction

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clinical profile and risk factors of Strongyloides stercoralis infection

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Asian Pacific Journal of Tropical medicine 2024年第1期17卷 43-44页

作者： Rupak Chatterjee Alisha Acharya Subhoroop Ghosh Shatavisa Mukherjee Tapashi Ghosh Nandini Chatterjee Netai Pramanik department of Tropical medicine School of Tropical MedicineKolkataWest BengalIndia department of microbiology School of Tropical MedicineKolkataWest BengalIndia Eastern Regional Centre National One Health Program for Prevention and Control of ZoonosesSchool of Tropical Medicine KolkataWest BengalIndia department of clinical&Experimental Pharmacology School of Tropical MedicineKolkataWest BengalIndia department of medicine IPGMER-SSKM HospitalKolkataWest BengalIndia

Strongyloides(S.)stercoralis,endemic in tropical and subtropical countries,is a soil-transmitted geohelminth human parasite belonging to a group of nematodes called *** is one of the most overlooked parasitic infections enlisted among the WHO"neglected tropical diseases"[1].*** mainly infects humans but can also be found naturally in domestic dogs,cats,and some primates.

关键词： tropical subtropical listed

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Graph based recurrent network for context specific synthetic lethality prediction

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Science China Life Sciences 2024年

作者： Yuyang Jiang Jing Wang Yixin Zhang ZhiWei Cao Qinglong Zhang Jinsong Su Song He Xiaochen Bo Academy of Medical Engineering and Translational medicine Tianjin University department of Bioinformatics Institute of Health Service and Transfusion MedicineBeijing School of medicine Tsinghua University School of Informatics Xiamen University

The concept of synthetic lethality (SL) has been successfully used for targeted therapies. To further explore SL for cancer therapy, identifying more SL interactions with therapeutic potential are essential. Recently, graph neural network-based deep learning methods have been proposed for SL prediction, which reduce the SL search space of wet-lab based methods. However, these methods ignore that most SL interactions depend strongly on genetic context, which limits the application of the predicted results. In this study, we proposed a graph recurrent network-based model for specific context-dependent SL prediction (SLGRN). In particular, we introduced a Graph Recurrent Network-based encoder to acquire a context-specific, low-dimensional feature representation for each node, facilitating the prediction of novel SL. SLGRN leveraged gate recurrent unit (GRU) and it incorporated a context-dependent-level state to effectively integrate information from all nodes. As a result, SLGRN outperforms the state-of-the-arts models for SL prediction. We subsequently validate novel SL interactions under different contexts based on combination therapy or patient survival analysis. Through in vitro experiments and retrospective clinical analysis, we emphasize the potential clinical significance of this context-specific SL prediction model.

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Ferroptosis in liver diseases:Fundamental mechanism and clinical implications

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World Journal of Gastroenterology 2024年第32期30卷 3730-3738页

作者： Ming-Shuang Lai Xi-Peng Yan Donald R Branch Melika Loriamini Li-Min Chen The Joint Laboratory on transfusion-Transmitted Diseases(TTDs)Between Institute of Blood transfusion Chinese Academy of Medical Sciences and Nanning Blood CenterNanning 530003Guangxi Zhuang Autonomous RegionChina department of medicine and Laboratory medicine and Pathobiology Centre for InnovationCanadian Blood ServicesHamilton 397086Canada Institute of Blood transfusion Chinese Academy of Medical Sciences and Peking Union Medical CollegeKey Laboratory for Transfusion-transmitted Infectious Diseases of the Health Commission of Sichuan ProvinceChengdu 610052Sichuan ProvinceChina

This editorial discusses a recently published paper in the World Journal of *** research focuses on p53's regulatory mechanism for controlling ferroptosis,as well as the intricate connection between ferroptosis and liver *** is a specific form of programmed cell death that is dependent on iron and displays unique features in terms of morphology,biology,and genetics,distinguishing it from other forms of cell *** can affect the liver,which is a crucial organ responsible for iron storage and *** evidence indicates a robust correlation between ferroptosis and the advancement of liver disorders.P53 has a dual effect on ferroptosis through various distinct signaling ***,additional investigations are required to clarify the regulatory function of p53 metabolic targets in this complex association with *** the future,researchers should clarify the mechanisms by which ferroptosis and other forms of programmed cell death contribute to the progression of liver *** and controlling important regulatory factors associated with ferroptosis present a promising therapeutic strategy for liver disorders.

关键词： Liver disease P53 Programmed cell death Ferroptosis Therapeutic target

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Occurrence of K1 and K2 serotypes and genotypic characteristics of extended spectrumβ-lactamases-producing Klebsiella pneumoniae isolated from selected hospitals in Malaysia

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Asian Pacific Journal of Tropical medicine 2024年第1期17卷 30-38页

作者： Nurul Syazrah Anuar Hazmin Hazman Sharven Raj Jeyakumar Mohd Nasir Mohd Desa Hasni Idayu Saidi Siti Norbaya Masri Nur Afiza Aziz Nurshahira Sulaiman department of Biomedical Science Faculty of Medicine and Health SciencesUniversiti Putra Malaysia43400UPM SerdangSelangorMalaysia department of Medical microbiology Faculty of Medicine and Health SciencesUniversiti Putra Malaysia43400UPM SerdangSelangorMalaysia microbiology Unit Department of PathologyHospital Sultanah AminahJalan Persiaran Sultan Abu Bakar80100 Johor BahruJohorMalaysia

Objective:To determine the distribution,phenotypic and genetic background of extended spectrumβ-lactamases(ESBL)-producing Klebsiella(K.)pneumoniae clinical isolates associated with K1 and K2 serotypes in two selected hospitals in ***:A total of 192 *** isolates were collected and subjected to antibiotic susceptibility,hypermucoviscosity test and multiplex PCR to detect the presence of K1-and K2-serotype associated *** sequence typing(MLST)was performed on ESBL-producing *** isolates presented with K1 and K2 serotypes,followed by phylogenetic ***:A total of 87 out of 192(45.3%)of the *** isolates collected were ESBL ***,only 8.3%(16/192)and 10.9%(21/192)of the total isolates were detected to carry K1-and K2-serotype associated genes,*** analysis showed that K1 and K2 capsular serotypes were not significantly associated with ESBL phenotype(P=0.196).However,they were significantly associated with hypervirulent,as demonstrated by the positive string test(P<0.001).MLST analysis revealed that ST23 as the predominant sequence type(ST)in the K1 serotype,while the ST in the K2 serotype is more ***:Although the occurrence of ESBL-producing isolates among the hypervirulent strains was low,their coexistence warrants the need for continuous *** showed that these isolates were genetically heterogeneous.

关键词： Extended spectrumβ-lactamases Klebsiella pneumoniae Capsular serotypes Genotypic

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