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A synthetic differencein-differences model for the influence of CR Express on Chongqing's economy

Railway Sciences 2024年第3期3卷 295-310页

作者： Rong Zhang Qi Li School of Traffic and Transportation Beijing Jiaotong UniversityBeijingChina Institute of Transportation planning China Railway Design CorporationTianjinChina

Purpose-The China-Europe Railway Express(CR Express)in Chongqing has operated regularly and undergone large-scale *** impact on Chongqing's economic growth has become increasingly evident,necessitating further research in this ***/methodology/approach-This study employs the opening of CR Express as a quasi-natural experiment,designating Chongqing,which inaugurated the CR Express in 2011,as the treatment group.13 provinces and cities that had not yet opened the CR Express until 2017 were selected as the control *** panel data from 14 provinces across China spanning from 2006 to 2017,the synthetic control method(SCM)is employed to synthetically construct *** quantify the difference in economic development levels between Chongqing with the operation of the CR express and Chongqing without its *** metrics such as gross domestic product(GDP),per capita GDP,total retail sales of consumer goods,import and export value and the proportions of the secondary and tertiary industries are employed to measure urban economic development *** is designated as the experimental group,and a double-difference model is constructed to regress the operation of the CR Express against economic development *** tests are conducted to validate the analytical ***-The results indicate that,compared to provinces without the operation of the CR Express,the initiation of the CR Express in Chongqing significantly enhances the economic development level of the *** opening of the CR Express exhibits a pronounced positive impact on Chongqing's economic development,and these findings remain robust and effective even after parallel trend tests and placebo ***-The study represents an expansion of the theoretical *** contrast to previous studies that relied on a single indicator such as GDP,this study selects six indicators from the dimensions of economy,trade and industry

关键词： CR Express Regional economic development Synthetic model Difference-indifferences method Papertype Research paper

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In search of optimal building behavior models for model predictive control in the context of flexibility

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Building Simulation 2024年第1期17卷 71-91页

作者： Arash Erfani Tohid Jafarinejad Staf Roels Dirk Saelens KU Leuven Department of Civil EngineeringBuilding Physics and Sustainable Design SectionKasteelpark Arenberg 40 Bus 24473001 HeverleeBelgium EnergyVille Thor Park 8310Genk 3600Belgium

Model predictive control(MPC)is an advanced control *** has been deployed to harness the energy flexibility of a *** requires a dynamic model of the building to achieve such an ***,developing a suitable predictive model is the main challenge in MPC implementation forflexibility *** studyfocuses on the application of key performance indicators(KPls)to evaluate the suitability of MPC models via feature *** this end,multiple models were developed for two houses.A feature selection method was developed to select an appropriate feature space to train the *** predictive models were then quantified based on one-step ahead prediction error(OSPE),a standard KPI used in multiple studies,and a less-often KPl:multi-step ahead prediction error(MSPE).An MPC workflow was designed where different models can serve as the predictive *** showed that MSPE better demonstrates the performance of predictive models used for flexibility *** revealed that up to 57% of the flexibility potential and 48% of energy use reduction are not exploited if MSPE is not minimized while developing a predictive model.

关键词： building flexibility model predictive control for building building behaviour identification smart home

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Heterobimetallic lanthanide tetrahedral cages:Synthesis,design and application for potential multimodal imaging contrast agent

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Journal of Rare Earths 2024年第2期42卷 278-285,I0002页

作者： Yongxiu Li Feng Guo Siwei Wei Duofu Li Jun Zhang Kai Xu Dongping Li department of Chemistry Nanchang UniversityNanchang330031China Key Laboratory of Functional Molecule design and Interface Process Anhui Jianzhu UniversityHefei230601China department of Otolaryngology Head and Neck SurgeryThe Second Affiliated Hospital of Nanchang UniversityNanchang330006China

The construction and functionalization of lanthanide-organic cages have been a research hotspot in coordination *** from the unique luminescent and magnetic properties of lanthanide ions,the potential applications of lanthanide-organic cages in biological imaging applications are promising,but only a few corresponding explorations have been *** rein,we introduced a series of lanthanide tetrahedral cages,(Eu_(n)Gd_(4-n)L_(4))(sol)_8(n=0,1,2,3 and 4,where L=(4,4',4"-tris(4,4,4-trifluoro-1,3-dioxobutyl)-triphenylamine,and sol=dimethyl sulfoxide and methanol),with potential applications in biological *** the good luminescent and magnetic properties of Eu^(3+) and Gd^(3+) ions,Eu_(4)L_(4) and Gd_(4)L_(4) complexes show a high luminescence quantum yield of 29% in DMSO and large longitudinal relaxivity(r_(1)) of 11.4(mmol/L)^(-1)/s at 0.5 T in water containing 1 vol% DMSO,*** heterobimetallic Eu-Gd complexes achieve a dual imaging mode by combining luminescent and magnetic centers in one *** the Gd:Eu ratio increases from 1:3 to 3:1,the r_(1) values increases from 5.33 to 8.64(mmoI/L)^(-1)/s,higher than that of commercial contrast agent Gd-DOTA(3.23(mmol/L)^(-1)/s).Owing to their low toxicity and good cell imaging ability toward ECA 109 cells,the selfassembled Eu-Gd heterobimetallic tetrahedral cages could be potential candidates for the multimodal imaging contrast agent.

关键词： Lanthanide organic cage Luminescence Cell imaging Contrast agents Rare earths

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评《城市更新制度与北京探索:主体-资金-空间-运维》

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China City planning Review 2024年第2期33卷 87-89页

作者：石晓冬 Qian Fang Tang Yan Beijing Municipal Institute of City planning&design the Council Urban Planning Society of ChinaBeijingP.R.China. 不详

Urban Regeneration Institutions and Beijing’s Exploration:Multiple Stakeholders,Capital Source,Physical Space,and Operational Service Authors:Tang Yan,Zhang Lu,and Yin Xiaoyong Year:2023 Publisher:China Architecture&Building Press ISBN:9787507435603(300 pages,in Chinese)The mode shift of urban development from“incremental expansion”to“stock regeneration”is inevitable when the urbanization process enters the middle and later *** China,it has been considered as an important national strategy in the new period,as well as a key field for innovation and exploration in various cities,to take urban regeneration as a means to achieve the goals of optimizing urban functions,improving space quality,promoting economic and social development,and enhancing people’s sense of *** promoting the high-quality development of cities,urban regeneration practices have shifted from large-scale demolition and reconstruction to small-scale micro-regeneration,from the development-focused approach to multi-objective approaches,and from government-led to joint governance and sharing,which have made the pursuit of comprehensive values,the participation of multiple stakeholders,and the balance of various benefits in urban regeneration the hot topics in the current society.

关键词：城市更新 Institution Regeneration

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Contemplative neuroaesthetics and architecture:A sensorimotor exploration

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Frontiers of Architectural Research 2024年第1期13卷 97-111页

作者： Zakaria Djebbara Juliet King Amir Ebadi Yoshio Nakamura Julio Bermudez department of Architecture DesignMediaand TechnologyAalborg UniversityAalborgDenmark Biopsychology und Neuroergonomy Technical University BerlinBerlinGermany Art Therapy department The George Washington UniversityWashington DCUnited States department of Neurology Indiana University School of MedicineIndianapolisUnited States Dellustration Washington DCUnited States Pain Research Center Division of Pain MedicineDepartment of AnesthesiologyUniversity of Utah School of MedicineUtahUnited States School of Architecture and planning The Catholic University of AmericaWashington DCUnited States

This paper takes initial steps towards developing a theoretical framework of contemplative neuroaesthetics through sensorimotor *** first argue that this new area has been largely omitted from the contemporary research agenda in neuroaesthetics and thus remains a domain of untapped *** seek to define this domain to foster a clear and focused investigation of the capacity of the arts and architecture to induce phenomenological states of a contemplative *** proposing a sensorimotor account of the experience of architecture,we operationalize how being attuned to architecture can lead to contemplative *** contrasting the externally-induced methods with internally-induced methods for eliciting a contemplative state of mind,we argue that architecture may spontaneously and effortlessly lead to such states as certain built features naturally resonate with our sensorimotor *** suggest that becoming sensible of the resonance and attunement process between internal and external states is what creates an occasion for an externallyinduced contemplative ***,we review neuroscientific studies of architecture,elaborate on the brain regions involved in such aesthetic contemplative responses,provide architectural examples,and point at the contributions that this new area of inquiry may have in fields such as the evidence-based design movement in architecture.

关键词： Neuropheno menology Neuroaesthetics Contemplative states Architectural experience Well-being

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Discovery of first-in-class DOT1L inhibitors against the R231Q gain-of-function mutation in the catalytic domain with therapeutic potential of lung cancer

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Acta Pharmaceutica Sinica B 2024年第8期14卷 3605-3623页

作者： Zehui Tan Ning Guo Zhi Cao Shuyu Liu Jiayu Zhang Deyi Ma Jiahao Zhang Wencai Lv Nan Jiang Linghe Zang Lihui Wang Xin Zhai Key Laboratory of Structure-Based Drug design and Discovery Ministry of EducationShenyang Pharmaceutical UniversityShenyang 110016China department of Pharmacology Shenyang Pharmaceutical UniversityShenyang 110016China

Recent research certified that DOT1L and its mutations represented by R231Q were potential targets for the treatment of lung ***,a series of adenosine-containing derivatives were identified with DOT1LR231Q inhibition through antiproliferation assay and Western blot analysis in the H460R231Q *** most promising compound 37 significantly reduced DOT1LR231Q mediated H3K79 methylation and effectively inhibited the proliferation,self-renewal,migration,and invasion of lung cancer cell lines at low micromolar *** cell permeability and cellular target engagement of 37 were verified by both CETSA and DARTS *** the H460R231Q OE cell-derived xenograft(CDX)model,37 displayed pronounced tumor growth inhibition after intraperitoneal administration at 20 mg/kg dose for 3 weeks(TGI=54.38%),without obvious toxicities.A pharmacokinetic study revealed that 37 possessed tolerable properties(t_(1/2)=1.93±0.91 h,F=97.2%)after intraperitoneal administration in *** study confirmed that 37 suppressed malignant phenotypes of lung cancer carrying R231Q gain-of-function mutation via the MAPK/ERK signaling ***,analysis of the binding modes between molecules and DOT1LWT/R231Q proteins put forward the“Induced-fit”allosteric model in favor to the discovery of potent DOT1L candidates.

关键词： DOT1L R231Q mutation Lung cancer Adenosine-containing inhibitors Epigenetics

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An Efficient Method to Estimate Admittance of Black-boxed Inverter-based Resources for Varying Operating Points

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CSEE Journal of Power and Energy Systems 2024年第1期10卷 421-426页

作者： Weihua Zhou Bin Liu Nabil Mohammed Behrooz Bahrani department of Electrical and Computer Systems Engineering Monash UniversityMelbourne 3800Australia Energy Centre Commonwealth Scientific and Industrial Research Organisation(CSIRO)Newcastle 2300Australia.He is now with the Network Planning DivisionTransgridSydney 2000Australia

Traditional analytical approaches for stability assessment of inverter-based resources(IBRs),often requiring detailed knowledge of IBR internals,become impractical due to IBRs’proprietary *** measurements,relying on electromagnetic transient simulation or laboratory settings,are not only time-intensive but also operationally inflexible,since various non-linear control loops make IBRs’admittance models operating-point ***,such admittance measurements must be performed repeatedly when operating point *** avoid time-consuming and cumbersome measurements,admittance estimation for arbitrary operating points is highly ***,existing admittance estimation algorithms usually face challenges in versatility,data demands,and *** this challenge,this letter presents a simple and efficient admittance estimation method for blackboxed IBRs,by utilizing a minimal set of seven operating points to solve a homogeneous linear equation *** studies demonstrate this proposed method ensures high accuracy across various types of *** accuracy is satisfying even when non-negligible measurement errors exist.

关键词： Admittance estimation black box inverterbased resource measurement error operating point

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Feasibility of condensate water recycle of split air handling unit in Chinese University buildings

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Energy and Built Environment 2024年第2期5卷 309-315页

作者： Xiang Deng Yiyun Shen Senwang Yang Jingyang Feng Si Wang Dongyue Li Yanru Li College of Architecture and Urban-Rural planning Sichuan Agricultural UniversityDujiangyan CampusChengdu611130China

Recycling the condensate water of the air conditioner could be explored as an alternative water source to con-tribute to building the green *** paper explored the condensate water production through actual mea-surement based on a split air handling unit(SAHU)in a university ***,the statistical analysis was used to analyze the recycling feasibility and the impact factors of the condensate water production in 31 Chinese provincial capital cities to obtain the recycling potential map of the condensate water generated from a *** showed that:(1)In the measurement,the amount of condensate water produced by a single split air conditioner was 1.6 kg from 12:40 to 13:***,the daily output of condensate water of the air condi-tioner with the university operation schedule could reach 52.99 kg during the main air-conditioning season.(2)Among the 31 provincial capital cities in China,the largest condensate water outputs could be found in the Hot Summer and Warm Winter zone and the Hot Summer and Cold Winter zone,with an average monthly output of 1600 kg and 1100 kg,respectively.(3)Regression analysis showed that the dry-bulb temperature and dew point temperature of outdoor air had the highest positive and significant influence on condensate water *** objective of this study is to provide theoretical guidance for the design and energy conservation evaluation of the feasibility of SAHU condensate water recycling in universities.

关键词： Condensate water Recycling Regression analysis Split air handling unit University buildings

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Contemporary construction in historical sites:The missing factors

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Frontiers of Architectural Research 2024年第3期13卷 487-504页

作者： Sina Kamali Tabrizi Mohamed Gamal Abdelmonem School of Architecture Design and the Built EnvironmentNottingham Trent UniversityNottinghamUK department of Architecture and the Built Environment University of YorkYorkUK

Historical sites(HSs)are akin to living entities,and their existence is perpetuated through the erection of new buildings or *** HSs need sustainable development and new construction,as existing monuments fail to meet contemporary user *** the urgent demand,many new buildings within HSs have been constructed without considering the influencing factors on contextual value,built,and natural *** oversight has led to irreversible damage to their historical *** studies have independently explored interventions,construction,and development within ***,there is a conspicuous absence of comprehensive research that concurrently addresses these issues while preserving the intrinsic value of the *** study aims to identify the variables and factors contributing to the successful design and construction of new buildings within HSs,satisfying user needs,conserving contextual values,and achieving sustainability with the natural and built *** research employs a mixed-method approach,gathering raw data through literature reviews,case studies,and expert *** study population comprised 97 experts in architectural heritage conservation and sustainable *** factor analysis was utilized for data analysis,leading to the identification of influential *** study highlights the significance of the location,function,scale,form,material,skyline,viewpoint,accessibility,reversibility,topography,sustainability,technology,structural system,lifespan,and interior design in constructing new buildings within a ***,the design of new additions should adhere to five guiding principles:integrated design,volume design,green design,compatible design,and modern *** this context,the new structures will fulfill user needs,preserve or enhance contextual values,and harmonize with the built and natural environment.

关键词： New building Contemporary construction Historical sites Sustainable development Architectural heritage

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Combining Deep Learning with Knowledge Graph for design Knowledge Acquisition in Conceptual Product design

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工程与科学中的计算机建模(英文) 2024年第1期138卷 167-200页

作者： Yuexin Huang Suihuai Yu Jianjie Chu Zhaojing Su Yangfan Cong Hanyu Wang Hao Fan Key Laboratory of Industrial design and Ergonomics Ministry of Industry and Information TechnologyNorthwestern Polytechnical UniversityXi’an710072China School of Industrial design Engineering Delft University of TechnologyDelft2628 CEThe Netherlands department of Industrial design College of ArtsShandong University of Science and TechnologyTsingtao266590China College of Computer Science and Technology Zhejiang UniversityHangzhou310027China

The acquisition of valuable design knowledge from massive fragmentary data is challenging for designers in conceptual product *** study proposes a novel method for acquiring design knowledge by combining deep learning with knowledge ***,the design knowledge acquisition method utilises the knowledge extraction model to extract design-related entities and relations from fragmentary data,and further constructs the knowledge graph to support design knowledge acquisition for conceptual product ***,the knowledge extraction model introduces ALBERT to solve memory limitation and communication overhead in the entity extraction module,and uses multi-granularity information to overcome segmentation errors and polysemy ambiguity in the relation extraction *** comparison verified the effectiveness and accuracy of the proposed knowledge extraction *** case study demonstrated the feasibility of the knowledge graph construction with real fragmentary porcelain data and showed the capability to provide designers with interconnected and visualised design knowledge.

关键词： Conceptual product design design knowledge acquisition knowledge graph entity extraction relation extraction

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