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PI3K/AKT Mediated p53 Down-Regulation Participates in CpG DNA Inhibition of Spontaneous B Cell Apoptosis

Cellular & Molecular Immunology 2009年第3期6卷 175-180页

作者： Yongxin Zhou Huiling Zhen Yunqing Mei Yongwu Wang Jing Feng Shuchang Xu Xiaoying Fu department of thoracic-cardiovascular surgury Tongji Hospital Tongji University Shanghai 200065 China department of Gastroenterology Tongji Hospital Tongji University Shanghai 200065 China

The unmethylated CpG DNA can prevent spontaneous apoptosis of B cells. However, the precise mechanisms by which CpG DNA blocks apoptosis remain unclear. In this study, we showed B cell apoptosis was significantly inhibited by addition of CpG DNA. Treatment of CpG DNA could reduce the expression of caspase 3, increase IAP and Bcl-xL expressions, and inhibit p53 protein expression which level was increased in B cell spontaneous apoptosis at 24 h. AKT kinase activity was increased with the incubation of CpG DNA. The wortmannin and Ly294002 could abrogate the protection of B cell from apoptosis by CpG DNA. The up-regulations of Bcl-xL and IAP by CpG DNA were not inhibited when blocking PI3K by specific inhibitor Ly294002, while the inhibition of p53 by CpG DNA could be blocked by Ly294002. These results demonstrated that the inhibition of spontaneous B cell apoptosis by CpG DNA was correlated to up-regulation of Bcl-xL, IAP and down-regulation of p53 and caspase 3. CpG DNA inhibition of p53 is mediated through PI3K/AKT signaling.

关键词： CpG DNA PI3K AKT p53 apoptosis

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一例最初表现为对侧疼痛性肩胛骨转移的肺癌和肺结核复杂病例(英文)

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The Chinese-German Journal of Clinical Oncology 2012年第5期11卷 294-296页

作者： Hassan-Ali Mohebbi Amin Saburi Mohammad-Hasan Bagheri Ehsan Saburi surgury department Faculty of MedicineBaqiyatallah University of Medical SciencesTehranIR.Iran Trauma Research Center Baqiyatallah University of Medical SciencesTehranIR.Iran Chemical Injuries Research Center Baqiyatallah University of Medical SciencesTehranIR.Iran Laboratory Medicine department Shahid Beheshti University of Medical SciencesTehranIR.Iran

We report a 43-year-old man who presented with a right painful shoulder mass and bilateral lung masses in computed tomography(CT).Scapular mass was excised and pathology report demonstrated high-grade metastatic *** side lung biopsy and histopathological study characterized tuberculosis but biopsy of the left lung lesion identified adenocarcinoma of the *** final diagnosis was right scapular metastatic lesion from left lung *** symptoms are commonly encountered in lung malignancies due to paraneoplastic syndrome or hematogenous metastasis but scapular metastasis on the other side as the presentation of lung cancer is extremely rare.

关键词：肺结核肩胛骨肺癌痛苦计算机断层扫描恶性肿瘤组织学特点肺腺癌

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