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An unusual anterior mitral leaflet perforation in a patient with no infective endocarditis:a case report

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Emergency and Critical Care Medicine 2024年第1期4卷 39-41页

作者： Kaiming Wei Yu Yao Chuanzhen Liu Yuan Cao department of cardiovascular surgery Qilu Hospital of Shandong UniversityJinanShandongChina department of Emergency Medicine Qilu Hospital of Shandong UniversityJinanShandongChina National Key Laboratory for Innovation and Transformation of Luobing Theory The Key Laboratory of Cardiovascular Remodeling and Function ResearchChinese Ministry of EducationChinese National Health Commission and Chinese Academy of Medical SciencesDepartment of CardiologyQilu Hospital of Shandong UniversityJinanShandongChina.

Background:Mitral valve perforation refers to the occurrence of cracks or openings in the structure of the mitral valve,allowing blood to escape through these ***,this is caused by infective endocarditis and the most common site is the anterior ***,it is crucial to explore other potential causes of valve damage,particularly when conventional risk factors are not *** presentation:We present a case of a middle-aged male patient who developed mitral valve perforation because of aortic valve regurgitation in the absence of infective ***:Exploring such rare cases contributes to a deeper understanding of valvular diseases and enhances clinical decision making for effective management.

关键词： Anterior mitral leaflet Aortic valve Case report Perforation Prolapse Regurgitation

Direct reprogramming of fibroblasts into functional hepatocytes via CRISPRa activation of endogenous Gata4 and Foxa3

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Chinese Medical Journal 2024年第11期137卷 1351-1359页

作者： Jiacheng Li Ruopu Li Xue Bai Wenlong Zhang Yu Nie Shengshou Hu State Key Laboratory of cardiovascular Disease Fuwai Hospital and Cardiovascular InstituteNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100037China department of Obstetrics and Gynecology Beijing Advanced Innovation Center for GenomicsThird HospitalSchool of Life SciencesPeking UniversityBeijing 100871China

Background:The ability to generate functional hepatocytes without relying on donor liver organs holds significant therapeutic promise in the fields of regenerative medicine and potential liver disease *** regularly interspaced short palindromic repeats(CRISPR)activator(CRISPRa)is a powerful tool that can conveniently and efficiently activate the expression of multiple endogenous genes simultaneously,providing a new strategy for cell fate *** main purpose of this study is to explore the feasibility of applying CRISPRa for hepatocyte reprogramming and its application in the treatment of mouse liver ***:The differentiation of mouse embryonic fibroblasts(MEFs)into functional induced hepatocyte-like cells(iHeps)was achieved by utilizing the CRISPRa synergistic activation mediator(SAM)system,which drove the combined expression of three endogenous transcription factors-Gata4,Foxa3,and Hnf1a-or alternatively,the expression of two transcription factors,Gata4 and *** vivo,we injected adeno-associated virus serotype 6(AAV6)carrying the CRISPRa SAM system into liver fibrotic Col1a1-Cre^(ER);Cas9^(fl/fl)mice,effectively activating the expression of endogenous Gata4 and Foxa3 in *** endogenous transcriptional activation of genes was confirmed using real-time quantitative polymerase chain reaction(RT-qPCR)and RNA-seq,and the morphology and characteristics of the induced hepatocytes were observed through *** level of hepatocyte reprogramming in vivo is detected by immunofluorescence staining,while the improvement of liver fibrosis is evaluated through Sirius red staining,alpha-smooth muscle actin(α-SMA)immunofluorescence staining,and blood alanine aminotransferase(ALT)***:Activation of only two factors,Gata4 and Foxa3,via CRISPRa was sufficient to successfully induce the transformation of MEFs into *** iHeps could be expanded in vitro and displayed functional characteristics similar to th

关键词： Liver fibrosis CRISPRa Cell reprogramming Transcriptional activation Hepatocytes

Predictive value of neutrophil-to-lymphocyte ratio in coronary chronic total occlusion patients

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Journal of Geriatric Cardiology 2024年第5期21卷 542-549页

作者： Qian LI Yue YU Ya-Qiong ZHOU Yi ZHAO Jin WU Yuan-Jing WU Bin DU Pei-Jian WANG Tao ZHENG department of cardiovascular Medicine the First Affiliated Hospital of Xi’an Jiaotong UniversityXi’anChina department of Cardiology First Affiliated Hospital of Chengdu Medical CollegeChengduChina department of Neurology the First Affiliated Hospital of Xi’an Jiaotong UniversityXi’anChina

BACKGROUND The neutrophil to lymphocyte ratio(NLR)has been reported as a novel predictor for atherosclerosis and car-diovascular *** study aimed to determine the effects of NLR on long-term clinical outcomes of chronic total occlusion(CTO)*** A total of 670 patients with CTO who met the inclusion criteria were included at the end of the follow-up *** were divided into tertiles according to their baseline NLR levels at admission:low(n=223),intermediate(n=223),and high(n=224).The incidence of major adverse cardiac events(MACEs)during the follow-up period,including all-cause death,nonfatal myocardial infarction(MI),or ischemia-driven revascularization,were compared among the three *** Major adverse cardiac events were observed in 27 patients(12.1%)in the low tertile,40(17.9%)in the intermediate tertile,and 61(27.2%)in the high NLR tertile(Pcardiovascular risk in patients with CTO.

关键词： patients coronary occlusion

Diagnostic performance of intravascular ultrasound-based fractional flow reserve in evaluating of intermediate left main stenosis

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Journal of Geriatric Cardiology 2024年第1期21卷 34-43页

作者： Yong-Gang SUI Cheng YANG Chang-Dong GUAN Yan-Lu XU Na-Qiong WU Wei-Xian YANG Yong-Jian WU Ke-Fei DOU Yue-Jin YANG Shu-Bin QIAO Wei YU Bo XU Sheng-Xian TU Jie QIAN department of Cardiology Fuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Catheterization Laboratories Fuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Biomedical Instrument Institute School of Biomedical EngineeringShanghai Jiao Tong UniversityShanghaiChina National Clinical Research Center for cardiovascular Diseases BeijingChina

BACKGROUND The recently introduced ultrasonic flow ratio(UFR),is a novel fast computational method to derive fractional flow reserve(FFR)from intravascular ultrasound(IVUS)*** the present study,we evaluate the diagnostic performance of UFR in patients with intermediate left main(LM)*** This is a prospective,single center study enrolling consecutive patients with presence of intermediated LM lesions(diameter stenosis of 30%-80%by visual estimation)underwent IVUS and FFR *** independent core laboratory assessed offline UFR and IVUS-derived minimal lumen area(MLA)in a blinded *** Both UFR and FFR were successfully achieved in 41 LM patients(mean age,62.0±9.9 years,46.3%diabetes).An acceptable correlation between UFR and FFR was identified(r=0.688,P50%(AUC=0.66,P<0.001)and numerically higher than IVUS-derived MLA(AUC=0.82;P=0.09).Patient level diagnostic accuracy,sensitivity and specificity for UFR to identify FFR≤0.80 was 82.9%(95%CI:70.2-95.7),93.1%(95%CI:82.2-100.0),58.3%(95%CI:26.3-90.4),*** In patients with intermediate LM diseases,UFR was proved to be associated with acceptable correlation and high accuracy with pressure wire-based FFR as standard *** present study supports the use of UFR for functional evaluation of intermediate LM stenosis.

关键词： stenosis flow fractional

Central nervous injury risk factors after endovascular repair of a thoracic aortic aneurysm with type B aortic dissection

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World Journal of Clinical Cases 2024年第22期12卷 4873-4880页

作者： Feng Liang Jie-Qiong Su department of Vascular surgery Qinghai Province Cardiovascular and Cerebrovascular Disease Specialist HospitalXining 810012Qinghai ProvinceChina department of Neurology Qinghai Province Cardiovascular and Cerebrovascular Disease Specialist HospitalXining 810012Qinghai ProvinceChina

Aortic dissection is the deadliest disease of the cardiovascular *** B aortic dissection accounts for 30%-60%of aortic dissections and is mainly treated by endovascular repair of thoracic endovascular aneurysm repair(TEVAR).However,patients are prone to various complications after surgery,with central nervous system injury being the most common,which seriously affects their prognosis and increases the risk of disability and ***,exploring the risk factors of central nervous system injury after TEVAR can provide a basis for its prevention and *** To investigate the risk factors for central nervous system injury after the repair of a thoracic endovascular aneurysm with type B aortic *** We enrolled 306 patients with type B aortic dissection who underwent TEVAR at our hospital between December 2019 and October *** patients were categorized into injury(n=159)and non-injury(n=147)groups based on central nervous system injury following *** risk factors for central nervous system injury after TEVAR for type B aortic dissection were screened by comparing the two *** logistic regression analysis was *** The Association between age,history of hypertension,blood pH value,surgery,mechanical ventilation,intensive care unit stay,postoperative recovery times on the first day after surgery,and arterial partial pressure of oxygen on the first day after surgery differed substantially(Psurgery time,history of hypertension,duration of mechanical ventilation,and intensive care unit stay were independent risk factors for central nervous system injury after TEVAR of type B aortic dissection(Psurgery in high-risk patients

关键词： Plateau area Type B aortic dissection thoracic endovascular aneurysm repair Central nervous system injury Risk factors

Comparing pharmacotherapy and transcranial magnetic stimulation for the treatment of anxiety and depression after aortic dissection surgery

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World Journal of Clinical Cases 2024年第21期12卷 4476-4482页

作者： Jie-Qiong Su Feng Liang department of Neurology Qinghai Province Cardiovascular and Cerebrovascular Disease Specialist HospitalXining 810012Qinghai ProvinceChina department of Vascular surgery Qinghai Province Cardiovascular and Cerebrovascular Disease Specialist HospitalXining 810012Qinghai ProvinceChina

BACKGROUND Aortic coarctation is a potentially fatal condition that is primarily treated *** successful procedures,patients frequently experience postoperative anxiety and depression,which can hinder recovery and worsen *** interventions,such as 5-hydroxytryptamine(5-HT)and norepinephrine reuptake inhibitors,are commonly prescribed;however,their efficacy alone or in combination with non-invasive brain stimulation techniques,such as repetitive transcranial magnetic stimulation(TMS),remains *** To assess the effect of medications and TMS on post-aortic surgery anxiety and *** We analyzed the outcomes of 151 patients with anxiety and depression who were hospitalized for aortic dissection between January 2020 and September *** the random number table method,75 and 76 patients were allocated to the normal control and study groups,*** the patients were treated using routine *** control group was administered anti-anxiety and antidepression drugs,whereas the study group was treated with TMS in addition to these *** patients in both groups showed improvement after two courses of *** Hamilton Anxiety Scale(HAMA)and the Hamilton Depression Scale(HAMD)were used to assess anxiety and depression,*** serum levels of brain-derived neurotrophic factor(BDNF)and 5-HT were determined using enzyme-linked immunosorbent *** Pittsburgh Sleep Quality Index(PSQI)was used to estimate sleep quality,and the Repeatable Battery for the Assessment of Neuropsychological Status(RBANS)was used to assess cognitive *** The HAMD and HAMA scores reduced in 2 groups,with the study group achieving a lower level than control(P<0.05).In the control group,43 patients recovered,17 showed improvement,and 15 were deemed *** the study group,52 recovered,20 improved,and four were *** efficacy rate in study group was 94.74%compared to 80.00%in control(P<0.05

关键词： Aortic dissection Anxiety and depression Simple anti-anxiety and depression medications Repetitive transcranial magnetic stimulation Curative effect

Adventitial Rupture of the Ascending thoracic Aorta Extended to the Buttock by thoracic Crushing between Two Tanks at the thoracic and cardiovascular surgery department at the Besançon CHRU

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Open Journal of thoracic surgery 2018年第4期8卷 74-78页

作者： Abdoulaye Kante Andrea Perrotti Brehima Coulibaly Mamadou Almamy Keita Drissa Traore Siaka Diallo Mariam Daou Mamadou Diakite Babou Bah Brehima Bengaly MoustaphIssa Magane Bakary Keita Birama Togola Drissa Ouattara Souleymane Sanogo Timbely Guidere Nouhom Ongoiba Harrison Haight Anne Sophie Lacagne Julie Ritter Anne Claire Mogenet Enrica Dorigo Camille Durst Djamel Kaili Francois Clement Sidney Chocron Service of General surgery CHU Point GBamakoMali Servicet of thoracic and cardiovascular surgery University Hospital of BesanconBesanconFrance Service of Neurology Gabriel Toure Teaching HospitalBamakoMali Service of Cardiology CHU Point GFaculty of Medicine and OdontostomatologyBamakoMali Service of Anesthesia Service and Resuscitation CHU Gabriel ToureBamakoMali

Traumatic rupture of the ascending aorta is rare. We report the case of a 23-year-old man who suffered a service accident by crushing the thorax between two tanks during army maneuvers that resulted in an adventitial rupture of the ascending thoracic aorta extending to the Crosse. Treatment consisted of replacement of the ascending aorta with a 24 mm Hemashield straight tube and re-implantation of supra-aortic vessels at the dome of the prosthesis.

关键词： Traumatic Rupture Ascending Aorta Extended to Lacrosse Service Accident

Association between prolactin/testosterone ratio and breast cancer in Chinese women

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Chinese Medical Journal 2024年第3期137卷 368-370页

作者： Qian Cai Xiaohan Tian Yuyi Tang Han Cong Jie Liu Song Zhao Rong Ma Jianli Wang Jiang Zhu department of Geriatric Medicine Qilu Hospital of Shandong UniversityJinanShandong 250012China Key Laboratory of cardiovascular Proteomics of Shandong Province Qilu Hospital of Shandong UniversityJinanShandong 250012China department of Pharmacology School of Basic Medical SciencesShandong UniversityJinanShandong 250012China department of Breast surgery General SurgeryQilu Hospital of Shandong UniversityJinanShandong 250012China department of Thyroid and Breast surgery Guangdong Second Provincial General HospitalGuangzhouGuangdong 510310China department of Toxicology and Cancer Biology Collage of MedicineUniversity of KentuckyLexingtonKY 40536USA department of Immunology School of Basic Medical ScienceShandong UniversityJinanShandong 250012China department of Gynaecology and Obstetrics Qilu Hospital of Shandong UniversityJinanShandong 250012China

To the Editor:Breast cancer is a prevalent malignant tumor and ranks as the second leading cause of cancer-related deaths globally.^([1])The breast is the target organ of some endocrine hormones,which regulate its growth and *** from estrogen and progesterone,the relationship among prolactin,androgen,and breast cancer has recently garnered increasing attention.

关键词： breast cancer prolactin

GLP-1 receptor agonists and myocardial metabolism in atrial fibrillation

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Journal of Pharmaceutical Analysis 2024年第5期14卷 653-665页

作者： Jiani Zhong Hang Chen Qiming Liu Shenghua Zhou Zhenguo Liu Yichao Xiao department of cardiovascular Medicine Second Xiangya HospitalCentral South UniversityChangsha410011China Xiangya School of Medicine Central South UniversityChangsha410008China Center for Precision Medicine and Division of cardiovascular Medicine Department of MedicineSchool of MedicineUniversity of MissouriColumbiaMO65211USA

Atrial fibrillation(AF)is the most common cardiac *** medical conditions,including hypertension,diabetes,obesity,sleep apnea,and heart failure(HF),increase the risk for *** have unique metabolic characteristics to maintain adenosine triphosphate *** changes occur in myocardial metabolism in ***-like peptide-1 receptor agonists(GLP-1RAs)have been used to control blood glucose fluctuations and weight in the treatment of type 2 diabetes mellitus(T2DM)and ***-1RAs have also been shown to reduce oxidative stress,inflammation,autonomic nervous system modulation,and mitochondrial *** article reviews the changes in metabolic characteristics in cardiomyocytes in *** the clinical trial outcomes are unsatisfactory,the findings demonstrate that GLP-1 RAs can improve myocardial metabolism in the presence of various risk factors,lowering the incidence of AF.

关键词： Atrial fibrillation Glucagon-like peptide-1 receptor agonists Metabolism