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Decoding molecular mechanisms:brain aging and Alzheimer's disease

Neural Regeneration Research 2025年第8期20卷 2279-2299页

作者： Mahnoor Hayat Rafay Ali Syed Hammad Qaiser Mohammad Uzair Khalid Al-Regaiey Roaa Khallaf Lubna Abdullah Mohammed Albassam Imdad Kaleem Xueyi Wang Ran Wang Mehwish SBhatti Shahid Bashir Atta-ur-Rahman School of Applied Biosciences(ASAB) National University of Sciences and Technology(NUST)IslamabadPakistan department of Biotechnology Quaid-i-Azam UniversityIslamabadPakistan department of Biological Sciences Faculty of Basic&Applied SciencesInternational Islamic University Islamabad(IIUI)IslamabadPakistan department of Bioengineering King Fahd University of Petroleum and MineralsDhahranSaudi Arabia department of Physiology College of MedicineKing Saud UniversityRiyadhSaudi Arabia department of Neurology Neuroscience CenterKing Fahad Specialist HospitalDammamSaudi Arabia department of Mental Health Neuroscience CenterKing Fahad Specialist HospitalDammamSaudi Arabia department of Biosciences Commission on Science and Technology for Sustainable Development in the South(COMSATS University)IslamabadPakistan department of Psychiatry The First Hospital of Hebei Medical UniversityShijiazhuangHebei ProvinceChina Mental Health Institute of Hebei Medical University ShijiazhuangHebei ProvinceChina department of Neurobiology and Behavior University of CaliforniaIrvineCAUSA Neuroscience Center King Fahad Specialist Hospital DammamDammamSaudi Arabia

The complex morphological,anatomical,physiological,and chemical mechanisms within the aging brain have been the hot topic of research for *** aging process alters the brain structure that affects functions and cognitions,but the worsening of such processes contributes to the pathogenesis of neurodegenerative disorders,such as Alzheimer's *** these observable,mild morphological shifts,significant functional modifications in neurotransmission and neuronal activity critically influence the aging *** these changes is important for maintaining cognitive health,especially given the increasing prevalence of age-related conditions that affect *** review aims to explore the age-induced changes in brain plasticity and molecular processes,differentiating normal aging from the pathogenesis of Alzheimer's disease,thereby providing insights into predicting the risk of dementia,particularly Alzheimer's disease.

关键词： Alzheimer’s disease brain aging cognitive health dementia molecular mechanisms neuronal activity neuroplasticity neurotransmission

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Merging bound states in the continuum in an open acoustic resonator

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 124-131页

作者： Lujun Huang Bin Jia Artem S.Pilipchuk Sibo Huang Chen Shen Almas F.Sadreev Yong Li Andrey E.Miroshnichenko School of Physics and Electronic Sciences East China Normal University Institute of Acoustics Tongji University L.V.Kirensky Institute of Physics department of Mechanical Engineering Rowan University School of Engineering and technology University of New South Wales at Canberra

Bound states in the continuum （BICs） are perfectly localized resonances despite embedding in the continuum ***,an isolated BIC is very sensitive to the structure ***,we report merging acoustic BICs in a single open resonator,robust against the structure *** find that both symmetry-protected BIC and Friedrich-Wintgen BIC are sustained in a single coupled waveguide-resonator *** varying the height and length of the resonator,these two BICs move toward each other and merge into a single one at a critical *** to an individual BIC,the merged BIC is robust against fabrication error because its Q-factor is proportional to ΔL-4,whereΔL embodies the structure *** essence of this extraordinary phenomenon is perfectly explained by the two-and three-level approximations of the effective nonHermitian ***,we present direct experimental demonstrations of the moving and merging of BICs in a coupled 3D waveguide-resonator,which are evidenced by the vanishing of the linewidth of Fano resonance in the transmission *** results may find exciting applications in designing high-quality acoustic sources,sensors and filters.

关键词： acoustic resonances bound state in the continuum high-Q resonances

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Wetland and habitat dynamics in the evolving landscape of the Middle Yangtze River Basin

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Journal of Geographical Sciences 2025年第1期35卷 88-111页

作者： YANG Peng SUN Kaiya ZHU Yanchao XIA Jun HUANG Heqing SONG Jingxia SHI Xiaorui LU Xixi Hubei Key Laboratory of Regional Ecology and environmental Change School of Geography and Information Engineering China University of Geosciences department of Geography National University of Singapore State Key Laboratory of Water Resources and Hydropower Engineering Science Wuhan University

Wetlands play a critical role in the global environment. The Middle Yangtze River Basin(MYRB), known for its abundant wetland resources, has experienced notable changes resulting from the complex interplay of environmental factors. Therefore, we investigated the spatiotemporal characteristics of wetland ecological quality in the MYRB from 2001 to *** the random forest(RF) regression algorithm and patch-generated land-use simulation(PLUS) model, we forecasted variations in wetland habitat quality and their determinants under the Shared Socioeconomic Pathway-Representative Concentration Pathway(SSPRCP) framework from 2035 to 2095. The main findings are as follows:(1) The RF algorithm was optimal for land-use and land-cover(LULC) classification in the MYRB from 2001 to 2020,when notable changes were observed in water bodies and buildings. However, the forested area exhibited an increase and decrease of 3.9% and 1.2% under the SSP1-2.6 and SSP5-8.5 scenarios, respectively, whereas farmland exhibited a diminishing trend.(2) Wetlands were primarily concentrated in the central and eastern MYRB, with counties in the southwest exhibiting superior ecological-environmental quality from 2001 to 2020. Notably,wetland coverage revealed significantly high level, significant changes, frequent but relatively minor changes under the SSP1-2.6, SSP2-4.5, and SSP 5-8.5 scenarios, respectively.(3)Regions with lower habitat quality were primarily concentrated in urbanized areas characterized by frequent human activities, indicating a clear degradation in habitat quality across different scenarios. In conclusion, we established a foundational framework for future investigations into the eco-hydrological processes and ecosystem quality of watersheds.

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Efficient fixation of CO_(2) to cyclic carbonates and oxazolidinones with multi-hydroxyl bis-(quaternary ammonium) ionic liquids as catalysts under mild conditions

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中南民族大学学报（自然科学版） 2025年第1期44卷 1-8页

作者： BAI Yumeng YANG Haijian School of environmental Engineering and Chemistry Luoyang Institute of Science and TechnologyLuoyang 471023Henan China College of Chemistry and Materials Science South-Central Minzu UniversityWuhan 430074China

A series of multi-hydroxyl bis-(quaternary ammonium)ionic liquids(Ils1‒7)was prepared as bifunctional catalysts for the chemical fixation of CO_(2).All these ionic liquid compounds were efficient for the catalytic synthesis of cyclic carbonates and oxazolidinones via the cycloaddition reactions between CO_(2) and epoxides or aziridines with excellent yield and high selectivity in the absence of co-catalyst,metal and *** to the synergistic effects of hydroxyl groups and halogen anion,the cycloaddition reactions proceeded smoothly either at atmospheric pressure or room *** selectivity for substituted oxazolidinones at 5-and 4-positions can be tuned via changing the reaction ***,possible mechanisms including the activation of both CO_(2) and epoxide or aziridines were proposed based on the literatures and experimental results.

关键词： chemical conversion of CO_(2) multi-hydroxyl bis-(quaternary ammonium) ionic liquids

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UNCOVERING BENEFITS AND RISKS OF INTEGRATED PRODUCT SERVICE OFFERINGS-USING A CASE OF technology ENCAPSULATION

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Journal of Systems Science and Systems Engineering 2013年第4期22卷 421-439页

作者： Tomohiko SAKAO Anna HRWALL RNNBCK Gunilla LUNDH SANDSTRM Division of environmental technology and Management Department of Management and Engineering Division of Industrial Economics Department of Management and EngineeringLinkoping UniversitySweden Unit of Integrated Product Development Department of Machine DesignKTH Royal Institute of TechnologySweden

The objective of this article is to uncover benefits and risks of Integrated Product Service Offering （IPSO） in a systematic manner. To do so, it adopts an explorative longitudinal in-depth case study （development of an IPSO based on a new technology） and adds insights to the existing literature. The article first proposes a theoretical and generic framework termed the PCP （Provider - Customer - Product） triangle with associated information flow and uncertainty. Second, various types of benefits and risks are presented based on the framework. Among others, the benefit of keeping IPR （Intellectual Property Rights） with the provider and the risk of regulation change are new findings from the case study. In addition, the case study reveals that IPSO is regarded as a positive contributor to innovation. Applying the framework and classification of benefits and risks as norms to other cases has yet to be done for verification. However, the framework contributes scientifically to a better understanding of the benefits and risks of IPSO. In addition, this framework is advantageous with its easiness to understand, which contributes practically to the dissemination of IPS0 insight to industry.

关键词： Product/service system (PSS) new technology intellectual property right (IPR) time to market innovation uncertainty

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Dual‑Donor‑Induced Crystallinity Modulation Enables 19.23% Efficiency Organic Solar Cells

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Nano-Micro Letters 2025年第3期17卷 376-388页

作者： Anhai Liang Yuqing Sun Sein Chung Jiyeong Shin Kangbo Sun Chaofeng Zhu Jingjing Zhao Zhenmin Zhao Yufei Zhong Guangye Zhang Kilwon Cho Zhipeng Kan Center On Nanoenergy Research Institute of Science and Technology for Carbon Peak&NeutralitySchool of Physical Science&TechnologyGuangxi UniversityNanning 530004People’s Republic of China department of Chemical Engineering Pohang University of Science and TechnologyPohang 37673South Korea College of New Materials and New Energies Shenzhen Technology UniversityShenzhen 518118People’s Republic of China Zhejiang Engineering Research Center for Fabrication and Application of Advanced Photovoltaic Materials School of Materials Science and EngineeringNingboTech UniversityNingbo 315100People’s Republic of China State Key Laboratory of Featured Metal Materials and Life-Cycle Safety for Composite Structures Nanning 530004People’s Republic of China

Trap-assisted charge recombination is one of the primary limitationsof restricting the performance of organic solar cells. However, effectivelyreducing the presence of traps in the photoactive layer remains ***, wide bandgap polymer donor PTzBI-dF is demonstrated as an effectivemodulator for enhancing the crystallinity of the bulk heterojunction active layerscomposed of D18 derivatives blended with Y6, leading to dense and orderedmolecular packings, and thus, improves photoluminescence quenching *** a result, the photovoltaic devices exhibit reduced trap-assisted charge recombinationlosses, achieving an optimized power conversion efficiency of over 19%.Besides the efficiency enhancement, the devices comprised of PTzBI-dF as athird component simultaneously attain decreased current leakage, improved chargecarrier mobilities, and suppressed bimolecular charge recombination, leading toreduced energy losses. The advanced crystalline structures induced by PTzBI-dFand its characteristics, such as well-aligned energy level, and complementaryabsorption spectra, are ascribed to the promising performance *** findings suggest that donor phase engineering is a feasible approach to tuning the molecular packings in the active layer, providingguidelines for designing effective morphology modulators for high-performance organic solar cells.

关键词： Trap-assisted charge recombination Photoluminescence Miscibility Current leakage Power conversion efficiency

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Hybrid Simulation of the Initiation and Runout Characteristics of a Catastrophic Debris Flow

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Journal of Mountain Science 2013年第2期10卷 219-232页

作者： CHEN Hong-Xin ZHANG Li-Min ZHANG Shuai XIANG Bo WANG Xiao-Feng department of Civil and environmental Engineering The Hong Kong University of Science and Technology Highway Planning SurveyDesign and Research InstituteSichuan Province Communications Department

On 13 August 2010, a catastrophic debris flow with a volume of 1.17 million m3 occurred in Xiaojiagou Ravine near Yingxiu town of Wenchuan county in Sichuan Province, China. The main source material was the landslide deposits retained in the ravine during the 2008 Wenchuan earthquake. This paper describes a two-dimensional hybrid numerical method that simulates the entire process of the debris flow from initiation to transportation and finally to deposition. The study area is discretized into a grid of square zones. A two dimensional finite difference method is then applied to simulate the rainfall-runoff and debris flow runout processes. The analysis is divided into three steps; namely, rainfall-runoff simulation, mixing water and solid materials, and debris flow runout simulation. The rainfall-runoff simulation is firstly conducted to obtain the cumulative runoff near the location of main source material and at the outlet of the first branch. The water and solid materials are then mixed to create an inflow hydrograph for the debris flow runout simulation. The occurrence time and volume of the debris flow can be estimated in this step. Finally the runout process of the debris flow is simulated. When the yield stress is high, it controls the deposition zone. When the yield stress is medium or low, both yield stress and viscosity influence the deposition zone. The flow velocity is largely influenced by the viscosity. The estimated yield stress by the equation, ty = pghsinO, and the estimated viscosity by the equation established by Bisantino et al. （2010） provide good estimates of the area of the debris flow fan and the distribution of deposition depth.

关键词： Debris flow Landslide Rain-inducedlandslide Surface runoff Runout distance Wenchuan earthquake Numerical simulation

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Use of partially shrouded impeller in a small centrifugal compressor

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Journal of Thermal Science 2008年第1期17卷 21-27页

作者： Teemu Turunen-Saaresti JaakkoLarjola department of Energy and environmental technology Lappeenranta University of TechnologyLappeenrantaFinland

Numerical analysis is conducted for the 3-dimensional impeller and vaneless diffuser of a small centrifugal com- pressor. The influence of impeller tip clearance on the flow field of the impeller is investigated. Detailed investigation on the leaking flow across the tip clearance of the impeller shows that the leaking flow rate is higher near the exit of the impeller than that near the inlet of the impeller. Based on this phenomenon, a new partially shrouded impeller is designed. The impeller is shrouded near the exit of the impeller. Numerical results show that the secondary flow region becomes smaller at the exit of the impeller. Better performance is achieved than that with the unshrouded impeller.

关键词： centrifugal compressor tip clearance partial shroud CFD.

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Electrochemical conversion of methane to bridge the gap in the artificial carbon cycle

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Journal of Energy Chemistry 2025年第1期100卷 286-308页

作者： Yuhao Peng Yuefeng Song Ihar Razanau Juanxiu Xiao Wei Xiao Di Hu Guoxiong Wang College of Chemistry and Molecular Sciences Hubei Key Laboratory of Electrochemical Power Sources Wuhan University State Key Laboratory of Catalysis Dalian National Laboratory for Clean Energy iChEM (Collaborative Innovation Center of Chemistry for Energy Materials) Dalian Institute of Chemical Physics Chinese Academy of Sciences Laboratory of Physical-Chemical Technologies SSPA Scientific and Practical Materials Research Centre of NAS of Belarus State Key Laboratory of Marine Resources Utilization in South China Sea Collaborative Innovation Center of Marine Science and Technology School of Marine Science and Engineering Hainan University department of Chemical and environmental Engineering University of Nottingham Ningbo China

Methane, an abundant one-carbon（C1） resource, is extensively used in the industrial production of vital fuels and value-added chemicals. However, current industrial methane conversion technologies are energy-and carbon-intensive, mainly due to the high activation energy required to break the inert C–H bond, low selectivity, and problematic side reactions, including CO2emissions and coke deposition. Electrochemical conversion of methane（ECM） using intermittent renewable energy offers an attractive solution, due to its modular reactor design and operational flexibility across a broad spectrum of temperatures and pressures. This review emphasizes conversion pathways of methane in various reaction systems, highlighting the significance and advantages of ECM in facilitating a sustainable artificial carbon cycle. This work provides a comprehensive overview of conventional methane activation mechanisms and delineates the complete pathways of methane conversion in electrolysis contexts. Based on surface/interface chemistry, this work systematically analyzes proposed reaction pathways and corresponding strategies to enhance ECM efficiency towards various target products, including syngas, hydrocarbons, oxygenates, and advanced carbon materials. The discussion also encompasses opportunities and challenges for the ECM process, including insights into ECM pathways, rational electrocatalyst design, establishment of benchmarking protocols, electrolyte engineering, enhancement of CH4conversion rates, and minimization of CO2emission.

关键词： Activation energy

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Inspires effective alternatives to backpropagation:predictive coding helps understand and build learning

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Neural Regeneration Research 2025年第11期20卷 3215-3216页

作者： Zhenghua Xu Miao Yu Yuhang Song School of Health Sciences and Biomedical Engineering Hebei University of TechnologyTianjinChina department of Computer Science University of OxfordOxfordUK

Artificial neural networks are capable of machine learning by simulating the hiera rchical structure of the human *** enable learning by brain and machine,it is essential to accurately identify and correct the prediction errors,referred to as credit assignment(Lillicrap et al.,2020).It is critical to develop artificial intelligence by understanding how the brain deals with credit assignment in neuroscience.

关键词： assignment learning enable

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