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Panax notoginseng saponins prevent colitis-associated colorectal cancer via inhibition IDO1 mediated immune regulation

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Chinese Journal of Natural Medicines 2022年第4期20卷 258-269页

作者： LI Xue-Ming YUAN Ding-Yi LIU Ya-Hui ZHU Lei QIN Hong-Kun YANG Yu-Bing LI Yan YAN Fang WANG Ya-Jing department of physiology School of Basic Medicine and Clinical PharmacyChina Pharmaceutical UniversityNanjing 210009China department of Pharmaceutical Analysis School of pharmacologyChina Pharmaceutical UniversityNanjing 210009China department of Chronic communicable Disease Jiangsu Provincial Center for Disease Prevention and ControlNanjing 210009China

Colorectal cancer(CRC)is the third most lethal cancer and leading cause of cancer mortality worldwide.A key driver of CRC development is colon inflammatory responses especially in patients with inflammatory bowl disease(IBD).It has been proved that Panax notoginseng saponins(PNS)have anti-inflammatory,anti-oxidant and anti-tumor *** chemopreventive and immunomodulatory functions of PNS on colitis-associated colorectal cancer(CAC)have not been *** present study was designed to study the potential protective effects of PNS on AOM/DSS-induced CAC mice to explore the possible mechanism of PNS against *** study showed that PNS significantly alleviated colitis severity and prevented the occurrence of *** assays revealed that PNS relieved immunosuppression of Treg cells in the CAC microenvironment by inhibiting the expression of IDO 1 mediated directly by signal transducer and activator of transcription 1(STAT1)rather than phosphorylated ***,Rhl,one of the PNS metabolites,exhibited the best inhibitory effect on IDO1 enzyme *** study showed that PNS exerted significant chemopreventive function and immunomodulatory properties on *** could reduce macrophages accumulation and Treg cells differentiation to reshape the immune microenvironment of *** findings provided a promising approach for CAC intervention.

关键词： Panax notoginseng saponins Colitis-associated colorectal cancer Chemoprevention Treg cells IDO1

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Hepatitis C Virus Infection Caused by Infrequent Exposure in China Should Be of Concern

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Virologica Sinica 2020年第4期35卷 481-485页

作者： Xin-Cheng Qin Li-Hua Zhong Li-Ying Zhu Alexander Plyusnin Yong-Zhen Zhang State Key Laboratory of Infectious Disease Prevention and Control Department of ZoonosesNational Institute for Communicable Disease Control and PreventionChinese Center for Disease Control and PreventionBeijing 102206China department of Infectious diseases The Fourth Hospital of Harbin Medical UniversityHarbin 150081China department of Virology Haartman InstituteUniversity of Helsinki00014 HelsinkiFinland Shanghai Public Health Clinical Center&Institute of Biomedical Sciences Fudan UniversityShanghai 200433China

Dear Editor,Hepatitis C Virus(HCV)infection is a huge public health problem globally,because it can lead to adverse long-term clinical *** China,the population has experienced a skyrocketing growth of HCV infections b... 详细信息

关键词： al. frequent clinical

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Primary antibiotic resistance of Helicobacter pylori strains isolated from patients with dyspeptic symptoms in Beijing: A prospective serial study

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World Journal of Gastroenterology 2015年第9期21卷 2786-2792页

作者： Yue-Xi Zhang Li-Ya Zhou Zhi-Qiang Song Jian-Zhong Zhang Li-Hua He Yu Ding department of Gastroenterology Beijing Sixth Hospital department of Gastroenterology Peking University Third Hospital State Key Laboratory for Infectious Disease Prevention and Control National Institute for Communicable Disease Control and PreventionChinese Center for Disease Control and Prevention

AIM:To determine the resistance patterns of Helicobacter pylori(***) strains isolated from patients in Beijing and monitor the change of antibiotic resistance over ***:In this prospective,serial and crosssectional study,*** cultures were successfully obtained from 371 and 950 patients(never receiving eradication) during 2009-2010 and 2013-2014,*** to amoxicillin,clarithromycin,metronidazole,levofloxacin,tetracycline,and rifampicin was determined by Epsilometer ***:The resistance rates of isolates obtained during 2009-2010 were 66.8%,39.9%,34.5%,15.4%,6.7%,and 4.9% to metronidazole,clarithromycin,levofloxacin,rifampicin,amoxicillin and tetracycline,respectively; and the corresponding rates for isolates during 2013-2014 were 63.4%,52.6%,54.8%,18.2%,4.4% and 7.3%,*** resistance rates to clarithromycin and levofloxacin were significantly increased after four *** 2009-2010,14.6% of *** isolates were susceptible to all tested antibiotics,with mono(33.7%),double(28.3%),triple(16.7%),quadruple(6.2%),quintuple(0.3%) and sextuple resistance(0.3%) also being *** 2013-2014,9.4% were susceptible to all tested antibiotics,and mono(27.6%),double(28.4%),triple(24.9%),quadruple(7.3%),quintuple(2.3%) and sextuple resistance(0.1%) was also *** multiple resistant *** isolates were found during ***(to levofloxacin and metronidazole),age(to levofloxacin) and endoscopic findings(to clarithromycin) were independent factors influencing antibiotic ***:*** resistance to commonly used antibiotics in Beijing is high with increased multiple antibiotic resistance.

关键词： Helicobacter pylori Antibiotic resistance Beijing

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Effects of synbiotic supplementation on anthropometric indices and body composition in overweight or obese children and adolescents:a randomized,double-blind,placebo-controlled clinical trial

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World Journal of Pediatrics 2023年第4期19卷 356-365页

作者： Mohammad Amin Atazadegan Motahar Heidari-Beni Mohammad Hassan Entezari Fariborz Sharifianjazi Roya Kelishadi department of Clinical Nutrition School of Nutrition and Food SciencesIsfahan University of Medical SciencesIsfahanIran department of Nutrition Child Growth and Development Research CenterResearch Institute for Primordial Prevention of Non-Communicable DiseaseIsfahan University of Medical SciencesIsfahanIran department of Clinical Nutrition School of Nutrition and Food ScienceIsfahan University of Medical SciencesIsfahanIran School of Science and Technology The University of GeorgiaTbilisiGeorgia department of Pediatrics Child Growth and Development Research CenterResearch Institute for Primordial Prevention of Non-Communicable DiseaseIsfahan University of Medical SciencesIsfahanIran

Background Recently,beneficial effects of probiotics and/or prebiotics on cardio-metabolic risk factors in adults have been ***,existing evidence has not been fully established for pediatric age *** study aimed to assess the effect of synbiotic on anthropometric indices and body composition in overweight or obese children and *** This randomized double-blind,placebo-controlled trial was conducted among 60 participants aged 8-18 years with a body mass index(BMI)equal to or higher than the 85th *** were randomly divided into two groups that received either a synbiotic capsule containing 6x109 colony forming units(CFU)Lactobacillus coagulans SC-208,6 x 109 CFU Lactobacillus indicus HU36 and fructooligosaccharide as a prebiotic(n=30)or a placebo(n=30)twice a day for eight *** indices and body composition were measured at baseline and after the *** The mean(standard deviation,SD)age was 11.07(2.00)years and 11.23(2.37)years for the placebo and synbiotic groups,respectively(P=0.770).The waist-height ratio(WHtR)decreased significantly at the end of the intervention in comparison with baseline in the synbiotic group(0.54±0.05 vs.0.55±0.05,P=0.05).No significant changes were dem-onstrated in other anthropometric indices or body composition between *** Synbiotic supplementation might be associated with a reduction in *** were no significant changes in other anthropometric indices or body composition.

关键词： Anthropometry Body composition Pediatrics Synbiotics

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Prevalence and Determinants of Traditional,Complementary and Alternative Medicine Provider Use among Adults from 32 Countries

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Chinese Journal of Integrative Medicine 2018年第8期24卷 584-590页

作者： Karl Peltzer Supa Pengpid Southeast Asian Nations (ASEAN) Institute for Health Development Mahidol University department of Research and Innovation University of LimpopoTurfloop Campus HIV/AIDS/STIs and tb (HAST) Human Sciences Research Council

Objective： To estimate recent prevalence data（2011-2013） on traditional,complementary and alternative medicine（TCAM） provider use and sociodemographic and health related correlates in nationally representative population samples from 32 countries from all world ***： This secondary analysis was based on the International Social Survey Program（ISSP）,2011-2013,Health and Health Care *** a cross-sectional population-based survey（N=52,801）,simple or multi-stage stratified random sampling was used,resulting in representative samples of the adult population of respective ***： Overall,the 12-month TCAM provider use prevalence was 26.4%,ranging from under 10% in Bulgaria,Poland and Slovenia to over 50% in China mainland,the Philippines and Republic of *** 80% TCAM treatment satisfaction was found in Europe in Denmark,Slovenia,Spain and Switzerland,in Asia in Taiwan（China） and *** logistic regression found sociodemographic variables（middle age,female sex,lower educational status,not having a religious affiliation,and lower economic indicators） and health variables（perceived poor or fair health status,being unhappy and depressed,having a chronic condition or disability,and having positive attitudes towards TCAM） were associated with TCAM provider ***： A high prevalence TCAM provider use was found in all world regions and several sociodemographic and health related factors of its use were identified.

关键词： utilization traditional complementary medicine Africa Asia America Australia Europe

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Evaluation of the effects of Alkyl Phenolic compounds on kinetic coefficients and biomass activity in MBBR by means of respirometric techniques

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Chinese Journal of Chemical Engineering 2018年第4期26卷 822-829页

作者： Bijan Bina Farzaneh Mohammadi Mohammad Mehdi Amin Hamid Reza Pourzamani Zeynab Yavari Environment Research Center Research Institute for Primordial Prevention of Non-communicable Disease Isfahan University of Medical Sciences department of Environmental Health Engineering School of Health Isfahan University of Medical Sciences Student Research Committee Isfahan University of Medical Sciences

The presence of Alkyl Phenols(APs) in aquatic systems is considered as one of the environmental concerns in recent decades which are generally used as surfactants. APs are endocrine disruptors and estrogen-mimicking,causing harmful effects such as feminization and carcinogenesis on aquatic environment and human *** most commercially important APs are 4-Nonyl Phenol(4-NP) and 4-tert-OctylP henol(4-t-OP). Moving bed biofilm reactor(MBBR), which combined attached and suspended growth advantages, is an advanced biological treatment process for municipal and industrial wastewaters that has drawn considerable attention from many researchers to remove toxic pollutants from wastewater. The aim of this research was to evaluate Bacterial activities and kinetic coefficients in the presence of APs. This study was carried out using laboratory-scale MBBR fed with synthetic wastewater containing 4-NP and 4-t-OP. The reactor was operated at different loads of chemical oxygen demand(COD) and APs and different hydraulic retention time(HRT). The respirometric technique was applied to investigate the effect of APs on heterotrophic and autotrophic activity and kinetic coefficients in biomass obtained from MBBR. Respirometric technique demonstrates a reliable tool in order to assess the biofilm kinetic coefficients and biomass viability to insert in the mathematical models. The calculated kinetic parameters were in the range of conventional and extended aeration activated sludge processes. The results demonstrate that APs have significant inhibitory effects on activity and growth rate of heterotrophic and autotrophic bacteria, heterotrophs have been less affected by the presence of 4-NP and 4-t-OP, and these compounds had greater inhibitory effects on autotrophic bacteria.

关键词： Alkyl Phenols Autotrophs Heterotrophs Kinetic coefficients MBBR Respirometric techniques

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The occurrence,fate,and distribution of natural and synthetic hormones in different types of wastewater treatment plants in Iran

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Chinese Journal of Chemical Engineering 2018年第5期26卷 1132-1139页

作者： Mohammad Mehdi Amin Bijan Bina Afshin Ebrahimi Zeynab Yavari Farzaneh Mohammadi Somayeh Rahimi Environment Research Center Research Institute for Primordial Prevention of Non-communicable Disease Isfahan University of Medical Sciences department of Environmental Health Engineering School of Health Isfahan University of Medical Sciences Student Research Committee Isfahan University of Medical Sciences

Over the past few years, the presence of steroid estrogens in the environment has become a major concern. In this study, the concentrations of estrone （El）, 17β-estradinl （E2）, and 17α-ethinyl estradiol （EE2） were measured in some wastewater treatment plants （WWTPs） in lran. These samples were collected from the municipal, rural, livestock, commercial, and hospital WWTPs, extracted by dispersive liquid-liquid micro extraction （DLLME） technique, derivatized, and detected by GC/MS. In these treatment plants, various processes including conven- tional activated sludge （CAS）, aerated lagoon （AL）, moving bed biofilm reactor （MBBR）, and activated sludge with wetland （AS ＋ WL） are used. The highest concentration of hormones was observed in the influents and effluents of livestock, municipal, commercial, and hospital WWTPs, respectively. The maximum elimination rate was obtained in MBBR followed by AS ＋ WL CAS and AL The biodegradation and adsorption rates along with adsorption coefficients of 1g kd and 1g koc were measured for all target compounds.

关键词： Influent Effluent Estrogen Wastewater Biodegradation

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China Stroke Statistics 2019:A Report From the National Center for Healthcare Quality Management in Neurological diseases,China National Clinical Research Center for Neurological diseases,the Chinese Stroke Association,National Center for Chronic and Non-communicable Disease Control and Prevention,Chinese Center for Disease Control and Prevention and Institute for Global Neuroscience and Stroke Collaborations

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Stroke & Vascular Neurology 2020年第3期5卷 211-239页

作者： Yong-Jun Wang Zi-Xiao Li Hong-Qiu Gu Yi Zhai Yong Jiang Xing-Quan Zhao Yi-Long Wang Xin Yang Chun-Juan Wang Xia Meng Hao Li Li-Ping Liu Jing Jing Jing Wu An-Ding Xu Qiang Dong David Wang Ji-Zong Zhao On behalf of China Stroke Statistics 2019 Writing Committee China National Clinical Research Center for Neurological diseases Beijing Tiantan HospitalCapital Medical UniversityBeijingChina National Center for Healthcare Quality Management in Neurological diseases Beijing Tiantan HospitalCapital Medical UniversityBeijingChina National Center for Chronic and Non-communicable Disease Control and Prevention Chinese Center for Disease Control and PreventionBeijingChina department of Neurology and Stroke Center The First Affiliated HospitalJinan UniversityGuangzhouGuangdongChina department of Neurology Huashan HospitalFudan UniversityShanghaiChina Neurovascular Division Department of NeurologyBarrow Neurological InstituteSt.Joseph's Hospital and Medical CenterPhoenixArizonaUSA 不详

China faces the greatest challenge from stroke in the *** death rate for cerebrovascular diseases in China was 149.49 per 100000,accounting for 1.57 million deaths in *** ranked third among the leading causes of death behind malignant tumours and heart *** age-standardised prevalence and incidence of stroke in 2013 were 1114.8 per 100000 population and 246.8 per 100000 person-years,*** to the Global Burden of Disease Study 2017,the years of life lost(YLLs)per 100000 population for stroke increased by 14.6%;YLLs due to stroke rose from third highest among all causes in 1990 to the highest in *** absolute numbers and rates per 100000 population for all-age disability-adjusted life years(DALYs)for stroke increased substantially between 1990 and 2017,and stroke was the leading cause of all-age DALYs in *** main contributors to cerebrovascular diseases include behavioural risk factors(smoking and alcohol use)and pre-existing conditions(hypertension,diabetes mellitus,dyslipidaemia and atrial fibrillation(AF)).The most prevalent risk factors among stroke survivors were hypertension(63.0%-84.2%)and smoking(31.7%-47.6%).The least prevalent was AF(2.7%-7.4%).The prevalences for major risk factors for stroke are high and most have increased over *** on the latest national epidemiological data,26.6%of adults aged≥15 years(307.6 million adults)smoked tobacco *** those aged≥18 years,age-adjusted prevalence of hypertension was 25.2%;adjusted prevalence of hypercholesterolaemia was 5.8%;and the standardised prevalence of diabetes was 10.9%.For those aged≥40 years,the standardised prevalence of AF was 2.31%.Data from the Hospital Quality Monitoring System showed that 3010204 inpatients with stroke were admitted to 1853 tertiary care hospitals during *** those,2466785(81.9%)were ischaemic strokes(ISs);447609(14.9%)were intracerebral haemorrhages(ICHs);and 95810(3.2%)were subarachnoid haemorrhages(SAHs).The average age

关键词： admitted smoke insurance

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Sleep Status Among Children and Adolescents Aged 6-17 Years—China,2016-2017

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China CDC weekly 2023年第1期5卷 11-16页

作者： Yushu Zhang Zhengjing Huang Mei Zhang Chun Li Zhenping Zhao Xiao Zhang Yunqi Guan Nyasha Grace Mudoti Limin Wang Division of Chronic Disease and Risk Factor Surveillance National Center for Chronic and Non-communicable Disease Control and PreventionChinese Center for Disease Control and PreventionBeijingChina department of Health Statistics School of Public HealthChina Medical UniversityShenyang CityLiaoning ProvinceChina department of Non-communicable Disease Control and Prevention Zhejiang Provincial Center for Disease Control and PreventionHangzhou CityZhejiang ProvinceChina International Education School China Medical UniversityShenyang CityLiaoning ProvinceChina

Summary What is already known about this topic?There has been little to no description of sleep status among children and adolescents nationwide in recent *** is added by this report?This report assesses the sleep duration and sleep patterns of children and adolescents in *** half of the adolescents did not get the recommended amount of sleep on school days,and more than half overslept on weekends.

关键词： sleep China. nationwide

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Molecular Detection of Ofloxacin and Kanamycin Resistance in Patients with MDR and Non-MDR tb from Suburban Districts in Hangzhou,China,2019–2020

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Biomedical and Environmental Sciences 2022年第5期35卷 468-471页

作者： JIA Qing Jun ZENG Mei Chun XIE Li CHENG Qing Lin HUANG Yin Yan LI Qing Chun WU Yi Fei AI Li Yun LU Min FANG Zi Jian department of tb Control and Prevention Hangzhou Center for Disease Control and PreventionHangzhou 310021ZhejiangChina department of Pathology The First Affiliated HospitalCollege of MedicineZhejiang UniversityHangzhou 310003ZhejiangChina

The continuing emergence and spread of drugresistant Mycobacterium tuberculosis complex(MtbC)poses a challenge to global tuberculosis(tb)control *** resistance in tb is mainly conferred by specific point mutations in ... 详细信息

关键词： tuberculosis Patients Molecular

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