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Prediction and stratification for the surgical adverse events after minimally invasive esophagectomy:A two-center retrospective study

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World Journal of Gastroenterology 2025年第3期31卷 50-61页

作者： Qi-Hong Zhong Jiang-Shan Huang Fei-Long Guo Jing-Yu Wu Mao-Xiu Yuan Jia-Fu Zhu Wen-Wei Lin Sui Chen Zhen-Yang Zhang Jiang-Bo Lin department of Thoracic surgery Fujian Medical University Union HospitalFuzhou 350001Fujian ProvinceChina The Graduate School Fujian Medical UniversityFuzhou 350001Fujian ProvinceChina department of Thoracic surgery Affiliated Hospital of Jinggangshan UniversityJi’an 343000Jiangxi ProvinceChina

BACKGROUND Minimally invasive esophagectomy(MIE)is a widely accepted treatment for esophageal cancer,yet it is associated with a significant risk of surgical adverse events(SAEs),which can compromise patient recovery and long-term *** preoperative identification of high-risk patients is critical for improving *** To establish and validate a risk prediction and stratification model for the risk of SAEs in patients with *** This retrospective study included 747 patients who underwent MIE at two centers from January 2019 to February *** were separated into a train set(n=549)and a validation set(n=198).After screening by least absolute shrinkage and selection operator regression,multivariate logistic regression analyzed clinical and intraoperative variables to identify independent risk factors for SAEs.A risk stratification model was constructed and validated to predict the probability of *** SAEs occurred in 10.2%of patients in train set and 13.6%in the validation *** with SAE had significantly higher complication rate and a longer hospital stay after *** key independent risk factors identified included chronic obstructive pulmonary disease,a history of alcohol consumption,low forced expiratory volume in the first second,and low albumin *** stratification model has excellent prediction accuracy,with an area under the curve of 0.889 for the training set and an area under the curve of 0.793 for the validation *** The developed risk stratification model effectively predicts the risk of SAEs in patients undergoing MIE,facilitating targeted preoperative interventions and improving perioperative management.

关键词： Surgical adverse events Minimally invasive esophagectomy Esophageal cancer Stratification model Perioperative management

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Retroperitoneal fibrosis: A rare cause of both ureteral and small bowel obstruction

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World Journal of Gastroenterology 2006年第43期12卷 7061-7063页

作者： Faisal Aziz Srinivasulu Conjeevaram Than Phan department of surgery New York Medical College Valhallah NY 10595 United States department of surgery. north oakland medical centers MI 48341 United States Attending Physician Department of Surgery North Oakland Medical Centers MI 48341 United States

Retroperitoneal fibrosis (RPF) is a rare condition of unclear etiology. It can cause ureteral obstruction. We present the unique case of a 54 years old female, who initially presented with spontaneous perforation of the cecum. Upon exploring the abdomen, the classical glistening white, unyielding retroperitoneal fibrosis was encountered. A right hemicolectomy was performed. Subsequently, the patient presented with bilateral ureteral obstruction, and later on with small bowel obstruction. Ureteral obstruction was treated with stents, and small bowel obstruction was treated with bypass. To our knowledge no case of idiopathic RPF presenting with features of both bilateral ureteral and small bowel obstruction has been reported in the literature.

关键词： Retroperitoneal fibrosis Ureteral obstruction Small bowel obstruction surgery.for retroperitonealfibrosis

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Small extracellular vesicles derived from cerebral endothelial cells with elevated microRNA 27a promote ischemic stroke recovery

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Neural Regeneration Research 2025年第1期20卷 224-233页

作者： Yi Zhang Zhongwu Liu Michael Chopp Michael Millman Yanfeng Li Pasquale Cepparulo Amy Kemper Chao Li Li Zhang Zheng Gang Zhang department of Neurology Henry Ford HospitalDetroitMIUSA department of Physics Oakland UniversityRochesterMIUSA department of Pathology Henry Ford HospitalDetroitMIUSA Division of Pharmacology Department of NeuroscienceReproductive and Dentistry SciencesSchool of MedicineUniversity of Naples“Federico Ⅱ”NaplesItaly

Axonal remodeling is a critical aspect of ischemic brain repair processes and contributes to spontaneous functional *** previous in vitro study demonstrated that exosomes/small extracellular vesicles(sEVs)isolated from cerebral endothelial cells(CEC-sEVs)of ischemic brain promote axonal growth of embryonic cortical neurons and that microRNA 27a(miR-27a)is an elevated miRNA in ischemic *** the present study,we investigated whether normal CEC-sEVs engineered to enrich their levels of miR-27a(27a-sEVs)further enhance axonal growth and improve neurological outcomes after ischemic stroke when compared with treatment with non-engineered CEC-sEVs.27a-sEVs were isolated from the conditioned medium of healthy mouse CECs transfected with a lentiviral miR-27a expression *** EVs isolated from CECs transfected with a scramble vector(Scra-sEVs)were used as a *** male mice were subjected to permanent middle cerebral artery occlusion and then were randomly treated with 27a-sEVs or *** array of behavior assays was used to measure neurological *** with treatment of ischemic stroke with Scra-sEVs,treatment with 27a-sEVs significantly augmented axons and spines in the peri-infarct zone and in the corticospinal tract of the spinal grey matter of the denervated side,and significantly improved neurological *** vitro studies demonstrated that CEC-sEVs carrying reduced miR-27a abolished 27a-sEV-augmented axonal *** analysis revealed that 27a-sEVs systemically administered preferentially localized to the pre-synaptic active zone,while quantitative reverse transcription-polymerase chain reaction and Western Blot analysis showed elevated miR-27a,and reduced axonal inhibitory proteins Semaphorin 6A and Ras Homolog Family Member A in the peri-infarct *** of the Clathrin-dependent endocytosis pathway substantially reduced neuronal internalization of *** data provide evidence that 27a-sEVs have

关键词： axonal remodeling cerebral endothelial cells exosomes miR-27a mitochondria Semaphorin 6A small extracellular vesicles stroke

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Animal models of human colorectal cancer:Current status, uses and limitations

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World Journal of Gastroenterology 2015年第41期21卷 11854-11861页

作者： Vijay K Mittal Jasneet Singh Bhullar Kumar Jayant department of surgery Providence Hospital and Medical Centers department of Colorectal surgery University of MinnesotaMN 55114 United States

AIM: To make orthotopic colon cancer murine modelsa more clearly understood subject. The orthotopic tumor models have been found to be more relevant in replicating the human disease process as compared to heterotopic models, many techniques for making orthotopic colorectal murine models have been ***: We evaluated the current literature for various reported orthotopic colon cancer models to understand their techniques, advantages and limitations. An extensive literature review was performed by searching the National Library of Medicine Database(Pub Med) using Me SH terms animal model; colon cancer; orthotopic model; murine model. Twenty studies related to colon cancer orthotopic xenograft model were evaluated in detail and discussed here. RESULTS: The detailed analysis of all relevant reports on orthotopic model showed tumor take rate between 42%-100%. While models using the enema technique and minimally invasive technique have reported development of tumor from mucosa with tumor take rate between 87%-100% with metastasis in 76%-90%.CONCLUSION: Over the years, the increased understanding of the murine models of human colon cancer has resulted in the development of various models. Each reported model has some limitations. These latest models have opened up new doors for continuing cancer research for not only understanding the colon cancer pathogenesis but also aid in the development of newer chemotherapeutic drugs as they mimic the human disease closely.

关键词： Murine model Colon cancer Colon cancer murine mode

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Pancreatic intraepithelial neoplasia arising from an ectopic pancreas in the small bowel

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Hepatobiliary & Pancreatic Diseases International 2014年第6期13卷 658-661页

作者： Francisco Igor Macedo Deepa Taggarshe Tafadzwa Makarawo Barry Herschman Michael J Jacobs department of General surgery Providence Hospital and Medical Centers Southfield MI 48075 USA department of General surgery. Providence Hospital and Medical Centers Southfield MI 48075 USA department of Pathology Providence Hospital and Medical Centers Southfield MI 48075 USA

BACKGROUND： Ectopic pancreatic tissue is relatively uncommon, and is characterized as pancreatic tissue with no contact with the normal pancreas, and with its own ductal system and blood supply. It is usually asymptomatic, and can be incidentally diagnosed by conventional imaging studies. METHOD： A 69-year-old woman with a prior history of bilateral breast carcinoma presented with ectopic pancreatic intraepithelial neoplasia （PanIN） that was identified incidentally in the small bowel during an oncological resection of a synchronous primary pancreatic adenocarcinoma, and renal cell carcinoma. RESULTS： The patient underwent subtotal pancreatectomy with splenectomy, regional lymphadenectomy, radical left nephrectomy, and small bowel resection with primary anastomosis of ectopic PanlN-2. She had an uneventful hospitalization and was discharged home on postoperative day 7. CONCLUSIONS： The occurrence of ectopic PanIN is extremely unusual with only few cases previously reported in the literature. The need for negative margins after surgical resection of ectopic PanIN lesions remains controversial.

关键词： ectopic pancreas pancreatic intraepithelial neoplasia PanIN pancreatic adenocarcinoma

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Propensity score analysis demonstrated the prognostic advantage of anatomical liver resection in hepatocellular carcinoma

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World Journal of Gastroenterology 2014年第12期20卷 3335-3342页

作者： Masayuki Ishii Toru Mizuguchi Masaki Kawamoto Makoto Meguro Shigenori Ota Toshihiko Nishidate Kenji Okita Yasutohsi Kimura Thomas T Hui Koichi Hirata department of surgery Surgical Oncology and ScienceSapporo Medical University Hospital Sapporo medical University department of surgery Children’s Hospital and Research Center Oakland

AIM: To compare the prognoses of hepatocellular carcinoma (HCC) patients that underwent anatomic liver resection (AR) or non-anatomic liver resection (NAR) using propensity score-matched populations.

关键词： Anatomical liver resection Propensity score analysis Hepatocellular carcinoma

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Couinaud’s corrosion casts of the liver

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Hepatobiliary surgery.and Nutrition 2022年第2期11卷 174-175页

作者： Thomas M.van Gulik department of surgery Amsterdam University Medical CentersUniversity of AmsterdamAmsterdamThe Netherlands

Claude Couinaud[1922-2008],a French surgeon-anatomist,became famous for his classification of the segmental division of the *** defined each segment by its distinct portal venous anatomy and its intersegmental,watershed *** segment would function as an independent functional unit with its own biliary ductal system draining into the central bile *** from all segments is collected into the three main hepatic veins that drain into the caval vein.

关键词： drain watershed Blood

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*** of Assisi receives the stigma on his liver

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Hepatobiliary surgery.and Nutrition 2023年第3期12卷 300-301页

作者： Thomas M.van Gulik department of surgery Amsterdam University Medical CentersUniversity of AmsterdamAmsterdamThe Netherlands

A remarkable painting of *** of Assisi is on display in the Indianapolis Museum of Art at Newfields,USA,painted by the Italian master Pietro da Rimini around 1330(Figure 1)(1).The painting is entitled‘Saint Francis receives the stigmata’,and depicts the saint experiencing a vision as he *** sees Christ,bearing the wounds from his crucifixion,flying with an angel-like creature called a *** wounds of Christ represent the four places where nails were driven through his hands and feet during his crucifixion,each denoting a stigma.A fifth stigma appears as a wound on the right side of his chest,where he was stabbed with a lance between the ribs by the Roman soldier who wanted to ascertain his death.

关键词： Italian Figure painting

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Liver anatomy by Francis Glisson

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Hepatobiliary surgery.and Nutrition 2022年第4期11卷 502-503页

作者： Thomas M.van Gulik department of surgery Amsterdam University Medical CentersUniversity of AmsterdamAmsterdamThe Netherlands

Francis Glisson(1598-1677)was born in Bristol and studied to become a doctor at Caius College,Cambridge,where he eventually was appointed as professor of *** wrote the first monograph on the anatomy of the liver in hi... 详细信息

关键词： anatomy College eventually

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Babylonian clay tablet of the liver

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Hepatobiliary surgery.and Nutrition 2023年第1期12卷 1-2页

作者： Thomas M.van Gulik department of surgery Amsterdam University Medical CentersUniversity of AmsterdamAmsterdamThe Netherlands

The Babylonians were an ancient people living from approximately 2000 BC to 1600 BC in southern Mesopotamia,a fertile region situated between the Tigris and Euphrates river,an area for the greater part corresponding with modern *** reached a high level of civilization with their own Akkadian language,writings and *** the realm of their religion,they worshipped a host of gods and goddesses,each with different names and distinct functions.

关键词： situated approximate realm

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