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Neural Regeneration Research 2025年第6期20卷 1705-1706页

作者： Kazuki Watanabe Atsuhiko Hattori department of Immunobiology Institute of Development Aging and CancerTohoku UniversitySendaiMiyagiJapan department of sport and wellness College of Sport and WellnessRikkyo UniversityNiizaSaitamaJapan

Melatonin(N-acetyl-5-methoxytryptamine)is known as the hormone of darkness because it is synthesized at night and involved in regulating the circadian *** hormone is primarily synthesized by the vertebrate pineal gland,but is ubiquitous among invertebrates,unicellular organisms,plants,and even cyanobacteria(Hattori and Suzuki,2024).Melatonin is well-conserved evolutionarily and possesses several physiological functions,such as immune response,bone and glucose metabolism,and memory formation besides regulating the circadian rhythm.

关键词： metabolism primarily agent

Movement analysis in the diagnosis and management of Parkinson’s disease

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Neural Regeneration Research 2025年第2期20卷 485-486页

作者： Johannes Burtscher Nicolas Bourdillon Jules MJanssen Daalen Aurélien Patoz Julien FBally Martin Kopp Davide Malatesta Bastiaan RBloem Institute of sport Sciences University of LausanneLausanneSwitzerland Radboud University Medical Center Department of NeurologyDonders Institute for BrainCognition and BehaviorCenter of Expertise for Parkinson and Movement DisordersNijmegenThe Netherlands Radboud University Medical Center Department of Medical BioSciencesNijmegenThe Netherlands Research and Development department Volodalen Swiss Sport LabAigleSwitzerland Service of Neurology Department of Clinical NeurosciencesLausanne University Hospital(CHUV)and University of Lausanne(UNIL)LausanneSwitzerland department of sport Science University of InnsbruckInnsbruckAustria

Challenges in the diagnosis and treatment of Parkinson’s disease:Parkinson’s disease(PD)is an increasingly prevalent neurodegenerative disease,at first sight primarily characterized by motor symptoms,although non-motor symptoms also constitute a major part of the overall ***,this disease cannot be diagnosed reliably until a large part of the vulnerable dopaminergic neurons has been irretrievably lost,and the disease progresses *** biological criteria for PD have been proposed recently and might eventually improve early diagnosis,but they require further validation,and their use will initially be restricted to a research environment(Darweesh et al.,2024).

关键词： diagnosis Clinical eventually

Multilevel analysis of the central-peripheral-target organ pathway:contributing to recovery after peripheral nerve injury

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Neural Regeneration Research 2025年第10期20卷 2807-2822页

作者： Xizi Song Ruixin Li Xiaolei Chu Qi Li Ruihua Li Qingwen Li Kai-Yu Tong Xiaosong Gu Dong Ming Academy of Medical Engineering and Translational Medicine Tianjin UniversityTianjinChina Haihe Laboratory of Brain-Machine Interface and Human-Machine Fusion TianjinChina department of Rehabilitation Tianjin University Tianjin HospitalTianjinChina department of Hand Microsurgery Tianjin University Tianjin HospitalTianjinChina School of Exercise and Health Tianjin University of SportTianjinChina department of Biomedical Engineering the Chinese University of Hong KongHong Kong Special Administrative RegionChina

Peripheral nerve injury is a common neurological condition that often leads to severe functional limitations and *** on the pathogenesis of peripheral nerve injury has focused on pathological changes at individual injury sites,neglecting multilevel pathological analysis of the overall nervous system and target *** has led to restrictions on current therapeutic *** this paper,we first summarize the potential mechanisms of peripheral nerve injury from a holistic perspective,covering the central nervous system,peripheral nervous system,and target *** peripheral nerve injury,the cortical plasticity of the brain is altered due to damage to and regeneration of peripheral nerves;changes such as neuronal apoptosis and axonal demyelination occur in the spinal *** nerve will undergo axonal regeneration,activation of Schwann cells,inflammatory response,and vascular system regeneration at the injury *** damage to target organs can occur,including skeletal muscle atrophy and sensory receptor *** then provide a brief review of the research advances in therapeutic approaches to peripheral nerve *** main current treatments are conducted passively and include physical factor rehabilitation,pharmacological treatments,cell-based therapies,and physical ***,most treatments only partially address the problem and cannot complete the systematic recovery of the entire central nervous system-peripheral nervous system-target organ ***,we should further explore multilevel treatment options that produce effective,long-lasting results,perhaps requiring a combination of passive(traditional)and active(novel)treatment methods to stimulate rehabilitation at the central-peripheral-target organ levels to achieve better functional recovery.

关键词： central nervous system central peripheral target organ multilevel pathological analysis nerve regeneration peripheral nerve injury peripheral nervous system target organs therapeutic approach

Impacts of Nutlin-3a and exercise on murine double minute 2-enriched glioma treatment

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Neural Regeneration Research 2025年第4期20卷 1135-1152页

作者： Yisheng Chen Zhongcheng Fan Zhiwen Luo Xueran Kang Renwen Wan Fangqi Li Weiwei Lin Zhihua Han Beijie Qi Jinrong Lin Yaying Sun Jiebin Huang Yuzhen Xu Shiyi Chen department of sport Medicine Huashan HospitalFudan UniversityShanghaiChina department of Orthopedic Surgery Hainan Province Clinical Medical CenterHaikou Affiliated Hospital of Central South University Xiangya School of MedicineHaikouHainan ProvinceChina department of Basic Medicine Shanghai Jiao Tong University School of MedicineShanghai Jiao Tong UniversityShanghaiChina department of Neurosurgery Second Affiliated Hospital of Zhejiang University School of MedicineZhejiang UniversityHangzhouZhejiang ProvinceChina department of Orthopedics Shanghai General HospitalSchool of Medicine Shanghai Jiao Tong UniversityShanghaiChina department of Infectious Diseases Children’s Hospital of Fudan UniversityNational Children’s Medical CenterShanghaiChina department of Rehabilitation The Second Affiliated Hospital of Shandong First Medical UniversityTaianShandong ProvinceChina

Recent research has demonstrated the impact of physical activity on the prognosis of glioma patients,with evidence suggesting exercise may reduce mortality risks and aid neural *** role of the small ubiquitin-like modifier(SUMO)protein,especially post-exercise,in cancer progression,is gaining attention,as are the potential anti-cancer effects of *** used machine learning to create the exercise and SUMO-related gene signature(ESLRS).This signature shows how physical activity might help improve the outlook for low-grade glioma and other *** demonstrated the prognostic and immunotherapeutic significance of ESLRS markers,specifically highlighting how murine double minute 2(MDM2),a component of the ESLRS,can be targeted by *** underscores the intricate relationship between natural compounds such as nutlin-3 and immune *** comprehensive CRISPR screening,we validated the effects of specific ESLRS genes on low-grade glioma *** also revealed insights into the effectiveness of Nutlin-3a as a potent MDM2 inhibitor through molecular docking and dynamic ***-3a inhibited glioma cell proliferation and activated the p53 *** efficacy decreased with MDM2 overexpression,and this was reversed by Nutlin-3a or *** using a low-grade glioma mouse model highlighted the effect of physical activity on oxidative stress and molecular pathway ***,both physical exercise and Nutlin-3a administration improved physical function in mice bearing tumors derived from MDM2-overexpressing *** results suggest the potential for Nutlin-3a,an MDM2 inhibitor,with physical exercise as a therapeutic approach for glioma *** research also supports the use of natural products for therapy and sheds light on the interaction of exercise,natural products,and immune regulation in cancer treatment.

关键词： exercise and SUMO-related gene signatures(ESLRS) glioblastoma management low-grade glioma natural bioactives neural regeneration physical exercise

Prognostic impact of inflammatory and nutritional biomarkers in pancreatic cancer

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World Journal of Clinical Oncology 2025年第1期16卷 5-9页

作者： Macarena Teja María I Garrido Abrahams Ocanto Felipe Counago department of Radiation Oncology GenesisCare-San Francisco de Asís University HospitalMadrid 28002Spain department of Radiation Oncology GenesisCare-Vithas La Milagrosa University HospitalMadrid 28010Spain National Director GenesisCare SpainMadrid 28043Spain department of Medicine School of MedicineHealth and SportEuropean University of MadridMadrid 28670Spain

Pancreatic cancer is usually associated with a poor *** is the main curative treatment but pancreatic operations are aggressive and new tools that help clinicians to predict surgical and prognostic outcomes are *** et al recently published a retrospective,single centre cohort study evaluating the impact of seven nutritional and inflammatory markers in pancreatic cancer surgical patients:The albumin-to-globulin ratio,prognostic nutritional index(PNI),systemic immune-inflammation index(SII),neutrophil-to-lymphocyte ratio(NLR),platelet-to-lymphocyte ratio(PLR),nutritional risk index,and the geriatric nutritional risk index.A significant correlation was found between the PNI,SII,NLR,and PLR and a hospital discharge of less than 15 *** a univariable analysis,PNI,SII,NLR and PLR were significantly related to recurrence-free survival and,in a multivariable analysis PNI was associated with overall *** meta-analyses corroborate the results in terms of prognosis but individual studies are discordant on their ***,the cut-off values for these markers vary significantly between studies and there are no clinical trials comparing them to identify the most relevant *** are limitations when implementing nutritional and inflammatory biomarkers into clinical practice and further studies are needed in order to answer these questions.

关键词： Inflammatory biomarkers Nutritional biomarkers Pancreatic cancer Prognosis Surgical complications

Modulation of antioxidant status in streptozotocin-induced diabetic male wistar rats following intake of red palm oil and/or rooibos

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Asian Pacific Journal of Tropical Medicine 2014年第7期7卷 536-544页

作者： Ademola Ayeleso Nicole Brooks Oluwafemi Oguntibeju Oxidative Stress Research Centre.department of Biomedical Sciences Faculty of Health & Wellness SciencesCape Peninsula University of Technology department of wellness Sciences.Faculty of Health & wellness Sciences Cape Peninsula University of Technology

Objective:To investigate the role of red palm oil(RPO),rooibos tea extract(RTE)and their combined treatment(RPO+RTE)on antioxidant status in streptozotocin(STZ)-induced diabetic ***:Diabetes mellitus was induced by a single administration of streptozotocin(50 mg/kg)and the rats were treated for 7 *** enzymes[calalase(CAT),glutathione peroxidase(GPx),superoxide dismutase(SOD)],antioxidant capacity[trolox equivalence antioxidant capacity(TEAC),oxygen radical absorbance capacity(ORAC)]as well as total protein,albumin,globulin,total glutathione,conjugated diene and thiobarbituric acid reactive substances(TBARS)were ***:Treatment with RPO,RTE and RPO+RTE significantly(p>0.05)improved liver SOD and plasma ORAC in the diabetic ***,diabetic rats treated with RTE and RPO+RTE enhanced liver GPx.A significant(P<0.05)increase in the plasma TBARS in the diabetic control group was observed when compared with the normal control *** of diabetic rats with RTE and RPO+RTE reduced plasma TBARS to a level not significantly different at P<0.05 from the normal control ***:The results revealed the anti-oxidative potentials of red palm oil,rooibos and their combination in diabetic conditions and hence,they could be useful in the management of diabetes and its complications.

关键词： Red palm oil Rooibos Antioxidant Streptozotocin Diabetes Rats

Waist circumference thresholds and cardiorespiratory fitness

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Journal of sport and Health Science 2019年第1期8卷 17-22页

作者： Sindre M.Dyrstad Elisabeth Edvardsen Bj?rge H.Hansen Sigmund A.Anderssen department of Education and sport Science University of Stavanger department of sports Medicine Norwegian School of Sport Sciences department of Pulmonary Medicine Oslo University Hospital

Purpose: This study's purpose was to examine whether established risk categories of waist circumference(WC)—normal, high risk, and very high health risk—reflected significant differences in cardiorespiratory fitness(CRF) and physical activity(PA) ***: CRF was directly measured as maximal oxygen uptake during a progressive graded treadmill test to exhaustion in 722 individuals(349 women) aged 20à85 years. WC was measured between the lower rib and the iliac crest. Objectively measured PA was assessed using an ***: Men in the normal risk group(WC 102 cm). Corresponding numbers for women within normal(WC 88 cm) were 25% and 18%(p < 0.05). There was a high negative correlation between CRF and WC in men(r = ?0.68), and a moderate correlation for women(r = ?0.49; p < 0.001). For each cm increase in WC, CRF was reduced by 0.48 and 0.27 mL/kg/min in men and women,respectively(p < 0.001).Conclusion: The recommended WC thresholds for abdominal obesity reflected significant differences in CRF for both men and women, and could serve as a useful instrument for estimating health-related differences in CRF.

关键词： Abdominal obesity Fit fat Maximal oxygen uptake Obesity Public health Waist circumference

Advances in the study of mitophagy in osteoarthritis

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2024年第3期25卷 197-211页

作者： Hong CAO Xuchang ZHOU Bowen XU Han HU Jianming GUO Miao WANG Nan LI Jun ZOU department of sport Rehabilitation Shanghai University of SportShanghai 200438China National Key Laboratory of Immunity and Inflammation Naval Medical UniversityShanghai 200433China School of sport Medicine and Rehabilitation Beijing Sport UniversityBeijing 100084China

Osteoarthritis(OA),characterized by cartilage degeneration,synovial inflammation,and subchondral bone remodeling,is among the most common musculoskeletal disorders globally in people over 60 years of *** initiation and progression of OA involves the abnormal metabolism of chondrocytes as an important pathogenic *** degeneration features mitochondrial dysfunction as one of the important causative factors of abnormal chondrocyte ***,maintaining mitochondrial homeostasis is an important strategy to mitigate *** is a vital process for autophagosomes to target,engulf,and remove damaged and dysfunctional mitochondria,thereby maintaining mitochondrial *** studies have revealed a strong association between mitophagy and OA,suggesting that the regulation of mitophagy may be a novel therapeutic direction for *** reviewing the literature on mitophagy and OA published in recent years,this paper elaborates the potential mechanism of mitophagy regulating OA,thus providing a theoretical basis for studies related to mitophagy to develop new treatment options for OA.

关键词： Mitophagy Osteoarthritis Chondrocyte Mitochondria Apoptosis

Neurophysiological correlates of interference control and response inhibition processes in children and adolescents engaging in open-and closed-skill sports

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Journal of sport and Health Science 2022年第2期11卷 224-233页

作者： Sebastian Ludyga Manuel Mücke Christian Andra Markus Gerber Uwe Pühse department of sport Exercise and HealthUniversity of BaselBasel 4052Switzerland department of School sport Leipzig UniversityLeipzig 04109Germany

Background:Accumulating evidence suggests that sports participation promotes the development of inhibitory control,but the influences of the sports category and inhibition type still remain *** categorization of sports based on the open-skill(externally paced)and closed-skill(self-paced)continuum allows for the integration of the environment as a factor contributing to sports-related benefits for inhibitory ***:Cross-sectional data from different studies were combined(n=184)to examine the association between open-and closed-skill sports and cognitive control processes related to interference control and response ***(aged 9-14 years)filled in 7-day physical activity recall protocols and completed a Stroop Color-Word or a Go/NoGo *** N200,N450,and P300 components of event-related potentials elicited by these tasks were recorded using ***:Partial correlations supported the belief that time spent in open-skill sports was related to higher performance on inhibition ***,path analyses revealed an association between this sports type and a greater negativity in the N200 and N450 amplitudes in both the full sample and group-level *** contrast,no relation was found between sports type and P300 ***:The findings suggest that only the engagement in open-skill sports is associated with more effective conflict monitoring and higher performance on tasks demanding inhibitory control.

关键词： Conflict monitoring Event-related potentials Exercise Go/NoGo Stroop Color-Word Physical activity

A Novel Smart Forwarding Scheme in LTE-Advanced Networks

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China Communications 2015年第3期12卷 120-131页

作者： CHEN Jengyueng YANG Chunchuan MAI Yiting department of Information Networking Technology Hsiuping University of Science & Technology department of Computer Science and Information Engineering National Chi Nan University department of sport Management National Taiwan University of Sport

Long Term Evolution(LTE) and IEEE 802.16 WiMAX are competing access network technologies adopted in 4G wireless networks in recent *** complies with3 GPP standards whereas 802.16 WiMAX is regulated by the Institute of Electrical and Electronics Engineers(IEEE).Although WiMAX is already operating commercially in Taiwan,the system is limited to an independent new system that is incompatible with the current 3G ***,the cost of implementing the WiMAX system is relatively high,this being an impediment to its rapid uptake and widespread *** the other hand,LTE conforms to 3GPP that is supported by telecommunication manufacturers and operators and is,moreover,backward compatible with 3G/UMTS cellular *** LTE specifications define how user equipment(UE) connects and communicates with evolved Node B(eNB) base *** enhanced version,LTE-Advanced,adds a new entity called the relay node(RN) to widen service coverage,although this change has resulted in a more complex *** management and data forwarding are essential components in wireless mobile *** paper focuses on the efficient handover procedure in LTE-Advanced networks,and proposes a Smart Forwarding mechanism to improve the handover *** studies show that the proposed Smart Forwarding scheme employs a better operational transmission path that effectively reduces handover latency and signal overhead.

关键词： 4G LTE LTE-Advanced Relay Handover