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Gut microbial characteristics of the damp-heat constitution:a population-based multicenter cross-sectional study

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Journal of Traditional Chinese Medicine 2025年第1期45卷 140-151页

作者： LI Tianxing ZHU Linghui WANG Xueke TANG Jun YANG Lingling PANG Guoming LI Huang WANG Liying DONG Yang ZHAO Shipeng LI Yingshuai LI Lingru Institute of Basic Theory for Chinese Medicine China Academy of Chinese Medical Sciences National Institute of TCM Constitution and Preventive Medicine Beijing University of Chinese Medicine the Second Clinical Medical College Henan University of Chinese Medicine department of Hepatobiliary spleen and stomach the First Affiliated Hospital of Zhejiang Chinese Medical University Henna Province Hospital of Traditional Chinese Medicine department of Endocrinology Kaifeng Hospital of traditional Chinese Medicine State Key Laboratory of Dampness Syndrome of Chinese Medicine the Second Affiliated Hospital of Guangzhou University of Chinese Medicine College of Chinese Medicine Beijing University of Chinese Medicine Graduate School of China Academy of Chinese Medical Sciences

OBJECTIVE: To investigate the difference in gut microbiota between population with damp-heat constitution(DHC) and balanced constitution(BC). METHODS: A multi-centered cross-sectional casecontrol study was conducted, which included 249 participants with damp-heat constitution or balanced constitution. Baseline information of participants was collected, and stool samples were collected for gut microbiota analysis. Principal coordinate analysis, linear discriminant analysis effect size analysis, receiver operating characteristic, random forest model, and phylogenetic investigation of communities by reconstruction of unobserved states methods were used to reveal the relationship between gut microbiota and the damp-heat constitution. RESULTS: Compared to those in the BC group, the richness and diversity of the microbiota, specifically those of several short-chain fatty acid producing genera such as Barnesiella, Coprobacter, and Butyricimonas, were significantly decreased in the DHC group. Regarding biological functions, flavonoid biosynthesis, propanoate metabolism, and nucleotide sugar metabolism were suppressed, while arachidonic acid metabolism and glutathione metabolism were enriched in the DHC group. Finally, a classifier based on the microbiota was constructed to discriminate between the DHC and BC populations. CONCLUSION: The gut microbiota of the DHC population exhibits significantly reduced diversity and is closely related to inflammation, metabolic disorders, and liver steatosis, which is consistent with clinical observations, thus serving as a potential diagnostic tool for traditional Chinese medicine constitution discrimination.

关键词： PICRUSt Traditional Chinese medicine constitution balanced constitution cross-sectional studies damp-heat constitution inflammatory microbiota multicenter study

Kangfuxin solution alleviates esophageal stenosis after endoscopic submucosal dissection:A natural ingredient strategy

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World Journal of Gastroenterology 2025年第1期31卷 110-125页

作者： Xin Zhou Dan Ma Yi-Xiang He Jing Jin Hong-Lian Wang Yun-Feng Wang Fan Yang Jian-Qin Liu Jie Chen Zhi Li department of spleen and stomach Diseases the Affiliated Traditional Chinese Medicine HospitalSouthwest Medical UniversityLuzhou 646000Sichuan ProvinceChina The Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Treatment of Digestive System Diseases of Luzhou City The Affiliated Traditional Medicine HospitalSouthwest Medical UniversityLuzhou 646000Sichuan ProvinceChina department of Gastroenterology Changhai HospitalNaval Medical UniversityShanghai 20082China Research Center of Integrated Chinese and Western Medicine The Affiliated Traditional Chinese Medicine HospitalSouthwest Medical UniversityLuzhou 646000Sichuan ProvinceChina School of Integrated Traditional Chinese and Western Clinical Medicine North Sichuan Medical CollegeNanchong637100Sichuan ProvinceChina

BACKGROUND Esophageal stricture ranks among the most significant complications following endoscopic submucosal dissection(ESD).Excessive fibrotic repair is a typical pathological feature leading to stenosis after *** To examine the effectiveness and underlying mechanism of Kangfuxin solution(KFX)in mitigating excessive fibrotic repair of the esophagus *** Pigs received KFX at 0.74 mL/kg/d for 21 days after esophageal full circumferential *** examinations occurred on days 7 and 21 *** vitro,recombinant transforming growth factor(TGF)-β1(5 ng/mL)induced a fibrotic microenvironment in primary esophageal fibroblasts(pEsF).After 24 hours of KFX treatment(at 1.5%,1%,and 0.5%),expression ofα-smooth muscle actin-2(ACTA2),fibronectin(FN),and type collagen I was *** signaling was analyzed,including TGF-β1,Smad2/3,and phosphor-smad2/3(p-Smad2/3).RESULTS Compared to the Control group,the groups treated with KFX and prednisolone exhibited reduced esophageal stenosis,lower weight loss rates,and improved food tolerance 21 d after *** treatment,Masson staining revealed thinner and less dense collagen fibers in the submucosal ***,the expression of fibrotic effector molecules was notably ***,KFX downregulated the transduction levels of fibrotic functional molecules such as TGF-β1,Smad2/3,and p-Smad2/*** vitro,pEsF exposed to TGF-β1-induced fibrotic microenvironment displayed increased fibrotic activity,which was reversed by KFX treatment,leading to reduced activation of ACTA2,FN,and collagen *** 1.5%KFX treatment group showed decreased expression of p-Smad 2/3 in TGF-β1-activated *** KFX showed promise as a therapeutic option for post-full circumferential esophageal ESD strictures,potentially by suppressing fibroblast fibrotic activity through modulation of the TGF-β1/Smads signaling pathway.

关键词： Kangfuxin solution Natural component Endoscopic submucosal dissection Esophagus stricture Fibrosis

Protective effect of omeprazole on gastric mucosal of cirrhotic portal hypertension rats

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Asian Pacific Journal of Tropical Medicine 2014年第5期7卷 402-406页

作者： Wei Gao Hai-Ying Li Li-Xin Wang Li-Jun Hao Jian-Li Gao Rong-Juan Zheng Chun-Jiang Cai Yan-Ling Si department of Gastroenterology Tangshan Workers' Hospital department of spleen and stomach Tangshan TCM Hospital

Objective:To observe the protective effect of omeprazole on gastric mucosal of cirrhotic portal hypertension ***:All rats were randomly divided into normal control group,cirrhosis and treatment *** was used to establish rat model of cirrhotic portal *** necrotic tissue of gastric mucosa ulcer focus,degree of neutrophils infiltration at the ulcer margin,portal pressure,portal venous flow,abdominal aortic pressure,abdominal aortic blood flow at front end,gastric mucosal blood flow（GMBF）,glycoprotein（GP）of gastric mucosa,basal acid secretion,H’ back-diffusion,gastric mucosal damage index,NO,prostaglandin E2（PGE2） and tumor necrosis factor-α（TNF-α） were determined respectively,and the pathological changes of gastric mucosa were also observed by ***:Compared with cirrhosis group and the control group,the ulcer bottom necrotic material,gastric neutrophil infiltration and UI of the treatment group were all decreased significantly（P<0.01）,GMBF value,GP values,serum NO,PGE2,TNF- a were all significantly ***:Omeprazole has an important protective effect on gastric mucosal and it can increase gastric mucosal blood flow and related to many factors.

关键词： Omeprazole Cirrhotic portal hypertension Gastric mucosal injury Prostaglandins Tumor necrosis factor-alpha

“Identification Card”: Sites on Histone Modification of Cancer Cell

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Chinese Medical Sciences Journal 2015年第4期30卷 203-209页

作者： Chao Huang Bin Wen Institute of spleen and stomach Guangzhou University of Chinese Medicine

Formation of malignant tumor originating from normal healthy cell is a multistep process including genetic and epigenetic lesions. Previous studies of cell line model systems displayed that early important epigenetic events happened in stepwise fashion prior to cell immortalization. Once these epigenetic alterations are integrated into chromatin, they will perform vertical propagation through cell subculture. Hence, status of epigenetics is dramatically important in maintaining of cell identity. Histone modification is another factor of epigenetic alterations during human oncogenesis. Histones, one of main components of chromatin, can be modified post-translationally. Histone tail modifications are regulated by corresponding modification enzymes. This review focuses on the description of relationship between the main sites of histone modification and oncogenesis.

关键词： histone modification epigenetics oncogenesis methylation histone acetylation cancer

A Breakthrough Point in Integrative Medical Research:Challenge of Treating Overlapping Symptoms in Functional Gastrointestinal Disorders

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Chinese Journal of Integrative Medicine 2022年第6期28卷 554-559页

作者： TANG Xu-dong MA Xiang-xue Institute of spleen and stomach Diseases Xiyuan HospitalChina Academy of Chinese Medical SciencesBeijing100091China

Functional gastrointestinal disorders(FGIDs)are common disorders that are characterized by persistent and recurring gastrointestinal *** patients with FGIDs have overlapping symptoms,which impaired the quality of life and ability to work of patients,and left a considerable impact on health-care systems and *** medicines(CMs)are commonly utilized by many patients with *** article discusses the current status of diagnosis and treatment of FGIDs,the advantages and characteristics of CM treatment,and how integrated medicine can make a breakthrough in FGIDs diagnosis and treatment.

关键词： functional gastrointestinal disorders overlapping symptoms integrative medicine

Clinical effects of a traditional Chinese medicine nursing programme to intervene in gastric pain of the spleen and stomach with Qi deficiency

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World Journal of Clinical Cases 2023年第21期11卷 5056-5062页

作者： Yin-Hong Yu Yu-Shuang Yu Xiao-He Cheng spleen and stomach Diseases department Zhejiang Province Chun’an County Traditional Chinese Medicine HospitalChun’an County 311700Zhejiang ProvinceChina

BACKGROUND Gastroparesis is a common digestive disorder characterized by delayed gastric emptying,which can lead to symptoms such as nausea,vomiting,abdominal pain,and poor *** Chinese medicine(TCM)has been used for centuries to treat gastrointestinal disorders,including *** theory suggests that spleen and stomach qi deficiency syndrome is one of the main pathogenic factors in *** care plays an important role in the treatment of gastroparesis,and TCM nursing interventions have shown promising results in improving patient ***,there is limited research on the clinical effectiveness of TCM nursing interventions for gastroparesis with spleen stomach deficiency *** study aimed to evaluate the clinical effect of TCM nursing intervention in the treatment of gastroparesis with spleen stomach deficiency syndrome and to compare it with routine nursing *** To analyze the clinical effect of traditional Chinese medicine nursing intervention in the treatment of gastric paraplegia with spleen stomach deficiency *** From January 2020 to July 2021,80 patients with gastroparesis of spleen stomach qi deficiency type diagnosed in our hospital were selected for the *** 80 patients were randomly divided into a control group and an experimental group,with 40 cases in each *** the treatment period,the control group received routine nursing interventions,while the experimental group received traditional Chinese medicine nursing *** the nursing effects of the two groups and observe the changes in traditional Chinese medicine symptom scores,pain levels,and sleep quality before and after *** After treatment,comparing the treatment effects of the two groups,the total effective rate of the experimental group was significantly higher than that of the control group,with statistical significance(P<0.05).There was no statistically significant difference in th

关键词： Chinese medicine nursing programme spleen and stomach qi deficiency type Gastric and epigastric pain Nursing effect Pain Sleep quality

5’tiRNA-Pro-TGG,a novel tRNA halve,promotes oncogenesis in sessile serrated lesions and serrated pathway of colorectal cancer

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World Journal of Gastrointestinal Oncology 2023年第6期15卷 1005-1018页

作者： Xin-Yuan Wang Yu-Jie Zhou Hai-Ying Chen Jin-Nan Chen Shan-Shan Chen Hui-Min Chen Xiao-Bo Li Division of Gastroenterology and Hepatology Renji HospitalShanghai Jiaotong University School of MedicineShanghai 200000China department of spleen and stomach and rheumatology Affiliated Traditional Chinese Medicine Hospital of Southwest Medical UniversityLuzhou 646000Sichuan ProvinceChina

BACKGROUND Transfer RNA(tRNA)-derived small RNAs(tsRNAs)are small fragments that form when tRNAs *** halves(tiRNAs),a subcategory of tsRNA,are involved in the oncogenic processes of many ***,their specific role in sessile serrated lesions(SSLs),a precancerous lesion often observed in the colon,has not yet been *** To identify SSL-related tiRNAs and their potential role in the development of SSLs and serrated pathway of colorectal cancer(CRC).METHODS Small-RNA sequencing was conducted in paired SSLs and their adjacent normal control(NC)*** expression levels of five SSL-related tiRNAs were validated by q-polymerase chain *** counting kit-8 and wound healing assays were performed to detect cell proliferation and *** target genes and sites of tiRNA-1:33-Pro-TGG-1(5′tiRNA-Pro-TGG)were predicted by TargetScan and miRanda ***-associated and immune-related pathways were analyzed by single-sample gene set enrichment *** analyses were performed to establish the roles of 5′tiRNA-Pro-TGG based on the target *** In total,we found 52 upregulated tsRNAs and 28 downregulated tsRNAs in SSLs compared to *** expression levels of tiRNA-1:33-Gly-CCC-2,tiRNA-1:33-Pro-TGG-1,and tiRNA-1:34-Thr-TGT-4-M25′tiRNAs were higher in SSLs than those in NC,while that of 5′tiRNA-Pro-TGG was associated with the size of *** was demonstrated that 5′tiRNAPro-TGG promoted cell proliferation and migration of RKO cell in ***,heparanase 2(HPSE2)was identified as a potential target gene of 5′*** lower expression was associated with a worse prognosis in ***,lower expression of HPSE2 was observed in SSLs compared to normal controls or conventional adenomas and in BRAF-mutant CRC compared to BRAF-wild *** analyses revealed that its low expression was associated with a low interferonγresponse and also with many metabolic pathways such as riboflavin,retinol,and cy

关键词： Noncoding RNA tRNA halves Sessile serrated lesions Colon cancer Serrated pathway

Treatment of constipation-predominant irritable bowel syndrome by focusing on the liver in terms of Traditional Chinese Medicine:a meta-analysis

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Journal of Traditional Chinese Medicine 2013年第5期33卷 562-571页

作者： Qianwen Li Fengbin Liu Zhengkun Hou Di Luo department of Chinese Medicine Health Care Guangdong Food and Drug Vocational College spleen-stomach Diseases department FirstAffiliated Hospital of Guangzhou University of Chinese Medi-cine spleen-stomach Dis-eases department First Affiliated Hospital of GuangzhouUniversity of Chinese Medicine

OBJECTIVE:To assess the efficacy of Traditional Chinese Medicine(TCM)on constipation-predominant irritable bowel syndrome by focusing on the ***:Databases(domestic and foreign)were searched with the key words"irritable bowel syndrome","constipation",and"Chinese medicine";the relevant articles were retrieved and *** rate,"remarkable efficacy",recurrence rate and the incidence of adverse reactions were the outcome *** Manager ver 5.1 was used for this meta-analysis,and funnel plots used to detect publication ***:Nineteen randomized controlled trials were included and 1510 patients *** treatment guided byTCM based on the liver was superior to Western Medicine[odds ratio(OR)=2.46,95%confidence interval(CI)1.80,3.35)],cure rate[OR=2.61,95%CI(1.93,3.52)],remarkable efficacy[OR=2.68,95%CI(1.82,3.95)],recurrence rate[OR=0.19,95%CI(0.12,0.29)]and the incidence of adverse reactions[OR=0.24,95%CI(0.09,0.65)].However,funnel plots showed publication ***:Compared with Western Medicine,the treatment of IBS-C based on the liver is significantly better but the results must be treated with caution because publication bias was recorded.

关键词： Meta-analysis Medicine Chinese traditional Constipation Irritable bowel syndrome Randomized controlled trial

Consensus on Epigastralgia Diagnosis and Treatment of Chinese Medicine (2017)

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World Journal of Integrated Traditional and Western Medicine 2018年第3期4卷 11-20页

作者：无 Zhang Shengsheng zhou qiang The spleen and stomach Disease Branch of China Association of Chinese Medicine 不详

Epigastralgia is one of the most common syndromes in internal medicine of Traditional Chinese Medicine (TCM). Many upper gastrointestinal diseases such as peptic ulcer, chronic gastritis, functional dyspepsia and so on can induce the symptom of epigastralgia. In September 1983, National Symposium on spleen and stomach Disease was held by China Association of Chinese Medicine of Physicians, and programmed Diagnosis and evaluation standard of stomachache (draft )[1]. In 1993, Clinical research guideline of new drugs for traditional Chinese medicine on epigastralgia was promulgated by Ministry of Health of the People's Republic of China[2].

关键词： Epigastralgia internal medicine China Association