检索结果-南通市图书馆

Transfer RNA-derived small RNA serves as potential non-invasive diagnostic marker and a novel therapeutic target for acute pancreatitis

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2025年第1期31卷 152-156页

作者： Jing Zhang Chun-Lin Ou department of Immunology School of Basic MedicineCentral South UniversityChangsha 410000Hunan ProvinceChina department of pathology Xiangya HospitalCentral South UniversityChangsha 410008Hunan ProvinceChina

Transfer RNA(tRNA)-derived fragments,a new type of tRNA-derived small RNA(tsRNA),can be cleaved from tRNA by enzymes to regulate target gene expression at the transcriptional and translational *** are not only degradation fragments but also have biological functions,including those in immune inflammation,metabolic disorders,and cell *** dysregulation is closely associated with multiple diseases,including various cancers and acute pancreatitis(AP).AP is a common gastrointestinal disease,and its incidence increases *** development is associated with tsRNAs,which regulate cell injury and induce inflammation,especially pyroptosis and ***,serum tRF36 has the potential to serve as a non-invasive diagnostic biomarker and leads to pancreatic acinar cell ferroptosis causing inflammation to promote *** show the characteristics of tsRNAs and their diagnostic value and function in AP,and discuss the potential opportunities and challenges of using tsRNAs in clinical applications and research.

关键词： Transfer RNA derived small RNAs Acute pancreatitis Liquid biopsy Biomarker Cell pyroptosis Ferroptosis

The relationship between age,acceptable noise level,and listening effort in middle-aged and older-aged individuals

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Otology 2023年第4期18卷 220-229页

作者： Hemanth Narayan Shetty Suma Raju Sanjana Singh S department of Audiology JSS Institute of Speech and HearingMysuruKarnatakaIndia department of speech-language pathology JSS Institute of Speech and HearingMysuruKarnatakaIndia

Objective:The purpose of the study was to evaluate listening effort in adults who experience varied annoyance towards *** and methods:Fifty native Kannada-speaking adults aged 41e68 years *** evaluated the participant's acceptable noise level while listening to ***,a sentence-final wordidentification and recall test at 0 dB SNR(less favorable condition)and 4 dB SNR(relatively favorable condition)was used to assess listening *** repeat and recall scores were obtained for each ***:The regression model revealed that the listening effort increased by 0.6%at 0 dB SNR and by 0.5%at 4 dB SNR with every one-year advancement in *** effort increased by 0.9%at 0 dB SNR and by 0.7%at 4 dB SNR with every one dB change in the value of Acceptable Noise Level(ANL).At 0 dB SNR and 4 dB SNR,a moderate and mild negative correlation was noted respectively between listening effort and annoyance towards noise when the factor age was ***:Listening effort increases with age,and its effect is more in less favorable than in relatively favorable ***,if the annoyance towards noise was controlled,the impact of age on listening effort was *** effort correlated with the level of annoyance once the age effect was ***,the listening effort was predicted from the ANL to a moderate degree.

关键词： Listening effort Acceptable noise level Cognitive reservoir Repeat and recall task

Small extracellular vesicles derived from cerebral endothelial cells with elevated microRNA 27a promote ischemic stroke recovery

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第1期20卷 224-233页

作者： Yi Zhang Zhongwu Liu Michael Chopp Michael Millman Yanfeng Li Pasquale Cepparulo Amy Kemper Chao Li Li Zhang Zheng Gang Zhang department of Neurology Henry Ford HospitalDetroitMIUSA department of Physics Oakland UniversityRochesterMIUSA department of pathology Henry Ford HospitalDetroitMIUSA Division of Pharmacology Department of NeuroscienceReproductive and Dentistry SciencesSchool of MedicineUniversity of Naples“Federico Ⅱ”NaplesItaly

Axonal remodeling is a critical aspect of ischemic brain repair processes and contributes to spontaneous functional *** previous in vitro study demonstrated that exosomes/small extracellular vesicles(sEVs)isolated from cerebral endothelial cells(CEC-sEVs)of ischemic brain promote axonal growth of embryonic cortical neurons and that microRNA 27a(miR-27a)is an elevated miRNA in ischemic *** the present study,we investigated whether normal CEC-sEVs engineered to enrich their levels of miR-27a(27a-sEVs)further enhance axonal growth and improve neurological outcomes after ischemic stroke when compared with treatment with non-engineered CEC-sEVs.27a-sEVs were isolated from the conditioned medium of healthy mouse CECs transfected with a lentiviral miR-27a expression *** EVs isolated from CECs transfected with a scramble vector(Scra-sEVs)were used as a *** male mice were subjected to permanent middle cerebral artery occlusion and then were randomly treated with 27a-sEVs or *** array of behavior assays was used to measure neurological *** with treatment of ischemic stroke with Scra-sEVs,treatment with 27a-sEVs significantly augmented axons and spines in the peri-infarct zone and in the corticospinal tract of the spinal grey matter of the denervated side,and significantly improved neurological *** vitro studies demonstrated that CEC-sEVs carrying reduced miR-27a abolished 27a-sEV-augmented axonal *** analysis revealed that 27a-sEVs systemically administered preferentially localized to the pre-synaptic active zone,while quantitative reverse transcription-polymerase chain reaction and Western Blot analysis showed elevated miR-27a,and reduced axonal inhibitory proteins Semaphorin 6A and Ras Homolog Family Member A in the peri-infarct *** of the Clathrin-dependent endocytosis pathway substantially reduced neuronal internalization of *** data provide evidence that 27a-sEVs have

关键词： axonal remodeling cerebral endothelial cells exosomes miR-27a mitochondria Semaphorin 6A small extracellular vesicles stroke

The emerging role of nitric oxide in the synaptic dysfunction of vascular dementia

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第2期20卷 402-415页

作者： Xiaorong Zhang Zhiying Chen Yinyi Xiong Qin Zhou Ling-Qiang Zhu Dan Liu department of pathology Affiliated Hospital of Jiujiang UniversityJiujiangJiangxi ProvinceChina Jiujiang Clinical Precision Medicine Research Center JiujiangJiangxi ProvinceChina Center for Cognitive Science and Transdisciplinary Studies Jiujiang UniversityJiangxi ProvinceChina department of Neurology Affiliated Hospital of Jiujiang UniversityJiujiangJiangxi ProvinceChina department of Rehabilitation Affiliated Hospital of Jiujiang UniversityJiujiangJiangxi ProvinceChina department of Pathophysiology School of Basic MedicineTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina

With an increase in global aging,the number of people affected by cerebrovascular diseases is also increasing,and the incidence of vascular dementia-closely related to cerebrovascular risk-is increasing at an epidemic ***,few therapeutic options exist that can markedly improve the cognitive impairment and prognosis of vascular dementia *** in Alzheimer’s disease and other neurological disorders,synaptic dysfunction is recognized as the main reason for cognitive *** oxide is one of the ubiquitous gaseous cellular messengers involved in multiple physiological and pathological processes of the central nervous ***,nitric oxide has been implicated in regulating synaptic plasticity and plays an important role in the pathogenesis of vascular *** review introduces in detail the emerging role of nitric oxide in physiological and pathological states of vascular dementia and summarizes the diverse effects of nitric oxide on different aspects of synaptic dysfunction,neuroinflammation,oxidative stress,and blood-brain barrier dysfunction that underlie the progress of vascular ***,we propose that targeting the nitric oxide-sGC-cGMP pathway using certain specific approaches may provide a novel therapeutic strategy for vascular dementia.

关键词： endoplasmic reticulum stress endothelial nitric oxide synthase gene therapy nitric oxide NO-sGC-cGMP pathway synaptic dysfunction vascular dementia

Immunohistochemical expression of matrix metalloproteinase-9 and 13 in oral squamous cell carcinoma and their role in predicting lymph node metastasis

在线全文

学校读者我要写书评

暂无评论

World Journal of Methodology 2025年第2期15卷 108-116页

作者： Bhari Sharanesha Manjunatha Keshav T Handge Vandana Sandeep Shah Yasser Eid Al-Thobaiti Deepak Gowda Sadashivappa Pateel department of Basic Oral Medicine and Allied Dental Sciences Taif UniversityAt`Taif 26571MakkahSaudi Arabia department of Oral and Maxillofacial pathology Dr.Vasantrao Pawar Medical CollegeHospital and Research CentreNashik 423101MaharashtraIndia department of Oral pathology and Microbiology KM Shah Dental College and HospitalSumandeep VidyapeethVadodara 391760GujaratIndia department of Oral and Maxillofacial Surgery and Diagnostic Sciences Faculty of DentistryTaif UniversityAl-Haweiah 26571 MakkahSaudi Arabia department of Oral pathology and Microbiology Faculty of DentistryMAHSA UniversitySelangor 42610Malaysia

BACKGROUND One of the main characteristics of oral squamous cell carcinoma(OSCC)is that it metastasizes to cervical lymph nodes frequently with a high degree of local invasiveness.A primary feature of malignant tumors is their penetration of neighboring tissues,such as lymphatic and blood arteries,due to the tumor cells'capacity to break down the extracellular matrix(ECM).Matrix metalloproteinases(MMPs)constitute a family of proteolytic enzymes that facilitate tissue remo-deling and the degradation of the ***-9 and MMP-13 belong to the group of extracellular matrix degrading enzymes and their expression has been studied in OSCC because of their specific ***-13,a collagenase family member,is thought to play an essential role in the MMP activation cascade by breaking down the fibrillar collagens,whereas MMP-9 is thought to accelerate the growth of *** MMP-13 expression has been associated with tumor behavior and patient prognosis in a number of malignant *** authors wish to thank Jadhav KB for his valuable opinion during the preparation of the manuscript.

关键词： Matrix metalloproteinases Oral squamous cell carcinoma Tumor staging Immunohistochemistry Invasion Lymph node metastasis TNM stage

Pan-TRK positive uterine sarcoma in immunohistochemistry without neurotrophic tyrosine receptor kinase gene fusions:A case report

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2025年第2期13卷 39-49页

作者： Seungmee Lee Yu-Ra Jeon Changmin Shin Sun-Young Kwon Sojin Shin department of Obstetrics and Gynecology Keimyung University School of MedicineDaegu 42601South Korea department of pathology and Institute for Cancer Research Keimyung University School of MedicineDaegu 42601South Korea

BACKGROUND The classification of uterine sarcomas is based on distinctive morphological and immunophenotypic characteristics,increasingly supported by molecular genetic *** on neurotrophic tyrosine receptor kinase(NTRK)gene fusionpositive uterine sarcoma,potentially aggressive and morphologically similar to fibrosarcoma,are limited due to its recent ***-TRK immunohistochemistry(IHC)analysis serves as an effective screening tool with high sensitivity and specificity for NTRK-fusion *** SUMMARY We report a case of a malignant mesenchymal tumor originating from the uterine cervix,which was pan-TRK IHC-positive but lacked NTRK gene fusions,accompanied by a brief literature review.A 55-year-old woman presented to the emergency department with abdominal pain and distension,exhibiting significant ascites and multiple solid pelvic *** examination revealed a tumor encompassing the uterine cervix,extending to the vagina and uterine corpus.A punch biopsy of the cervix indicated NTRK sarcoma with positive immunochemical pan-TRK ***,subsequent next generation sequencing revealed no NTRK gene fusion,leading to a diagnosis of poorly differentiated,advanced-stage *** The clinical significance of NTRK gene fusion lies in potential treatment with TRK inhibitors for positive *** such rare tumors is crucial due to the potential applicability of tropomyosin receptor kinase inhibitor treatment.

关键词： Uterine sarcoma Cervical sarcoma Neurotrophic tyrosine receptor kinase gene fusion Next generation sequencing Case report

Sensitivity and specificity of hearing tests for screening hearing loss in older adults

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Otology 2023年第1期18卷 1-6页

作者： Hsin-Chen Ting Yung-Yao Huang PSA Charitable Foundation New Taipei CityTaiwanChina department of Audiology and speech-language pathology MacKay Medical CollegeNew Taipei CityTaiwanChina

Objectives: The study aimed to determine the most appropriate hearing screening test to identify disabling hearing loss for adults aged 65 years or ***: This study included 577 older adults. Four hearing screening tests were considered in the study, including the Hearing Handicap Inventory for Elderly Screening(HHIE-s), three single question tests, the whisper test, and the finger rub test. The sensitivity and specificity of these tests referenced to the hearing threshold of disabling hearing loss were ***: Among all tests, only the single self-perception question(0.7064 for sensitivity;0.7225 for specificity) and whisper test(0.7833 for sensitivity;0.7708 for specificity) could obtain both sensitivity and specificity higher than 70% for adults aged ≥65 ***: Overall, we suggest using the whisper test to identify disabling hearing loss(>40 dB HL at the better ear) for adults aged 65 years or older. However, if the conditions do not permit, the single selfperception question is also acceptable. Moreover, HHIE-s might not be a good test to detect disabling hearing loss for adults aged 80 years or older.

关键词： Sensitivity and specificity Hearing screening Questionnaire Whisper test Finger rub test

Unveiling the impact:COVID-19's influence on bacterial resistance in the Kingdom of Bahrain

在线全文

学校读者我要写书评

暂无评论

World Journal of Virology 2025年第1期14卷 83-98页

作者： Nermin K Saeed Safiya K Almusawi Noor A Albalooshi Mohammed Al-Beltagi Medical Microbiology Section Department of PathologySalmaniya Medical ComplexGovernmental HospitalsManama 12Bahrain Medical Microbiology Section Department of PathologyRoyal College of Surgeons in Ireland-Medical University of BahrainBusaiteen 15503MuharraqBahrain department of Paediatrics Faculty of MedicineTanta UniversityTanta 31511AlghrabiaEgypt department of Pediatric University Medical CenterKing Abdulla Medical CityArabian Gulf UniversityManama 26671AlgharbiaBahrain

BACKGROUND Antibiotic resistance is a growing global health threat,and understanding local trends in bacterial isolates and their susceptibility patterns is crucial for effective infection control and antimicrobial *** coronavirus disease 2019(COVID-19)pandemic has introduced additional complexities,potentially influencing these *** To analyze trends in bacterial isolates and their antibiotic susceptibility patterns at Salmaniya Medical Complex from 2018 to 2023,with a specific focus on the impact of the COVID-19 pandemic on these *** A retrospective analysis of microbiological data was conducted,covering the period from 2018 to *** study included key bacterial pathogens such as Escherichia coli(***),Klebsiella pneumoniae,Acinetobacter baumannii,Pseudomonas aeruginosa,and Staphylococcus aureus,among *** antibiotic susceptibility profiles of these isolates were assessed using standard laboratory *** contextualize the findings,the findings were compared with similar studies from other regions,including China,India,Romania,Saudi Arabia,the United Arab Emirates,Malaysia,and United *** The study revealed fluctuating trends in the prevalence of bacterial isolates,with notable changes during the COVID-19 *** example,a significant increase in the prevalence of Staphylococcus aureus was observed during the pandemic years,while the prevalence of *** showed a more variable *** resistance rates varied among the different pathogens,with a concerning rise in resistance to commonly used antibiotics,particularly among Klebsiella pneumoniae and ***,the study identified an alarming increase in the prevalence of multidrug-resistant(MDR)strains,especially within Klebsiella pneumoniae and *** *** impact of the COVID-19 pandemic on these trends was evident,with shifts in the frequency,resistance patterns,and the emergence of MDR bacteria among several key ***

关键词： Multidrug-resistant organisms Antibiotic susceptibility COVID-19 pandemic Antimicrobial stewardship Bacterial isolates Salmaniya Medical Complex Bahrain

Auditory cortical stimulability in non habilitated individuals-An evidence from CAEPs

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Otology 2022年第3期17卷 146-155页

作者： Hariprakash Palaniswami Aju Abraham Krishna Yerraguntla department of speech and Hearing Manipal College of Health ProfessionalsManipal Academy of Higher EducationManipalKarnataka576104India department of Audiology and speech language pathology Kasturba Medical CollegeMangaloreManipal Academy of Higher EducationManipalKarnataka575001India

Objective:The effect of long term auditory deprivation on Cortical Auditory Evoked Potentials(CAEPs)especially in human models is not well ***,the current study was aimed to investigate the effects of long-term auditory deprivation and stimulability of auditory cortex in non habilitated congenitally deaf adolescents and adults using *** and Results:A total of 27 non-habilitated congenitally deaf adolescents/adults with age and gender matched normal hearing adolescents/adults participated in the *** congenitally deaf group was fitted with high gain hearing aids(first fit).Further,the CAEPs were *** obtained CAEP components were assessed for group effect,source and topographical *** between group analysis for CAEP responses showed a significant difference only for P2 latency and *** source analysis revealed that,in the normal hearing group for CAEPs,the sources were within the temporal ***,in the congenitally deaf group,along with the temporal cortex,the bilateral prefrontal cortex also was ***:The findings revealed that it is possible to stimulate and evoke a matured CAEP response from a long deprived auditory system with adequate acoustic *** presence of CAEP responses is indicative of the functionality of the innate auditory pathway and the crossmodal plasticity in long auditory deprived individuals.

关键词： Auditory deprivation CAEPs Auditory Cortex Congenital deafness Non habilitated adults