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Influence of donor age on liver transplantation outcomes: A multivariate analysis and comparative study

World Journal of Gastrointestinal Surgery 2024年第2期16卷 331-344页

作者： Miran Bezjak Ivan Stresec Branislav Kocman Stipislav Jadrijević Tajana Filipec Kanizaj Miro Antonijević Bojana Dalbelo Bašić Danko Mikulić department of Surgery University Hospital MerkurZagreb 10000Croatia department of Electronics MicroelectronicsComputer and Intelligent SystemsFaculty of Electrical Engineering and ComputingZagreb 10000Croatia department of Gastroenterology University Hospital MerkurZagreb 10000Croatia development of Software Nanobit Ltd.Zagreb 10000Croatia

BACKGROUND The growing disparity between the rising demand for liver transplantation(LT)and the limited availability of donor organs has prompted a greater reliance on older liver ***,utilizing livers from elderly donors has been associated with outcomes inferior to those achieved with grafts from younger *** accounting for additional risk factors,we hypothesize that the utili-zation of older liver grafts has a relatively minor impact on both patient survival and graft *** To evaluate the impact of donor age on LT outcomes using multivariate analysis and comparing young and elderly donor *** In the period from April 2013 to December 2018,656 adult liver transplants were performed at the University Hospital *** multivariate Cox propor-tional hazards models were developed to independently assess the significance of donor *** age was treated as a continuous *** approach involved univariate and multivariate analysis,including variable selection and assessment of interactions and ***,to exemplify the similarity of using young and old donor liver grafts,the group of 87 recipients of elderly donor liver grafts(≥75 years)was compared to a group of 124 recipients of young liver grafts(≤45 years)from the *** rates of the two groups were estimated using the Kaplan-Meier method and the log-rank test was used to test the differences between *** Using multivariate Cox analysis,we found no statistical significance in the role of donor age within the constructed *** when retained during the entire model development,the donor age's impact on survival remained insignificant and transformations and interactions yielded no substantial effects on *** insigni-ficance and low coefficient values suggest that donor age does not impact patient survival in our ***,there was no statistical evidence that the five developed models did not adhe

关键词： Liver transplantation Elderly donors Survival analysis Postoperative complications Cox proportional hazard models

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CONSTANS alters the circadian clock in Arabidopsis thaliana

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Molecular Plant 2024年第8期17卷 1204-1220页

作者： Pedro de los Reyes Gloria Serrano-Bueno Francisco J.Romero-Campero He Gao Jose M.Romero Federico Valverde Plant development Group-Institute for Plant Biochemistry and Photosynthesis Consejo Superior de Investigaciones CientificasUniversidad de SevillaSevilleSpain department of Computer Science and Artificial Intelligence Universidad de SevillaSevilleSpain department of Plant developmental Biology Max Planck Institute for Plant Breeding ResearchCologneGermany department of Plant Biochemistry and Molecular Biology Universidad de SevillaSevilleSpain

Plants are sessile organisms that have acquired highly plastic developmental strategies to adapt to the *** these processes,the floral transition is essential to ensure reproductive success and is finelyregulated by several internal andexternal genetic *** photoperiodic pathway,which controls plant response to day length,is one of the most important pathways controlling *** Arabidopsis photoperiodic flowering,CONSTANS(CO)is the central gene activating the expression of the florigen FLOWERING LOCUS T(FT)in the leaves at the end of a long *** circadian clock strongly regulates Co ***,to date,no evidence has been reported regarding a feedbackloop from the photoperiod pathway back to the circadian *** transcriptional networks,we have identified relevant network motifs regulating the interplay between the circadian clock and the photoperiod *** expression,chromatin immunoprecipitation experiments,and phenotypic analysis allowed us to elucidate the role of Co over the circadian *** with altered cO expression showed a different internal clock period,measured by daily leaf rhythmic *** showed that co upregulates the expression of key genes related to the circadian clock,such as CCA1,LHY,PRR5,and Gl,at the end of a long day by bindingto specific sites on their ***,a high numberof PRR5-repressed target genes are upregulated by CO,and this could explain the phase transition promoted by *** CO-PRR5 complex interacts with the bZiP transcriptionfactor HY5andhelps to localize the complex in the promoters of clock *** together,our results indicate that there may be a feedback loop in which co communicates back to the circadian clock,providing seasonal information to the circadian system.

关键词： CONSTANS circadian clock photoperiod

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Evaluation of Well Spacing for Primary development of Fractured Horizontal Wells in Tight Sandstone Gas Reservoirs

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Fluid Dynamics & Materials Processing 2024年第5期20卷 1015-1030页

作者： Fang Li Juan Wu Haiyong Yi Lihong Wu Lingyun Du Yuan Zeng Exploration and development Research Institute PetroChina Southwest Oil&Gas Field CompanyChengdu610041China Oil and Gas Resources department PetroChina Southwest Oil&Gas Field CompanyChengdu610000China

Methods for horizontal well spacing calculation in tight gas reservoirs are still adversely affected by the complexity of related control factors,such as strong reservoir heterogeneity and seepage *** this study,the stress sensitivity and threshold pressure gradient of various types of reservoirs are quantitatively evaluated through reservoir seepage *** the basis of these experiments,a numerical simulation model(based on the special seepage mechanism)and an inverse dynamic reserve algorithm(with different equivalent drainage areas)were *** well spacing ranges of Classes I,II,and III wells in the Q gas field are determined to be 802–1,000,600–662,and 285–400 m,respectively,with their average ranges as 901,631,and 342.5 m,*** considering both the pairs of parallel well groups and series well groups as examples,the reliability of the calculation results is *** is shown that the combination of the two models can reduce errors and provide accurate results.

关键词： Well spacing for primary development tight gas reservoir fractured horizontal well threshold pressure gradient stress sensitivity

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Lecanemab Unveiled:Exploring Alzheimer’s Treatment Advancements,Assessing Strengths,Limitations,and Its Therapeutic Landscape Position

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Biomedical and Environmental Sciences 2024年第4期37卷 428-431页

作者： VICTOR Abiola Adepoju OKECHUKWU Innocent Onyezue SAFAYET Jamil OLALEKAN John Okesanya DON Eliseo Lucero-Prisno Ⅲ department of HIV and Infectious Diseases Jhpiegoan affiliate of John Hopkins UniversityAbujaNigeria department of Prevention and Community Directorate APIN Public Health InitiativesAbujaNigeria department of Public Health Daffodil International UniversityDhaka-1216Bangladesh department of Public Health and Maritime Transport University of ThessalyVolosGreece department of Global Health and development London School of Hygiene and Tropical MedicineLondonUnited Kingdom

In the ever-evolving landscape of Alzheimer’s treatment,lecanemab(Leqembi)has emerged as a promising *** conventional therapies that merely alleviate symptoms,lecanemab is a humanized monoclonal antibody with a distinct *** targets protofibrils,insoluble fibrils,amyloid oligomers,and soluble amyloid-beta protofibrils,which are known to be especially damaging to neurons,with high accuracy.

关键词： Alzheimer amyloid Therapeutic

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A system-integrated approach for the design of tourist areas at the local level under changing conditions:A case study in the Altay Mountains

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Regional Sustainability 2024年第2期5卷 89-102页

作者： Alexandr Nikolaevich DUNETS Evgeniya Mikhailovna TABAKAEVA HAN Fang department of Scientific and Innovative development Altai State UniversityBarnaul656049Russia department of Recreational Geography ServiceTourism and HospitalityInstitute of GeographyAltai State UniversityBarnaul656049Russia State Key Laboratory of Desert and Oasis Ecology Key Laboratory of Ecological Safety and Sustainable Development in Arid LandsXinjiang Institute of Ecology and GeographyChinese Academy of SciencesUrumqi830011China

The existing approaches for the design of tourist areas often lead to limited flexibility in project *** realize a more flexible approach,in this study,we formulated a model for planning and designing tourist areas at the local ***,specific tools for analyzing tourist areas and ensuring sustainable development under changing conditions were *** study was conducted in two tourist regions,Biryuzovaya Katun tourist complex and Belokurikha destination(including Belokurikha City with Belokurikha 2 Gornaya tourist complex and surrounding areas),in the Altay *** employed the recreation opportunity spectrum and proposed a system-integrated programming approach for the design of tourist areas at the destination and site *** key of this approach was the collection and analysis of current spatial data,including the spatial distribution of attractions and visitor *** constructed heat maps using video recording and unmanned aerial vehicle(UAV)observation ***,we analyzed the video stream using an image-analyzing framework You Only Look Once(YOLO)v5 *** heat map of visitor flows based on video recording data in the Andreevskaya Sloboda museum of Belokurikha 2 Gornaya tourist complex allowed us to highlight the most attractive sites in this area and classify them into one of three types:points of functional concentration,points of transitional concentration,and points of *** heat maps in Biryuzovaya Katun tourist complex,created using UAV observation data,allowed us to determine the spatiotemporal patterns of visitor flows and tourists’preferences throughout the day within four time intervals:09:00-12:00,13:00-14:00,14:00-15:00,and 16:00-18:00(LST).The maximum visitor flow density occurred from 16:00 to 18:00 in the beach area of the artificial lake.A comparison between the visitor-concentrated sites and the current facilities provided insights into the demand for attractions and facilities and

关键词： Tourism planning Tourist areas Unmanned aerial vehicle(UAV) Visitor flows Heat map Altay Mountains

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Aging-induced memory loss due to decreased N1-acetyl-5-methoxykynuramine,a melatonin metabolite,in the hippocampus:a potential prophylactic agent for dementia

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Neural Regeneration Research 2025年第6期20卷 1705-1706页

作者： Kazuki Watanabe Atsuhiko Hattori department of Immunobiology Institute of Development Aging and CancerTohoku UniversitySendaiMiyagiJapan department of Sport and Wellness College of Sport and WellnessRikkyo UniversityNiizaSaitamaJapan

Melatonin(N-acetyl-5-methoxytryptamine)is known as the hormone of darkness because it is synthesized at night and involved in regulating the circadian *** hormone is primarily synthesized by the vertebrate pineal gland,but is ubiquitous among invertebrates,unicellular organisms,plants,and even cyanobacteria(Hattori and Suzuki,2024).Melatonin is well-conserved evolutionarily and possesses several physiological functions,such as immune response,bone and glucose metabolism,and memory formation besides regulating the circadian rhythm.

关键词： metabolism primarily agent

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Analysis of Progressively Type-Ⅱ Inverted Generalized Gamma Censored Data and Its Engineering Application

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Computer Modeling in Engineering & Sciences 2024年第10期141卷 459-489页

作者： Refah Alotaibi Sanku Dey Ahmed Elshahhat department of Mathematical Sciences College of SciencePrincess Nourah bint Abdulrahman UniversityP.O.Box 84428Riyadh11671Saudi Arabia department of Statistics St.Anthony’s CollegeShillong793001India Faculty of Technology and development Zagazig UniversityZagazig44519Egypt

A novel inverted generalized gamma(IGG)distribution,proposed for data modelling with an upside-down bathtub hazard rate,is *** many real-world practical situations,when a researcher wants to conduct a comparative study of the life testing of items based on cost and duration of testing,censoring strategies are frequently *** this point of view,in the presence of censored data compiled from the most well-known progressively Type-Ⅱ censoring technique,this study examines different parameters of the IGG *** a classical point of view,the likelihood and product of spacing estimation methods are *** Fisher information and the deltamethod are used to obtain the approximate confidence intervals for any unknown parametric function of the *** the Bayesian paradigm,the same traditional inferential approaches are used to estimate all unknown ***-Chain with Monte-Carlo steps are considered to approximate all Bayes’*** numerical comparisons are presented to examine the performance of the proposed methodologies using various criteria of ***,using several optimality criteria,the optimumprogressive censoring design is *** highlight how the proposed estimators can be used in practice and to verify the flexibility of the proposed model,we analyze the failure times of twenty mechanical components of a diesel engine.

关键词： Inverted generalized gamma censoring spacing function likelihood Bayesian optimal plan

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Dynamic analysis of a novel multilink-spring mechanism for vibration isolation and energy harvesting

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Chinese Physics B 2024年第5期33卷 366-379页

作者：谢佳衡杨涛唐介 Research & development Institute of Northwestern Polytechnical University in Shenzhen Shenzhen 518057China department of Engineering Mechanics Northwest Polytechnical UniversityXi'an 710072China Applied Mechanics and Structure Safety Key Laboratory of Sichuan Province School of Mechanics and AerospaceSouthwest Jiaotong UniversityChengdu 610031China

Due to technical limitations,existing vibration isolation and energy harvesting(VIEH)devices have poor performance at low *** paper proposes a new multilink-spring mechanism(MLSM)that can be used to solve this *** VIEH performance of the MLSM under harmonic excitation and Gaussian white noise was *** was found that the MLSM has good vibration isolation performance for low-frequency isolation and the frequency band can be widened by adjusting parameters to achieve a higher energy harvesting *** comparison with two special cases,the results show that the MLSM is basically the same as the other two oscillators in terms of vibration isolation but has better energy harvesting performance under multistable *** MLSM is expected to reduce the impact of vibration on high-precision sensitive equipment in some special sites such as subways and mines,and at the same time supply power to structural health monitoring devices.

关键词： multilink-spring mechanism nonlinear dynamics vibration isolation energy harvester

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OsWRKY65 enhances immunity against fungal and bacterial pathogens in rice

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The Crop Journal 2024年第2期12卷 470-481页

作者： Seungmin Son Giha Song Suhyeon Nam Jinjeong Lee Duk-Ju Hwang Eun-Jung Suh Sang Ryeol Park National Institute of Agricultural Sciences Rural Development AdministrationJeonju 54874Republic of Korea department of Agriculture Forestry and BioresourcesPlant Genomics and Breeding InstituteResearch Institute of Agriculture and Life SciencesSeoul National UniversitySeoul 08826Republic of Korea department of Crop Science and Biotechnology Jeonbuk National UniversityJeonju 54896Republic of Korea

Diverse bacterial and fungal pathogens attack plants,causing biotic stress and severe yield losses *** losses are expected to become more serious as climate change improves conditions for many ***,identifying genes conferring broad-spectrum disease resistance and elucidating their underlying mechanisms provides important resources for plant *** transcription factors affect plant growth and stress ***,the functions of many WRKY proteins remain to be ***,we demonstrated the role of rice(Oryza sativa)WRKY groupⅢtranscription factor OsWRKY65 in ***65 localized to the nucleus and acted as transcriptional *** and molecular functional analyses showed that OsWRKY65 increases resistance to the fungal pathogen Fusarium fujikuroi through downregulation of GA signaling and upregulation of JA ***,OsWRKY65 modulated the expression of the key genes that confer susceptibility or resistance to Xanthomonas oryzae *** to enhance immunity against the *** particular,OsWRKY65directly bound to the promoter region of OsSWEET13 and repressed its *** together,our findings demonstrate that the OsWRKY65 enhances resistance to fungal and bacterial pathogens in rice.

关键词： Bacterial blight Bakanae disease Broad-spectrum disease resistance Oriza sativa OsWRKY65 Rice

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The circuitry landscape of perovskite solar cells:An in-depth analysis

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Journal of Energy Chemistry 2024年第7期94卷 393-413页

作者： Siddhi Vinayak Pandey Daniel Prochowicz Apurba Mahapatra Saravanan Pandiaraj Abdullah N.Alodhayb Seckin Akin Pankaj Yadav department of Solar Energy School of Energy TechnologyPandit Deendayal Energy UniversityGandhinagar 382007GujaratIndia department of Physical Chemistry Polish Academy of SciencesKasprzaka 44/5201-224 WarsawPoland department of Self-development Skills King Saud UniversityRiyadh 11451Saudi Arabia department of Physics and Astronomy College of ScienceKing Saud UniversityP.O.Box 2455Riyadh 11451Saudi Arabia department of Metallurgical and Materials Engineering Necmettin Erbakan University42060 KonyaTurkey department of Physics School of Energy TechnologyPandit Deendayal Energy UniversityGandhinagar 382007GujaratIndia

The extensive research and development in perovskite solar cells (PSCs) have rekindled the hopes of converting solar energy into *** elusive understanding of underlying mechanisms is required for the development of efficient *** the years,Impedance Spectroscopy (IS) characterization,along with complementary techniques,has proven to be an effective way to understand and analyze the charge transport and recombination at interface and bulk of *** IS of PSCs have been analyzed,interpreted,and improvised continuously,revealing intricate details about the ***,there is a lack of centralized source of these details,which make it tougher to account for the generalized approach to understand the device *** present work is focused on compiling the research done on various PSC device architectures via IS to construct a comprehensive foundation of information on impedance plots,equivalent circuits,and associated processes.

关键词： Impedance Spectroscopy Perovskite solar cells Equivalent Circuits

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