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Multi-Scale Dilated Convolution Network for SPECT-MPI Cardiovascular Disease Classification with Adaptive Denoising and Attenuation Correction

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Computer Modeling in Engineering & Sciences 2025年第1期142卷 299-327页

作者： A.Robert Singh Suganya Athisayamani Gyanendra Prasad Joshi Bhanu Shrestha department of Computational Intelligence SRM Institute of Science and TechnologyKattankulathur603203Tamil NaduIndia School of Computing Sastra Deemed to be UniversityThanjavur613401Tamil NaduIndia department of Artificial Intelligence&Software Kangwon National UniversitySamcheok25913Republic of Korea department of Information Convergence system Graduate School of Smart ConvergenceKwangwoon UniversitySeoul01897Republic of Korea

Myocardial perfusion imaging(MPI),which uses single-photon emission computed tomography(SPECT),is a well-known estimating tool for medical diagnosis,employing the classification of images to show situations in coronary artery disease(CAD).The automatic classification of SPECT images for different techniques has achieved near-optimal accuracy when using convolutional neural networks(CNNs).This paper uses a SPECT classification framework with three steps:1)Image denoising,2)Attenuation correction,and 3)Image *** denoising is done by a U-Net architecture that ensures effective image *** correction is implemented by a convolution neural network model that can remove the attenuation that affects the feature extraction process of ***,a novel multi-scale diluted convolution(MSDC)network is *** merges the features extracted in different scales and makes the model learn the features more *** scales of filters with size 3×3 are used to extract *** three steps are compared with state-of-the-art *** proposed denoising architecture ensures a high-quality image with the highest peak signal-to-noise ratio(PSNR)value of *** proposed classification method is compared with the five different CNN models,and the proposed method ensures better classification with an accuracy of 96%,precision of 87%,sensitivity of 87%,specificity of 89%,and F1-score of 87%.To demonstrate the importance of preprocessing,the classification model was analyzed without denoising and attenuation correction.

关键词： SPECT-MPI CAD MSDC denoising attenuation correction classification

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Metabolic reprogramming: a new option for the treatment of spinal cord injury

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Neural Regeneration Research 2025年第4期20卷 1042-1057页

作者： Jiangjie Chen Jinyang Chen Chao Yu Kaishun Xia Biao Yang Ronghao Wang Yi Li Kesi Shi Yuang Zhang Haibin Xu Xuesong Zhang Jingkai Wang Qixin Chen Chengzhen Liang department of Orthopedics The Second Affiliated Hospital of Zhejiang University School of MedicineHangzhouZhejiang ProvinceChina Orthopedics Research Institute of Zhejiang University Zhejiang UniversityHangzhouZhejiang ProvinceChina Key Laboratory of Motor system Disease Research and Precision Therapy of Zhejiang Province HangzhouZhejiang ProvinceChina Clinical Research Center of Motor system Disease of Zhejiang Province HangzhouZhejiang ProvinceChina Qiandongnan Prefecture People’s Hospital KailiGuizhou ProvinceChina department of Orthopedics Fourth Medical CenterChinese PLA General HospitalBeijingChina

Spinal cord injuries impose a notably economic burden on society,mainly because of the severe after-effects they *** the ongoing development of various therapies for spinal cord injuries,their effectiveness remains ***,a deeper understanding of metabolism has opened up a new therapeutic opportunity in the form of metabolic *** this review,we explore the metabolic changes that occur during spinal cord injuries,their consequences,and the therapeutic tools available for metabolic *** spinal cord metabolism is characterized by independent cellular metabolism and intercellular metabolic ***,spinal cord injury results in metabolic disorders that include disturbances in glucose metabolism,lipid metabolism,and mitochondrial *** metabolic disturbances lead to corresponding pathological changes,including the failure of axonal regeneration,the accumulation of scarring,and the activation of *** rescue spinal cord injury at the metabolic level,potential metabolic reprogramming approaches have emerged,including replenishing metabolic substrates,reconstituting metabolic couplings,and targeting mitochondrial therapies to alter cell *** available evidence suggests that metabolic reprogramming holds great promise as a next-generation approach for the treatment of spinal cord *** further advance the metabolic treatment of the spinal cord injury,future efforts should focus on a deeper understanding of neurometabolism,the development of more advanced metabolomics technologies,and the design of highly effective metabolic interventions.

关键词： axons glycolysis metabolic reprogramming metabolism mitochondria neural regeneration neuroprotection oxidative phosphorylation spinal cord injury therapy

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High-dose dexamethasone regulates microglial polarization via the GR/JAK1/STAT3 signaling pathway after traumatic brain injury

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Neural Regeneration Research 2025年第9期20卷 2611-2623页

作者： Mengshi Yang Miao Bai Yuan Zhuang Shenghua Lu Qianqian Ge Hao Li Yu Deng Hongbin Wu Xiaojian Xu Fei Niu Xinlong Dong Bin Zhang Baiyun Liu Beijing Tiantan Hospital Capital Medical UniversityBeijingChina department of Neurology The First Hospital of Tsinghua UniversityBeijingChina department of Neurotrauma and Beijing Key Laboratory of Central Nervous system Injury Beijing Neurosurgical InstituteCapital Medical UniversityBeijingChina department of Critical Care Medicine Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Center for Nerve Injury and Repair Beijing Institute of Brain DisordersChina National Clinical Research Center for Neurological DiseasesBeijingChina

Although microglial polarization and neuroinflammation are crucial cellular responses after traumatic brain injury,the fundamental regulatory and functional mechanisms remain insufficiently *** potent anti-inflammato ry agents,the use of glucoco rticoids in traumatic brain injury is still controversial,and their regulatory effects on microglial polarization are not yet *** the present study,we sought to determine whether exacerbation of traumatic brain injury caused by high-dose dexamethasone is related to its regulatory effects on microglial polarization and its mechanisms of *** vitro cultured BV2 cells and primary microglia and a controlled cortical impact mouse model were used to investigate the effects of dexamethasone on microglial ***,dexamethasone,RU486(a glucocorticoid receptor antagonist),and ruxolitinib(a Janus kinase 1 antagonist)were ***-sequencing data obtained from a C57BL/6 mouse model of traumatic brain injury were used to identify potential targets of *** Morris water maze,quantitative reverse transcription-polymerase chain reaction,western blotting,immunofluorescence and confocal microscopy analysis,and TUNEL,Nissl,and Golgi staining were performed to investigate our ***-throughput sequencing results showed that arginase 1,a marker of M2 microglia,was significantly downregulated in the dexamethasone group compared with the traumatic brain injury group at3 days post-traumatic brain *** dexamethasone inhibited M1 and M2 microglia,with a more pronounced inhibitory effect on M2microglia in vitro and in *** receptor plays an indispensable role in microglial polarization after dexamethasone treatment following traumatic brain ***,glucocorticoid receptor activation increased the number of apoptotic cells and neuronal death,and also decreased the density of dendritic spines.A possible downstream receptor signaling mechanism is th

关键词： apoptosis BV2 microglia dexamethasone glucocorticoid receptor glucocorticoids innate immune system microglial polarization neuroinflammation primary microglia traumatic brain injury

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Three novel opportunistic scheduling algorithms in CoMP-CSB scenario

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Science China(Information Sciences) 2013年第8期56卷 250-261页

作者： WANG Hao LIU Nan WU Ping PAN ZhiWen YOU XiaoHu National Mobile Communications Research Laboratory School of Information Science and EngineeringSoutheast University signal and system at department of Engineering Sciences Uppsala University

Coordinated scheduling/beamforming(CSB),which belongs to the coordinated multi-point(CoMP) transmission,has received lots of attention recently due to its great potential to mitigate inter-cell interference(ICI) and to increase the cell-edge throughput,and meanwhile it only requires limited base station cooperation and is easy to ***,to the best of our knowledge,there are no effective scheduling algorithms with low complexity and overhead in CoMP-CSB scenario as ***,in this paper,we propose three novel opportunistic scheduling algorithms in CoMP-CSB *** of them jointly consider the intended channel condition of the scheduled user from its serving cell and the orthogonality between the intended channel and the corresponding interference channels to concurrently scheduled users in nearby cells,thus exploiting multi-user diversity(MUD) and mitigating ICI at the same *** 1 cooperatively chooses the most orthogonal user pair within a candidate user set in which all users have a large local channel feedback,while Algorithm 2 concurrently schedules the user pair with the largest ratio between the local channel feedbacks and the aforementioned orthogonality within the same candidate user *** 3 performs in the way similar to the proportional fairness scheduling,while making a proper modification for its usage in CoMP-CSB *** performance of the proposed scheduling algorithms are evaluated through *** show that,they all can significantly enhance the received signal to interference plus noise ratio(SINR) with relatively good fairness guarantee,thus achieving larger throughputs and utilities than several well-known scheduling *** 2 even outperforms Algorithm 1 when the aforementioned candidate user set is big enough in size and has a bit more overhead/***,Algorithms 3 is the best one among all the three proposed algorithms,but it requires more overhead/complexity than Alg

关键词： coordinated multi-point(CoMP) coordinated scheduling/beamforming(CSB) inter-cell interference(ICI) multi-user diversity(MUD) opportunistic scheduling.

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An Experimental Study on Aerodynamic Sound Generated from Wake Interaction of Circular Cylinder and Airfoil with Attack Angle in Tandem

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Journal of Thermal Science 2008年第3期17卷 212-217页

作者： Mizue MUNEKATA Ryuta KOSHIISHI Hiroyuki YOSHIKAWA Hideki OHBA department of Mechanical system Engineering

In our previous study, the effects of the interval between the cylinder and the airfoil on the aerodynamic sound were investigated and compared with the cases of single circular and single airfoil. In this study, the effects of the attack angle of the airfoil located downstream on the characteristics of aerodynamic sound and the wake structure are investigated at a given interval between the cylinder and the airfoil. It is found that the sound pressure level of DFN and the peak frequency decrease with increasing attack angle of airfoil because of the diffusive wake structure due to the increased back pressure of circular cylinder, which is caused by the blocking effect of airfoil. It is shown that the sound sources are corresponded to the attack points of shedding vortex form the upstream circular cylinder to the downstream airfoil. We conclude that the pressure fluctuation at the airfoil surface effects on the sound pressure level, from the flow visualizations and the exploration test of sound source.

关键词： aerodynamic sound wake interaction circular cylinder airfoil Karman's vortex flow visualization

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Intrinsic mode characteristic analysis and extraction in underwater cylindrical shell acoustic radiation

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Science China(Physics,Mechanics & Astronomy) 2013年第7期56卷 1339-1345页

作者： LIU QingYu FANG ShiLiang CHENG Qiang CAO Jin AN Liang LUO XinWei Complex Ship system Simulation Laboratory Key Laboratory of Underwater Acoustic signal Processing (MoE) Southeast University

Target dimension is important information in underwater target classification. An intrinsic mode characteristic extraction method in underwater cylindrical shell acoustic radiation was studied in this paper based on the mechanism of shell vibration to gain the information about its dimension instead of accurate inversion processing. The underwater cylindrical shell vibration and acoustic radiation were first analyzed using mode decomposition to solve the wave equation. The characteristic of acoustic radiation was studied with different cylindrical shell lengths, radii, thickness, excitation points and fine structures. Simulation results show that the intrinsic mode in acoustic radiation spectrum correlates closely with the geometry dimensions of cylindrical shells. Through multifaceted analysis, the strongest intrinsic mode characteristic extracted from underwater shell acoustic radiated signal was most likely relevant to the radiated source radius. Then, partial information about unknown source dimension could be gained from intrinsic mode characteristic in passive sonar applications for underwater target classification. Experimental data processing results verified the effectiveness of the method in this paper.

关键词： cylindrical shell mode decomposition acoustic radiation characteristic

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First endoscopic procedure for diagnosis and staging of mediastinal lymphadenopathy

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World Journal of Gastroenterology 2009年第48期15卷 6096-6101页

作者： Kay-Leong Khoo Khek-Yu Ho Christopher Jen-Lock Khor Barbro Nilsson Tow-Keang Lim department of Medicine National University Health System department of Gastroenterology National University Health System department of Pathology National University Health System

AIM:To compare a first diagnostic procedure of transbronchial needle aspiration(TBNA)with selection of endoscopic ultrasound-guided fine-needle aspiration(EUS-FNA)or TBNA for mediastinal ***:Sixty-eight consecutive patients with mediastinal lymphadenopathy on computed tomography(CT),who required cytopathological diagnosis,were *** first 34 underwent a sequential approach in which TBNA was performed first,followed by EUS-FNA if TBNA was *** next 34 underwent a selective approach where either TBNA or EUS-FNA was selected as the first procedure based on the CT ***:The diagnostic yield of TBNA as the first diagnostic procedure in the sequential approach was 62%.In the selective approach,the diagnostic yield of the first procedure was 71%.There was no significant difference in the overall diagnostic yield,but there were significantly fewer combined procedures with the selective ***:Selecting either EUS-FNA or TBNA as the first diagnostic procedure achieved a comparable diagnostic yield with significantly fewer procedures than performing TBNA first in all patients.

关键词： Aspiration biopsy Needle biopsy Endoscopy Ultrasound Mediastinum Lymphadenopathy Lung neoplasms Diagnosis Neoplasms staging

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Multisensory mechanisms of gait and balance in Parkinson’s disease:an integrative review

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Neural Regeneration Research 2025年第1期20卷 82-92页

作者： Stiven Roytman Rebecca Paalanen Giulia Carli Uros Marusic Prabesh Kanel Teus van Laar Nico I.Bohnen department of Radiology University of MichiganAnn ArborMIUSA department of Neurology University of MichiganAnn ArborMIUSA Morris K.Udall Center of Excellence for Parkinson’s Disease Research University of MichiganAnn ArborMIUSA Institute for Kinesiology Research Science and Research Centre KoperKoperSlovenia department of Health Sciences Alma Mater Europaea–ECMMariborSlovenia Parkinson’s Foundation Research Center of Excellence University of MichiganAnn ArborMIUSA department of Neurology University of GroningenUniversity Medical Center GroningenGroningenThe Netherlands Neurology Service and GRECC VA Ann Arbor Healthcare SystemAnn ArborMIUSA

Understanding the neural underpinning of human gait and balance is one of the most pertinent challenges for 21st-century translational neuroscience due to the profound impact that falls and mobility disturbances have on our aging *** and gait control does not happen automatically,as previously believed,but rather requires continuous involvement of central nervous *** effectively exert control over the body,the brain must integrate multiple streams of sensory information,including visual,vestibular,and somatosensory *** mechanisms which underpin the integration of these multisensory signals are the principal topic of the present *** multisensory integration theories focus on how failure of cognitive processes thought to be involved in multisensory integration leads to falls in older *** emphasis,however,has been placed on specific contributions of individual sensory modalities to multisensory integration processes and cross-modal interactions that occur between the sensory modalities in relation to gait and *** the present work,we review the contributions of somatosensory,visual,and vestibular modalities,along with their multisensory intersections to gait and balance in older adults and patients with Parkinson’s *** also review evidence of vestibular contributions to multisensory temporal binding windows,previously shown to be highly pertinent to fall risk in older ***,we relate multisensory vestibular mechanisms to potential neural substrates,both at the level of neurobiology(concerning positron emission tomography imaging)and at the level of electrophysiology(concerning electroencephalography).We hope that this integrative review,drawing influence across multiple subdisciplines of neuroscience,paves the way for novel research directions and therapeutic neuromodulatory approaches,to improve the lives of older adults and patients with neurodegenerative diseases.

关键词： aging balance encephalography functional magnetic resonance imaging gait multisensory integration Parkinson’s disease positron emission tomography somatosensory vestibular visual

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Characteristics of Transient Vortices in the Boundary Layer on a Rotating Disk under Orbital Motion

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Journal of Thermal Science 2013年第6期22卷 600-605页

作者： Mizue Munekata Naoya Jobi Keiichiro Kubo Hiroyuki Yoshikawa department of Mechanical system Engineering Kumamoto University

The objective of this study is to experimentally examine the characteristics of transient vortices in the boundary layer on a disk undergoing both rotation and orbital motion. The velocity fluctuations on a rotating, orbiting disk （disk radius equal to orbital radius） are measured by the hot-wire method, and the effects of orbital motion on the transient vortices in the boundary layer are examined. When the ratio of the orbital speed to the speed of rotation is i-0.025, the interval of transient vortices depends on only the orbital radius, regardless of the directions of rota- tion and orbital motion. The rate of low-frequency disturbances increases as the orbital speed increases, and the vortices induced by these low-frequency disturbances travel over the disk and then develop in the region of in- creased velocity. Consequently, no vortices generated on a rotating disk under orbital motion are stationary rela- tive to the disk.

关键词： Boundary layer transition Transient vortex Rotating disk Velocity measurement Hot-wire ane-mometer

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Structure learning on Bayesian networks by finding the optimal ordering with and without priors

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Journal of systems Engineering and Electronics 2018年第6期29卷 1209-1227页

作者： HE Chuchao GAO Xiaoguang GUO Zhigao department of system Engineering Northwestern Polytechnical University

Ordering based search methods have advantages over graph based search methods for structure learning of Bayesian networks in terms on the efficiency. With the aim of further increasing the accuracy of ordering based search methods, we first propose to increase the search space, which can facilitate escaping from the local optima. We present our search operators with majorizations, which are easy to implement. Experiments show that the proposed algorithm can obtain significantly more accurate results. With regard to the problem of the decrease on efficiency due to the increase of the search space, we then propose to add path priors as constraints into the swap process. We analyze the coefficient which may influence the performance of the proposed algorithm, the experiments show that the constraints can enhance the efficiency greatly, while has little effect on the accuracy. The final experiments show that, compared to other competitive methods, the proposed algorithm can find better solutions while holding high efficiency at the same time on both synthetic and real data sets.

关键词： Bayesian network structure learning ordering search space graph search space prior constraint

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