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Topological reorganization and functional alteration of distinct genomic components in gallbladder cancer

Frontiers of Medicine 2024年第1期18卷 109-127页

作者： Guoqiang Li Peng Pu Mengqiao Pan Xiaoling Weng Shimei Qiu Yiming Li Sk Jahir Abbas Lu Zou Ke Liu Zheng Wang Ziyu Shao Lin Jiang Wenguang Wu Yun Liu Rong Shao Fatao Liu Yingbin Liu department of Biliary-Pancreatic Surgery Renji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai200127China State Key Laboratory of Oncogenes and Related Genes Shanghai Cancer InstituteShanghai200127China Shanghai Key Laboratory of Biliary Tract Disease Shanghai200082China department of Health science and Engineering University of Shanghai for Science and TechnologyShanghai200082China Shanghai Tenth People’s Hospital of Tongji University Shanghai200072China department of General Surgery Xinhua HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai200082China department of Pharmacology Shanghai Jiao Tong University School of MedicineShanghai200025China

Altered three-dimensional architecture of chromatin influences various genomic regulators and subsequent gene expression in human ***,knowledge of the topological rearrangement of genomic hierarchical layers in cancer is largely ***,by taking advantage of in situ Hi-C,RNA-sequencing,and chromatin immunoprecipitation sequencing(ChIP-seq),we investigated structural reorganization and functional changes in chromosomal compartments,topologically associated domains(TADs),and CCCTC binding factor(CTCF)-mediated loops in gallbladder cancer(GBC)tissues and cell *** observed that the chromosomal compartment A/B switch was correlated with CTCF binding levels and gene expression *** inter-TAD interactions with weaker TAD boundaries were identified in cancer cell lines relative to normal ***,the chromatin short loops and cancer unique loops associated with chromatin remodeling and epithelial–mesenchymal transition activation were enriched in cancer compared with their control ***-specific enhancer–promoter loops,which contain multiple transcription factor binding motifs,acted as a central element to regulate aberrant gene *** of individual enhancers in each loop anchor that connects with promoters led to the inhibition of their corresponding gene ***,our data offer the landscape of hierarchical layers of cancer genome and functional alterations that contribute to the development of GBC.

关键词： 3D genome cancer TADs loop gene regulation

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The role of snapin in regulation of brain homeostasis

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Neural Regeneration Research 2024年第8期19卷 1696-1701页

作者： Jiawen Li Xinqi Huang Yumei An Xueshi Chen Yiyang Chen Mingyuan Xu Haiyan Shan Mingyang Zhang Shanghai Key Lab of Forensic Medicine Key Lab of Forensic ScienceMinistry of JusticeChina(Academy of Forensic Science)ShanghaiChina Institute of Forensic sciences Suzhou Medical CollegeSoochow UniversitySuzhouJiangsu ProvinceChina department of Obstetrics and Gynecology The Affiliated Suzhou Hospital of Nanjing Medical UniversitySuzhouJiangsu ProvinceChina

Brain homeostasis refe rs to the normal working state of the brain in a certain period,which is impo rtant for overall health and normal life ***,there is a lack of effective treatment methods for the adverse consequences caused by brain homeostasis *** is a protein that assists in the formation of neuronal synapses and plays a crucial role in the normal growth and development of ***,many researchers have reported the association between snapin and neurologic and psychiatric disorders,demonstrating that snapin can improve brain *** manifestations of brain disease often involve imbalances in brain homeostasis and may lead to neurological and behavioral *** article aims to explo re the role of snapin in restoring brain homeostasis after injury or diseases,highlighting its significance in maintaining brain homeostasis and treating brain ***,it comprehensively discusses the implications of snapin in other extracerebral diseases such as diabetes and viral infections,with the objective of determining the clinical potential of snapin in maintaining brain homeostasis.

关键词： brain homeostasis diabetes neurological diseases snapin traumatic brain injury vesicle fusion

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Convex-up Style of Deformation within Grabens in Regions of Incomplete Crossing Conjugate Normal Faults: A Numerical Simulation Investigation and Case Study

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Journal of Earth science 2024年第3期35卷 839-849页

作者： Zheng Li Kai Wang Xiong Xiong Bing Zhou School of Geophysics and Geomatics China University of GeosciencesWuhan 430074China State Key Laboratory of Geodesy and Earth’s Dynamics Innovation Academy for Precision Measurement Science and TechnologyChinese Academy of SciencesWuhan 430077China department of Earth Sicences Khalifa UniversityAbu DhabiUnited Arab Emirates

Crossing conjugate normal faults(CCNFs)are extensively developed in many hydrocarbon-producing basins,generally existing in the form of incomplete ***,the effect of the non-conjugate zone of the CCNFs on the conjugate relay zone post late tectonic action has not been previously *** use 3D elastic-plastic modeling to investigate the influence of incomplete(i.e.,partially intersecting)CCNFs on the pattern of deformation of strata in the intersection region.A series of model simulations were performed to examine the effects of horizontal tectonic extension,fault size,and fault depth on the deformation of conjugate relay zones of incomplete *** analyses yielded the following results.(1)The model of incomplete conjugation predicts a convex-up style of deformation in the conjugate graben region superimposed on overall subsidence under applied horizontal tectonic extension.(2)The degree of convex-up deformation of the conjugate graben depends on the influence of the non-conjugate zone on the conjugate relay zone,which varies with the amount of horizontal tectonic extension,fault size,and fault burial depth.(3)Our results indicate that incomplete CCNFs can form convex-up deformation,similar to that in the Nanpu Sag area and provide a sound understanding of hydrocarbon migration and accumulation.

关键词： incomplete conjugate normal fault conjugate graben convex-up deformation hydrocarbons Nanpu Sag tectonics.

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Complex-frequency waves:beat loss and win sensitivity

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Light(science & Applications) 2024年第2期13卷 181-183页

作者： Qingqing Cheng Tao L School of Optical-Electrical and Computer Engineering University of Shanghai for Science and TechnologyShanghai200093China department of Respiratory Diseases and Critical Medicine Quzhou Hospital Affiliated to Wenzhou Medical UniversityQuzhou324000China National Laboratory of Solid State Microstructures College of Engineering and Applied SciencesNanjing UniversityNanjing210093China

Recent experiments have demonstrated that synthesized complex-frequency waves can impart a virtual gain to molecule sensing systems,which can effectively restore information lost due to intrinsic molecular *** enhancement notably amplifies the signal of trace molecular vibrational fingerprints,thereby substantially improving the upper limit of sensitivity.

关键词： thereby Complex limit

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Harvesting Energy Via Water Movement and Surface Ionics in Microfibrous Ceramic Wools

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Energy & Environmental Materials 2024年第6期7卷 332-341页

作者： Manpreet Kaur Avinash Alagumalai Omid Mahian Sameh M.Osman Tadaaki Nagao Zhonglin Wang Research Center for Materials Nanoarchitectonics(WPI-MANA) National Institute for Materials Science(NIMS)1-1 NamikiTsukuba 305-0044IbarakiJapan department of Chemical and Petroleum Engineering University of Calgary2500 University Dr.NWCalgaryAB T2N 1N4Canada department of Mechanical Engineering GMR Institute of TechnologyRajamAndhra Pradesh 532127India Faculty of Mechanical Engineering and Mechanics Zhejiang Provincial Engineering Research Center for the Safety of Pressure Vessel and PipelineNingbo UniversityNingbo 315211China department of Chemical Engineering Imperial College LondonLondon SW72AZUK Beijing Institute of Nanoenergy and Nanosystems Chinese Academy of SciencesBeijing 100083China Chemistry department College of ScienceKing Saud UniversityP.O.Box 2455Riyadh 11451Saudi Arabia department of Condensed Matter Physics Hokkaido UniversitySapporoHokkaido 060-0810Japan School of Materials science and Engineering Georgia Institute of TechnologyAtlanta 30332GAUSA Laboratory on Convective Heat and Mass Transfer Tomsk State UniversityTomsk 634045Russia

Due to the push for carbon neutrality in various human activities,the development of methods for producing electricity without relying on chemical reaction processes or heat sources has become highly ***,the challenge lies in achieving microwatt-scale outputs due to the inherent conductivity of the materials and diverting electric *** address this challenge,our research has concentrated on utilizing nonconductive mediums for water-based low-cost microfibrous ceramic wools in conjunction with a NaCl aqueous solution for power *** main source of electricity originates from the directed movement of water molecules and surface ions through densely packed microfibrous ceramic wools due to the effect of dynamic electric double *** occurrence bears resemblance to the natural water transpiration in plants,thereby presenting a fresh and straightforward approach for producing electricity in an ecofriendly *** generator module demonstrated in this study,measuring 12×6 cm^(2),exhibited a noteworthy open-circuit voltage of 0.35 V,coupled with a short-circuit current of 0.51 *** low-cost ceramic wools are suitable for ubiquitous,permanent energy sources and hold potential for use as self-powered sensors and systems,eliminating the requirement for external energy sources such as sunlight or heat.

关键词： ceramic microfibers energy harvesting power generation self-powered systems water evaporation

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Advances in metal-organic framework-derived single-atom catalysts for biomedicine

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Nano Materials science 2024年第4期6卷 396-412页

作者： Li Qiu Yingxi Lin Jun Song Chen Hong Luo Rui Wu department of Ultrasound West China Second University Hospital Sichuan University Key Laboratory of Obstetric and Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education Sichuan University School of Materials and Energy University of Electronic Science and Technology of China Interdisciplinary Materials Research Center Institute for Advanced Study Chengdu University

As a alternative for natural enzymes, nanozymes has shown enzyme-like activity and selectivity in the field of various kinds of biomedical application, which has attracted considerable research interest. Recently, single-atom catalysts(SACs) have been extensively studied due to their similar active centers, coordination environment and better stability to natural enzymes. Metal-organic frameworks(MOFs) have been demonstrated as highly promising precursors for the synthesis of various types of SACs. MOF-derived SACs can not only significantly enhance the catalytic activity, but also improve the selectivity of nanozymes due to tunable coordination environment and structure, thereby receiving widespread attention in biomedicine. This review provided an overview of the preparation strategies for MOF-derived SACs, and then detailed the latest research progress of the SACs in the biomedical field for cancer, antibacterial, antioxidation and biosensors. Finally, the challenges and potential future opportunities of MOF-derived SACs in biomedical applications are proposed.

关键词： Biomedicine MOF-Derived SAC nanozymes Catalytic mechanisms

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A case of solitary choroidal tuberculoma with highly positive tuberculin skin test and negative interferon gamma release assays

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International Journal of Ophthalmology(English edition) 2024年第5期17卷 969-972页

作者： Lin Zhou Bin Hu Zhu-Ping Xu department of Ophthalmology Sichuan Provincial People’s HospitalUniversity of Electronic Science and Technology of ChinaChengdu 610072Sichuan ProvinceChina department of Ophthalmology Chengdu Tianfu New District People’s HospitalChengdu 641400Sichuan ProvinceChina department of Ophthalmology West China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina

Dear Editor,Tuberculosis(TB)is an infectious disease which has been considered as a global public health emergency problem during the past *** World Health Organization has estimated that approximately one-third of the world’s population are infected by ***,only 10%of patients with TB is *** can affect multiple organs throughout the *** percent of those infected are pulmonary *** TB can occur with or without lung or other systemic *** is a rare extrapulmonary form of the disease and occupied about 3.5%–5%of all of the *** should not be disregarded as its potential influence on vision *** intraocular and/or extraocular structures could be impacted by ocular TB[1].Uvea was the most common affected structure[2].

关键词： organs ocular infected

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Implementing and evaluating an automatic centroid moment tensor procedure for the Indonesia region and surrounding areas

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Earth and Planetary Physics 2024年第4期8卷 609-620页

作者： Madlazim Muhammad Nurul Fahmi Dyah Permata Sari Ella Meilianda Sorja Koesuma Physics department Faculty of Mathematics and Natural SciencesUniversitas Negeri SurabayaSurabaya 60231Indonesia science Education Study Program Faculty of Mathematics and Natural SciencesUniversitas Negeri Surabaya 60231SurabayaIndonesia Disaster science department Faculty of Mathematics and Natural SciencesUniversitas Syiah KualaAceh 23126Indonesia Physics department Faculty of Mathematics and Natural SciencesUniversitas Sebelas MaretSolo 57126Indonesia

The purpose of this research was to suggest an applicable procedure for computing the centroid moment tensor(CMT)automatically and in real time from earthquakes that occur in Indonesia and the surrounding *** software was used to estimate the CMT solution by selecting the velocity model that best suited the local and regional geological conditions in Indonesia and the surrounding *** data used in this study were earthquakes with magnitudes of 5.4 to ***-quality,real-time broadband seismographic data were provided by the International Federation of Digital Seismograph Networks Web Services(FDSNWS)and the European Integrated Data Archive(EIDA)Federation in Indonesia and the surrounding ***,the inversion process and filter adjustment were carried out on the seismographic data to obtain good CMT *** CMT solutions from Gisola provided good-quality solutions,in which all earthquake data had A-level quality(high quality,with good variant reduction).The Gisola CMT solution was justified with the Global CMT(GCMT)solution by using the Kagan angle value,with an average of approximately 11.2°.This result suggested that the CMT solution generated from Gisola was trustworthy and *** Gisola CMT solution was typically available within approximately 15 minutes after an earthquake *** it met the quality requirement,it was automatically published on the *** catalog of local and regional earthquake records obtained through this technology holds great promise for improving the current understanding of regional seismic activity and ongoing tectonic *** accurate and real-time CMT solution generated by implementing the Gisola algorithm consisted of moment tensors and moment magnitudes,which provided invaluable insights into earthquakes occurring in Indonesia and the surrounding areas.

关键词： centroid moment tensor Gisola International Federation of Digital Seismograph Networks Web Services(FDSNWS) real time Indonesia

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Synergistic Swarm Optimization Algorithm

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Computer Modeling in Engineering & sciences 2024年第6期139卷 2557-2604页

作者： Sharaf Alzoubi Laith Abualigah Mohamed Sharaf Mohammad Sh.Daoud Nima Khodadadi Heming Jia Faculty of Computer sciences and Informatics Amman Arab UniversityAmman11953Jordan Computer science department Al Al-Bayt UniversityMafraq25113Jordan department of Electrical and Computer Engineering Lebanese American UniversityByblos13-5053Lebanon Hourani Center for Applied Scientific Research Al-Ahliyya Amman UniversityAmman19328Jordan MEU Research Unit Middle East UniversityAmman11831Jordan Applied science Research Center Applied Science Private UniversityAmman11931Jordan School of Computer sciences Universiti Sains MalaysiaPulau Pinang11800Malaysia School of Engineering and technology Sunway University MalaysiaPetaling Jaya27500Malaysia department of Industrial Engineering College of EngineeringKing Saud UniversityP.O.Box 800Riyadh11421Saudi Arabia College of Engineering Al Ain UniversityAbu Dhabi112612United Arab Emirates department of Civil and Architectural Engineering University of MiamiCoral Gables1251USA School of information Engineering Sanming UniversitySanming365004China

This research paper presents a novel optimization method called the Synergistic Swarm Optimization Algorithm(SSOA).The SSOA combines the principles of swarmintelligence and synergistic cooperation to search for optimal solutions efficiently.A synergistic cooperation mechanism is employed,where particles exchange information and learn from each other to improve their search *** cooperation enhances the exploitation of promising regions in the search space while maintaining exploration ***,adaptive mechanisms,such as dynamic parameter adjustment and diversification strategies,are incorporated to balance exploration and *** leveraging the collaborative nature of swarm intelligence and integrating synergistic cooperation,the SSOAmethod aims to achieve superior convergence speed and solution quality performance compared to other optimization *** effectiveness of the proposed SSOA is investigated in solving the 23 benchmark functions and various engineering design *** experimental results highlight the effectiveness and potential of the SSOA method in addressing challenging optimization problems,making it a promising tool for a wide range of applications in engineering and *** codes of SSOA are available at:https://***/matlabcentral/fileexchange/153466-synergistic-swarm-optimization-algorithm.

关键词： Synergistic swarm optimization algorithm optimization algorithm metaheuristic engineering problems benchmark functions

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Colloidal quantum dots and two-dimensional material heterostructures for photodetector applications

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Electron 2024年第2期2卷 123-158页

作者： Jingying Luo Gurpreet Singh Selopal Xin Tong Zhiming Wang Institute of Fundamental and Frontier sciences University of Electronic Science and Technology of ChinaChengduChina department of Engineering Faculty of AgricultureDalhousie UniversityTruroNova ScotiaCanada Key Laboratory of Quantum Physics and Photonic Quantum information Ministry of EducationUniversity of Electronic Science and Technology of ChinaChengduChina Yangtze Delta Region Institute(Huzhou) University of Electronic Science and Technology of ChinaHuzhouChina Institute for Advanced Study Chengdu UniversityChengduChina

Photodetectors(PDs)are optoelectronic devices that convert optical signals into electrical ***,there has been a tremendous increase in research interest in PDs based on colloidal quantum dots(QDs)and two-dimensional(2D)material heterostructures owing to the strong light-absorption capacity and the well-adjustable band gap of QDs and the superior charge carriers transfer ability of 2D *** particular,the heterojunction formed between QDs and 2D materials can effectively enhance the separation and transport of photogenerated charge carriers,which is expected to establish PDs with ultrahigh photoconductive gain,high responsivity,and *** review aimed to summarize the state-of-the-art advances in the research of QDs/2D material nanohybrid PDs,including the device parameters,archi-tectures,working mechanisms,and fabrication *** prog-ress of hybrid PDs based on the heterojunction of QDs with different 2D materials,along with their innovative applications,are comprehensively *** the end,the challenges and feasible strategies in future research and development are briefly proposed.

关键词： heterostructures photodetectors quantum dots two-dimensional materials

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