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Multidisciplinary approach to suspected sudden unexpected infant death caused by milk-aspiration:A case report

World Journal of Clinical Cases 2020年第18期8卷 4128-4134页

作者： Aniello Maiese Raffaele La Russa Mauro Arcangeli Gianpietro Volonnino Alessandra De Matteis Paola Frati Vittorio Fineschi department of Surgical Pathology MedicalMolecular and Critical AreaInstitute of Legal MedicineUniversity of PisaPisa 56126Italy department of Anatomy HistologyForensic Medicine and OrthopedicsSapienza University of RomaRoma 00185Italy department of Life Health and Environmental SciencesUniversity of L'AquilaL'Aquila 67100Italy department saimlal Sapienza University of RomaRoma 00185Italy

BACKGROUND The term sudden unexpected infant death(SUID)is not always properly *** refers to a broad range of conditions that sometimes defy *** is not only a strong emotional impact on the family,but such cases are also quite *** causes may be multiple,not always readily apparent,and have potential repercussions,especially in terms of *** SUMMARY A 5-month-old male baby was pronounced dead following acute lung failure and cardiopulmonary *** parents had immediately rushed their child to the hospital,stating the baby was found prone and not ***-body postmortem computed tomography(PMCT)was performed,revealing a hypodense material of indeterminate nature within the main airways and areas of ground-glass parenchymal *** autopsy,the respiratory tract mucosa appeared edematous and was coated with a whitish stringy *** was widespread airspace reduction due to parenchymal *** sacs and bronchial openings contained abundant amorphous material admixed with white blood *** studies were performed,targeting CD15,CD68,and ***,the focus was on alpha-lactalbumin(milk protein),which showed marked immunopositivity within alveolar *** staining of macrophages was also particularly *** Postmortem investigations are thus essential to identify causes of death and surrounding *** is a useful tool in this setting,given the frequent dearth of autopsy findings and ambiguity as to cause of death in SUID *** findings,later confirmed by immunohistochemical investigations,were indicative of active pneumonia due to aspirated *** present account illustrates the importance a broad diagnostic approach to SUID in cases of forensic *** is a very valuable aid in cases of forensic interest,as it can provide useful information in all those situations in which the cause of death is uncertain or

关键词： Sudden unexpected infant death Aspiration pneumonia Postmortem computed tomography Case report Diagnosis Immunohistochemistry

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Conduction disorder and primary cardiac tumor: a fatal case of multiple lipomas of the right atrium

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Journal of Geriatric Cardiology 2019年第5期16卷 431-433页

作者： Stefano D’Errico Andrea Mazzanti Paola Frati Vittorio Fineschi department of Legal Medicine Azienda Ospedaliera Universitaria Sant’Andreavia di GrottarossaRomaItaly Molecular Cardiology Istituti Clinici Scientifici MaugeriIstituto di Ricovero e Cura a Carattere ScientificoPaviaItalyDepartment of Molecular MedicineUniversity of PaviaPaviaItaly department saimlal Sapienza University of RomaViale Regina ElenaRomaItaly

Cardiac primary tumors are uncommon with an estimated prevalence between 0.17%and 0.19%.[1,2]Cardiac lipoma are extremely rare representing only 10%?19%of primary cardiac tumors and only few are symptomatic,depending on their location within the heart.[3,4]They originate from the subendocardium(50%),subepicardium(25%)or myocardium(25%)and with different sizes and locations.[5]Few cases of sudden death due to primary cardiac tumors are reported in literature(0.0025%);in these cases,conductive and haemodinamic abnormalities have been indicated as the cause of death.

关键词： Autopsy Lipoma Primary cardiac tumor Sudden cardiac death

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Role of induced pluripotent stem cells in diagnostic cardiology

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World Journal of Stem Cells 2021年第5期13卷 331-341页

作者： Steven B Karch Vittorio Fineschi Pietro Francia Matteo Scopetti Martina Padovano Federico Manetti Alessandro Santurro Paola Frati Massimo Volpe School of Medicine University of NevadaLas VegasNV 89102United States department of Anatomical HistologicalForensic and Orthopaedic SciencesSapienza University of RomeRome 00185Italy Division of Cardiology Department of Clinical and Molecular MedicineSapienza University of RomeSt.Andrea HospitalVia di Grottarossa103500189 RomeItaly department saimlal Sapienza University of RomaRome 00185Italy department of Clinical and Molecular Medicine Sapienza University of RomeRome 00197Italy

Ethical concerns about stem cell-based research have delayed important advances in many areas of medicine,including *** introduction of induced pluripotent stem cells(iPSCs)has supplanted the need to use human stem cells for most purposes,thus eliminating all ethical *** then,many new avenues have been opened in cardiology research,not only in approaches to tissue replacement but also in the design and testing of antiarrhythmic *** methodology has advanced to the point where induced human cardiomyocyte cell lines can now also be obtained from commercial sources or tissue *** studies with readily available iPSCs have generally confirmed that their behavioral characteristics accurately predict the behavior of beating cardiomyocytes in *** a result,iPSCs can provide new ways to study arrhythmias and heart disease in general,accelerating the development of new,more effective antiarrhythmic drugs,clinical diagnoses,and personalized medical *** focus on producing cardiomyocytes that can be used to replace damaged heart tissue has somewhat diverted interest in a host of other *** manuscript is intended to provide non-specialists with a brief introduction and overview of the research carried out in the field of heart rhythm disorders.

关键词： Human induced pluripotent stem cells Diagnostic cardiology Heart rhythm disorders Microelectrode array Stem cell research Ethical principles

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Reproducing Cochlear Signals by a Minimal Electroacoustic Model

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Open Journal of Biophysics 2012年第2期2卷 33-39页

作者： Giovanna Zimatore Marta Cavagnaro Alessandro Giuliani Alfredo Colosimo department of Environment and Primary Prevention Istituto Superiore di Sanità (I.S.S.) Rome Italy department of saimlal Section of Anatomy Sapienza University Rome Italy departmentt of Information Engineering Electronics and Telecommunications Sapienza University Rome Italy Institute of Otolaryngology School of Medicine Catholic University Rome Italy

Transient-Evoked Otoacoustic Emissions (TEOAEs) were studied, with particular reference to their subject-dependent features. To this end, an electric model of the ear was implemented and validated. Simulated and natural TEOAEs were analyzed through a nonlinear analysis technique. The simulated signals were able to reproduce the dynamical features of the experimentally observed TEOAEs and, most importantly, the natural variability among individuals. The unexpected inverse relation between model complexity and adherence to the natural signals is commented.

关键词： Otoacustic Emissions Recurrence Quantification Analysis Biosignals

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