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Phytochemical analysis, antioxidant, acetylcholinesterase, and α-amylase inhibitors from Hippeastrum hybridum extract

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Journal of Traditional Chinese Medicine 2024年第3期44卷 496-504页

作者： Naila Sher Mushtaq Ahmed Nadia Mushtaq department of Biotechnology University of Science and Technology department of Botany University of Science and Technology

OBJECTIVE:To investigate the effects of Hippeastrum hybridum（HH） as a free radical scavenger,and an inhibitor of the two enzymes i-e Alpha-amylase（α-amylase） and acetylcholinesterase（AChE）.METHODS:In this study,HH plant was preliminary analyzed for phytochemical screening and then tested for its antioxidant,anti-α-amylase,and anti-AChE efficiency via standard ***:Phytochemical analysis shows the existence of different compounds;while Coumarins and quinones were *** total phenolic,flavonoid,and tannins content were found to be（78.52±0.69） mg GAE/g,（2.01±0.04） mg RUE/g,and（58.12±0.23） mg TAE/g of plant extract respectively.28.02%±0.02% alkaloid and 2.02%±0.05% saponins were present in the HH *** HH extract showed the anti-oxidant property with IC50（50%inhibition） of（151.01±0.13）(HH),（79.01±0.04）(Ascorbic acid) for ferric reducing,（91.48±0.13）(HH),（48.02±0.11）(Ascorbic acid) against Ammonium molybdenum,（156.02±0.31）(HH),（52.38±0.21）(Ascorbic acid) against DPPH,136.01±0.21（HH）,52.02±0.31（Ascorbic acid） against H2O2,and 154.12±0.03（HH）,（40.05±0.15）(Ascorbic acid)μg/mL against ABTS *** analysis indicated that HH caused a competitive type of inhibition of α-amylase(Vmaxremained constant and Km increases from 10.65 to84.37%) while Glucophage caused the un-competitive type of inhibition i-e both Km and Vmaxdecreased from40.49 to 69.15%and 38.86 to 69.61%*** Ki,（inhibition constant）;KI,（dissociation constant）,Km,（Michaelis-Menten constant）,and IC50 were found to be62,364,68.1,and 38.08±0.22 for HH and 12,101.05,195,34.01±0.21 for ***,HH causes an anon-competitive type of inhibition of AChE i-e Km remains constant while Vmaxdecreases from 60.5%to74.1%.The calculated Ki,KI,Km,and IC50 were found to be 32,36.2,0.05,and 18.117±***:From the current results,it is concluded that HH extract contains bioactive compounds,and could be a good alternative to controlling oxidants,Alzheimer‘s and T

关键词： Hippeastrum hybridum acetylcholinesterase alpha-amylase antioxidant phytochemicals

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A Hybrid Optimization Approach of Single Point Incremental Sheet Forming of AISI 316L Stainless Steel Using Grey Relation Analysis Coupled with Principal Component Analysiss

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Journal of Wuhan University of technology(Materials Science) 2024年第1期39卷 160-166页

作者： A Visagan P Ganesh department of Production technology Madras Institute of TechnologyChennai-600044India

We investigated the parametric optimization on incremental sheet forming of stainless steel using Grey Relational Analysis(GRA) coupled with Principal Component Analysis(PCA). AISI 316L stainless steel sheets were used to develop double wall angle pyramid with aid of tungsten carbide tool. GRA coupled with PCA was used to plan the experiment conditions. Control factors such as Tool Diameter(TD), Step Depth(SD), Bottom Wall Angle(BWA), Feed Rate(FR) and Spindle Speed(SS) on Top Wall Angle(TWA) and Top Wall Angle Surface Roughness(TWASR) have been studied. Wall angle increases with increasing tool diameter due to large contact area between tool and workpiece. As the step depth, feed rate and spindle speed increase,TWASR decreases with increasing tool diameter. As the step depth increasing, the hydrostatic stress is raised causing severe cracks in the deformed surface. Hence it was concluded that the proposed hybrid method was suitable for optimizing the factors and response.

关键词： single point incremental forming AISI 316L taguchi grey relation analysis principal component analysis surface roughness scanning electron microscopy

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Molecular Chaperone-Dependent Polymer Translocation through Nanopores: The Effects of Chaperone Concentration and Chaperone-Polymer Interaction

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Chinese Journal of Polymer Science 2024年第1期42卷 125-132,I0011页

作者： Chang-Sheng Zuo Kang Wang Li-Zhen Sun Ting-Ting Sun department of Physics Zhejiang University of Science and TechnologyHangzhou 310023China department of Applied Physics Zhejiang University of TechnologyHangzhou 310014China

The polymer translocation through a nanopore from a donor space(or named cis side) to a receiver space(trans side) in the chaperone-induced crowded environment has attracted increasing attention in recent years due to its significance in biological systems and technological applications. In this work, we mainly focus on the effects of chaperone concentration and chaperone-polymer interaction on the polymer translocation. By assuming the polymer translocation to be a quasi-equilibrium process, the free energy F of the polymer can be estimated by Rosenbluth-Rosenbluth method and then the translocation time τ can be calculated by Fokker-Plank equation based on the obtained free energy landscape. Our calculation results show that the translocation time can be controlled by independently tuning the chaperone concentration and chaperone-polymer interaction at the cis side or the trans side. There exists a critical chaperone-polymer attraction ε~*=-0.2 at which the volume exclusion and interaction effects of the chaperone can balance each other. Additionally, we also find that at large chaperone-polymer attraction, the translocation time is mainly governed by the diffusion coefficient of the polymer.

关键词： Polymer translocation Rosenbluth-Rosenbluth method Fokker-Plank equation Free energy landscapes

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Development of design charts to predict the dynamic response of pile supported machine foundations

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Frontiers of Structural and Civil Engineering 2024年第4期18卷 663-679页

作者： Deepthi SUDHI Sanjit BISWAS Bappaditya MANNA department of Civil Engineering National Institute TechnologyWarangal 506004India department of Civil Engineering Indian Institute of TechnologyDelhi 110016India

This paper proposes design charts for estimating imperative input parameters for continuum approach analysis of the nonlinear dynamic response of *** and analytical studies using continuum approach have been conducted on single and 2×2 grouped piles under coupled and vertical modes of vibration,for different dynamic forces and pile *** these design charts are derived from model piles,the charts have been validated for prototype pile foundations using scaling *** experimental responses of model piles are scaled up and these responses exhibit good agreement with analytical *** study also extends to estimation of the errors in computing frequency–amplitude responses with an increase in pile *** is found that,with an increase in pile length,the errors also *** effectiveness of the proposed design charts is also checked with data based on different field setups given in existing literature,and these charts are found to be ***,the developed design charts can be beneficial in estimating the input parameters for continuum approach analysis for determining the nonlinear responses of pile supported machine foundations.

关键词： pile foundation vertical vibration coupled vibration continuum approach soil-pile separation boundary zone parameters

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Numerical analysis of moving train induced vibrations on tunnel,surrounding ground and structure

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Earthquake Engineering and Engineering Vibration 2024年第1期23卷 179-192页

作者： Swati Srivastav Sowmiya Chawla Swapnil Mishra department of Applied Geophysics Indian Institute of Technology(ISM)Dhanbad 826004India department of Civil Engineering Indian Institute of Technology(ISM)Dhanbad 826004India department of Mining Engineering Indian Institute of Technology(ISM)Dhanbad 826004India

This study is focused on the effect of vibration induced by moving trains in tunnels on the surrounding ground and structures.A three-dimensional finite element model is established for a one-track railway tunnel and an adjacent twelve-storey building frame by using commercial software Midas GTS-NX(2019)and Midas *** study considered the moving load effect of a complete train,which varies with space as well as with *** effect of factors such as train speed,overburden pressure on the tunnel and variation in soil properties are studied in the time *** a result,the variations in horizontal and vertical acceleration for two different sites,i.e.,the free ground surface(without structure)and the area containing the structure,are ***,the displacement pattern of the raft foundation is plotted for different train *** lower speeds,the heaving phenomenon is negligible,but as the speed increases,both the heaving and differential settlement increase in the *** study demonstrates that the effect of moving train vibrations should be considered in the design of new nearby structures and proper ground improvement should be considered for existing structures.

关键词： moving train load tunnels vibration effect finite element method(FEM) wave propagation

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A high aspect ratio surface micromachined accelerometer based on a SiC-CNT composite material

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Microsystems & Nanoengineering 2024年第2期10卷 219-230页

作者： Jiarui Mo Shreyas Shankar Roberto Pezone Guoqi Zhang Sten Vollebregt Laboratory of Electronic Components Technology and Materials(ECTM)Department of MicroelectronicsDelft University of TechnologyDelftThe Netherlands

Silicon carbide(SiC)is recognized as an excellent material for microelectromechanical systems(MEMS),especially those operating in challenging environments,such as high temperature,high radiation,and corrosive ***,SiC bulk micromachining is still a challenge,which hinders the development of complex SiC *** address this problem,we present the use of a carbon nanotube(CNT)array coated with amorphous SiC(a-SiC)as an alternative composite material to enable high aspect ratio(HAR)surface *** using a prepatterned catalyst layer,a HAR CNT array can be grown as a structural template and then densified by uniformly filling the CNT bundle with LPCVD *** electrical properties of the resulting SiC-CNT composite were characterized,and the results indicated that the electrical resistivity was dominated by the *** demonstrate the use of this composite in MEMS applications,a capacitive accelerometer was designed,fabricated,and *** fabrication results showed that the composite is fully compatible with the manufacturing of surface micromachining *** Young’s modulus of the composite was extracted from the measured spring constant,and the results show a great improvement in the mechanical properties of the CNTs after coating with *** accelerometer was electrically characterized,and its functionality was confirmed using a mechanical shaker.

关键词： composite surface electrical

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An SDN-Based Algorithm for Caching,Routing,and Load Balancing in ICN

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China Communications 2024年第5期21卷 64-76页

作者： MohammadBagher Tavasoli Hossein Saidi Ali Ghiasian department of Electrical and Computer Engineering Isfahan University of TechnologyIsfahanIran department of technology and Engineering Shahrekord UniversityShahrekordIran

One of the challenges of Informationcentric Networking(ICN)is finding the optimal location for caching content and processing users’*** this paper,we address this challenge by leveraging Software-defined Networking(SDN)for efficient ICN *** achieve this,we formulate the problem as a mixed-integer nonlinear programming(MINLP)model,incorporating caching,routing,and load balancing *** explore two distinct scenarios to tackle the ***,we solve the problem in an offline mode using the GAMS environment,assuming a stable network state to demonstrate the superior performance of the cacheenabled network compared to non-cache ***,we investigate the problem in an online mode where the network state dynamically changes over *** the computational complexity associated with MINLP,we propose the software-defined caching,routing,and load balancing(SDCRL)algorithm as an efficient and scalable *** evaluation demonstrates that the SDCRL algorithm significantly reduces computational time while maintaining results that closely resemble those achieved by GAMS.

关键词： in-network caching information-centric network power efficiency routing software-defined networking

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Effect of cold-working on corrosion induced damage in lug joints

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Defence technology（防务技术） 2024年第6期36卷 175-182页

作者： Ramanath M.N Chikmath L. Murthy H. department of Aerospace Engineering Indian Institute of Technology-MadrasChennai 600036India department of Aeronautical Engineering KLS Gogte Institute of TechnologyBelagavi 590008India

Lug joints are preferred joineries for transferring heavy loads to parent components in aerospace *** experience corrosion due to environmental conditions,improper surface finishes and rubbing displacement between the pin and *** causes damage of different sizes and shapes near the *** degradation due to corrosion-induced damage is modelled as a through-pit at one of the identified critical locations through stress *** effect of this pit on fatigue crack initiation life is ***-hole is pre-stressed by cold-working and the benefits of inducing plastic wake on the intended performance of the lug joint during the damages due to corrosion are brought out and compared with non-cold-worked *** analysis is performed on this lug joint with *** results obtained highlight the benefits of cold-working and the methodology can be extended to damage growth and analyse the effect of surface treatments for better structural integrity of components of aerospace vehicles.

关键词： Lug joint Corrosion Crack initiation Cold-working Structural integrity

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The unitary subgroups of group algebras for a class of finite 2-groups with the derived subgroup of order 2

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Science China Mathematics 2024年第9期67卷 1989-2018页

作者： Yulei Wang Heguo Liu department of Mathematics Henan University of Technology department of Mathematics Hainan University

Let p be a prime and F be a finite field of characteristic *** that FG is the group algebra of the finite p-group G over the field *** V（FG） denote the group of normalized units in FG and let V*（FG）denote the unitary subgroup of V（FG）.If p is odd,then the order of V*（FG） is |F|（|G-1）/***,the case p=2 still is *** this paper,the order of V*（FG） is computed when G is a nonabelian 2-group given by a central extension of the form 1→Z2~n×Z2m→G→Z2×…×Z2→1 and G'■Z2,n,m≥***,a conjecture is confirmed,i.e.,the order of V*（FG） can be divisible by|F|~(1/2(|G|+|Ω1（G）|)-1),where Ω1（G）={g∈G|g2=1}.

关键词： normalized unit unitary subgroup inner abelian $p$-group central extension

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Skill enhancement learning with knowledge distillation

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Science China(Information Sciences) 2024年第8期67卷 206-220页

作者： Naijun LIU Fuchun SUN Bin FANG Huaping LIU department of Computer Science and technology Tsinghua University

Skill learning through reinforcement learning has significantly progressed in recent years. However, it often struggles to efficiently find optimal or near-optimal policies due to the inherent trial-and-error exploration in reinforcement learning. Although algorithms have been proposed to enhance skill learning efficacy, there is still much room for improvement in terms of skill learning performance and training stability. In this paper, we propose an algorithm called skill enhancement learning with knowledge distillation(SELKD), which integrates multiple actors and multiple critics for skill learning. SELKD employs knowledge distillation to establish a mutual learning mechanism among actors. To mitigate critic overestimation bias,we introduce a novel target value calculation method. We also perform theoretical analysis to ensure the convergence of SELKD. Finally, experiments are conducted on several continuous control tasks, illustrating the effectiveness of the proposed algorithm.

关键词： skill learning enhancement learning reinforcement learning knowledge distillation

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