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Percutaneous transgastric computed tomography-guided biopsy of the pancreas using large needles

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World Journal of Gastroenterology 2009年第47期15卷 5972-5975页

作者： Hsiuo-Shan Tseng Chia-Yuen Chen Wing P Chan Jen-Huey Chiang department of radiology Taipei Veterans General HospitalTaipei 112Taiwan China department of radiology School of MedicineNational Yang-Ming UniversityTaipei 112TaiwanChina department of radiology Taipei Medical University-Municipal Wan Fang HospitalTaipei 116TaiwanChina department of radiology School of MedicineTaipei Medical UniversityTaipei 116TaiwanChina

AIM:To assess the safety,yield and clinical utility of percutaneous transgastric computed tomography(CT)-guided biopsy of pancreatic tumor using large needles, in selected patients. METHODS:We reviewed 34 CT-guided biopsies in patients with pancreas mass,of whom 24(71%)had a direct path to the mass without passing through a major *** needle passed through the liver in one case(3%).Nine passes(26%)were made through the *** nine transgastric biopsies which used a coaxial technique(i.e.a 17-gauge coaxial introducer needle and an 18-gauge biopsy needle)were the basis of this *** and late follow-up CT images to detect complications were obtained. RESULTS:Tumor tissues were obtained in nine pancreatic biopsies,and histologic specimens for diagnosis were obtained in all *** patient,who had a rare sarco-matoid carcinoma,received a second *** patient had a complication of transient pneumoperitoneum but no subjective *** immediate imaging study and clinical follow-up detected neither hemorrhage nor *** delayed procedure-related complication was seen during the survival period of our ***:Pancreatic biopsy can be obtained by a transgastric route using a large needle as an alternative method,without complications of peritonitis or bleeding.

关键词： Biopsy Computed tomography Pancreas Stomach

Effects of arginine supplementation on splenocyte cytokine mRNA expression in rats with gut-derived sepsis

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World Journal of Gastroenterology 2005年第45期11卷 7091-7096页

作者： Huey-fang Shang Chun-Sen Hsu Chiu-Li Yeh Man-Hui Pai Sung-Ling Yeh department of Microbiology and Immunology Taipei Medical University Taipei Taiwan China department of Obstetrics and Gynecology TaipeiMedical University Municipal Wan Fang Hospital Taipei TaiwanChina department of Anatomy Taipei Medical UniversityTaipei Taiwan China School of Nutrition and HealthSciences Taipei Medical University Taipei Taiwan China

AIM： To investigate the effects of arginine （Arg）-enriched diets before sepsis and/or Arg-containing total parenteral nutrition （TPN） after sepsis or both on cytokine mRNA expression levels in splenocytes of rats with gut-derived sepsis. METHODS： Rats were assigned to four experimental groups. Groups 1 and 2 were fed with a semipurified diet, while groups 3 and 4 had part of the casein replaced by Arg which provided 2% of the total calories. After the rats were fed with these diets for 10 d, sepsis was induced by cecal ligation and puncture （CLP）, at the same time an internal jugular vein was cannulated. All rats were maintained on TPN for 3 d. Groups 1 and 3 were infused with conventional TPN, while groups 2 and 4 were supplemented with Arg which provided 2% of the total calories in the TPN solution. All rats were killed 3 d after CLP to examine their splenocyte subpopulation distribution and cytokine expression levels. RESULTS： Plasma interleukin （IL）-2, IL-4, tumor necrosis factor-α （TNF-α） and interferon （IFN-γ） were not detectable 3 d after CL.P. There were no differences in the distributions of CD45Ra＋, CD3＋, CD4＋, and CD8＋ cells in whole blood and splenocytes among the four groups. The splenocyte IL-2 mRNA expression in the Arg-supplemented groups was significantly higher than that in group 1. IL-4 mRNA expression in groups 3 and 4 was significantly higher than that in groups 1 and 2. The mRNA expression of IL-10 and IFN-γ was significantly higher in group 4 than in the other three groups. There was no difference in TNF-α mRNA expression among thefour groups CONCLUSION： The influence of Arg on the whole blood and splenic lymphocyte subpopulation distribution is not obvious. However, Arg administration, especially before and after CLP, significantly enhances the mRNA expression levels of Thl and Th2 cytokines in the spleen of rats with gut-derived sepsis.

关键词： Arginine Sepsis Cytokine mRNA expression

Premedication with pronase or N-acetylcysteine improves visibility during gastroendoscopy: An endoscopist-blinded, prospective, randomized study

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World Journal of Gastroenterology 2007年第3期13卷 444-447页

作者： Chun-Chao Chang Sheng-Hsuan Chen Chih-Ping Lin Ching-Ruey Hsieh Horng-Yuan Lou Fat-Moon Suk Shiann Pan Ming-Shun Wu Jun-Nan Chen Yung-Fa Chen Division of Gastroenterology Department of Internal Medicine Taipei Medical University Hospital Digestive Disease Research Center Taipei Medical University taipei Taiwan China department of Internal Medicine Min-Sheng General Hospital Taoyuan Taiwan China taipei Medical University-municipal wan-fang hospital Taipei Taiwan China

AIM： To assess the efficacy of premedicaton with pronase or N-acetylcysteine （NAC） at 20 min before upper gastrointestinal （UGI） endoscopy and to determine whether pronase or NAC pretreatment influences the reliability of the rapid urease test. METHODS： A total of 146 patients were prospectively and randomly assigned into the study groups according to different premedications before endoscopy. One endoscopist assessed mucosal visibility （MV） with scores ranged from 1 to 4 at four sites in the stomach. The sum of the MV scores from these four locations was defined as the total mucosal visibility （TMV） score. Identification of Hpylori was performed using CLO test, histology, and serology. RESULTS： The Group with pronase premedication had a significantly lower TMV score than did the groups with gascon and gascon water （P 〈 0.001 and P 〈 0.01, respectively）. The group with NAC had a significantly lower TMV score than the group with gascon （P 〈 0.01） and a trend of a lower MV score than the group with gascon water （P = 0.06）. The THV score did not significantly differ between the group with pronase and the group with NAC （P = 0.39 and P = 0.14, respectively）. The sensitivity and specifidty of the CLO test were 92.5% and 93.9%, respectively, in groups premedicated with pronase and NAC together.CONCLUSION： Premedication with pronase or NAC at 20 min before UGI endoscopy improves the mucosal visibility of the stomach. Neither pronase nor NAC produces any obvious interference with the CLO test for the identification of H pylori infection.

关键词： Pronase N-acetylcysteine H pylori Gastrointestinal endoscopy

Magnetic resonance imaging of soft-tissue tumors of the extremities: A practical approach

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World Journal of radiology 2013年第12期5卷 455-459页

作者： Wing P Chan department of radiology Wan Fang Hospital Taipei Medical University department of radiology School of Medicine College of Medicine Taipei Medical University

Diagnosis of extremity soft-tissue tumors can be *** of tumor margins can help precisely identify locally aggressive or non-aggressive behavior for surgical planning,but cannot differentiate benign from malignant *** malignant tumors can have inhomogeneous signals on T2-weighted *** a uniform signal on T2-weighted images can be a reliable indication of a benign lesion,a well-defined mass with homogeneous internal signal intensity does not definitively identify a benign *** common and distinctive soft-tissue lesions can have specific clinical and imaging features allowing a diagnosis without *** are known as determinate *** illustrative report presents a diagnostic guide for extremity soft-tissue tumors based on tissue signal and morphological characteristics on magnetic resonance *** is important for clinicians to be familiar with the imaging characteristics of common determinate lesions.

关键词： Extremity Magnetic resonance imaging Musculoskeletal neoplasm Sarcoma Soft-tissue tumors

绝经后女性骨质疏松性压缩性骨折的腰部肌肉体积:MRI定量测量

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国际医学放射学杂志 2019年第6期 747-747页

作者： C.W.C.Huang I.J.Tseng S.W.Yang Y.K.Lin W.P.Chan 袁源 department of radiology Wan Fang Hospital Taipei Medical University

摘要目的探讨绝经后女性椎旁肌、腰大肌体积与急性骨质疏松或低骨量腰椎压缩性骨折的关系。方法回顾性分析骨质疏松/低骨量绝经后女性的腰椎MRI和双能X线骨密

关键词：绝经后女性骨质疏松性压缩性骨折 MRI 肌肉体积定量测量

H1-antihistamine use and head and neck cancer risk in type 2 diabetes mellitus

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Oncology Research 2023年第1期31卷 23-34页

作者： YI-NONG CHEN YING-LIN CHEN wan-MING CHEN MINGCHIH CHEN BEN-CHANG SHIA JENQ-YUH KO SZU-YUAN WU department of Otorhinolaryngology Lo-Hsu Medical FoundationLotung Poh-Ai HospitalYilanTaiwanChina Graduate Institute of Business Administration College of ManagementFu Jen Catholic UniversityTaipeiTaiwanChina Artificial Intelligence Development Center Fu Jen Catholic UniversityTaipeiTaiwanChina department of Otolaryngology National Taiwan University Hospital and National Taiwan University College of MedicineTaipeiTaiwanChina department of Food Nutrition and Health Biotechnology College of Medical and Health ScienceAsia UniversityTaichungTaiwanChina Division of Radiation Oncology Lo-Hsu Medical FoundationLotung Poh-Ai HospitalYilanTaiwanChina Big Data Center Lo-Hsu Medical FoundationLotung Poh-Ai HospitalYilanTaiwanChina department of Healthcare Administration College of Medical and Health ScienceAsia UniversityTaichungTaiwanChina Cancer Center Lo-Hsu Medical FoundationLotung Poh-Ai HospitalYilanTaiwanChina Centers for Regional Anesthesia and Pain Medicine Taipei Municipal Wan Fang HospitalTaipei Medical UniversityTaipeiTaiwanChina department of Management College of ManagementFo Guang UniversityYilanTaiwanChina

This study aimed to examine the association between the use of H1-antihistamines(AHs)and head and neck cancer(HNC)risk in patients with type 2 diabetes mellitus(T2DM).Data from the National Health Insurance Research Database of Taiwan were analyzed for the period from 2008 to 2018.A propensity-score-matched cohort of 54,384 patients each in the AH user and nonuser groups was created and analyzed using Kaplan-Meier method and Cox proportional hazards *** results showed that the risk of HNC was significantly lower in AH users(adjusted hazard ratio:0.55,95%CI:0.48 to 0.64)and the incidence rate was also lower(5.16 vs.8.10 per 100,000 person-years).The lower HNC incidence rate in AH users(95%CI:0.63;0.55 to 0.73)suggests that AH use may reduce the risk of HNC in T2DM patients.

关键词： Type 2 diabetes H1-Antihistamine Head and neck cancer Incidence Incidence rate

Neuroprotection of Agmatine Against Neuronal Death via Attenuating of Blood Flow and Inhibiting the Increase of Aquaporine-4 Induced by Cerebral Ischemia/Reperfusion:the MRI Study

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Neuroprotection of Agmatine Against Neuronal Death via Atten...