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经导管主动脉瓣置换术前的CT和MR成像：扫描方案、测量和报告的标准化——欧洲心血管放射学会（ESCR）专家共识

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国际医学放射学杂志 2020年第4期 495-496页

作者： M.Francone R.P.J.Budde J.Bremerich J.N.Dacher C.Loewe F.Wolf 董龙春 department of radiological Oncological and Pathological Sciences Sapienza University

经导管主动脉瓣置换术(TAVR)是对伴有主动脉狭窄的严重系统性疾病病人,或因存在禁忌证无法进行传统手术置换主动脉瓣病人的微创替代疗法。该方法能提高病人

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The promise of liquid biopsy in cancer:a clinical perspective

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Chinese Journal of Cancer Research 2015年第5期27卷 488-490页

作者： Enrico Cortesi Michela Palleschi Valentina Magri Giuseppe Naso Medical Oncology Unit Department of Radiological Oncological and Pathological SciencesSapienzaUniversity of Rome

The clinical utility of liquid biopsy in cancer treatment will increase as circulating tumor cells （CTCs） analysis move from the enumeration to the real-time measurement of tumor characteristics. Intratumor heterogeneity is becoming increasingly recognized as a major drawback to the shift to personalized medicine. Spatial and temporal heterogeneity might be reflected by the serial assessment of CTCs. Indeed, the developing technologies for CTCs analysis now allow digital genomic and next- generation sequencing approaches, able to differentiate molecular subtypes of the disease and to monitor genetic variation over time. The liquid biopsy of cancer might offer a real-time assessment of tumor biology, providing the opportunity to serially evaluate patients most likely to benefit from targeted drugs based on a dynamic characterization of the disease at the molecular level. Mthough hurdles remain before liquid biopsy is seen in routine clinical practice, the information derived from CTCs may facilitate the real-time identification of actionable mutations in cancer leading the way toward personalized medicine.

关键词： Circulating tumor cells （CTCs） breast liquid biopsy cancer

骨样骨瘤:MR引导下聚焦超声的完全无创性治疗

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国际医学放射学杂志 2013年第4期 372-372页

作者： A. Napoli M. Mastantuono B.C. Marincola M. Anzidei F. Zaccagna O. Moreschini 乔辉 department of radiological Oncological and Anatomopathological Sciences Policlinico Umberto I -Sapienza University of RomeViale Regina Elena 324 00161 Rome Italy department of radiological Oncological and Anatomopathological Sciences Policlinico Umberto I-Sapienza University of RomeViale Regina Elena 324 00161 Rome Italy

目的初步探讨MR引导下聚焦超声治疗疼痛性骨样骨瘤的可行性、安全性和临床有效性。材料与方法本项前瞻性研究获得经机构审查委员会批准,共包括连续6例(男5例,女1例;平均年龄21岁)临床和影像诊断为骨样骨瘤的病人。所有病人均在签署知情... 详细信息

目的初步探讨MR引导下聚焦超声治疗疼痛性骨样骨瘤的可行性、安全性和临床有效性。材料与方法本项前瞻性研究获得经机构审查委员会批准,共包括连续6例(男5例,女1例;平均年龄21岁)临床和影像诊断为骨样骨瘤的病人。所有病人均在签署知情同意书后行MR引导下聚焦超声消融治疗。除外位于椎体内的病灶。记录声裂数和能量沉积。治疗后第1、3、6个月时确定治疗是否成功。应用直观类比标度(VAS)疼痛评分法评估症状的变化。观察在基线时和术后随访过程中骨样骨瘤的MR影像特征(水肿、充血和血管巢)。结果应用平均声裂为(4±1.8)和平均能量为(866±211)J的条件行此项治疗。无治疗或麻醉相关的并发症发生。术前和术后的平均VAS评分变化显著(分别为7.9±1.4和0.0±0.0)。所有病灶内的骨样骨瘤相关水肿和充血均逐渐消退。然而,4/6例病人的血管巢在治疗后依然存在。结论有限的研究样本显示骨样骨瘤的MR引导下聚焦超声治疗的安全性良好、成功率高且治疗相关的死亡率很低。

关键词：骨样骨瘤聚焦超声 MR

扩散张量成像和纤维示踪技术在评估由子宫内膜异位症引发疼痛中骶神经根变异的试验性研究

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国际医学放射学杂志 2014年第2期 185-185页

作者： L.Manganaro M.G.Porppora V.Vinci S.Bernardo P.Lodise P.Sollazzo 肖雅雯 Department of Radiological Oncological and Anatomopathological Sciences Umberto I Hospital "Sapienza" University of RomeViale Regina Elena 324 00161 RomeItaly

目的前瞻性研究子宫内膜异位症引发慢性盆腔疼痛的女性骶神经根微观结构的改变。方法30例经超声诊断为子宫内膜异位症并有中重度盆腔疼痛的女性病人纳入

关键词：盆腔 MRI 扩散张量成像纤维示踪技术子宫内膜异位症慢性盆腔疼痛

The indeterminable resilience of the fascial system

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Journal of Integrative Medicine 2017年第5期15卷 337-343页

作者： Bruno Bordoni Fabiola Marelli Bruno Morabito Beatrice Sacconi department of Cardiology Institute of Hospitalization and Care with Scientific AddressFoundation Don Carlo Gnocchi IRCCSMilan 20100Italy department of Fascial Osteopathic Research:FORe School of Osteopathic Centre for Research and StudiesCRESOGorla Minore(VA)21055Italy department of Fascial Osteopathic Research:FORe School of Osteopathic Centre for Research and StudiesCRESOFano(Pesaro Urbino)61032Italy departmente of Neurology Foundation Polyclinic University A.Gemelli University Cattolica del Sacro CuoreRome 00168Italy department of radiological Oncological and Anatomopathological SciencesSapienza University of RomeRome 00185Italy

The most recent information on fascial tissue indicates that there are not fascial layers, but polyhedral microvacuoles of connective tissue, which connect the body systems and, by hosting specialized cells, permit several functions, such as motor, nervous, vascular and visceral. These microvacuoles（a repetition of polyhedral units of connective fibrils） under internal or external tension change shape and can manage the movement variations, regulating different body functions and ensuring the maintenance of efficiency of the body systems. Their plasticity is based on perfect functional chaos： it is not possible to determine the motion vectors of the different fibrils, which differ in behavior and orientation; this strategy confers to the fascial continuum the maximum level of adaptability in response to the changing internal and external conditions of the cell. The present commentary deals with this concept, providing clinical examples of different disease patterns, providing contrary examples in which this adaptability does not occur, and lastly suggesting considerations for the approach to manipulative therapy of the fascial tissue. The fascial continuum is like a flock of birds flying together without a predetermined logic and maintaining their individuality at the same time.

关键词： fascia osteopathic manual therapy fibroblast fascial continuum

MUTYH-associated polyposis: Is it time to change upper gastrointestinal surveillance? A single-center case series and a literature overview

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World Journal of Gastrointestinal Oncology 2023年第11期15卷 1891-1899页

作者： Lupe Sanchez-Mete Lorenzo Mosciatti Marco Casadio Luigi Vittori Aline Martayan Vittoria Stigliano Gastroenterology and Digestive Endoscopy Regina Elena National Cancer InstituteIRCCSRome 00144Italy department of radiological Oncological and Pathological SciencesRegina Elena National Cancer InstituteIRCCSRome 00144Italy

BACKGROUND The presence of Spigelman stage(SS)IV duodenal polyposis is considered the most significant risk factor for duodenal cancer in patients with MUTYH-associated polyposis(MAP).However,advanced SS disease is rarely reported in MAP patients,and no clear recommendations on small bowel(SB)surveillance have been proposed in this patient setting.AIM To research more because that case reports of duodenal cancers in MAP suggest that they may develop in the absence of advanced benign SS disease and often involve the distal portion of the duodenum.METHODS We describe a series of MAP patients followed up at the Regina Elena National Cancer Institute of Rome(Italy).A literature overview on previously reported SB cancers in MAP is also provided.RESULTS We identified two(6%)SB adenocarcinomas with no previous history of duodenal polyposis.Our observations,supported by literature evidence,suggest that the formula for staging duodenal polyposis and predicting risk factors for distal duodenum and jejunal cancer may need to be adjusted to take this into account rather than focusing solely on the presence or absence of SS IV disease.Core Tip:Case reports of duodenal cancers in MUTYH-associated polyposis suggest that they may develop in the absence of advanced Spigelman stage(SS)benign disease and often involve the distal portion of the duodenum.In our case series,we identified two(6%)small-bowel adenocarcinomas with no previous history of duodenal polyposis.Our observations,supported by literature evidence,suggest that the formula for staging duodenal polyposis and predicting risk factors for distal duodenum and jejunal cancer should be adjusted to take into consideration the presence of SS IV disease,rather than focusing only on this feature.suggestive of invasive adenocarcinoma.

关键词： MUTYH-associated polyposis Duodenal adenomatosis Duodenal cancer Endoscopic management Case report

微血管梗阻程度预测急性心肌梗死且射血分数正常的病人发生主要心血管不良事件

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国际医学放射学杂志 2019年第4期 495-495页

作者：金莹莹 N.Galea G.M.Dacquino R.M.Ammendola S.Coco L.Agati L.D.Luca department of radiological Oncological and Pathological Sciences Sapienza University of Rome "Sapienza"

摘要目的研究梗死早期的心脏磁共振(CMR)预估ST段抬高型心肌梗死(STEMI)同时左心室射血分数(LVEF)正常的病人的长期危险分层。方法选取77例STEMI病人,均

关键词：射血分数正常主要心血管不良事件急性心肌梗死微血管

Dual-specificity phosphatase 6(DUSP6): a review of its molecular characteristics and clinical relevance in cancer

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Cancer Biology & Medicine 2018年第1期15卷 14-28页

作者： Muhammad Khairi Ahmad Nur Ainina Abdollah Nurul Husna Shafie Narazah Mohd Yusof Siti Razila Abdul Razak oncological and radiological sciences Cluster Advanced Medical and Dental Institute Universiti Sains Malaysia department of Nutrition and Dietetics Faculty of Medicine and Health SciencesUniversiti Putra Malaysia Regenerative Medicine Cluster Advanced Medical and Dental Institute Universiti Sains Malaysia

Mitogen-activated protein kinases(MAPKs) are the main regulators of cellular proliferation, growth, and survival in physiological or pathological conditions. Aberrant MAPK signaling plays a pivotal role in carcinogenesis, which leads to development and progression of human cancer. Dual-specificity phosphatase 6(DUSP6), a member of the MAPK phosphatase family, interacts with specifically targeted extracellular signal-regulated kinase 1/2 via negative feedback regulation in the MAPK pathway of mammalian cells. This phosphatase functions in a dual manner, pro-oncogenic or tumor-suppressive, depending on the type of cancer. To date, the tumor-suppressive role of DUSP6 has been demonstrated in pancreatic cancer, non-small cell lung cancer, esophageal squamous cell and nasopharyngeal carcinoma, and ovarian cancer. Its pro-oncogenic role has been observed in human glioblastoma, thyroid carcinoma, breast cancer, and acute myeloid carcinoma. Both roles of DUSP6 have been documented in malignant melanoma depending on the histological subtype of the cancer. Loss-or gain-of-function effects of DUSP6 in these cancers highlights the significance of this phosphatase in carcinogenesis. Development of methods that use the DUSP6 gene as a therapeutic target for cancer treatment or as a prognostic factor for diagnosis and evaluation of cancer treatment outcome has great potential. This review focuses on molecular characteristics of the DUSP6 gene and its role in cancers in the purview of development, progression, and cancer treatment outcome.

关键词：癌症治疗磷酸酶特征和特性评论分子关联临床

Application of ultrasonography-elastography score to suspect porto-sinusoidal vascular disease in patients with portal vein thrombosis

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Hepatobiliary & Pancreatic Diseases International 2024年第1期23卷 20-24页

作者： Stefania Gioia Adriano De Santis Giulia d’Amati Silvia Nardelli Alessandra Spagnoli Arianna Di Rocco Lorenzo Ridola Oliviero Riggio department of Translational and Precision Medicine Sapienza University of RomeRomeItaly department of radiological Oncologicaland Pathological SciencesSapienza University of RomeRomeItaly department of Public Health and Infectious Diseases Sapienza University of RomeRomeItaly

Background:Porto-sinusoidal vascular disease(PSVD)and portal vein thrombosis(PVT)are causes of portal hypertension characterized respectively by an intrahepatic and a pre-hepatic obstacle to the flow in the portal system.As PVT may be a consequence of PSVD,in PVT patients at presentation,a pre-existing PSVD should be suspected.In these patients the identification of an underlying PSVD would have relevant implication regarding follow-up and therapeutic management,but it could be challenging.In this setting ultrasonography may be valuable in differential diagnosis.The aim of the study was to use ultrasonography to identify parameters to discriminate between PSVD and“pure”PVT and then to suspect PVT secondary to a pre-existing PSVD.Methods:Fifty-three patients with histologically proven PSVD and forty-eight patients affected by chronic PVT were enrolled and submitted to abdominal ultrasonography with elastography by acoustic radiation force impulse(ARFI).Results:ARFI was higher and superior mesenteric vein(SMV)diameter was wider in PSVD patients than in PVT patients.Thus,a prognostic score was obtained as linear combinations of the two parameters with a good discrimination capacity between PSVD and PVT(the area under the curve=0.780;95%confidence interval:0.690-0.869).Conclusions:A score based on ARFI and SMV diameter may be useful to suspect an underlying PSVD in patients with PVT and to identify a subgroup of patients to be submitted to liver biopsy.

关键词： Non-cirrhotic portal hypertension Porto-sinusoidal vascular disease Chronic portal vein thrombosis Liver stiffness Portal hypertension Acoustic radiation force impulse