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生物医学工程学杂志 2005年第S1期22卷 103-104页

作者： Wen Jie ZHANG~Δ Yun-Feng ZHOU Cong-Hua XIE(department of radio-chemotherapy, Zhongnan Hospital and Cancer Research Center,Wuhan University, Wuhan 430071, China) department of radio-chemotherapy Zhongnan Hospital and Cancer Research Center Wuhan University Wuhan 430071 China

1 IntroductionIL-4-induced Stat6 (Signal transducer and activator of transcription 6) pathway is active in many cell types including cancer cells and immune cells which plays an important role in cell differenciation/growth and resistance to apoptosis[1]. IL-4/Stat6 signaling up-regulates cell surface moleculi suchas CD23, MHC class Ⅱ and IL-4Rα, and down-regulates proinflammatory cytokines, i. e,IL-12 and TNFα.

关键词： IL EBV Defective IL-4/Stat6 Signaling Correlates with Increased Apoptosis of Human EBV-lymphoblastoid B Cells and Mouse Spleen Cells

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Maximizing biomass utilization: An integrated strategy for coproducing multiple chemicals

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Journal of Energy Chemistry 2025年第1期100卷 180-191页

作者： Byeongchan Ahn Sua Jo Jonggeol Na J.Jay Liu Young-Ju Kim Wangyun Won department of Chemical and Biological Engineering Korea University department of Chemical Engineering (Integrated process) Kyung Hee University department of Chemical Engineering and Materials Science Ewha Womans University department of Chemical Engineering Pukyong National University Resources Engineering Plant Research department Korea Institute of Geoscience and Mineral Resources

Lignocellulosic biomass is one of the viable solutions to alleviate the global warming. However, the limited utilization of biomass majorly focused on cellulose and hemicellulose restricts the economic and environmental feasibilities. To cope with this issue, we proposed an integrated process of co-producing 1,6-hexanediol（1,6-HDO） with tetrahydrofuran and adipic acid from biomass, referred to as Strategy A. To compare the impacts of lignin upgrading and feedstock, Strategy B, which co-produces tetrahydrofuran alone, and Strategy C, which is the traditional route to produce 1,6-HDO from fossil fuels, were used. Heat networks are also designed to reduce operating costs and indirect carbon emissions due to energy consumption, saving 87% and 83% of the heat and cooling requirements, respectively, in Strategy A. The market competitiveness of Strategy A was evaluated by determining the minimum selling price through techno-economic analysis, and sustainability was thoroughly investigated by quantifying the environmental impacts through both midpoint and endpoint life-cycle assessments（LCAs）.Strategy A was found to be the most favorable both economically（USRDSCHARDOLLAR3,402/ton） and environmentally（-26.9 kg CO2eq.）. This indicates that lignin valorization is not only economically but also environmentally preferred. Finally, changes in economic and environmental feasibilities depending on economic, process, and environmental parameters were investigated using sensitivity and uncertainty analyses. The results of these analyses provide valuable insight into bio-based chemical production.

关键词： Biorefinery Carbon mitigation Climate change Global warming Lignin utilization Bioeconomy

Status and prospects for symmetric organic redox flow batteries

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Journal of Energy Chemistry 2025年第1期100卷 125-143页

作者： Md Al Raihan C.Adam Dyker department of Chemistry University of New Brunswick

As environmental concerns from fossil fuel consumption intensify, large-scale energy storage becomes imperative for the integration of renewable sources like wind, hydro, and solar with the electrical *** flow batteries, particularly those employing organic molecules, are positioned as a key technology for this purpose. This review explores the growing field of symmetric organic redox flow batteries(ORFBs) within this context. Unlike traditional asymmetric designs based on unique active materials for each electrode, symmetric ORFBs involve a single bipolar species for both electrodes. This review highlights the benefits of a symmetric design, and categorizes five distinct classes of organic bipolar molecules used in both aqueous and non-aqueous solvents. By providing a comprehensive overview of their cell cycling and performance characteristics, the strengths and weaknesses of the diverse categories of bipolar molecules are highlighted for both solvent systems, as are opportunities for future development. This should guide new research directions and advance the development of practical symmetric ORFBs.

关键词： Redox flow battery Symmetric battery Organic battery Aqueous electrolyte Non-aqueous electrolyte

A Rapid Adaptation Approach for Dynamic Air‑Writing Recognition Using Wearable Wristbands with Self‑Supervised Contrastive Learning

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Nano-Micro Letters 2025年第2期17卷 417-431页

作者： Yunjian Guo Kunpeng Li Wei Yue Nam‑Young Kim Yang Li Guozhen Shen Jong‑Chul Lee department of Electronic Convergence Engineering Kwangwoon UniversitySeoul 01897South Korea radio Frequency Integrated Circuit(RFIC)Bio Centre Kwangwoon UniversitySeoul 01897South Korea department of Electronic Engineering Kwangwoon UniversitySeoul 01897South Korea School of Microelectronics Shandong UniversityJinan 250101People’s Republic of China State Key Laboratory of Integrated Chips and Systems Fudan UniversityShanghai 200433People’s Republic of China School of Integrated Circuits and Electronics Beijing Institute of TechnologyBeijing 100081People’s Republic of China

Wearable wristband systems leverage deep learning to revolutionize hand gesture recognition in daily *** existing approaches that often focus on static gestures and require extensive labeled data,the proposed wearable wristband with selfsupervised contrastive learning excels at dynamic motion tracking and adapts rapidly across multiple *** features a four-channel sensing array composed of an ionic hydrogel with hierarchical microcone structures and ultrathin flexible electrodes,resulting in high-sensitivity capacitance *** wireless transmission from a Wi-Fi module,the proposed algorithm learns latent features from the unlabeled signals of random wrist ***,only few-shot labeled data are sufficient for fine-tuning the model,enabling rapid adaptation to various *** system achieves a high accuracy of 94.9%in different scenarios,including the prediction of eight-direction commands,and air-writing of all numbers and *** proposed method facilitates smooth transitions between multiple tasks without the need for modifying the structure or undergoing extensive task-specific *** utility has been further extended to enhance human–machine interaction over digital platforms,such as game controls,calculators,and three-language login systems,offering users a natural and intuitive way of communication.

关键词： Wearable wristband Self-supervised contrastive learning Dynamic gesture Air-writing Human-machine interaction

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Recent progress of chemotherapy and biomarkers for gastroesophageal cancer

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World Journal of Gastrointestinal Oncology 2019年第7期11卷 518-526页

作者： Osamu Maeda Yuichi Ando department of Clinical Oncology and chemotherapy Nagoya University Hospital

Key cytotoxic drugs of chemotherapy for gastroesophageal cancer include fluoropyrimidine, platinum, taxanes and irinotecan. Concurrent chemoradiotherapy is one of the main treatment strategies, especially for esophageal cancer. As molecular target agents, the anti-HER2 antibody trastuzumab for HER2-positive gastric cancer and the anti-angiogenesis agent ramucirumab combined with paclitaxel have been proven to improve the survival of gastric cancer patients. Recently, anti-PD-1 antibodies have become available as second- or later-line chemotherapy. Microsatellite instability is also useful as a biomarker to select patients suitable for immunotherapy. Furthermore, genome-wide analysis has improved our understanding of the biological features and molecular mechanisms of gastroesophageal cancer and will provide optimized treatment selection.

关键词： Gastroesophageal cancer chemotherapy Biomarker HER2

Intensity Dependence of Cesium D_(2)-Line Saturation Spectra

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Chinese Physics Letters 1996年第6期13卷 424-427页

作者： LI Yi-min CHEN Xu-zong GAN Jian-hua JI Wang-xi HUA Jing-shan YANG Dong-hai WANG Yi-qiu department of radio-Electronics Peking UniversityBeijing 100871

The intensity dependence of the cesium D_(2)-line saturation absorption spectra in a nearly zero magnetic field was investigated theoretically and *** using rate equations the D_(2)-line saturation absorption spectra were calculated,which agree reasonably well with the experimental *** variation of the spectra with different cell lengths was also reported and explained with theoretical calculation.

关键词： calculation. spectra saturation

Multiscale Entropy under the Inverse Gaussian Distribution： Analytical Results

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Chinese Physics Letters 2007年第6期24卷 1490-1493页

作者：唐莹裴文江夏海山何振亚 department of radio Engineering Southeast University Nanjing 210096

The multiscale entropy （MSE） reveals the intrinsic multiple scales in the complexity of physical and physiological signals, which are usually featured by heavy-tailed distributions. However, most research results are pure experimental search. Recently, Costa et al. have made the first attempt to present the theoretical basis of MSE, but it only supports the Gaussian distribution [Phys Rev. E 71 （2005） 021906]. We present the theoretical basis of MSE under the inverse Gaussian distribution, a typical model for physiological, physical and financial data sets. The analysis allows for uncorrelated inverse Gaussian process and 1/f noise with the multivariate inverse Gaussian distribution, and then provides a reliable foundation for the potential applications of MSE to explore complev nhwical and Dhwical time series.

关键词： APPROXIMATE ENTROPY HEART-RATE NOISE

Feedback regulation between phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1 and transforming growth factor β1 and prognostic value in gastric cancer

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World Journal of Gastroenterology 2020年第1期26卷 21-34页

作者： Qi Shao Zhi-Ming Chen department of chemotherapy/radiotherapy Affiliated Hospital of Nantong University

BACKGROUND Phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1(PREX1)was reported to be overexpressed in some cancers and involved in cancer development,but its expression and significance in gastric cancer remain *** To evaluate the expression of PREX1 in gastric cancer and its significance in the development of gastric cancer,especially to evaluate the potential mechanism of PREX1 in gastric *** Bioinformatic analysis was performed in order to examine the expression of PREX1 in gastric *** relationship between the survival rate of gastric cancer patients and PREX1 expression was assessed by Kaplan Meier *** Gene Set Enrichment Analysis and the correlation between PREX1 and transforming growth factor(TGF)β1 pathway-related mediators were evaluated by cBioPortal for Cancer *** blotting and reverse transcriptase polymerase chain reaction assay were used to test the role of TGFβ1 on the expression of *** blotting and dual-luciferase reporter system was used to evaluate the effect of PREX1 on the activation of TGFβ1 *** healing and Transwell assay were used to assess the effect of PREX1 on the metastasis activity of gastric cancer *** PREX1 was overexpressed in the gastric tumors,and the expression levels were positively associated with the development of gastric ***,the high expression of PREX1 revealed poor prognosis,especially for those advanced and specific intestinal gastric cancer ***1 was closely involved in the positive regulation of cell adhesion and positively correlated with TGFβ1-related ***,TGFβ1 could induce the expression of PREX1 at both the protein and mRNA ***,PREX1 could activate the TGFβ1 *** induced PREX1 could increase the migration and invasion activity of gastric cancer *** PREX1 is overexpressed in gastric cancer,and the high level of PREX1 predicts poor ***1 is closely assoc

关键词： Phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1 Gastric cancer High expression Poor prognosis Metastasis Transforming growth factorβ1 pathway

Few-shot learning for screening 2D Ga2CoS4-x supported single-atom catalysts for hydrogen production

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Journal of Energy Chemistry 2025年第1期100卷 665-673页

作者： Nabil Khossossi Poulumi Dey department of Mechanical Engineering (ME) Delft University of Technology

Hydrogen generation and related energy applications heavily rely on the hydrogen evolution reaction（HER）,which faces challenges of slow kinetics and high *** electrocatalysts,particularly single-atom catalysts （SACs） on two-dimensional （2D） materials,are *** study presents a few-shot machine learning （ML） assisted high-throughput screening of 2D septuple-atomic-layer Ga2CoS4-xsupported SACs to predict HER catalytic ***,density functional theory （DFT）calculations showed that 2D Ga2CoS4is inactive for ***,defective Ga2CoS4-x（x=0–0.25）monolayers exhibit excellent HER activity due to surface sulfur vacancies （SVs）,with predicted overpotentials （0–60 mV） comparable to or lower than commercial Pt/C,which typically exhibits an overpotential of around 50 m V in the acidic electrolyte,when the concentration of surface SV is lower than 8.3%.SVs generate spin-polarized states near the Fermi level,making them effective HER *** demonstrate ML-accelerated HER overpotential predictions for all transition metal SACs on 2D *** DFT data from 18 SACs,an ML model with high prediction accuracy and reduced computation time was *** intrinsic descriptor linking SAC atomic properties to HER overpotential was *** study thus provides a framework for screening SACs on 2D materials,enhancing catalyst design.

关键词： Hydrogen production Electrocatalyst 2D material Density functional theory Machine learning Surface sulfur vacancy

A Synergistic Multi-Attribute Decision-Making Method for Educational Institutions Evaluation Using Similarity Measures of Possibility Pythagorean Fuzzy Hypersoft Sets

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Computer Modeling in Engineering & Sciences 2025年第1期142卷 501-530页

作者： Khuram Ali Khan Saba Mubeen Ishfaq Atiqe Ur Rahman Salwa El-Morsy department of Mathematics University of SargodhaSargodha40100Pakistan department of Mathematics University of Management and TechnologyLahore54000Pakistan department of Mathematics College of ScienceQassim UniversityBuraydah51452Saudi Arabia

Due to the numerous variables to take into account as well as the inherent ambiguity and uncertainty,evaluating educational institutions can be *** concept of a possibility Pythagorean fuzzy hypersoft set(pPyFHSS)is more flexible in this regard than other theoretical fuzzy set-like models,even though some attempts have been made in the literature to address such *** study investigates the elementary notions of pPyFHSS including its set-theoretic operations union,intersection,complement,OR-and *** results related to these operations are also modified for ***,the similarity measures between pPyFHSSs are formulated with the assistance of numerical examples and ***,an intelligent decision-assisted mechanism is developed with the proposal of a robust algorithm based on similarity measures for solving multi-attribute decision-making(MADM)problems.A case study that helps the decision-makers assess the best educational institution is discussed to validate the suggested *** algorithmic results are compared with the most pertinent model to evaluate the adaptability of pPyFHSS,as it generalizes the classical possibility fuzzy set-like theoretical ***,while considering significant evaluating factors,the flexibility of pPyFHSS is observed through structural comparison.

关键词： Hypersoft set Pythagorean fuzzy hypersoft set computational complexity multi-attribute decision-making optimization similarity measures uncertainty