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Dermatoprotective Effect of Ocoxin Cream® in Cancer Patients Treated with radiation Therapy. Case Series

Case Reports in Clinical Medicine 2025年第1期14卷 25-39页

作者： Iris B. Inguanzo-Valdés Helga Candanedo-Pazo Aixa Ulloa-Balmaseda Oslay Cervantes-Hernández Acralis de La Cruz-Galguera Martha Lugioyo-Lugo Rosa M. Ortiz-Reyes Mircea Betancourt-Cabeza Jorge Luis Soriano-García Ramón Ropero-Toirac department of radiation Therapy National Institute of Oncology and Radiobiology Havana Cuba Clinical Research department National Institute of Oncology and Radiobiology Havana Cuba Scientific department Catalysis S.L. Madrid Spain

Background: The effects of radiation therapy can impact patients’ quality of life, leading to treatment interruptions and therefore sub-optimal outcomes. The main aim was to evaluate the preliminary effects of Ocoxin cream® in the prevention of radiation therapy. Methods: Fifty patients were enrolled in an observational, longitudinal, prospective, single-centre clinical trial in the department of radiation Therapy at the National Institute of Oncology and radiobiology in Havana, Cuba. The radiation Therapy Oncology Group (RTOG) toxicity criteria were used to classify the radiation therapy, and the Dermatology Life Quality Index (DLQI) instrument was used to assess quality of life. Results: Patients who met the inclusion criteria were enrolled consecutively and were treated with teletherapy using a 60Co source with 1.25 MeV energy. 70.0% of the patients were head and neck cancer patients. No grade 3 - 4 radiation therapy was reported, nor were there any interruptions in radiation treatment due to skin toxicity. radiation therapy was observed in only 14.0% of patients, and of these, only two patients developed grade 2 toxicity. The perception of quality of life before vs. after radiation therapy remained within an average range of “no effect” (at the start of radiation therapy) to “small effect” (at the end of radiation therapy). Conclusions: This clinical study is the first report of the use of Ocoxin cream® in cancer patients and demonstrates that it is able to prevent radiation therapy and reduce the severity of toxicity of treatment with ionising radiation.

关键词： Dermatitis radiation Therapy Ocoxin Cream® Quality of Life

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Identifying adipocyte-derived exosomal miRNAs as potential novel prognostic markers for radiotherapy of esophageal squamous cell carcinoma

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World Journal of Gastrointestinal Oncology 2025年第2期17卷 211-229页

作者： Yang-Yang Ge Xiao-Chun Xia An-Qing Wu Chen-Ying Ma Ling-Hui Yu Ju-Ying Zhou department of radiation Oncology The First Affiliated Hospital of Soochow UniversitySuzhou 215006Jiangsu ProvinceChina department of Radiotherapy The Affiliated Tumor Hospital of Nantong UniversityNantong 226361Jiangsu ProvinceChina School of radiation Medicine and protection Soochow UniversitySuzhou 215123Jiangsu ProvinceChina department of Brachytherapy The Affiliated Tumor Hospital of Nantong UniversityNantong 226361Jiangsu ProvinceChina

BACKGROUND radiation resistance limits radiotherapy efficacy in esophageal squamous cell carcinoma(ESCC).The tumor microenvironment,particularly adipocytes,plays a role in promoting cancer *** vesicles and microRNAs(miRNAs)regulate gene expression and hold prognostic potential for esophageal *** radioresistance mechanisms and identifying radiosensitization targets can help enhance radiotherapy efficacy for esophageal *** To investigate the potential role of miRNAs derived from adipocyte exosomes as prognostic markers for radiotherapy efficacy in *** Free adipocytes were isolated from human thoracic adipose tissue.A co-culture model of adipocytes and ESCC cells was established to observe colony formation and cell survival *** cell apoptosis was assessed by flow *** Blot and immunofluorescence assays were performed to evaluate DNA damage in ESCC cells ***-derived exosomes were isolated by ultracentrifugation and identified by electron microscopy.A similar set of experiments was performed on ESCC cells to analyze cell survival,apoptosis,and DNA damage post-radiation *** from adipose tissue and serum exosomes from ESCC patients pre-and post-radiotherapy were subjected to high-throughput miRNA-sequencing and validated using real-time quantitative polymerase chain *** correlation between potential target miRNAs and the short-term prognosis of radiotherapy in ESCC was evaluated by receiver operating characteristic curve *** Co-culturing adipocytes with ESCC cells enhanced radioresistance,as evidenced by increased colony *** co-culture reduced ESCC cell apoptosis and DNA damage ***-derived exosomes similarly conferred radioresistance in ESCC cells,decreasing apoptosis and DNA damage *** miRNA-sequencing identified miR-660-5p in serum and adipose tissue ***

关键词： Esophageal squamous cell carcinoma Adipocyte Exosomes MicroRNA Radiotherapy

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Construction of a novel cationic polymeric nanotrap using valence and configuration matching strategy for benchmark removal of selenium oxoanions from nuclear waste streams

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Science China Chemistry 2025年

作者： Yunnan Tao Kui Tan Hongliang Huang Long Chen Bin Wang Chunyu Bao Junchang Chen Zhifang Chai Shuao Wang State Key Laboratory of radiation Medicine and protection School for Radiological and Interdisciplinary Sciences (RAD-X) and Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions Soochow University department of Chemistry University of North Texas State Key Laboratory of Separation Membranes and Membrane Processes Tiangong University

The persistent need for sorbents capable of efficiently extracting selenium from radioactive wastewater has been a significant challenge. Herein, we introduce SCU-CPN-5, a robust and saleable adsorbent designed through principles of valence and configuration matching, which achieves remarkable removal of selenium oxo-anions from nuclear waste liquids. SCU-CPN-5 demonstrates unprecedented adsorption capacities, with 617 mg/g for SeO42-and 333 mg/g for SeO32-. Additionally, it exhibits a removal efficiency of up to 99.7% for environmentally relevant concentrations of SeO42-. Notably, we employed in-situ Fouriertransform infrared spectroscopy to monitor the sorption process of selenium oxo-anions into the pores of the sorbent in real time,marking a significant advancement. This research not only introduces a novel approach to the design of functional materials for nuclear wastewater management but also provides a molecular-level understanding of the adsorption mechanism.

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GSN antibody pretreatment aggravates radiation-induced lung injury in mice

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Nuclear Science and Techniques 2014年第2期25卷 26-31页

作者：王洁袁小鹏顾成黄建峰俞家华刘芬菊 department of radiobiology School of Radiation Medicine and ProtectionMedical College of Soochow University School for Radiological and Interdisciplinary Sciences Soochow University

radiation-induced lung injury is one of the main dose limiting factors for thoracic radiation ***(GSN) is a widespread,multifunctional regulator of cellular structure and *** this work,the roles of GSN in radiation-induced lung injury in Balb/c mice were *** GSN levels in plasma reduced progressively in 72 hours after irradiation,and then increased *** contents in the bronchoalveolar lavage(BAL) fluid increased after thoracic irradiation,whereas mRNA levels of GSN in the lung tissue decreased significantly within 24 hours after irradiation and then increased *** were intravenously injected with 50 ug GSN antibody 0.5 hour before 20 Gy of thoracic *** antibody pretreatment increased lung inflammation,protein concentration in the BAL fluid and leukocytes infiltration in the irradiated *** activities of superoxidase dismutase(SOD) in the plasma and the BAL fluid in irradiated mice injected with GSN antibody were less than that of control groups,whereas the levels of malondialdehyde(MDA)*** results suggest that pretreatment of GSN antibody may aggravate radiation-induced pneumonitis.

关键词： GSN 肺损伤放射性预处理小鼠抗体 mRNA水平超氧化物歧化酶

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Establishment of Diagnostic Reference Levels for Childhood Head CT in the District of Abidjan in Côte d’Ivoire

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World Journal of Nuclear Science and Technology 2025年第1期15卷 45-52页

作者： Koutoua Joseph Anouan Raïssa-Michelle Kabas Jean-Paul Kouao Aboubakar Sidiki Diabaté Nuclear Physics and radiation protection Team Training and Research Unit Sciences of the Structures of Matter and Technology University Flix Houphouet-Boigny of Abidjan Abidjan Cte dIvoire department of Basic and Bioclinical Sciences Training and Research Unit Medical Sciences University Flix Houphouet-Boigny of Abidjan Abidjan Cte dIvoire department of Radiodiagnosis and Medical Imaging University Hospital of Treichville Abidjan Cte dIvoire

Computed tomography is an indispensable X-ray imaging modality used to diagnose numerous pathologies, but it can also involve the delivery of high ionizing radiation doses harmful to the health of patients. This study aims to survey the level of radiation doses delivered to child patients during head exams in CT imaging to set up the Dosimetric Reference Levels (DRLs), a routine dose optimization tool, based on data acquired at the University Hospital of Angré (UHA), the University Hospital of Treichville (UHT) and the Polyclinic Hospital Farah (Farah) for optimizing procedures in Ivorian hospitals. Prospectively performed on 334 CT images of 186 child patients, this study was carried out on CT systems such as Hitachi Scenaria, Sinovision Insitum, and Philips Incisive used respectively at UHA, UHT and Farah. Children’s scan data were classified into four age bands: vol or dose-length product as DLP) value, whatever the hospital, increases with respect to the age of child patients. Based on the 75th percentile of the whole dose distributions, the DRLs of the CTDIvol is 54.37 mGy whatever the age groups and those of the DLP with respect to age bands are 1224.55 mGy∙cm, 1414.06 mGy∙cm, 1632.24 *** and 1544.57 mGy∙cm, respectively. The averaged values of CTDIvol and DLP smaller than the corresponding DRLs values suggest that practices in our three facilities are optimized. However, comparing our results with those from different international studies, we see that the CTDIvol and DLP values obtained in the present work are higher. These results suggest additional surveys to ensure our DRLs values and efforts from radiologists, imaging technicians and medical physicists to strengthen clinical procedures for the radiation protection of children undergoing CT scans in Côte d’Ivoire.

关键词： Computed Tomography Childhood Head Imaging radiation protection Diagnostic Reference Levels

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A new method for position-sensitive measurement of beta surface contamination

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Nuclear Science and Techniques 2017年第2期28卷 49-56页

作者： Yan-Tao Qu Hui Wang Yang Liu Ling Chen Jie Hou Zhe Liu Ji-Zeng Ma department of radiation protection China Institute of Atomic Energy Beijing 102413 China Nuclear and radiation Safety Center Ministry of Environment Protection Beijing 100082 China Occupational radiation protection Unit Radiation Safety and Monitoring Section NSRW IAEA PO Box 1001400 Vienna Austria

In this paper, we propose a new method for position-sensitive measurement of beta surface contamination. With a position-sensitive detector of enlarged sensitive detection area, accurate information of the contamination distribution can be obtained. The positionsensitive detection is based on a large-area plastic scintillator and the wavelength shifting(WLS) fibers and adopts the ‘‘light center of gravity'' method. Optical transmission of the detector is simulated with a preliminary detector model, and feasibility of the detector design and measurement method is evaluated using an experiment *** simulation and experiment results at different beta-ray incident points on the scintillator surface show that there is a polynomial relationship between the average amplitude ratio of the output pulses from the two parallel WLS fibers in the same fiber layer and the relative distance from the incident point to the WLS fiber.

关键词： Beta surface contamination Position-sensitive measurement Wavelength shifting fibers Plastic scintillator

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Reliability analysis of the gasification process of nuclear fuel manufacturing facilities based on the GO methodology

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Nuclear Science and Techniques 2019年第10期30卷 85-94页

作者： Yan Wang Zhi-Jie Gu Bing Lian Jie Yang Yang-Jun Zhao department of Nuclear Environmental Sciences China Institute for Radiation Protection

Uranium hexafluoride(UF6)leakage accidents represent one of the most serious classes of accidents in the gasification process in nuclear fuel manufacturing *** UF6 leakage accidents include various fault conditions,such as pipeline and valve breakages or ruptures and pipeline *** establishing goal-oriented(GO)operators that can represent multi-fault states,this study estimates the probabilities of various fault states corresponding to UF6 leakage accidents in the gasification process using the GO methodology and analyzes the system *** article expands the scope of the GO methodology and provides technical support for reliability analysis using the GO methodology in multi-fault systems.

关键词： GO methodology Operator Multi-fault state Reliability analysis UF6 leakage

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Activation ofγ-globin expression by a common variant disrupting IKAROS-binding motif inβ-thalassemia

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Journal of Genetics and Genomics 2025年第2期52卷 157-167页

作者： Hualei Luo Jueheng Wang Lang Qin Xinhua Zhang Hailiang Liu Chao Niu Mengyang Song Congwen Shao Peng Xu Miao Yu Haokun Zhang Yuhua Ye Xiangmin Xu Innovation Center for Diagnostics and Treatment of Thalassemia Nanfang HospitalSouthern Medical UniversityGuangzhouGuangdong 510515China department of Medical Genetics School of Basic Medical SciencesSouthern Medical UniversityGuangzhouGuangdong 510515China State Key Laboratory of Genetic Engineering School of Life SciencesFudan UniversityShanghai 201114China department of Pediatrics 923rd Hospital of the People's Liberation ArmyNanningGuangxi 530021China Cyrus Tang Medical Institute National Clinical Research Centre for Hematologic DiseasesCollaborative Innovation Centre of HematologyState Key Laboratory of Radiation Medicine and ProtectionSoochow University SuzhouSuzhouJiangsu 215031China State Key Laboratory of Genetic Engineering MOE Engineering Research Center of Gene TechnologySchool of Life SciencesFudan UniversityShanghai 200438China

Programmed silencing ofγ-globin genes in adult erythropoiesis is mediated by several chromatin remodeling complexes,which determine the stage-specific genome architecture in this *** of cis-or trans-acting mutations contributing to the diverse extent of fetal hemoglobin(Hb F)might illustrate the underlying mechanism ofγ-β-globin ***,we recruit a cohort of 1142β-thalassemia patients and dissect the natural variants in the wholeβ-globin gene cluster through a targeted next-generation sequencing panel.A previously unreported SNP rs7948668,predicted to disrupt the binding motif of IKAROS as a key component of chromatin remodeling complexes,is identified to be significantly associated with higher levels of Hb F and age at ***-editing on this SNP leads to the elevation of Hb F in both HUDEP-2 and primary CD34+cells while the extent of elevation is amplified in the context ofβ-thalassemia mutations,indicating epistasis effects of the SNP in the regulation of Hb ***,we perform ChIP-qPCR and 4C assays to prove that this variant disrupts the binding motif of IKAROS,leading to enhanced competitiveness of HBG promoters to locus control *** study highlights the significance of common regulatory SNPs and provides potential targets for treatingβ-hemoglobinopathy.

关键词： β-thalassemia Fetal hemoglobin Single nucleotidepolymorphism IKAROS Locus control region

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DNA damage repair:historical perspectives,mechanistic pathways and clinical translation for targeted cancer therapy

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Signal Transduction and Targeted Therapy 2021年第8期6卷 2391-2425页

作者： Ruixue Huang Ping-Kun Zhou department of Occupational and Environmental Health Xiangya School of Public HealthCentral South UniversityChangshaHunanChina department of radiation Biology Beijing Key Laboratory for RadiobiologyBeijing Institute of Radiation MedicineAMMSBeijingChina

Genomic instability is the hallmark of various cancers with the increasing accumulation of DNA *** application of radiotherapy and chemotherapy in cancer treatment is typically based on this property of ***,the adverse effects including normal tissues injury are also accompanied by the radiotherapy and *** cancer therapy has the potential to suppress cancer cells'DNA damage response through tailoring therapy to cancer patients lacking specific DNA damage response ***,understanding the broader role of DNA damage repair in cancers has became a basic and attractive strategy for targeted cancer therapy,in particular,raising novel hypothesis or theory in this field on the basis of previous scientists'findings would be important for future promising druggable emerging *** this review,we first illustrate the timeline steps for the understanding the roles of DNA damage repair in the promotion of cancer and cancer therapy developed,then we summarize the mechanisms regarding DNA damage repair associated with targeted cancer therapy,highlighting the specific proteins behind targeting DNA damage repair that initiate functioning abnormally duo to extrinsic harm by environmental DNA damage factors,also,the DNA damage baseline drift leads to the harmful intrinsic targeted cancer *** addition,clinical therapeutic drugs for DNA damage and repair including therapeutic effects,as well as the strategy and scheme of relative clinical trials were intensive *** on this background,we suggest two hypotheses,namely"environmental gear selection”to describe DNA damage repair pathway evolution,and"DNA damage baseline drift”,which may play a magnified role in mediating repair during cancer *** two new hypothesis would shed new light on targeted cancer therapy,provide a much better or more comprehensive holistic view and also promote the development of new research direction and new overcoming strategies for

关键词： damage clinical targeted

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A Low-Cost Dual Energy CT System with Sparse Data

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Tsinghua Science and Technology 2014年第2期19卷 184-194页

作者： Yuanyuan Liu Jianping Cheng Li Zhang Yuxiang Xing Zhiqiang Chen Peng Zheng Nuclear and radiation Safety Center Ministry of Environmental Protection of China department of Engineering Physics Tsinghua University

Dual Energy CT （DECT） has recently gained significant research interest owing to its ability to discriminate materials, and hence is widely applied in the field of nuclear safety and security inspection. With the current technological developments, DECT can be typically realized by using two sets of detectors, one for detecting lower energy X-rays and another for detecting higher energy X-rays. This makes the imaging system expensive, limiting its practical implementation. In 2009, our group performed a preliminary study on a new low-cost system design, using only a complete data set for lower energy level and a sparse data set for the higher energy level. This could significantly reduce the cost of the system, as it contained much smaller number of detector elements. Reconstruction method is the key point of this system. In the present study, we further validated this system and proposed a robust method, involving three main steps：（1） estimation of the missing data iteratively with TV constraints; （2） use the reconstruction from the complete lower energy CT data set to form an initial estimation of the projection data for higher energy level; （3） use ordered views to accelerate the computation. Numerical simulations with different number of detector elements have also been examined. The results obtained in this study demonstrate that 1 ＋ 14% CT data is sufficient enough to provide a rather good reconstruction of both the effective atomic number and electron density distributions of the scanned object, instead of 2 sets CT data.

关键词： X-ray imaging dual energy CT system sparse samples reconstruction material discriminationAR^TV

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