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Potential of non-Western medicines in chemoradiotherapy for cervical cancer

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World Journal of Clinical Cases 2025年第2期13卷 21-23页

作者： Takashi Ono Masashi Koto department of radiation Oncology Faculty of MedicineYamagata UniversityYamagata 990-9585Japan

This editorial explores the potential integration of non-Western medicine into radiotherapy for cervical *** radiotherapy remains a radical treatment for cervical cancer,its associated toxicity and decline in quality of life can significantly impact patients’***,most treatments are supportive,with no specific treatment options available in Western ***-Western medicine,often less toxic and easier to administer,has shown promising results when used alongside radiotherapy for cervical *** these potential benefits,challenges such as limited evidence and restricted application areas *** non-Western medicines may offer potential improvements in chemoradiotherapy outcomes for cervical cancer,further research is necessary to substantiate these benefits.

关键词： Cervical cancer Radiotherapy Non-Western medicine Kampo Herbal medicine

Computed tomography enterography-based radiomics for assessing mucosal healing in patients with small bowel Crohn's disease

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World Journal of Gastroenterology 2025年第3期31卷 62-72页

作者： Hao Ding Yuan-Yuan Fang Wen-Jie Fan Chen-Yu Zhang Shao-Fei Wang Jing Hu Wei Han Qiao Mei department of Gastroenterology The First Affiliated Hospital of Anhui Medical UniversityHefei 230022Anhui ProvinceChina department of radiation Oncology The First Affiliated Hospital of Anhui Medical UniversityHefei 230022Anhui ProvinceChina department of Gastroenterology Suzhou First People's HospitalSuzhou 234099Anhui ProvinceChina

BACKGROUND Mucosal healing(MH)is the major therapeutic target for Crohn's disease(CD).As the most commonly involved intestinal segment,small bowel(SB)assessment is crucial for CD ***,it poses a significant challenge due to its limited accessibility through conventional endoscopic *** To establish a noninvasive radiomic model based on computed tomography enterography(CTE)for MH assessment in SBCD *** Seventy-three patients diagnosed with SBCD were included and divided into a training cohort(n=55)and a test cohort(n=18).Radiomic features were obtained from CTE images to establish a radiomic *** demographics were analysed to establish a clinical model.A radiomic-clinical nomogram was constructed by combining significant clinical and radiomic *** diagnostic efficacy and clinical benefit were evaluated via receiver operating characteristic(ROC)curve analysis and decision curve analysis(DCA),*** Of the 73 patients enrolled,25 patients achieved *** radiomic-clinical nomogram had an area under the ROC curve of 0.961(95%confidence interval:0.886-1.000)in the training cohort and 0.958(0.877-1.000)in the test cohort and provided superior clinical benefit to either the clinical or radiomic models alone,as demonstrated by *** These results indicate that the CTE-based radiomic-clinical nomogram is a promising imaging biomarker for MH and serves as a potential noninvasive alternative to enteroscopy for MH assessment in SBCD patients.

关键词： Crohn’s disease Computed tomography enterography Mucosal healing Nomogram Radiomics

Turning the tide:From cervical cancer's grip to complete response:A case report

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World Journal of Clinical Oncology 2025年第2期16卷 152-157页

作者： Shatha Abutaha Abdulla Alzibdeh Issa Mohamad Lina Wahbeh Samer Salah Ramiz Abuhijlih Fawzi Abuhijla department of radiation Oncology King Hussein Cancer CenterAmman 11941Jordan department of Medical Oncology King Fahad Specialist HospitalDammam 32210Saudi Arabia

BACKGROUND Cervical cancer is a formidable global health issue,particularly affecting women in lower-middle-income countries with little or no access to preventative vaccines,screening programs,and treatment *** case report presents a unique case of a large cervical cancer achieving complete response(CR)with concurrent chemoradiotherapy(CCRT),highlighting the effectiveness of this treatment approach even in advanced stages and underscoring the importance of adaptive radiotherapy(RT)in optimizing patient *** SUMMARY We present the case of a 53-year-old woman who presented with four years of abnormal vaginal bleeding and was found to have p16-positive,moderately differentiated cervical squamous cell *** tumor measured 14 cm×12 cm×8 cm,the largest size reported in the literature to achieve CR with *** this monumental feat,the patient remained disease-free and is currently on follow-up for 2 years;however,she continued to suffer from substantial morbidity caused by a vesicovaginal fistula and hydronephrosis,underscoring the continuing impact of cervical cancer on quality of *** In this case report,we highlight the effectiveness of CCRT in achieving CR,even in cases of bulky cervical cancer,with adaptive RT offering a customized strategy to improve patient *** also emphasize the necessity for multidisciplinary team discussions and highlight the need for strategies to mitigate treatment-related toxicities and long-term complications.

关键词： Cervical cancer Chemoradiotherapy Adaptive radiotherapy Case report

A new method for position-sensitive measurement of beta surface contamination

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Nuclear Science and Techniques 2017年第2期28卷 49-56页

作者： Yan-Tao Qu Hui Wang Yang Liu Ling Chen Jie Hou Zhe Liu Ji-Zeng Ma department of radiation protection China Institute of Atomic Energy Beijing 102413 China Nuclear and radiation Safety Center Ministry of Environment Protection Beijing 100082 China Occupational radiation protection Unit Radiation Safety and Monitoring Section NSRW IAEA PO Box 1001400 Vienna Austria

In this paper, we propose a new method for position-sensitive measurement of beta surface contamination. With a position-sensitive detector of enlarged sensitive detection area, accurate information of the contamination distribution can be obtained. The positionsensitive detection is based on a large-area plastic scintillator and the wavelength shifting(WLS) fibers and adopts the ‘‘light center of gravity'' method. Optical transmission of the detector is simulated with a preliminary detector model, and feasibility of the detector design and measurement method is evaluated using an experiment *** simulation and experiment results at different beta-ray incident points on the scintillator surface show that there is a polynomial relationship between the average amplitude ratio of the output pulses from the two parallel WLS fibers in the same fiber layer and the relative distance from the incident point to the WLS fiber.

关键词： Beta surface contamination Position-sensitive measurement Wavelength shifting fibers Plastic scintillator

Reliability analysis of the gasification process of nuclear fuel manufacturing facilities based on the GO methodology

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Nuclear Science and Techniques 2019年第10期30卷 85-94页

作者： Yan Wang Zhi-Jie Gu Bing Lian Jie Yang Yang-Jun Zhao department of Nuclear Environmental Sciences China Institute for Radiation Protection

Uranium hexafluoride(UF6)leakage accidents represent one of the most serious classes of accidents in the gasification process in nuclear fuel manufacturing *** UF6 leakage accidents include various fault conditions,such as pipeline and valve breakages or ruptures and pipeline *** establishing goal-oriented(GO)operators that can represent multi-fault states,this study estimates the probabilities of various fault states corresponding to UF6 leakage accidents in the gasification process using the GO methodology and analyzes the system *** article expands the scope of the GO methodology and provides technical support for reliability analysis using the GO methodology in multi-fault systems.

关键词： GO methodology Operator Multi-fault state Reliability analysis UF6 leakage

Prognostic impact of inflammatory and nutritional biomarkers in pancreatic cancer

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World Journal of Clinical Oncology 2025年第1期16卷 5-9页

作者： Macarena Teja María I Garrido Abrahams Ocanto Felipe Counago department of radiation Oncology GenesisCare-San Francisco de Asís University HospitalMadrid 28002Spain department of radiation Oncology GenesisCare-Vithas La Milagrosa University HospitalMadrid 28010Spain National Director GenesisCare SpainMadrid 28043Spain department of Medicine School of MedicineHealth and SportEuropean University of MadridMadrid 28670Spain

Pancreatic cancer is usually associated with a poor *** is the main curative treatment but pancreatic operations are aggressive and new tools that help clinicians to predict surgical and prognostic outcomes are *** et al recently published a retrospective,single centre cohort study evaluating the impact of seven nutritional and inflammatory markers in pancreatic cancer surgical patients:The albumin-to-globulin ratio,prognostic nutritional index(PNI),systemic immune-inflammation index(SII),neutrophil-to-lymphocyte ratio(NLR),platelet-to-lymphocyte ratio(PLR),nutritional risk index,and the geriatric nutritional risk index.A significant correlation was found between the PNI,SII,NLR,and PLR and a hospital discharge of less than 15 *** a univariable analysis,PNI,SII,NLR and PLR were significantly related to recurrence-free survival and,in a multivariable analysis PNI was associated with overall *** meta-analyses corroborate the results in terms of prognosis but individual studies are discordant on their ***,the cut-off values for these markers vary significantly between studies and there are no clinical trials comparing them to identify the most relevant *** are limitations when implementing nutritional and inflammatory biomarkers into clinical practice and further studies are needed in order to answer these questions.

关键词： Inflammatory biomarkers Nutritional biomarkers Pancreatic cancer Prognosis Surgical complications

Model calculating annual mean atmospheric dispersion factor for coastal site of nuclear power plant

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Journal of Environmental Sciences 2001年第3期13卷 280-290页

作者： HU Er bang 1, CHEN Jia yi 2, YAO Ren tai 1, ZHANG Mao shuan 1, GAO Zhan rong 1, WANG Shu xian 1, JIA Pei rong 3, Liao Qi lin 4(1 China Institute for radiation protection, Taiyuan 030006,China. 2 Beijing University, Beijing\ 100871 China Institute for radiation protection Taiyuan 030006 China.

This paper describes an atmospheric dispersion field experiment performed on the coastal site of nuclear power plant in the east part of China during 1995 to 1996. The three-dimension joint frequency are obtained by hourly observation of wind and temperature on a 100m high lower; the frequency of the 'event day of land and sea breeze' are given by observation of surface wind and land and sea breezes; the diffusion parameters are got from measurements of turbulent and wind tunnel simulation test. A new model calculating the annual mean atmospheric dispersion factor for coastal site of nuclear power plant is developed and established. This model considers not only the effect from mixing release and mixed layer but also the effect from the internal boundary layer and variation of diffusion parameters due to the distance from coast. The comparison between results obtained by the new model and current model shows that the ratio of annual mean atmospheric dispersion factor gained by the new model and the current one is about 2.0.

关键词： Coastal zones Diffusion Dispersions Earth atmosphere Temperature Wind

The behavior of cesium adsorption on zirconyl pyrophosphate

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Nuclear Science and Techniques 2016年第3期27卷 74-79页

作者： feng-li song xiao-wei yang xiao-long li wei he dan lü ji que chun-long zhang shan-gui zhao shi-jun wang yun-tao liu Nuclear and radiation Safety Center Ministry of Environmental ProtectionBeijing 100082China

Zirconyl pyrophosphate(ZrP_2O_7) was prepared and Cs adsorption behavior was *** show that the distribution coefficient of Cs adsorption on ZrP_2O_7 was about 2800 mL/*** exchange capacity of ZrP_2O_7 was0.35 mmol/*** dynamic tests,Cs can be separated from other fission products very well by ZrP_2O_*** ZrP_2O_7was stable both at high temperatures and in high concentration of nitric *** Cs adsorption by ZrP_2O_7 is a monolayer and chemical adsorption.

关键词：吸附行为磷酸锆铯动态测试分布系数交换能力裂变产物化学吸附

A Low-Cost Dual Energy CT System with Sparse Data

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Tsinghua Science and Technology 2014年第2期19卷 184-194页

作者： Yuanyuan Liu Jianping Cheng Li Zhang Yuxiang Xing Zhiqiang Chen Peng Zheng Nuclear and radiation Safety Center Ministry of Environmental Protection of China department of Engineering Physics Tsinghua University

Dual Energy CT （DECT） has recently gained significant research interest owing to its ability to discriminate materials, and hence is widely applied in the field of nuclear safety and security inspection. With the current technological developments, DECT can be typically realized by using two sets of detectors, one for detecting lower energy X-rays and another for detecting higher energy X-rays. This makes the imaging system expensive, limiting its practical implementation. In 2009, our group performed a preliminary study on a new low-cost system design, using only a complete data set for lower energy level and a sparse data set for the higher energy level. This could significantly reduce the cost of the system, as it contained much smaller number of detector elements. Reconstruction method is the key point of this system. In the present study, we further validated this system and proposed a robust method, involving three main steps：（1） estimation of the missing data iteratively with TV constraints; （2） use the reconstruction from the complete lower energy CT data set to form an initial estimation of the projection data for higher energy level; （3） use ordered views to accelerate the computation. Numerical simulations with different number of detector elements have also been examined. The results obtained in this study demonstrate that 1 ＋ 14% CT data is sufficient enough to provide a rather good reconstruction of both the effective atomic number and electron density distributions of the scanned object, instead of 2 sets CT data.

关键词： X-ray imaging dual energy CT system sparse samples reconstruction material discriminationAR^TV