检索结果-南通市图书馆

Cancer Communications 2024年第2期44卷 278-281页

作者： Tiantian Guo Yue Zhou Fei Liang Zezhou Wang Vincent Bourbonne Lukas Käsmann Nora Sundahl Abraham Jing-Ching Wu Jianjiao Ni Zhengfei Zhu department of radiation Oncology Fudan University Shanghai Cancer CenterShanghaiP.R.China department of Oncology Shanghai Medical CollegeFudan UniversityShanghaiP.R.China Shanghai Clinical Research Center for radiation Oncology ShanghaiP.R.China Shanghai Key Laboratory of radiation Oncology ShanghaiP.R.China department of Biostatistics Zhongshan HospitalFudan UniversityShanghaiP.R.China department of Cancer Prevention Fudan University Shanghai Cancer CenterShanghaiP.R.China radiation Oncology department University HospitalBrestFrance department of radiation Oncology University HospitalLMU MunichMunichGermany department of radiation Oncology AZ GroeningeKortrijkBelgium department of radiation Oncology Memorial Sloan Kettering Cancer CenterNew YorkNew YorkUSA Institute of Thoracic Oncology Fudan UniversityShanghaiP.R.China

Dear Editor:Brain metastasis(BM)has long been recognized as a prognostic factor associated with poor prognosis for non-small cell lung cancer(NSCLC)in the era of con-ventional chemotherapy and targeted therapy[1].In the era of immunotherapy,controversial findings have been reported regarding the prognostic significance of BM in patients with NSCLC treated with programmed death-1/programmed death-ligand 1(PD-1/PD-L1)inhibitors.

关键词： chemotherapy NSCLC metastasis death

An Elastoplastic Fracture Model Based on Bond-Based Peridynamics

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Computer Modeling in Engineering & Sciences 2024年第9期140卷 2349-2371页

作者： Liping Zu Yaxun Liu Haoran Zhang Lisheng Liu Xin Lai Hai Mei department of Engineering Structure and Mechanics Wuhan University of TechnologyWuhan430070China Hubei Key Laboratory of Theory and application of Advanced Materials Mechanics Wuhan University of TechnologyWuhan430070China

Fracture in ductile materials often occurs in conjunction with plastic ***,in the bond-based peridynamic(BB-PD)theory,the classic mechanical stress is not defined *** makes it difficult to describe plasticity directly using the classical plastic *** address the above issue,a unified bond-based peridynamics model was proposed as an effective tool to solve elastoplastic fracture *** to the existing models,the proposed model directly describes the elastoplastic theory at the bond level without the need for additional calculation *** results obtained in the context of this model are shown to be consistent with FEM results in regard to force-displacement curves,displacement fields,stress fields,and plastic deformation *** model exhibits good capability of capturing crack propagation in ductile material failure problems.

关键词： Ductile materials plastic deformation bond-based peridynamics isotropic hardening fracture analysis

Efficacy and safety of anlotinib combined with the STUPP regimen in patients with newly diagnosed glioblastoma: a multicenter, single-arm, phase Ⅱ trial

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Cancer Biology & Medicine 2024年第5期21卷 433-444页

作者： Shuzhen Lai Peijing Li Xiaohui Liu Guihong Liu Tieming Xie Xing Zhang Xiaoxuan Wang Jing Huang Yiqiang Tang Zhigang Liu Guoping Shen Chaoming Li Fangxiao Lu Lei Wang Fagui Jiang Caixing Sun Yuanyuan Chen Ming Chen department of radiation Oncology The Second Affiliated Hospital of Soochow UniversitySuzhou 215000China department of radiation Oncology Yuebei People’s Hospital Affiliated to the Medical College of Shantou UniversityShaoguan 512026China Chinese Academy of SciencesHangzhou 310022China department of radiation Oncology The Second Clinical Medical College of Zhejiang Chinese Medical UniversityHangzhou 311403China department of radiation Oncology The Affiliated Hospital of Xuzhou Medical UniversityXuzhou 221004China Chinese Academy of SciencesHangzhou 310022China State Key Laboratory of Translational Medicine and Innovative Drug Development Jiangsu Simcere Diagnostics Co.LtdNanjing 210000China department of radiation Oncology The Affiliated Huai’an First People’s Hospital of Nanjing Medical UniversityHuai’an 223399China department of radiation Oncology Jiangxi Cancer Hospital of Nanchang UniversityNanchang 330029China department of Radiotherapy Dongguan Institute of Clinical Cancer ResearchDongguan Key Laboratory of Precision Diagnosis and Treatment for TumorsAffiliated Dongguan HospitalSouthern Medical UniversityDongguan 523059China The Cancer Center The Fifth Affiliated Hospital of Sun Yat-Sen UniversityZhuhai 519000China department of radiation Oncology The First Affiliated Hospital of Sun Yat-Sen UniversityGuangzhou 510080China department of Oncology Maoming People’s HospitalMaoming 525000China department of radiation Oncology Kecheng District People’s HospitalQuzhou 324003China Chinese Academy of SciencesHangzhou 310022China department of radiation Oncology State Key Laboratory of Oncology in South ChinaSun Yat-sen University Cancer CenterGuangzhou 510060China United Laboratory of Frontier Radiotherapy Technology of Sun Yat-sen University&Chinese Academy of Sciences Ion Medical Technology Co. LtdGuangzhou 510060China

Objective:Glioblastomas are highly vascularized malignant *** determined the efficacy and safety of the anti-angiogenic multi-kinase inhibitor,anlotinib,for a newly diagnosed ***:This multicenter,single-arm trial(NCT04119674)enrolled 33 treatment-naïve patients with histologically proven glioblastomas between March 2019 and November *** underwent treatment with the standard STUPP regimen[fractionated focal irradiation in daily fractions of 1.8-2 Gy given 5 d/w×6 w(total=54-60 Gy)]or radiotherapy plus continuous daily temozolomide(TMZ)(75 mg/m^(2)of body surface area/d,7 d/w from the first to the last day of radiotherapy),followed by 6 cycles of adjuvant TMZ(150-200 mg/m^(2)×5 d during each 28-d cycle)plus anlotinib(8 mg/d on d 1-14 of each 3-w cycle for 2 cycles during concomitant chemoradiotherapy,8 maximal cycles as adjuvant therapy,followed by maintenance at 8 mg/*** primary endpoint was progression-free survival(PFS).Secondary endpoints included overall survival(OS)and adverse events(AEs).Results:Thirty-three patients received the planned *** median PFS was 10.9 months(95%CI,9.9-18.7 months)and the 12-month PFS rate was 48.5%.The median OS was 17.4 months(95%CI,14.5-21.1 months)and the 12-month OS rate was 81.8%.The most common AEs included hypertriglyceridemia[58%(n=19)],hypoalbuminemia[46%(n=15)],and hypercholesterolemia[46%(n=15)]during concurrent chemoradiotherapy and leukopenia[73%(n=24)],hypertriglyceridemia[67%(n=22)],and neutropenia[52%(n=17)]during adjuvant *** patients discontinued treatment due to ***1(HR,5.6;95%CI,1.3-23.7;P=0.021)and RP1L1 alterations(HR,11.1;95%CI,2.2-57.2;P=0.004)were associated with a significantly shorter ***:Anlotinib plus the STUPP regimen has promising anti-tumor activity against glioblastoma and manageable ***1 and RP1L1 alterations might be novel predictive biomarkers of the response to anlotinib.

关键词： Glioblastoma anti-angiogenesis multi-kinase inhibitor anlotinib temozolomide progression-free survival

Hemostatic radiotherapy for bleeding gastrointestinal

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastrointestinal Oncology 2024年第5期16卷 2261-2263页

作者： Vrushab Rao Soumya Singh Bhooshan Zade department of Cyberknife Radiosurgery and radiation Oncology Ruby Hall ClinicPune 411001MaharashtraIndia

Hemostatic radiotherapy is a non-invasive treatment for bleeding gastrointestinal(GI)tumors,promoting tumor shrinkage,blood supply reduction,and fibrotic tissue *** is effective in cases where traditional interventions are insufficient or contraindicated and can prevent recurrent bleeding in patients with GI bleeding *** schedules are also effective for tumor control and patient compliance.

关键词： Gastrointestinal tumors Hemostatic radiotherapy Palliative radiotherapy Acute bleeding Hypofractionation

Ionotropic receptors mediate olfactory learning and memory in Drosophila

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Insect Science 2024年第4期31卷 1249-1269页

作者： Md Zeeshan Ali Anushree Aarif Ahsan Mohammad Shamsul Ola Rizwanul Haque Jawaid Ahsan department of Biotechnology Central University of South BiharGayaBiharIndia department of radiation Oncology University of MichiganAnn ArborMichiganUSA department of Biochemistry College of ScienceKing Saud UniversityRiyadhSaudi Arabia

Phenylacetaldehyde(PAH),an aromatic compound,is present in a diverse range of fruits including overripe bananas and prickly pear cactus,the two major host fruits for Drosophila *** acts as a potent ligand for the ionotropic receptor 84a(IR84a)in the adult fruit fly and it is detected by the IR84a/IR8a heterotetrameric *** role in the male courtship behavior through IR84a as an environmental aphrodisiac is of additional *** ***,two distinct kinds of olfactory receptors,that is,odorant receptors(ORs)and ionotropic receptors(IRs),perceive the odorant *** display unique structural,molecular,and functional characteristics in addition to having different evolutionary ***,olfactory cues detected by the ORs such as ethyl acetate,1-butanol,isoamyl acetate,1-octanol,4-methylcyclohexanol,*** as aliphatic esters and alcohols have been employed in olfactory classical conditioning using fruit *** underlines the participation of OR-activated olfactory pathways in learning and memory *** study elucidates that likewise ethyl acetate(EA)(an OR-responsive odorant),PAH(an IR-responsive aromatic compound)too can form learning and memory when associated with an appetitive gustatory *** association of PAH with sucrose(PAH/SUC)led to learning and formation of the long-term memory(LTM).Additionally,the Orco^(1),Ir84a^(MI00501),and Ir8a^(1)mutant flies were used to confirm the exclusive participation of the IR84a/IR8a complex in PAH/SUC olfactory associative *** results highlight the involvement of IRs via an IR-activated pathway in facilitating robust olfactory behavior.

关键词： appetitive conditioning Drosophila melanogaster ethyl acetate ionotropic receptors learning and memory phenylacetaldehyde

Impact Performance Research of Re-Entrant Octagonal Negative Poisson’s Ratio Honeycomb with Gradient Design

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Computer Modeling in Engineering & Sciences 2024年第9期140卷 3105-3119页

作者： Yiyuan Li Yongjing Li Shilin Yan Pin Wen department of Engineering Structure and Mechanics Wuhan University of TechnologyWuhan430070China Hubei Key Laboratory of Theory and application of Advanced Materials Mechanics School of ScienceWuhan University of TechnologyWuhan430070China

Based on the traditional re-entrant honeycomb,a novel re-entrant octagon honeycomb(ROH)is *** deformation mode of the honeycomb under quasi-static compression is analyzed by numerical simulation,and the results are in good agreement with the experimental *** deformation modes,mechanical properties,and energy absorption characteristics of ROH along the impact and perpendicular directions gradient design are investigated under different *** results indicated that the deformation mode of ROH is affected by gradient design along the direction of impact and impact *** addition,gradient design along the direction of impact can increase the initial peak stress of ROH and accelerate its densification *** design perpendicular to the impact direction can enhance the energy absorption performance of ROH,especially for ROH,with wall thickness increasing from the inside *** to ROH with uniform wall thickness at the same relative density,ROH with a gradient design can increase the plateau stress by over *** the elevation of impact velocity,the plateau stress and specific energy absorption exhibit an upward trend,aligning with the dynamic performance pattern observed in conventional *** results can be used as a reference for the design and application of honeycomb and provide a new idea for developing more efficient and reliable energy-absorbing materials.

关键词： Re-entrant honeycomb gradient design finite element analysis additive manufacturing technologies

GAN‐MD:A myocarditis detection using multi‐channel convolutional neural networks and generative adversarial network‐based data augmentation

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

CAAI Transactions on Intelligence Technology 2024年第4期9卷 866-878页

作者： Hengame Ahmadi Golilarz Alireza Azadbar Roohallah Alizadehsani Juan Manuel Gorriz department of Medical radiation Engineering Faculty of EngineeringLahijan BranchIslamic Azad UniversityLahijanIran department of Medical radiation Engineering Lahijan BranchIslamic Azad UniversityLahijanIran Institute for Intelligent Systems Research and Innovation(IISRI) Deakin UniversityWaurn PondsVictoriaAustralia Data Science and Computational Intelligence Institute University of GranadaGranadaSpain

Myocarditis is a significant public health concern because of its potential to cause heart failure and sudden *** standard invasive diagnostic method,endomyocardial bi-opsy,is typically reserved for cases with severe complications,limiting its widespread ***,non‐invasive cardiac magnetic resonance(CMR)imaging presents a promising alternative for detecting and monitoring myocarditis,because of its high signal contrast that reveals myocardial *** assist medical professionals via artificial intelligence,the authors introduce generative adversarial networks‐multi discriminator(GAN‐MD),a deep learning model that uses binary classification to diagnose myocarditis from CMR *** approach employs a series of convolutional neural networks(CNNs)that extract and combine feature vectors for accurate *** authors suggest a novel technique for improving the classification precision of *** generative adversarial networks(GANs)to create synthetic images for data augmentation,the authors address challenges such as mode collapse and unstable *** a reconstruction loss into the GAN loss function requires the generator to produce images reflecting the discriminator features,thus enhancing the generated images'quality to more accurately replicate authentic data ***,combining this loss function with other reg-ularisation methods,such as gradient penalty,has proven to further improve the perfor-mance of diverse GAN models.A significant challenge in myocarditis diagnosis is the imbalance of classification,where one class dominates over the *** mitigate this,the authors introduce a focal loss‐based training method that effectively trains the model on the minority class *** GAN‐MD approach,evaluated on the Z‐Alizadeh Sani myocarditis dataset,achieves superior results(F‐measure 86.2%;geometric mean 91.0%)compared with other deep learning models and traditional machine learning methods.

关键词： 2‐D 3‐D

Comparative study between three carbonaceous nanoblades and nanodarts for antimicrobial applications

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Environmental Sciences 2024年第2期136卷 594-605页

作者： Mohamed S.Selim Ahmed M.Azzam Mohamed A.Shenashen Shimaa A.Higazy Bayaumy B.Mostafa Sherif A.El-Safty National Institute for Materials Science(NIMS) 1-2-1 SengenTsukuba-ShiIbaraki-Ken 305-0047Japan Petroleum application department Egyptian Petroleum Research InstituteNasr City 11727Egypt department of Environmental Research Theodor Bilharz Research InstituteGizaEgypt

The design of nanostructured materials occupies a privileged position in the development and management of affordable and effective technology in the antibacterial ***,we discuss the antimicrobial properties of three carbonaceous nanoblades and nanodarts materials of graphene oxide(GO),reduced graphene oxide(RGO),and single-wall carbon nanotubes(SWCNTs)that have a mechano-bactericidal effect,and the ability to piercing or slicing bacterial *** demonstrate the significance of size,morphology and composition on the antibacterial activity mechanism,the designed nanomaterials have been *** minimum inhibitory concentration(MIC),standard agar well diffusion,and transmission electron microscopy were utilized to evaluate the antibacterial activity of GO,RGO,and *** on the evidence obtained,the three carbonaceous materials exhibit activity against all microbial strains tested by completely encapsulating bacterial cells and causing morphological disruption by degrading the microbial cell membrane in the order of RGO>GO>*** of the external cell wall structure and outer membrane proteins,the synthesized carbonaceous nanomaterials exhibited higher antibacterial activity against Gram-positive bacterial strains than Gram-negative and fungal *** had the lowest MIC values(0.062,0.125,and 0.25 mg/mL against ***,***,and ***,respectively),as well as minimum fungal concentrations(0.5 mg/mL for both *** and ***).At 12 hr,the cell viability values against tested microbial strains were completely *** lysis and death occurred as a result of severe membrane damage caused by microorganisms perched on RGO *** work gives an insight into the design of effective graphene-based antimicrobial materials for water treatment and remediation.

关键词： Antimicrobial properties Nanoblades Mechano-bactericidal effect RGO nanosheets Gram-positive bacteria Cell viability

Five-view three-dimensional reconstructionfor ultrafast dynamic imaging of pulsedradiation sources

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Matter and radiation at Extremes 2024年第2期9卷 63-73页

作者： Jianpeng Gao Liang Sheng Xinyi Wang Yanhong Zhang Liang Li Baojun Duan Mei Zhang Yang Li Dongwei Hei department of Engineering Physics Tsinghua UniversityBeijing 100084China National Key Laboratory of Intense Pulsed radiation Simulation and Effect Northwest Institute of Nuclear TechnologyXi’an 710024China

Multiaxial neutron/x-ray imaging and three-dimensional (3D) reconstruction techniques play a crucial role in gaining valuable insights intothe generation and evolution mechanisms of pulsed radiation sources. Owing to the short emission time (∼200 ns) and drastic changes of thepulsed radiation source, it is necessary to acquire projection data within a few nanoseconds in order to achieve clear computed tomography3D imaging. As a consequence, projection data that can be used for computed tomography image reconstruction at a certain moment are oftenavailable for only a few angles. Traditional algorithms employed in the process of reconstructing 3D images with extremely incomplete datamay introduce significant distortions and artifacts into the final image. In this paper, we propose an iterative image reconstruction methodusing cylindrical harmonic decomposition and a self-supervised denoising network algorithm based on the deep image prior method. Weaugment the prior information with a 2D total variation prior and a 3D deep image prior. Single-wire Z-pinch imaging experiments have beencarried out at Qin-1 facility in five views and four frames, with a time resolution of 3 ns for each frame and a time interval of 40 ns betweenadjacent frames. Both numerical simulations and experiments verify that our proposed algorithm can achieve high-quality reconstructionresults and obtain the 3D intensity distribution and evolution of extreme ultraviolet and soft x-ray emission from plasma.

关键词： frames image sources

Advantages of nanocarriers for basic research in the field of traumatic brain injury

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2024年第2期19卷 237-245页

作者： Xingshuang Song Yizhi Zhang Ziyan Tang Lina Du School of Pharmaceutical Sciences Shandong University of Traditional Chinese MedicineJinanShandong ProvinceChina department of Pharmaceutics Beijing Institute of Radiation MedicineBeijingChina

A major challenge for the efficient treatment of traumatic brain injury is the need for therapeutic molecules to cross the blood-brain barrier to enter and accumulate in brain *** overcome this problem,researchers have begun to focus on nanocarriers and other brain-targeting drug delivery *** this review,we summarize the epidemiology,basic pathophysiology,current clinical treatment,the establishment of models,and the evaluation indicators that are commonly used for traumatic brain *** also report the current status of traumatic brain injury when treated with nanocarriers such as liposomes and *** can overcome a variety of key biological barriers,improve drug bioavailability,increase intracellular penetration and retention time,achieve drug enrichment,control drug release,and achieve brain-targeting drug ***,the application of nanocarriers remains in the basic research stage and has yet to be fully translated to the clinic.

关键词： blood-brain barriers brain targeting central nervous system extracellular vesicles inflammatory factor microglial cell nanocarriers nanoparticles neural restoration traumatic brain injury