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Clinical features and risk factors for viral pneumonia complicated with invasive pulmonary aspergillosis in adult patients

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Chinese Medical Journal 2023年第11期136卷 1361-1363页

作者： Lijuan Li Chuan Wang Yali Ren Jiangbo Liu Feifei Liu Xiaoqi Zhang Department of Pulmonary and Critical Care Medicine National Centre for Clinical Research on Respiratory DiseasesChina-Japan Friendship HospitalBeijing 100029China Department of Pulmonary and Critical Care Medicine First Hospital of ShijiazhuangShijiazhuangHebei 050011China Department of Pulmonary and Critical Care Medicine Second Hospital of Hebei Medical UniversityShijiazhuangHebei 050000China Department of Pulmonary and Critical Care Medicine Tianjin First Central HospitalTianjin 300192China department of Respiratory and critical care medicine First Hospital of Qin Huang DaoQinhuangdaoHebei 066000China Department of Pulmonary and Critical Care Medicine Second People’s Hospital of WeifangWeifangShandong 261041China

Viral pneumonia has recently been defined as a risk factor for invasive pulmonary aspergillosis(IPA).Wauters et al[1]reported that 23%of critically ill patients who were admitted to the intensive care unit(ICU)with swine-origin influenza A(H1N1)viral infection had developed invasive aspergillosis.IPA was diagnosed in 83 of 432(19%)patients who were admitted with influenza;for patients with influenza who were immunocompromised,the incidence of IPA reached up to 32%(38 of 117 patients).

关键词： patients admitted pneumonia

National survey of the awareness and implementation status of early pulmonary rehabilitation for patients with critical illness in departments of pulmonary and critical care medicine in 2019

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Chinese Medical Journal 2023年第2期136卷 227-229页

作者： Qing Zhao Liyuan Tao Quanguo Li Sinan Wu Dingyi Wang Peng Feng Nan Luo Yuxiao Xie Siyuan Wang Cunbo Jia Gang Zeng Hongmei Zhao Department of Pulmonary and Critical Care Medicine Center of Respiratory MedicineChina–Japan Friendship HospitalBeijing 100029China National Clinical Research Center for Respiratory Diseases Beijing 100029China Institute of Respiratory medicine Chinese Academy of Medical SciencesBeijing 100029China National Center for Respiratory medicine Beijing 100029China Research Center of Clinical Epidemiology Peking University Third HospitalBeijing 100091China Department of Pulmonary and Critical Care Medicine Weifang Respiratory Disease HospitalWeifang No.2 Renmin HospitalWeifangShandong 261041China department of Clinical Research and Data management Center of Respiratory MedicineChina-Japan Friendship HospitalBeijing 100029China department of Hospital Development Office China–Japan Friendship HospitalBeijing 100029China department of Medical Rehabilitation China–Japan Friendship HospitalBeijing 100029China department of Respiratory medicine North District of Suzhou Municipal HospitalNanjing Medical UniversitySuzhouJiangsu 215000China

To the Editor:The aim of early pulmonary rehabilitation(PR)in the intensive care unit(ICU)is to reduce the incidence of post-ICU syndrome,increase the number of ventilator-free days,reestablish and improve functional capacity,improve health-related life quality,promote mental health,and enhance participation in everyday life.PR in the ICU is highly effective and plays an important role in recovery of patients with reduced exercise endurance,functional capacity,and health-related life quality.Several surveys outside China have assessed the implementation of early rehabilitation in the ICU,[1]but there are few data from China.This study aimed to investigate the awareness and implementation of early PR in secondary-and tertiary-class hospitals with pulmonary and critical care medicine(PCCM)standardized certification.PCCM staff members were recruited to fill out a selfdesigned questionnaire.We defined early PR as PR within 5 days of ICU admission.

关键词： critical survey everyday

Malnutrition associated with readmission in elderly patients with chronic obstructive pulmonary disease

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Chinese Medical Journal 2023年第3期136卷 357-359页

作者： Ting Zhao Jiayan Chen Xiangyang Li Yinggang Zhu Department of Pulmonary and Critical Care Medicine Huadong HospitalFudan UniversityShanghai 200040China

To the Editor:Compared with non-readmission chronic obstructive pulmonary disease(COPD)patients,the mortality rate of readmission patients is significantly higher(2.3%vs.13.4%),[1]which undoubtedly causes socio-economic pressures on rehabilitation care and medical resources.The potential factors affecting the risk of readmission are required to be identified.The incidence of malnutrition,occurring frequently in elderly COPD patients,varies from 20%to 45%depending on the screening tools used.As a practical,economical and effective scoring system,the Mini Nutrition Assessment(MNA)is of great value to assessing nutritional status in the elderly.Malnutrition is a state of vulnerability in elder populations and is associated with a poor long-term prognosis.This study aimed to research the impact of nutritional status related risk factors on readmission and assess the value of MNA scoring system and updated sarcopenia diagnostic criteria in predicting readmission risk for elderly COPD patients.

关键词： patients mortality admission

Junctional adhesion molecule-like protein as a novel target for kaempferol to ameliorate lung adenocarcinoma

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Journal of Integrative medicine 2023年第3期21卷 268-276页

作者： Qian Wu Yong-bin Wang Xiao-wen Che Hui Wang Wei Wang Department of Pulmonary and Critical Care Medicine the Second Hospital of Shandong UniversityJinan 250033Shandong ProvinceChina

Objective:Although there have been improvements in targeted therapy and immunotherapy,the majority of lung adenocarcinoma(LUAD)patients still lack effective therapies.Consequently,it is urgent to screen for new diagnosis biomarkers and pharmacological targets.Junctional adhesion molecule-like protein(JAML)was considered to be an oncogenic protein and may be a novel therapeutic target in LUAD.Kaempferol is a natural flavonoid that exhibits antitumor activities in LUAD.However,the effect of kaempferol on JAML is still unknown.Methods:Small interfering RNA was used to knockdown JAML expression.The cell viability was determined using the cell counting kit-8 assay.The proliferation of LUAD cells was evaluated using the 5-ethynyl-2'-deoxyuridine incorporation assay.The migration and invasion of LUAD cells were evaluated by transwell assays.Molecular mechanisms were explored by Western blotting.Results:JAML knockdown suppressed proliferation,migration and invasion of LUAD cells,and JAML deficiency restrained epithelial-mesenchymal transition(EMT)via inactivating the phosphoinositide 3-kinase/protein kinase B/mammalian target of rapamycin(PI3K/AKT/mTOR)pathway.Using a PI3K activator(740Y-P),rescue experiments showed that phenotypes to JAML knockdown in LUAD cells were dependent on the PI3K/AKT/mTOR pathway.Kaempferol also inhibited proliferation,migration and invasion of A549 and H1299 cells and partially suppressed EMT through the PI3K/AKT/mTOR pathway.Knockdown of JAML ameliorated the inhibitory effect of kaempferol on LUAD cells.Kaempferol exerted anticancer effects by targeting JAML.Conclusion:JAML is a novel target for kaempferol against LUAD cells.

关键词： Junctional adhesion molecule-like protein Kaempferol Lung adenocarcinoma Proliferation Invasion Migration

pulmonary embolism and deep vein thrombosis caused by nitrous oxide abuse: A case report

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World Journal of Clinical Cases 2019年第23期7卷 4057-4062页

作者： Wen Sun Ji-Ping Liao Yan Hu Wei Zhang Jing Ma Guang-Fa Wang Department of Pulmonary and Critical Care Medicine Peking University First Hospital

BACKGROUND Nitrous oxide(N2O)has gained increasing popularity as a recreational drug,causing hallucinations,excitation,and psychological dependence.However,side effects have been reported in recent years.Our case report proposes a correlation among N2O,pulmonary embolism(PE),and deep vein thrombosis(DVT)and emphasizes the role of homocysteine(Hcy)in thrombotic events.CASE SUMMARY A 29-year-old man with long-term N2O abuse sought evaluation after acute chest pain.A diagnostic workup revealed PE,DVT,and hyperhomocysteinemia.The patient was successfully treated with thrombolytic and anticoagulant therapy.Moreover,his Hcy level decreased and returned to normal after Hcy-lowering therapy.CONCLUSION Chronic N2O abuse might increase the risk of PE and DVT,although there have been few studies previously.

关键词： Nitrous oxide pulmonary embolism Deep vein thrombosis Homocysteine Case report

Diffuse lung involvement in rheumatoid arthritis:a respiratory physician’s perspective

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Chinese Medical Journal 2023年第3期136卷 280-286页

作者： Hui Huang Ruxuan Chen Chi Shao Zuojun Xu Paul J.Wolters Department of Pulmonary and Critical Care Medicine Peking Union Medical College HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100730China Department of Pulmonary and Critical Care Medicine University of CaliforniaSan FranciscoCA 94117USA

The lungs are one of the most common extra-articular organs involved in rheumatoid arthritis(RA),which is reported to occur in up to 60%to 80%of RA patients.Respiratory complications are the second leading cause of death due to RA.Although there is a wide spectrum of RA-associated respiratory diseases,interstitial lung disease is the most common manifestation and it impacts the prognosis of RA.There has been progress in understanding the management and progression of rheumatoid arthritis-associated interstitial lung disease(RA-ILD)and RA-associated respiratory diseases recently,for example,opportunistic pulmonary infectious diseases and toxicity from RA therapies.From a chest physicians’perspective,we will update the diagnosis and treatment of RA-associated ILD,methotrexate-associated lung disease,and the complication of Pneumocystis jiroveci pneumonia in RA in this review.

关键词： Interstitial lung disease Lung Methotrexate pneumonitis Pneumocystis jiroveci pneumonia Rheumatoid arthritis

Executive summary of Chinese expert consensus for topical application of anti-microbial agents for lower respiratory tract infection in adults

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Chinese Medical Journal 2022年第22期135卷 2653-2655页

作者： Jing Zhang Qijian Cheng Yi Huang Hong Fan Guoxiang Lai Xiangdong Mu Wei Sha Danyang She Ning Shen Xin Su Jinfu Xu Feng Ye Xinlun Tian Tiantuo Zhang Hua Zhou Youning Liu Lixian He Heping Xiao Bei He Yi Shi Xiangyan Zhang Bin Cao Jieming Qu on behalf of pulmonary Infection Assembly of Chinese Thoracic Society Department of Pulmonary and Critical Care Medicine Zhongshan HospitalShanghai Medical CollegeFudan UniversityShanghai 200032China Department of Pulmonary and Critical Care Medicine Ruijin HospitalInstitute of Respiratory DiseasesShanghai Jiao Tong University School of MedicineShanghai 200025China Department of Pulmonary and Critical Care Medicine Shanghai Changhai hospitalNavy Medical UniversityShanghai 200433China Department of Pulmonary and Critical Care Medicine West China HospitalSichuan UniversityChengduSichuan 610041China department of Respiratory and critical care medicine The Second Affiliated People's Hospital of Fujian University of Traditional Chinese MedicineFuzhouFujian 350003China department of Respiratory and critical care medicine Beijing Tsinghua Changgung HospitalBeijing 102218China department of pulmonary Tuberculosis Shanghai Pulmonary HospitalSchool of MedicineTongji UniversityShanghai 200433China Department of Pulmonary and Critical Care Medicine The First Medical Center of the General Hospital of Chinese People's Liberation ArmyBeijing 100853China department of Respiratory medicine Peking University Third HospitalBeijing 100191China Department of Pulmonary and Critical Care Medicine Nanjing Jinling HospitalSchool of MedicineNanjing UniversityNanjingJiangsu 210002China department of Respiratory and critical care medicine Shanghai Pulmonary HospitalSchool of MedicineTongji UniversityShanghai 200433China State Key Laboratory of Respiratory Disease National Clinical Research Center for Respiratory DiseaseGuangzhou Institute of Respiratory HealthThe First Affiliated Hospital of Guangzhou Medical UniversityGuangzhou Medical UniversityGuangzhouGuangdong 510120China Department of Pulmonary and Critical Care Medicine Peking Union Medical College HospitalBeijing 100032China Department of Pulmonary and Critical Care Medicine The Third Affiliated HospitalSun Yat-Sen UniversityGuangzhouGuangdong 510630China department of pulmonary medicine The First Affil

In recent years,with the increased prevalence of multi-drug resistant(MDR)bacterial infection and chronic pulmonary infection,the topical application of anti-microbial agents,mainly inhaled antibiotics,has come back to clinical practice.Several formulations for nebulization and dry powder inhaler(DPI)have been approved for inhaled anti-infective therapy.Meanwhile,evidence and experience have been accumulated in the use of anti-microbial agents delivered via airway.However,the available studies in this field are heterogenous in the study population,drug delivery route and dosages.The efficacy and safety of inhaled anti-infective therapy in various types of lower respiratory tract infections(LRTIs)need to be evaluated.Moreover.

关键词： infection dosage application

Battling against the novel coronavirus: control strategies for and clinical management of the 2019 novel coronavirus infection in Shanghai, China

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Chinese Medical Journal 2020年第20期133卷 2395-2397页

作者： Jing-Ya Zhao Jing Zhang Yan-Ping Xu Jia-Yang Yan Jin-Fu Xu Jie-Ming Qu Department of Pulmonary and Critical Care Medicine Ruijin HospitalShanghai Jiaotong University School of MedicineShanghai 200025China Department of Pulmonary and Critical Care Medicine Zhongshan HospitalFudan UniversityShanghai 200032China Department of Pulmonary and Critical Care Medicine Shanghai Pulmonary HospitalTongji University School of MedicineShanghai 200433China

At the end of 2019,presentation of viral pneumonia due to a novel coronavirus(2019 novel coronavirus)was reported in a group of patients in Wuhan,Hubei Province,China.111 Now,coronavirus disease 2019(COVID-19)has pose... 详细信息

关键词： Wuhan Hubei management

pulmonary sarcoidosis:A novel sequelae of drug reaction with eosinophilia and systemic symptoms:A case report

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World Journal of Clinical Cases 2022年第35期10卷 13074-13080页

作者： Yu-Qi Hu Chen-Yang Lv Ai Cui Department of Pulmonary and Critical Care Medicine Beijing Chao-Yang HospitalCapital Medical UniversityBeijing 100020China Department of Pulmonary and Critical Care Medicine The First Hospital of Fangshan DistrictBeijing 102499China

BACKGROUND Drug reaction with eosinophilia and systemic symptoms(DRESS)syndrome is an uncommon yet serious adverse drug hypersensitivity reaction with the presentations including rash,fever,lymphadenopathy,and internal organ involvement.Sarcoidosis is a systematic granulomatous disease with unknown etiology.We herein report a case of pulmonary sarcoidosis secondary to allopurinol-induced DRESS.CASE SUMMARY A 37-year-old man with a history of hyperuricemia was treated with allopurinol for three weeks at a total dose of 7000 milligrams before developing symptoms including anorexia,fever,erythematous rash,and elevated transaminase.The patient was diagnosed with DRESS and was treated with prednisone for 6 mo until all the symptoms completely resolved.Three months later,the patient presented again because of a progressively worsening dry cough.His chest computed tomography images showed bilateral lung parenchyma involvement with lymph node enlargement,which was confirmed to be nonnecrotizing granuloma by pathological examination.Based on radiologic and pathological findings,he was diagnosed with sarcoidosis and was restarted on treatment with prednisone,which was continued for another 6 mo.Reexamination of chest imaging revealed complete resolution of parenchymal lung lesions and a significant reduction in the size of the mediastinal and hilar lymph nodes.Following a 6-month follow-up of completion of treatment,the patient's clinical condition remained stable with no clinical evidence of relapse.CONCLUSION This is the first case in which pulmonary sarcoidosis developed as a late complication of allopurinol-induced DRESS.The case indicated that the autoimmune reaction of DRESS may play an important role in the pathogenesis of sarcoidosis.

关键词： pulmonary sarcoidosis Drug reaction with eosinophilia and systemic symptoms Autoimmune sequelae Allopurinol Case report