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Three-dimensional diabetic macular edema thickness maps based on fluid segmentation and fovea detection using deep learning

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International Journal of Ophthalmology(English edition) 2022年第3期15卷 495-501页

作者： Jing-Jing Xu Yang Zhou Qi-Jie Wei Kang Li Zhen-Ping Li Tian Yu Jian-Chun Zhao Da-Yong Ding Xi-Rong Li Guang-Zhi Wang Hong Dai School of Medicine Tsinghua UniversityBeijing 100084China Visionary Intelligence Company Limited Beijing 100872China department of Ophthalmology Beijing HospitalNational Center of GerontologyInstitute of Geriatric MedicineChinese Academy of Medical ScienciesBeijing 100730China Key Lab of Data Engineering and Knowledge Engineering Renmin University of ChinaBeijing 100872China

AIM: To explore a more accurate quantifying diagnosis method of diabetic macular edema(DME) by displaying detailed 3D morphometry beyond the gold-standard quantification indicator-central retinal thickness(CRT) and apply it in follow-up of DME ***: Optical coherence tomography(OCT) scans of 229 eyes from 160 patients were *** manually annotated cystoid macular edema(CME), subretinal fluid(SRF) and fovea as ground *** convolution neural networks(DCNNs) were constructed including U-Net, sASPP, HRNetV2-W48, and HRNetV2-W48+Object-Contextual Representation(OCR) for fluid(CME+SRF) segmentation and fovea detection respectively, based on which the thickness maps of CME, SRF and retina were generated and divided by Early Treatment Diabetic Retinopathy Study(ETDRS) ***: In fluid segmentation, with the best DCNN constructed and loss function, the dice similarity coefficients(DSC) of segmentation reached 0.78(CME), 0.82(SRF), and 0.95(retina).In fovea detection, the average deviation between the predicted fovea and the ground truth reached 145.7±117.8 μ*** generated macular edema thickness maps are able to discover center-involved DME by intuitive morphometry and fluid volume, which is ignored by the traditional definition of CRT>250 μ*** maps could also help to discover fluid above or below the fovea center ignored or underestimated by a single OCT ***: Compared to the traditional unidimensional indicator-CRT, 3D macular edema thickness maps are able to display more intuitive morphometry and detailed statistics of DME, supporting more accurate diagnoses and follow-up of DME patients.

关键词： diabetic macular edema fluid segmentation fovea detection 3D macular edema thickness maps deep learning

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Circular RNAs: Biomarkers of cancer

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Cancer Innovation 2022年第3期1卷 197-206页

作者： Jingyi Cui Meng Chen Lanxin Zhang Sida Huang Fei Xiao Lihui Zou The Key Laboratory of geriatrics Beijing Institute of GeriatricsInstitute of Geriatric MedicineChinese Academy of Medical SciencesBeijing Hospital/National Center of Gerontology of National Health CommissionBeijingChina Clinical Biobank Beijing HospitalNational Center of GerontologyNational Health CommissionInstitute of Geriatric MedicineChinese Academy of Medical SciencesBeijingChina Key Laboratory for National Cancer Big Data Analysis and Implement National Cancer Data CenterNational Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina department of Public Policy Cornell UniversityIthacaNew YorkUSA

Circular RNAs(circRNAs)are a class of single‐stranded closed RNAs that are produced by the back splicing of precursor *** formation of circRNAs mainly involves intron‐pairing‐driven circularization,RNA‐binding protein(RBP)‐driven circularization,and lariat‐driven *** vast majority of circRNAs are found in the cytoplasm,and some intron‐containing circRNAs are localized in the *** have been found to function as microRNA(miRNA)sponges,interact with RBPs and translate proteins,and play an important regulatory role in the development and progression of *** exhibit tissue‐and developmental stage–specific expression and are stable,with longer half‐lives than linear *** have great potential as biomarkers for cancer diagnosis and prognosis,which is highlighted by their detectability in tissues,especially in fluid biopsy samples such as plasma,saliva,and ***,we review the current studies on the properties and functions of circRNAs and their clinical application value.

关键词： circRNA cancer biomarker

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Phosphorylation of Cofilin-1 Enhances Paclitaxel Resistance of Epithelial Ovarian Cancer Cells by Inhibiting Apoptosis

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Biomedical and Environmental Sciences 2021年第6期34卷 465-477页

作者： LI Min DONG Xu Dong LYU Qiu Bo ZHANG Wei HUANG Shuai YANG Chun Xue CUI Di LAI Hui Ying department of Obstetrics and Gynecology Beijing Hospital National Center of GerontologyInstitute of Geriatric MedicineChinese Academy of Medical SciencesBeijing 100730China department of Obstetrics the First People's Hospital of Yunnan ProvinceKunming 650032YunnanChina department of Pathology Beijing HospitalNational Center of GerontologyInstitute of Geriatric MedicineChinese Academy of Medical SciencesBeijing 100730China Peking University Health Science center Beijing 100069China Clinical Laboratory Beijing HospitalNational Center of GerontologyInstitute of Geriatric MedicineChinese Academy of Medical SciencesBeijing 100730China

Objective To investigate the molecular mechanism of high phosphorylation levels of cofilin-1(p-CFL-1)associated with paclitaxel resistance in epithelial ovarian cancer(EOC)*** Cells displaying varying levels of p-CFL-1 and CFL-1 were created by plasmid transfection and shRNA *** inhibition rate indicating paclitaxel efficacy was assessed by Cell Counting Kit-8(CCK-8)*** was assessed by flow cytometry and protein levels were detected by western *** real-time polymerase chain reaction(qRT-PCR)was used to measure the expression levels of phosphokinases and phosphatases of *** analysis evaluated the correlation between the prognosis of EOC patients and the levels of p-CFL-1 and slingshot-1(SSH-1).Results High levels of p-CFL-1 were observed in EOC cells that survived treatment with high doses of ***3 cell mutants with upregulated p-CFL-1 showed impaired paclitaxel efficacy,as well as decreased apoptosis rates and pro-survival patterns of apoptosis-specific protein *** accumulation of p-CFL-1 inhibited paclitaxel-induced mitochondrial ***-1 silencing mediated CFL-1 phosphorylation in paclitaxel-resistant SKOV3 ***,the high level of p-CFL-1 and the low level of SSH-1 in EOC tissues were closely related to chemotherapy resistance and poor prognosis in EOC *** The SSH-1/p-CFL-1 signaling pathway mediates paclitaxel resistance by apoptosis inhibition in EOC and is expected to be a potential prognostic predictor.

关键词： Cofilin-1 Slingshot-1 Epithelial ovarian cancer Chemo-resistance Apoptosis

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Cognitive magnetic resonance imaging-ultrasound fusion transperineal targeted biopsy combined with randomized biopsy in detection of prostate cancer

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World Journal of Clinical Cases 2021年第36期9卷 11183-11192页

作者： Cheng Pang Miao Wang Hui-Min Hou Jian-Yong Liu Zhi-Peng Zhang Xuan Wang Ya-Qun Zhang Chun-Mei Li Wei Zhang Jian-Ye Wang Ming Liu department of Urology Beijing HospitalNational Center of GerontologyInstitute of Geriatric MedicineChinese Academy of Medical SciencesBeijing 100730China Graduate School of Peking Union Medical College Chinese Academy of Medical SciencesBeijing 100730China department of Radiology Beijing HospitalNational Center of GerontologyInstitute of Geriatric MedicineChinese Academy of Medical SciencesBeijing 100730BeijingChina department of Pathology Beijing HospitalNational Center of GerontologyInstitute of Geriatric MedicineChinese Academy of Medical SciencesBeijing 100730BeijingChina

BACKGROUND Prostate cancer(PCa)is one of the most common cancers among *** strategies for targeted biopsy based on multiparametric magnetic resonance imaging(mp-MRI)have emerged,which may improve the accuracy of detecting clinically significant PCa in recent *** To investigate the diagnostic efficiency of a template for cognitive MRIultrasound fusion transperineal targeted plus randomized biopsy in detecting *** Data from patients with an increasing prostate-specific antigen(PSA)level but less than 20 ng/mL and at least one lesion suspicious for PCa on MRI from December 2015 to June 2018 were retrospectively *** patients underwent cognitive fusion transperineal template-guided targeted biopsy followed by randomized biopsy outside the targeted area.A total of 127 patients with complete data were included in the final analysis.A multivariable logistic regression analysis was conducted,and a two-sided Pcentered study proposed a feasible template for cognitive MRIultrasound fusion transperineal targeted plus randomized *** with higher PSAD and PI-RADS scores were more likely to be diagnosed with PCa.

关键词： Prostate neoplasms Magnetic resonance imaging Cognitive fusion Prostate biopsy Prostate cancer

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The effect of drug loading and multiple administration on the protein corona formation and brain delivery property of PEG-PLA nanoparticles

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Acta Pharmaceutica Sinica B 2022年第4期12卷 2043-2056页

作者： Yuyun Tang Jinchao Gao Tao Wang Qian Zhang Antian Wang Meng Huang Renhe Yu Hongzhuan Chen Xiaoling Gao department of Pharmacology and Chemical Biology Shanghai Universities Collaborative Innovation Center for Translational MedicineShanghai Jiao Tong University School of MedicineShanghai 200025China department of geriatric psychiatry Shanghai Mental Health CenterShanghai Jiao Tong University School of MedicineAlzheimer’s Disease and Related Disorder CenterShanghai Jiao Tong UniversityShanghai 200025China Institute of Interdisciplinary Integrative Biomedical Research Shuguang HospitalShanghai University of Traditional Chinese MedicineShanghai 201210China

The presence of protein corona on the surface of nanoparticles modulates their physiological interactions such as cellular association and targeting *** has been shown that α-mangostin(αM)-loaded poly(ethylene glycol)-poly(l-lactide)(PEG-PLA)nanoparticles(NP-αM)specifically increased low density lipoprotein receptor(LDLR)expression in microglia and improved clearance of amyloid beta(Aβ)after multiple ***,how do the nanoparticles cross the blood‒brain barrier and access microglia remain ***,we studied the brain delivery property of PEG-PLA nanoparticles under different conditions,finding that the nanoparticles exhibited higher brain transport efficiency and microglia uptake efficiency afterαM loading and multiple *** reveal the mechanism,we performed proteomic analysis to characterize the composition of protein corona formed under various conditions,finding that both drug loading and multiple dosing affect the composition of protein corona and subsequently influence the cellular uptake of nanoparticles in ***3 and BV-2 *** proteins,immunoglobulins,RAB5A and CD36 were found to be enriched in the corona and associated with the process of nanoparticles ***,we bring a mechanistic understanding about the modulator role of protein corona on targeted drug delivery,and provide theoretical basis for engineering brain or microglia-specific targeted delivery system.

关键词： Protein corona Nanoparticles Brain delivery Microglia PEG-PLA

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A high-fiber diet synergizes with Prevotella copri and exacerbates rheumatoid arthritis

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Cellular & Molecular Immunology 2022年第12期19卷 1414-1424页

作者： Lingjuan Jiang Mengmeng Shang Shengnan Yu Yudong Liu Hui Zhang Yangzhong Zhou Min Wang Tingting Wang Hui Li Zhihua Liu Xuan Zhang department of Medical Research center National Science and Technology Key Infrastructure on Translational MedicinePeking Union Medical College HospitalDepartment of RheumatologyBeijing HospitalNational Center of GerontologyInstitute of Geriatric MedicineChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing100730China State Key Laboratory of Complex Severe and Rare Diseases Peking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing100730China department of Rheumatology Beijing HospitalNational Center of GerontologyInstitute of Geriatric MedicineClinical Immunology CenterChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing100730China department of Pathology Peking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing100730China department of Internal Medicine Peking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing100730China Key Laboratory of Infection and Immunity Institute of BiophysicsChinese Academy of SciencesBeijing100101China Institute for Immunology School of MedicineTsinghua UniversityBeijing100084China Tsinghua-Peking center for Life Sciences Beijing100084China

Both preclinical and established rheumatoid arthritis(RA)patients display alterations in the gut *** *** preferentially enriched in a subset of RA ***,we isolated a Prevotella strain,*** RA,from the feces of RA patients and showed that colonization of *** RA exacerbated arthritis in a collagen-induced arthritis(CIA)*** the presence of *** RA colonization,a high-fiber diet exacerbated arthritis via microbial alterations and intestinal *** of *** together with a high-fiber diet enabled the digestion of complex fiber,which led to the overproduction of organic acids,including fumarate,succinate and short-chain fatty *** promoted proinflammatory responses in macrophages,and supplementation with succinate exacerbated arthritis in the CIA *** findings highlight the importance of dysbiosis when evaluating the effects of dietary interventions on RA pathogenesis and provide new insight into dietary interventions or microbiome modifications to improve RA management.

关键词： Rheumatoid arthritis Dysbiosis Prevotella copri High-fber diet Microbiota-derived metabolites

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Oxidized galectin-1 in SLE fails to bind the inhibitory receptor VSTM1 and increases reactive oxygen species levels in neutrophils

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Cellular & Molecular Immunology 2023年第11期20卷 1339-1351页

作者： Xu Jiang Xinyue Xiao Hao Li Yiyi Gong Min Wang Huaxia Yang Lidan Zhao Ying Jiang Yanping Wei Chongchong Zhao Jin Li Yuling Chen Shan Feng Haiteng Deng Shiliang Ma Yue Xu Yudong Liu George C.Tsokos Minghong Jiang Xuan Zhan Medical Research center State Key Laboratory of Complex Severe and Rare DiseasesPeking Union Medical College HospitalDepartment of RheumatologyBeijing HospitalNational Center of GerontologyInstitute of Geriatric MedicineChinese Academy of Medical SciencesBeijingChina department of Rheumatology Key Laboratory of MyositisChina-Japan Friendship HospitalBeijingChina department of Medicine Beth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMAUSA Medical Research center Peking Union Medical College HospitalChinese Academy of Medical SciencesBeijingChina department of Rheumatology Beijing HospitalNational Center of GerontologyInstitute of Geriatric MedicineClinical Immunology CenterChinese Academy of Medical SciencesBeijingChina department of Rheumatology and Clinical Immunology Peking Union Medical College HospitalClinical Immunology CenterChinese Academy of Medical Sciences and Peking Union Medical CollegeThe Ministry of Education Key LaboratoryBeijingChina department of Rheumatology Xiangya HospitalCentral South UniversityHunanChina MOE Key Laboratory of Bioinformatics Center for Synthetic&Systems BiologySchool of Life SciencesTsinghua UniversityBeijingChina Key Laboratory of Structural Biology of Zhejiang Province School of Life SciencesWestlake UniversityHangzhouZhejiangChina State Key Laboratory of Common Mechanism Research for Major Diseases Institute of Basic Medical Sciences Chinese Academy of Medical SciencesSchool of Basic Medicine Peking Union Medical CollegeBeijingChina

Inhibitory immune receptors set thresholds for immune cell activation,and their deficiency predisposes a person to autoimmune ***,the agonists of inhibitory immune receptors remain largely unknown,representing untapped sources of treatments for autoimmune ***,we show that V-set and transmembrane domain-containing 1(VSTM1)is an inhibitory receptor and that its binding by the competent ligand soluble galectin-1(Gal1)is essential for maintaining neutrophil viability mediated by downregulated reactive oxygen species ***,in patients with systemic lupus erythematosus(SLE),circulating Gal1 is oxidized and cannot be recognized by VSTM1,leading to increased intracellular reactive oxygen species levels and reduced neutrophil *** neutrophil function or death contributes significantly to the pathogenesis of SLE by providing danger molecules and autoantigens that drive the production of inflammatory cytokines and the activation of autoreactive ***,serum levels of glutathione,an antioxidant able to convert oxidized Gal1 to its reduced form,were negatively correlated with SLE disease *** together,our findings reveal failed inhibitory Gal1/VSTM1 pathway activation in patients with SLE and provide important insights for the development of effective targeted therapies.

关键词： Systemic lupus erythematosus ROS VSTM1 Galectin-1 Glutathione

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ACE gene missense mutation in a case with early-onset, rapid progressing dementia

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General psychiatry 2019年第5期32卷 283-286页

作者： Jing Ni Shifu Xiao Xia Li Lin Sun department of psychiatry Shanghai Huangpu District Mental Health CenterShanghaiChina department of geriatric psychiatry Shanghai Mental Health CenterShanghaiChina Alzheimer's Disease and Related Disorders center Shanghai Jiao Tong UniversityShanghaiChina Deparment of geriatric psychiatry Shanghai Mental Health CenterShanghaiChina

The population of early-onset Alzheimer's disease(EOAD)accounts for 1%-2%of the total population of Alzheimer's disease,and genetic mutations are more common in *** first symptom of the patient in the present case report was the decline in memories of recent events,and the disease progressed rapidly in the following 2 *** testing has revealed the presence of genetic mutations(c.A479G,p.N160S)of ACE,which causes the 160th codon of the ACE protein to change from aspartic acid to serine,and at the same time genotype of apolipoprotein E(APOE)is ε3/ε*** think that this patient carries the mutation type of the sensitive gene ACE and the risk gene APOE of Alzheimer's disease,and this is the reason why the disease progressed ***,we discussed ACE genetic mutation's meaning in EOAD progression.

关键词： Alzheimer mutation testing

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Symptom experience in patients with cancer-related fatigue:A systematic review and meta-synthesis

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Journal of Integrative Nursing 2022年第4期4卷 193-201页

作者： Ke PENG Mi ZHANG Jie ZHANG Dan YANG Ling TANG department of Emergency Beijing HospitalNational Center of GerontologyInstitute of Geriatric MedicineChinese Academy of Medical SciencesBeijingChina Acupuncture and Moxibustion Minimally Invasive Oncology department The Third Hospital of Beijing University of Chinese MedicineBeijingChina College of Nursing Beijing University of Traditional Chinese MedicineBeijingChina department of Nursing Dongfang Hospital of Beijing University of Chinese MedicineBeijingChina

To understand the real experiences of patients with cancer-related fatigue and to promote quality of life,the researchers used computer searches of PubMed,EMbase,CINAHL,PsycINFO,Web of Science,and China National Knowledge Infrastructure,China Biology Medicine disc,Wanfang Data,China Science and Technology Journal Database for relevant qualitative studies from the inception to November 1,*** results showed that a total of 16 papers were included,and 57 outcomes were distilled into 9 categories,which were pooled into four integrated outcomes,such as somatic,psychological and social support and so *** is concluded that patients with cancer-related fatigue are not only in the midst of multidimensional,unspeakable somatic experiences,and complex psychological experiences,they are also hindered in coping with fatigue symptom and social ***,healthcare professionals should provide health interventions and psychological support to those patients whenever possible.

关键词： Cancer-related fatigue meta-synthesis patient experience qualitative research systematic review

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Association of non-synonymous variants in WIPF3 and LIPA genes with ab- dominal aortic aneurysm： an autopsy study

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Journal of geriatric Cardiology 2016年第12期13卷 960-967页

作者： Yuko Maeda Noriko Sato Makiko Naka-Mieno Seijiro Mori Tomio Arai Masashi Tanaka Masaaki Muramatsu Motoji Sawabe department of Molecular Epidemiology Medical Research Institute Tokyo Medical and Dental University Tokyo Japan department of Medical Informatics Center of Inormation Jichi Medical University Tochigi Japan center for Promotion of Clinical Investigation Tokyo Metropolitan Geriatric Hospital Tokyo Japan department of Pathology Tokyo Metropolitan Geriatric Hospital Tokyo Japan Research Teams for geriatric Pathology Tokyo Metropolitan Institute of Gerontology Tokyo Japan department of Genomics for Longevity and Health Tokyo Metropolitan Institute of Gerontology Tokyo Japan department of Molecular Pathology Graduate School of Health Care Sciences Tokyo Medical and Dental University Tokyo Japan

腹的大动脉的动脉瘤(AAA ) 是有强壮的基因部件的 multifactorial 疾病。各种各样的基因 loci 与临床的 AAA 被联系了，但是很少研究调查了病理学的 AAA， *** 的中间的显型在日本个人(JG-SNP 学习) 在衰老老人疾病上从研究检验了更老... 详细信息

腹的大动脉的动脉瘤(AAA ) 是有强壮的基因部件的 multifactorial 疾病。各种各样的基因 loci 与临床的 AAA 被联系了，但是很少研究调查了病理学的 AAA， *** 的中间的显型在日本个人(JG-SNP 学习) 在衰老老人疾病上从研究检验了更老的日本题目的 2263 具连续尸体。AAA 的存在在尸体期间与病理学的诊断被决定。与 AAA 联系的单个核苷酸变体(SNV ) 与一个 Illumina HumanExome Beadchip 数组被决定。逻辑回归分析被执行决定基因协会。当有 AAA 的 ***118 题目和没有 AAA 的 2145 个题目在一个盒子控制背景被分析，年龄，性，和 AAA 的另外的风险因素被分析。没有变体在使用 Bonferroni 修正以后到达了意义(P < 2.05 ???????  ???????????????????? 瀠瑡敩瑮 ? 潃据畬楳湯味敨 ?????????????? 吗？？

关键词：腹的大动脉的动脉瘤 Lysosomal 酸脂肪分解酵素 A WAS/WASL 交往蛋白质家庭 3

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