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Systemic lupus erythematosus combined with primary hyperfibrinolysis and protein C and protein S deficiency:A case report

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World Journal of Clinical Cases 2021年第8期9卷 2008-2014页

作者： Yi-Xuan Liao Yan-Fei Guo Yu-Xia Wang Ai-Hua Liu Chun-Li Zhang department of Pulmonary and Critical Care Medicine Beijing HospitalNational Center of GerontologyInstitute of Geriatric MedicineChinese Academy of Medical SciencesBeijing 100730China department of Rheumatology and Immunology Beijing HospitalNational Center of GerontologyInstitute of Geriatric MedicineChinese Academy of Medical SciencesBeijing 100730China department of Hematology Beijing HospitalNational Center of GerontologyInstitute of Geriatric MedicineChinese Academy of Medical SciencesBeijing 100730China

BACKGROUND Systemic lupus erythematosus(SLE)is an autoimmune disease characterized by systemic involvement and multiple autoantibodies in the *** with protein C(PC)and protein S(PS)deficiency are prone to *** contrast,patients with primary hyperfibrino-lysis tend to *** SUMMARY A 52-year-old female patient with bilateral pleural effusion was diagnosed with"tuberculous pleurisy"and treated with anti-tuberculosis drugs and *** coagulation-related laboratory results showed decreased fibrinogen,PC activity,PS activity,and antithrombinШ*** immune-related laboratory results showed positive antinuclear antibody,anti-Smith antibody,anticardiolipin antibody(ACL),anti-β2-glycoprotein I antibody(aβ2GPI)and direct Coomb’s test and decreased complement 3 and complement *** was performed and bloody pleural fluid was *** of the pleural biopsy showed lymphocytes,plasma cells,and a few eosinophils in adipose and fibrous connective *** of whole exome sequencing of blood showed no genetic mutations suggesting the presence of hereditary hematological *** patient was finally diagnosed with SLE and primary hyperfibrinolysis,and was treated with prednisolone,hydroxychloroquine,and compound *** PC and PS deficiency in SLE might be related to ACL and aβ*** and primary hyperfibrinolysis can coexist in one patient,with both a risk of thrombosis and a risk of bleeding.

关键词： Systemic lupus erythematosus Primary hyperfibrinolysis Antiphospholipid antibody Protein C deficiency Protein S deficiency Case report

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Clinical value of needleless sling in treatment of female stress urinary incontinence

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World Journal of Clinical Cases 2020年第18期8卷 4043-4050页

作者： Yu-Guo Chen Yao-Guang Zhang Wei Zhang Xin Li Xia Wang Dressing Room of Surgical Outpatient Beijing HospitalNational Center of GerontologyInstitute of Geriatric MedicineChinese Academy of Medical SciencesBeijing 100730China department of Urology Beijing HospitalNational Center of GerontologyInstitute of Geriatric MedicineChinese Academy of Medical SciencesBeijing 100730China Nursing department Beijing HospitalNational Center of GerontologyInstitute of Geriatric MedicineChinese Academy of Medical SciencesBeijing 100730China

BACKGROUND Stress urinary incontinence(SUI)is a common disease in *** emergence of the needle-free sling has led to a new clinical treatment for SUI in *** To explore the clinical value of the needleless sling without acupuncture in the treatment of SUI in *** From February 2017 to November 2018,according to the order of admission,44 patients(mid-suspension group)were treated by tension-free transobturator urethral suspension,and 44 patients(non-acupuncture group)were treated with a needleless non-acupuncture *** clinical effects of the two treatments were *** There was no significant difference between the two groups in the total clinical effectiveness rate(P=0.374),but intraoperative blood loss and visual analogue scale score at postoperative day 1 were significantly lower in the non-acupuncture suspension group than in the middle urethral suspension group(P=0.396).The incidence of complications in the needle-free sling group was significantly lower than that in the middle urethral suspension group(P=0.025).CONCLUSION The clinical effectiveness of acupuncture-free suspension in treating SUI in female patients is better than that of traditional tension-free transobturator mid-urethral suspension.

关键词： No needle sling Female stress urinary incontinence Mid-urethral suspension Controlled study Complications Application value

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Phosphorylation of Cofilin-1 Enhances Paclitaxel Resistance of Epithelial Ovarian Cancer Cells by Inhibiting Apoptosis

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Biomedical and Environmental Sciences 2021年第6期34卷 465-477页

作者： LI Min DONG Xu Dong LYU Qiu Bo ZHANG Wei HUANG Shuai YANG Chun Xue CUI Di LAI Hui Ying department of Obstetrics and Gynecology Beijing Hospital National Center of GerontologyInstitute of Geriatric MedicineChinese Academy of Medical SciencesBeijing 100730China department of Obstetrics the First People's Hospital of Yunnan ProvinceKunming 650032YunnanChina department of Pathology Beijing HospitalNational Center of GerontologyInstitute of Geriatric MedicineChinese Academy of Medical SciencesBeijing 100730China Peking University Health Science center Beijing 100069China Clinical Laboratory Beijing HospitalNational Center of GerontologyInstitute of Geriatric MedicineChinese Academy of Medical SciencesBeijing 100730China

Objective To investigate the molecular mechanism of high phosphorylation levels of cofilin-1(p-CFL-1)associated with paclitaxel resistance in epithelial ovarian cancer(EOC)*** Cells displaying varying levels of p-CFL-1 and CFL-1 were created by plasmid transfection and shRNA *** inhibition rate indicating paclitaxel efficacy was assessed by Cell Counting Kit-8(CCK-8)*** was assessed by flow cytometry and protein levels were detected by western *** real-time polymerase chain reaction(qRT-PCR)was used to measure the expression levels of phosphokinases and phosphatases of *** analysis evaluated the correlation between the prognosis of EOC patients and the levels of p-CFL-1 and slingshot-1(SSH-1).Results High levels of p-CFL-1 were observed in EOC cells that survived treatment with high doses of ***3 cell mutants with upregulated p-CFL-1 showed impaired paclitaxel efficacy,as well as decreased apoptosis rates and pro-survival patterns of apoptosis-specific protein *** accumulation of p-CFL-1 inhibited paclitaxel-induced mitochondrial ***-1 silencing mediated CFL-1 phosphorylation in paclitaxel-resistant SKOV3 ***,the high level of p-CFL-1 and the low level of SSH-1 in EOC tissues were closely related to chemotherapy resistance and poor prognosis in EOC *** The SSH-1/p-CFL-1 signaling pathway mediates paclitaxel resistance by apoptosis inhibition in EOC and is expected to be a potential prognostic predictor.

关键词： Cofilin-1 Slingshot-1 Epithelial ovarian cancer Chemo-resistance Apoptosis

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Cognitive magnetic resonance imaging-ultrasound fusion transperineal targeted biopsy combined with randomized biopsy in detection of prostate cancer

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World Journal of Clinical Cases 2021年第36期9卷 11183-11192页

作者： Cheng Pang Miao Wang Hui-Min Hou Jian-Yong Liu Zhi-Peng Zhang Xuan Wang Ya-Qun Zhang Chun-Mei Li Wei Zhang Jian-Ye Wang Ming Liu department of Urology Beijing HospitalNational Center of GerontologyInstitute of Geriatric MedicineChinese Academy of Medical SciencesBeijing 100730China Graduate School of Peking Union Medical College Chinese Academy of Medical SciencesBeijing 100730China department of Radiology Beijing HospitalNational Center of GerontologyInstitute of Geriatric MedicineChinese Academy of Medical SciencesBeijing 100730BeijingChina department of Pathology Beijing HospitalNational Center of GerontologyInstitute of Geriatric MedicineChinese Academy of Medical SciencesBeijing 100730BeijingChina

BACKGROUND Prostate cancer(PCa)is one of the most common cancers among *** strategies for targeted biopsy based on multiparametric magnetic resonance imaging(mp-MRI)have emerged,which may improve the accuracy of detecting clinically significant PCa in recent *** To investigate the diagnostic efficiency of a template for cognitive MRIultrasound fusion transperineal targeted plus randomized biopsy in detecting *** Data from patients with an increasing prostate-specific antigen(PSA)level but less than 20 ng/mL and at least one lesion suspicious for PCa on MRI from December 2015 to June 2018 were retrospectively *** patients underwent cognitive fusion transperineal template-guided targeted biopsy followed by randomized biopsy outside the targeted area.A total of 127 patients with complete data were included in the final analysis.A multivariable logistic regression analysis was conducted,and a two-sided Pcentered study proposed a feasible template for cognitive MRIultrasound fusion transperineal targeted plus randomized *** with higher PSAD and PI-RADS scores were more likely to be diagnosed with PCa.

关键词： Prostate neoplasms Magnetic resonance imaging Cognitive fusion Prostate biopsy Prostate cancer

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Clinical features and risk factors of severely and critically ill patients with COVID-19

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World Journal of Clinical Cases 2022年第3期10卷 840-855页

作者： Xin Chu Gui-Fang Zhang Yong-Ke Zheng Yi-Gang Zhong Li Wen Ping Zeng Chun-Yi Fu Xun-Liang Tong Yun-Fei Long Jing Li Ya-Lin Liu Zhi-Gang Chang Huan Xi department of Surgical Intensive Care Medicine Beijing HospitalNational Center of GerontologyInstitute of Geriatric MedicineChinese Academy of Medical SciencesBeijing 100730China The Key Laboratory of geriatrics Beijing Institute of GeriatricsInstitute of Geriatric MedicineChinese Academy of Medical SciencesBeijing Hospital/National Center of Gerontology of National Health CommissionBeijing 100730China department of Intensive Care Unit Affiliated Hangzhou First People's HospitalZhejiang University School of MedicineHangzhou 310006Zhejiang ProvinceChina department of Cardiology Affiliated Hangzhou First People's HospitalZhejiang University School of MedicineHangzhou 310006Zhejiang ProvinceChina department of Emergency Beijing HospitalNational Center of GerontologyInstitute of Geriatric MedicineChinese Academy of Medical SciencesBeijing 100730China department of Respiratory and Critical Care Medicine Beijing HospitalNational Center of GerontologyInstitute of Geriatric MedicineChinese Academy of Medical SciencesBeijing 100730China department of Neurology Beijing HospitalNational Center of GerontologyInstitute of Geriatric MedicineChinese Academy of Medical SciencesBeijing 100730China department of Cardiology Beijing HospitalNational Center of GerontologyInstitute of Geriatric MedicineChinese Academy of Medical SciencesBeijing 100730China department of geriatrics Beijing HospitalNational Center of GerontologyNational Health CommissionInstitute of Geriatric MedicineChinese Academy of Medical SciencesBeijing 100730China

BACKGROUND As of June 1,2020,over 370000 coronavirus disease 2019(COVID-19)deaths have been reported to the World Health ***,the risk factors for patients with moderate-to-severe or severe-to-critical COVID-19 remain *** To explore the characteristics and predictive markers of severely and critically ill patients with *** A retrospective study was conducted at the B11 Zhongfaxincheng campus and E1-3 Guanggu campus of Tongji Hospital affiliated with Huazhong University of Science and Technology in *** with COVID-19 admitted from 1st February 2020 to 8th March 2020 were enrolled and categorized into 3 groups:The moderate group,severe group and critically ill *** data,demographic data,clinical symptoms and outcomes,complications,laboratory tests and radiographic examinations were collected retrospectively from the hospital information system and then compared between *** A total of 126 patients were *** were 59 in the moderate group,49 in the severe group,and 18 in the critically ill *** logistic regression analysis showed that age[odd ratio(OR)=1.055,95%(confidence interval)CI:1.099-1.104],elevated neutrophil-to-lymphocyte ratios(OR=4.019,95%CI:1.045-15.467)and elevated high-sensitivity cardiac troponin I(OR=10.126,95%CI:1.088-94.247)were high-risk *** The following indicators can help clinicians identify patients with severe COVID-19 at an early stage:age,an elevated neutrophil-to-lymphocyte ratio and high sensitivity cardiac troponin I.

关键词： COVID-19 SARS-CoV-2 Critically ill Risk factors Aspartate transaminase Amino-terminal pro-brain natriuretic peptide Creatinine Calcium

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ACE gene missense mutation in a case with early-onset, rapid progressing dementia

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General psychiatry 2019年第5期32卷 283-286页

作者： Jing Ni Shifu Xiao Xia Li Lin Sun department of psychiatry Shanghai Huangpu District Mental Health CenterShanghaiChina department of geriatric psychiatry Shanghai Mental Health CenterShanghaiChina Alzheimer's Disease and Related Disorders center Shanghai Jiao Tong UniversityShanghaiChina Deparment of geriatric psychiatry Shanghai Mental Health CenterShanghaiChina

The population of early-onset Alzheimer's disease(EOAD)accounts for 1%-2%of the total population of Alzheimer's disease,and genetic mutations are more common in *** first symptom of the patient in the present case report was the decline in memories of recent events,and the disease progressed rapidly in the following 2 *** testing has revealed the presence of genetic mutations(c.A479G,p.N160S)of ACE,which causes the 160th codon of the ACE protein to change from aspartic acid to serine,and at the same time genotype of apolipoprotein E(APOE)is ε3/ε*** think that this patient carries the mutation type of the sensitive gene ACE and the risk gene APOE of Alzheimer's disease,and this is the reason why the disease progressed ***,we discussed ACE genetic mutation's meaning in EOAD progression.

关键词： Alzheimer mutation testing

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How non-rapid eye movement sleep and Alzheimer pathology are linked

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World Journal of psychiatry 2021年第11期11卷 1027-1038页

作者： Annelies Falter Maarten J A Van Den Bossche department of geriatric psychiatry University Psychiatric Center KU LeuvenLeuven 3000Belgium center for Neuropsychiatry Research Group PsychiatryDepartment of NeurosciencesLeuven Brain InstituteKU LeuvenLeuven 3000Belgium

Alzheimer's disease(AD)is a multifactorial neurodegenerative disorder characterized by the presence of senile plaques and neurofibrillary *** attempts to identify characteristic factors that are associated with the presence of the AD pathology on the one hand and that increase the risk of developing AD on the *** in non-rapid eye movement(NREM)sleep may meet both requirements for various ***,NREM-sleep is important for optimal memory *** addition,studies report that the presence of AD pathology is associated with NREM-sleep ***,more and more results appear to suggest that sleep problems are not only a symptom of AD but can also increase the risk of *** of these studies suggest that it is primarily a lack of NREM-sleep that is responsible for this increased ***,the majority investigated sleep only through subjective reporting,as a result of which NREMsleep could not be analyzed *** aim of this literature study is therefore to present the results of the studies that relate the AD pathology and NREM-sleep(registered by electroencephalography).Furthermore,we try to evaluate whether NREM-sleep analysis could be used to support the diagnosis of AD and whether NREM-sleep deficiency could be a causal factor in the development of AD.

关键词： Alzheimer’s disease Mild cognitive impairment Sleep Non-rapid eye movement sleep Amyloid beta-peptides Tau proteins Electroencephalography

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Microdeletion on Xq27.1 in a Chinese VACTERL-Like Family with Kidney and Anal Anomalies

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Biomedical and Environmental Sciences 2024年第5期37卷 503-510页

作者： LI Min ZHANG Yu Lan ZHANG Kai Li LI Ping Ping LYU Yu Han LIANG Ya Xin YU Yue department of Gynecology and Obstetrics Beijing HospitalNational Center of GerontologyInstitute of Geriatric MedicineChinese Academy of Medical SciencesBeijing 100730China Chinese Academy of Medical Sciences and Peking Union Medical College Beijing HospitalBeijing 100730China The Key Laboratory of geriatrics Beijing Institute of GeriatricsBeijing HospitalNational Center of GerontologyInstitute of Geriatric MedicineChinese Academy of Medical SciencesBeijing 100730China

Objective VATER/VACTERL-like association is associated with adverse pregnancy *** evidence of this disorder is *** this study,we aimed to provide genetic insights to improve the diagnosis of *** We have described a Chinese family in which four members were affected by renal defects or agenesis,anal atresia,and anovaginal fistula,which is consistent with the diagnosis of a VACTERL-like *** and genetic analyses were conducted using genome and exome *** Segregation analysis revealed the presence of a recessive X-linked microdeletion in two living affected individuals,harboring a 196–380 kb microdeletion on Xq27.1,which was identified by familial exome *** sequencing was performed on the affected male,confirming a-196 kb microdeletion in Xq27.1,which included a 28%loss of the CDR-1 *** family members were included in the co-segregation analysis,and only VACTERL-like cases with microdeletions were reported in *** These results suggest that the 196–380 kb microdeletion in Xq27.1 could be a possible cause of the VATER/VACTERL-like ***,further genetic and functional analyses are required to confirm or rule out genetic background as the definitive cause of the VACTERL association.

关键词： Prenatal diagnosis VACTERL whole-genome sequencing whole-exome sequencing X-linked

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Increased systemic RNA oxidative damage and diagnostic value of RNA oxidative metabolites during Shigella flexneri-induced intestinal infection

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World Journal of Gastroenterology 2021年第37期27卷 6248-6261页

作者： Jing-Jing Nie Ya-Ya Pian Ji-Hong Hu Guo-Qing Fan Lv-Tao Zeng Qiu-Geng Ouyang Zhen-Xiang Gao Zhen Liu Chen-Chen Wang Qian Liu Jian-Ping Cai department of Microbiology National Center for Clinical LaboratoriesBeijing HospitalNational Center of GerontologyInstitute of Geriatric MedicineChinese Academy of Medical SciencesBeijing 100730China The Key Laboratory of geriatrics Beijing Institute of GeriatricsBeijing HospitalNational Center of GerontologyNational Health CommissionInstitute of Geriatric MedicineChinese Academy of Medical SciencesBeijing 100730China department of Pharmacy Wenzhou Medical UniversityWenzhou 325035Zhejiang ProvinceChina

BACKGROUND Shigella flexneri(***)is a major pathogen causing acute intestinal infection,but the systematic oxidative damage incurred during the course of infection has not been *** To investigate the incurred systemic RNA oxidative damage and the diagnostic value of RNA oxidative metabolites during ***-induced intestinal *** In this study,a Sprague-Dawley rat model of acute intestinal infection was established by oral gavage with *** *** changes in white blood cells(WBCs)and cytokine levels in blood and the inflammatory response in the colon were *** also detected the RNA and DNA oxidation in urine and *** *** infection induced an increase in WBCs,C-reactive protein,interleukin(IL)-6,IL-10,IL-1β,IL-4,IL-17a,IL-10,and tumor necrosis factorα(TNF-α)in *** note,a significant increase in urinary 8-oxo-7,8-dihydroguanosine(8-oxo-Gsn),an important marker of total RNA oxidation,was detected after intestinal infection(P=0.03).The urinary 8-oxo-Gsn level returned to the baseline level after recovery from *** addition,the results of a correlation analysis showed that urinary 8-oxo-Gsn was positively correlated with the WBC count and the cytokines IL-6,TNF-α,IL-10,IL-1β,and IL-17α.Further detection of the oxidation in different tissues showed that *** infection induced RNA oxidative damage in the colon,ileum,liver,spleen,and *** Acute infection induced by *** causes increased RNA oxidative damage in various tissues(liver,spleen,and brain)and an increase of 8-oxo-Gsn,a urinary *** 8-oxo-Gsn may be useful as a biomarker for evaluating the severity and prognosis of infection.

关键词： 8-oxo-7,8-dihydroguanosine Shigella flexneri Infection Oxidative damage

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Comparative breakthrough: Umbilical cord mesenchymal stem cells vs bone marrow mesenchymal stem cells in heart failure treatment

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World Journal of Cardiology 2024年第12期16卷 776-780页

作者： Peng Li department of Geriatics Beijing HospitalNational Center of GerontologyInstitute of Geriatric MedicineChinese Academy of Medical SciencesBeijing 100730China

In this article,we evaluate the comparative efficacy and safety of mesenchymal stem cells(MSCs)derived from bone marrow(BM-MSCs)and umbilical cord(UC-MSCs)in the treatment of heart failure and myocardial *** have gained importance as living bio drug due to their regenerative potential,with BM-MSCs being the most extensively ***,UC-MSCs offer unique advantages,such as noninvasive collection and fewer ethical *** systematic review and meta-analysis summarizes data from 13 randomized controlled trials,which included a total of 693 *** study shows that UC-MSCs significantly improved left ventricular ejection fraction by 5.08%at 6 months and 2.78%at 12 months compared with controls,while BM-MSCs showed no significant *** cell type showed significant changes in 6-minute walk *** addition,UC-MSCs and BM-MSCs had comparable safety profiles,with no significant differences in major adverse cardiac events,except for a lower rehospitalization rate observed with *** results position UC-MSCs as a promising alternative in MSC-based therapies for cardiac disease,offering potential improvements in cardiac function while maintaining a favorable safety *** research should focus on optimizing adminis-tration protocols and further exploring the long-term benefits and mechanisms of UC-MSCs in cardiac repair.

关键词： Mesenchymal stem cells Heart failure Umbilical cord-derived mesenchymal stem cells Bone marrow-derived mesenchymal stem cells Left ventricular ejection fraction 6-minute walking distance Cardiac regeneration therapy

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