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Journal of Integrative nursing 2022年第3期4卷 157-165页

作者： Tuba ARPACİ Naime ALTAY department of nursing Faculty of Health SciencesKaramanoglu Mehmetbey UniversityKaramanTurkey department of nursing Faculty of Health SciencesGazi University AnkaraTurkey

Technology-based interventions are thought to be one of the innovative alternatives for improving the psychosocial health of adolescent *** article outlines an example of technology-based psychosocial intervention for adolescent survivors of *** technology-based psychosocial support intervention consists of five separate modules related to personal development,coping skills,and a healthy *** can be applied to adolescents(aged 12-18 years)who have completed leukemia treatment at least 2 years ago and are disease *** interventions are crucial to improving adolescent survivors’psychosocial well-being in long-term *** is thought that psychosocial interventions can be effective on survivors’self-efficacy,coping skills,and quality of life,and survivors will be satisfied with the *** the model of childhood cancer survivorship care,this intervention can be integrated into the follow-up program and guide pediatric oncology nurses in preparing support programs for adolescent survivors.

关键词： Adolescents leukemia long-term follow-up nursing psychosocial support survivors technology

miR-124 is upregulated in diabetic mice and inhibits proliferation and promotes apoptosis of high-glucose-inducedβ-cells by targeting EZH2

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World Journal of Diabetes 2023年第3期14卷 209-221页

作者： Xiao-Kai Duan Yong-Xiang Sun Hong-Yun Wang Yan-Yan Xu Shi-Zhen Fan Jin-Ya Tian Yong Yu Yan-YunZhao Yan-Li Jiang department of General practice Zhengzhou First People’s HospitalZhengzhou 450000Henan ProvinceChina

BACKGROUND Diabetes is a chronic metabolic disease,and a variety of miRNA are involved in the occurrence and development of *** clinical studies,miR-124 is highly expressed in the serum of patients with diabetes and in pancreatic isletβ-***,few reports exist concerning the role and mechanism of action of miR-124 in *** To investigate the expression of miR-124 in diabetic mice and the potential mechanism of action in isletβ-*** The expression levels of miR-124 and enhancer of zeste homolog 2(EZH2)in pancreatic tissues of diabetic mice were *** targeted relationship between miR-124 and EZH2 was predicted by Targetscan software and verified by a double luciferase reporter *** isletβ-cells Min6 were grown in a high glucose(HG)medium to mimic a diabetes *** insulin secretion,proliferation,cell cycle and apoptosis of HG-induced Min6 cells were detected after interference of miR-124a and/or *** The expression of miR-124 was upregulated and EZH2 was downregulated in the pancreatic tissue of diabetic mice compared with control mice,and the expression of miR-124 was negatively correlated with that of ***-124 was highly expressed in HG-induced Min6 *** of miR-124 promoted insulin secretion and cell proliferation,induced the transition from the G0/G1 phase to the S phase of the cell cycle,and inhibited cell apoptosis in HG-induced Min6 ***2 was one of the targets of ***-transfection of miR-124 inhibitor and siRNA-EZH2 could reverse the effects of the miR-124 inhibitor in HG-induced Min6 *** miR-124 is highly expressed in diabetic mice and HG-induced Min6 cells and regulates insulin secretion,proliferation and apoptosis of isletβ-cells by targeting EZH2.

关键词： miR-124 Enhancer of zeste homolog 2 Diabetes Insulin secretion Proliferation Apoptosis

Non-pharmacological management for chemotherapy-induced nausea and vomiting in patients with cancer:a scoping review

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Frontiers of nursing 2023年第1期10卷 9-20页

作者： Dewi Maulidawati Erna Rochmawati Nina Granel department of Medical Surgical nursing Nursing ProgramUniversitas Muhammadiyah YogyakartaJl BrawijayaTamantirtoKasihanBantul 55183Indonesia department of nursing Universitat Autònoma de BarcelonaCerdanyola del VallesSpain

Objective:This review aimed to map and summarize published studies that tested non-pharmacological management for chemotherapyinduced nausea and vomiting(CINV).Methods:We searched for eligible studies in 5 electronic databases and screened the retrieved studies using the inclusion and exclusion *** were then collated according to the types of interventions,measurement tool,and ***:The search yielded 2343 records,of which 11 were *** categories of non-pharmacological CINV management were made;manipulative and body-based therapy(n=5 studies);mind–body therapy(n=3 studies);biologically based practice(n=1 study),and energy therapy(n=2 studies).Seven different scales were used to measure *** studies repor ted improvement in ***:This scoping review demonstrates the breadth of non-pharmacological management to address *** types of CINV scales were used to measure CINV *** management and scale can be utilized to improve nursing care,par ticularly in cancer care.

关键词： cancer chemotherapy-induced nausea and vomiting complementary therapies nausea and vomiting review

Impact of applying the theory of human becoming and self-care deficit theory of nursing on insomnia in after stroke urinary incontinence patients

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Frontiers of nursing 2024年第3期11卷 259-266页

作者： Heltty Heltty Ratna Sitorus Haryanto Haryanto Medical Surgical nursing department Faculty of Health ScienceUniversitas Mandala WaluyaKendariSulawesi Tenggara 93121Indonesia Medical Surgical nursing department Nursing FacultyUniversitas IndonesiaDepokJawa Barat 16424Indonesia Medical Surgical nursing and Wound Management department Nursing FacultyWest Kalimantan Muhammadiyah Institute of Technology and HealthKalimantan Barat 78122Indonesia

Objective:To determine the impact of applying the theory of human becoming and self-care deficit theory of nursing in overcoming insomnia in patients of urinary incontinence(UI)after *** is a sleep disorder experienced by UI patients after stroke which can exacerbate problems related to brain damage and can complicate the recovery ***:This study was a quasi-experimental conducted in 4 ***-six patients were selected by convenience sampling and divided into 2 groups(the intervention and control group).Participants in the intervention group received“applying the theory of Human becoming and self-care deficit theory of nursing,”starting when the patient is about to go home from the hospital and continuing at the *** of insomnia is done using the Pittsburgh Sleep Quality Index(PSQI).Results:The mean insomnia scores of participants from both groups increased in the first and third *** second and third insomnia measurements found a significant difference(Pnursing in this study significantly decreased the insomnia score of post-stroke UI *** can be used as a guide for nurses,patients,and families in managing *** addition,the application of nursing theory in nursing practice can systematize nursing care plans and organize the knowledge of professionals into a conceptual framework,as well as provide effective guidance for nurses on what to do.

关键词： human becoming theory insomnia self-care deficit theory stroke urinary incontinence

Pulmonary rehabilitation protocols in urgent lung transplantation patients

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World Journal of Emergency Medicine 2024年第1期15卷 47-51页

作者： Fei Zeng Lingyun Cai Luyao Guo Meijuan Lan Jiangshuyuan Liang Peipei Gu nursing department the Second Affi liated Hospital of Zhejiang University School of MedicineHangzhou 310009China

BACKGROUND:Prolonged invasive respiratory support and extracorporeal membrane oxygenation(ECMO)in patients requiring urgent lung transplantation(ULTx)present signifi cant challenges to clinical practice due to severe underlying diseases and complex *** aim of the study was to report the clinical outcomes of patients who received ULTx and followed the perioperative rehabilitation protocol implemented in a lung transplant ***:A retrospective analysis was conducted in ULTx patients who required preoperative invasive mechanical ventilation(IMV)and ECMO between January 2018 and January *** were retrieved from electronic medical records at our lung transplant ***:Fourteen patients(mean age 57.43±10.97 years;12 males,2 females)underwent ULTx with bridging ECMO and *** mean body mass index was 23.94±3.33 kg/m²,and the mean Acute Physiology and Chronic Health Evaluation(APACHE)II score was 21.50±*** Nutritional Risk Screening 2002(NRS 2002)scores were≥*** was performed after an 8.5-day waiting period(interquartile interval[IQR]5.0-26.5 d).Following the surgeries,the average lengths of ECMO and IMV were 1.0(IQR 1.0-2.0)d and 5.0(IQR 3.0-7.3)d,*** total length of hospital stay was 60.1±30.8 d,with an average intensive care unit stay of 38.3±22.9 d and post-operative hospitalization stay of 45.8±26.1 *** patients died within 30 d after ULTx,with a 30-day survival rate of 85.71%.CONCLUSION:Patients receiving ULTx showed an acceptable short-term survival rate,validating the practicality and safety of the treatment protocols implemented in our center.

关键词： Urgent lung transplantation End-stage lung disease Extracorporeal membrane oxygenation Invasive respiratory support Pulmonary rehabilitation.

Use of the knowledge,attitude,and practice(KAP)model to examine sustainable agriculture in Thailand

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Regional Sustainability 2022年第1期3卷 41-52页

作者： LIAO Xuewei Thi Phuoc Lai NGUYEN Nophea SASAKI development Planning Management and Innovation(DPMI) Department of Development and SustainabilitySchool of EnvironmentResources and DevelopmentAsian Institute of Technology(AIT)Pathumthani12120Thailand Natural Resource Management(NRM) Department of Development and SustainabilitySchool of EnvironmentResources and DevelopmentAsian Institute of Technology(AIT)Pathumthani12120Thailand

Sustainable agriculture plays an important role in achieving sustainable development goals with regard to food security and environmental *** agriculture relies on sustainable farming practices that reduce greenhouse gas production,the wise use of local natural resources,and reductions in negative impacts on the environment and human *** farming practices can be driven by various factors,such as the socio-environmental setting,socio-cognitive factors,agricultural institutions,and *** study used the knowledge,attitude,and practice(KAP)model to examine farmers’knowledge,attitudes,and practices in the area of sustainable *** also considered the factors affecting farmers’knowledge,attitudes,and *** different socio-environmental contextual settings in Surin Province(a Thai-Cambodian border province)of Thailand are *** results show that there are differences between the two different socio-environmental contextual settings with regard to farmers’sustainable agricultural practice perceptions,knowledge,and ***’perceptions of environmental degradation,the number of years of agricultural experience,and agricultural policy drive farmers’attitudes and individual sustainable *** major result of the study is that individual farmers’attitudes and practices promote collective sustainable agricultural *** implication of these findings is that it is necessary to improve the learning ability of individual farmers on the environment and sustainable agricultural practices through social learning and scientific knowledge dissemination,so as to produce sustainable collective development behaviors.

关键词： Socio-environmental context Individual and collective practices Sustainable agriculture KAP model Thailand

Aquaporin,beyond a transporter

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Horticultural Plant Journal 2023年第1期9卷 29-34页

作者： Weikun Jing Yonghong Li Shuai Zhang Xiaofeng Zhou Junping Gao Nan Ma Beijing Key Laboratory of development and Quality Control of Ornamental Crops Department of Ornamental HorticultureCollege of HorticultureChina Agricultural UniversityBeijing 100193China School of Applied Chemistry and Biological Technology Shenzhen PolytechnicShenzhenGuangdong 518055China Postdoctoral Innovation practice Base Shenzhen PolytechnicShenzhenGuangdong 518055China

Aquaporins(AQPs)are one of the most ancient superfamily proteins,which are essential for maintaining the fluid homeostasis of most organisms against various ***,the latest findings for function of AQPs in cell signal ... 详细信息

关键词： Aquaporin ABA Signal transduction H_(2)O_(2) Phosphorylation

Emerging therapeutic options for the management of hepatitis C infection

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World Journal of Gastroenterology 2014年第23期20卷 7079-7088页

作者： J Richard Thompson department of Pharmacy practice One University Park DriveLipscomb University College of PharmacyNashvilleTN 37204United States

Until recently the traditional treatment for hepatitis C infection included pegylated interferon and ribavirin combination *** sustained virological response(SVR)seen with this combination is poor and requires lengthy treatment to ***,significant side effects and numerous contraindications prevented many patients from being successfully treated with this *** 2011,two new protease inhibitors,telaprevir and boceprevir,were approved for use with pegylated interferon and ribavirin in the United States by the United States Food and Drug *** agents have significantly improved SVR rates;however significant problems with toxicity remain including severe skin rash and *** are a wide range of compounds in late stage development for the future treatment of hepatitis C that exploit many different mechanisms of viral *** of these compounds include additional protease inhibitors,like telaprevir and boceprevir,as well as inhibitors of other nonstructural proteins in the viral genome such as NS5A and NS5B,and compounds that target host proteins within the *** of these agents are being developed for oral administration once daily and various combinations are being assessed for use without the need for pegylated interferon and *** paper reviews agents in late phase development that may be commercially available within 1-2 years.

关键词： Hepatitis C Pharmacotherapy Interferon Ribavirin Protease inhibitors Polymerase inhibitors Cyclophilin inhibitors

Preceptors'experiences in guiding nursing students to use research findings and to implement evidence-based practice

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Frontiers of nursing 2024年第3期11卷 313-318页

作者： Titan Ligita Suma Nurbianti Nita Arisanti Yulanda Yoga Pramana Cindiarty Kurnia Saputri Eka Ersa Mayang Kumala department of Medical Surgical nursing School of NursingFaculty of Medicine Universitas TanjungpuraPontianakWest Kalimantan 78124Indonesia Neurology department General Hospital of Doctor Soedarso PontianakPontianakWest Kalimantan 78124Indonesia department of Basic nursing School of NursingFaculty of Medicine Universitas TanjungpuraPontianakWest Kalimantan 78124Indonesia

Objective:Evidence-based practices(EBPs)have been taught to students by identifying the best evidence/evidence from research ***,the experiences of Indonesian nurse preceptors in helping students implement research findings have not been explored *** study aimed to explore Indonesian nurse preceptors in guiding nursing students to use research ***:This study used interpretive phenomenology analysis that involves 9 nurse preceptors from hospitals in West Kalimantan,***-structured in-depth interviews were recorded and then transcribed ***:Three themes were generated during the analysis:“types of student supervision,”“issues during supervision,”and“the need for research literacy and supervision.”Conclusions:Nurse preceptors need support to supervise the nursing students to use research *** addition to upgrading nursing skills,nurse preceptors must receive training in research and its *** an appropriate strategy to assist students in using research findings will enhance the promotion of evidence-based nursing practices on a daily basis.

关键词： evidence based practice Indonesia nurses nursing students phenomenology

Progressive exhaustion:A qualitative study on the experiences of Iranian family caregivers regarding patients undergoing hemodialysis

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International Journal of nursing Sciences 2018年第2期5卷 193-200页

作者： Shahriar Salehitali Fazlollah Ahmadi Ali Hasanpour Dehkordi Kobra Noorian Malek Fereidooni-Moghadam Kouroush Zarea nursing department Faculty of Nursing&MidwiferyShahrekord University of Medical SciencesShahrekordIran nursing department Faculty of Medical SciencesTarbiat Modares UniversityTehranIran nursing and Midwifery Care Research Center Faculty of Nursing and MidwiferyIsfahan University of Medical SciencesIsfahanIran nursing Care Research Center in Chronic Diseases Ahvaz Jundishapur University of Medical SciencesAhvazIran

Objective:The aim of this study was to explore the burden of care for patients undergoing hemodialysis from the experiences of family ***:In this qualitative study,a content analysis approach was used for data collection and *** were 16 family caregivers selected through purposive sampling from four medical education centers affiliated with Ahvaz Jundishapur University of Medical Sciences,***-structured interviews were held to collect ***:Four categories were developed as follows:‘care challenges’,‘psychological vulnerabilities’,‘the chronic nature of care’and“care in the shade”.The categories led to the development of the main theme of‘progressive exhaustion’experienced by the family caregivers during the provision of care to patients undergoing ***:Family caregivers have a significant role in the process of patient care,and this role leads them to progressive exhaustion;therefore,the overall health of the caregivers should be taken into account and more attention should be paid to their quality of life,social welfare,and satisfaction level.

关键词： Family caregivers Hemodialysis Progressive exhaustion Qualitative study