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Salvianolic acids improve liver lipid metabolism in ovariectomized rats via blocking STAT-3/SREBP1 signaling

Chinese Journal of Natural Medicines 2018年第11期16卷 838-845页

作者： CHEN Juan YUE Jia LIU Jiao LIU Yun JIAO Kai-Lin TENG Meng-Ying HU Chun-Yan ZHEN Jing WU Mao-Xuan ZHOU Ming LI Zhong LI Yuan department of nutrition and Food hygiene School of Public Health Nanjing Medical University department of nutrition and Food hygiene School of Public Health Gansu University of Chinese Medicine

Postmenopausal women, who have reduced circulating estrogen levels, are more prone to develop obesity and related metabolic diseases than premenopausal women. The absence of safe and effective treatments for postmenopausal obesity has changed the focus to natural products as alternative remedies. Total salvianolic acids(TSA) are the major water-soluble ingredients of Danshen. Salvianolic acid(SA) is the major constituent of the TSA. Salvianolic acids, including TSA and SA, are widely used in traditional Chinese medicine. In the present study, ovariectomized rats and LO2 cells were used to study the effects of salvianolic acids on body weight gain and hepatic steatosis. Salvianolic acids reduced ovariectomy(OVX)-induced body weight gain, attenuated the expressions of hepatic lipogenic genes, such as sterol regulatory element binding protein(SREBP)1, fatty acid synthase(FAS), and stearoyl-CoA desaturase(SCD)1, and decreased the liver triglyceride(TG) and total cholesterol(TC). For the molecular mechanisms, OVX and high glucose-induced phosphorylation of signal transducer and activator of transcription(STAT)-3 was inhibited by salvianolic acids treatment. In LO2 cells, inhibition of STAT-3 by siRNA attenuated the increased expression of SREBP1 and TG induced by high glucose. Salvianolic acids reduced the upregulation of SREBP1 and TG induced by high glucose in LO2 cells. In conclusion, these findings illustrated that salvianolic acids markedly alleviated the lipid metabolism disorders and protected against the postmenopausal obesity. The underlying mechanism was probably associated with the regulation of STAT-3 signaling.

关键词： Salvianolic acids Lipid metabolism Weight gain Signal transducer and activator of transcription 3

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The survey of prolamin and gluten content in beers produced in Central Europe-The biochemical characterization of immunoreactive protein fractions

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Food Bioscience 2023年第3期53卷 1354-1359页

作者： Barbara Mickowska Maja Grabacka Małgorzata Pierzchalska Frantisek Bunka department of plant products technology and nutrition hygiene Faculty of Food TechnologyUniversity of Agriculture in Krakowul.Balicka 12230-149 KrakówPoland department of Biotechnology and General technology of Foods Faculty of Food TechnologyUniversity of Agriculture in Krakowul.Balicka 12230-149 KrakówPoland University of Defence Faculty of Military LeadershipDepartment of LogisticFood Research LaboratoryKounicova 6566210 BrnoCzech Republic

Prolamins(gliadin-related proteins)are cereal proteins which are a source of polypeptides that are toxic to people showing intolerance or allergy to ***,serious safety concerns regarding occasional and routine beer consumption emerge due to the presence of immunoreactive amino acid sequences of cereal origin that remain in the final *** aim of the study was to investigate the presence of prolamins and gluten in samples of beers(72 commercially available beverages)produced in Central Europe.A competitive ELISA and immunoblotting methods were applied to analyze the presence and concentration of immunoreactive proteins/*** level in the studied beers ranged from 10 to over 6000 mg/*** 30%beers could be regarded as gluten-free,around 40%were very low gluten and only 25%beers contained considerable amounts of *** highest level of prolamin content was detected in wheat *** demonstrated that these high concentrations of prolamins are probably derived from residues of non-degraded wheat gliadins.

关键词： Beer Prolamin Gluten ELISA Immunoblot

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The transformation of agriculture in China: Looking back and looking forward

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Journal of Integrative Agriculture 2018年第4期17卷 755-764页

作者： JIAO Xiao-qiang Nyamdavaa Mongol ZHANG Fu-suo Center for Resources Environment and Food Security Department of Plant Nutrition/Key Laboratory of Plant-Soil InteractionsMinistry of Education China Agricultural University Lancaster Environment Centre Lancaster University

China’s grain yield increased from 1 t hain 1961 to 6 t hain 2015, while successfully feeding not only its large population but also supplying agricultural products all over the world. These achievements were greatly supported by modern technology and distinct governmental policy. However, China’s grain production has been causing a number of problems mainly related to declining natural resources and a lack of environmental protection. Due to the growing population and changing dietary requirements, increasing food production must be achieved by increasing resource use efficiency while minimizing environmental costs. We propose two novel development pathways that can potentially sustain agricultural crop production in the next few decades:(i) enhancing nutrient use efficiency with zero increase in chemical fertilizer input until 2020 and(ii) concurrently increasing grain yield and nutrient use efficiency for sustainable intensification with integrated nutrient management after 2020. This paper provides a perspective on further agricultural developments and challenges, and useful knowledge of our valuable experiences for other developing countries.

关键词： food security sustainable development agriculture grain production

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Application of Belgian endive(Cichorium intybus ***)dietary fiber concentrate to improve nutritional value and functional properties of plant-based burgers

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Food Bioscience 2022年第4期48卷 513-519页

作者： Anna Twarogowska Bart Van Droogenbroeck Ilse Fraeye Flanders Research Institute for Agriculture Fisheries and Food(ILVO)Technology and Food Science UnitBrusselsesteenweg 370BE-9090MelleBelgium Research Group for technology and Quality of Animal products Department M2SLeuven Food Science and Nutrition Research Centre(LFoRCe)KU Leuven Technology Campus GhentGebroeders De Smetstraat 19000GhentBelgium

Increasing consumer awareness of health and climate is being reflected in their dietary *** is reflected in the strong growth in the market for plant-based food,with plant-based burgers(PBB)being the most popular meat *** must be based on natural ingredients that increase nutritional value,improve technological properties,and create satisfying physical *** obtained from agri-food by-products can potentially meet all of these *** dietary fiber concentrate(DFC)produced from the forced roots of Belgian endive(Cichorium intybus ***)(by-product)has shown potential for application in *** soy protein with 5%and 10%of DFC from Belgian endive(DFC-BE)resulted in lower caloric value and sugar content and doubled dietary fiber concentration in the end product,enough to justify a“high fiber”nutrition claim(>6 g per 100 g).Baking properties such as baking yield,moisture retention,and dimeter reduction also *** of DFC-BE can also be used to regulate pH,color,texture profile,and sensory *** recipes must be adjusted to obtain the required results.

关键词： Belgian endive Cichorium intybus plant-based food Dietary fiber concentrates Functional properties

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Krill oil activates NRF2 to prevent diabetic endothelial injury in part through astaxanthin-induced inhibition of KEAP1

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Food Science and Human Wellness 2024年

作者： Huali Meng Xiaoli Huang Jian Zhou Yan Zheng Lei Du Hui Li Zhiyue Zhang Linlin Xu Hao Wu department of nutrition and Food hygiene， School of Public Health， Cheeloo College of Medicine， Shandong University Research Center of Translational Medicine， Jinan Central Hospital， Shandong University department of nutrition， Qilu Hospital， Cheeloo College of Medicine， Shandong University Medical Center of Gastrointestinal Surgery， Weifang People's Hospital NMPA Key Laboratory for technology Research and Evaluation of Drug products， Key Laboratory of Chemical Biology (Ministry of Education)， department of Pharmaceutics， School of Pharmaceutical Sciences， Cheeloo College of Medicine， Shandong University department of Neurology， The Second Hospital， Cheeloo College of Medicine， Shandong University

Objective: Diabetes mellitus (DM) is a severe chronic disease that results in high morbidity and mortality. DM causes endothelial injury， such as endothelial inflammation， oxidative stress and dysfunction， as a basis for cardiovascular complications of DM. Therefore， blockage of DM-induced endothelial injury (DEI) is a viable strategy for the prevention of DM-caused adverse outcomes. However， few effective approaches have been developed for the intervention of DEI. Krill oil (KO) has been reported to have anti-inflammatory and anti-oxidative activities， but its effect on DEI is unknown. Hence， the aims of this study were to investigate the effect and molecular mechanism of KO on ***: To investigated the preventive effect of krill oil (KO) on DEI， streptozotocin and high-fat diet-induced mice model of type 2 DM were fed with KO for 6months. RNA sequencing for endothelial cells (ECs) was used to explore the mechanism of KO’s protective function. To clarify the role of NRF2 signaling in KO’s protective function on DEI， KO was given to Nfe2l2 gene-silenced ECs or knockout mice. Molecular docking assay and surface plasmon resonance assay were carried out to reveal the ability of the main components of KO to bind KEAP1. Results: KO significantly alleviated DEI and aortic pathological injury in the wild-type diabetic mice. RNA sequencing revealed that KO dramatically activated nuclear factor erythroid 2-related factor 2 (Nfe2l2/NRF2) antioxidant signaling in high glucose-challenged ECs， the effect of which was further confirmed in the diabetic aortas. Nfe2l2 gene deletion or silencing completely abolished KO’s protection against DEI in vivo and in vitro， demonstrating that NRF2 was required for KO’s action. Further， molecular docking assay and surface plasmon resonance assay identified that KO’s functional component astaxanthin (AST)， but not docosahexaenoic acid and eicosapentaenoic acid， was able to bind the Kelch domain of Kelch like ECH associated protein 1 (KE

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Palmitoleic acid on top of HFD ameliorates insulin resistance independent of diacylglycerols and alters gut microbiota in C57BL/6J mice

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Food Science and Human Wellness 2024年第2期13卷 856-868页

作者： Qijian Liang Yan Zheng Fanli Meng Xiaofan Jiang Qingcai Zhen Zhongting Lu Shixiu Zhang Lei Du Hao Wu Xin Guo department of nutrition and Food hygiene School of Public HealthCheeloo College of MedicineShandong UniversityJinan 250012China Research Center of Translational Medicine Jinan Central Hospital Affiliated to Shandong First Medical UniversityJinan 250013China department of Hepatology Qilu Hospital of Shandong UniversityJinan 250012China Institute of Hepatology Shandong UniversityJinan 250012China

With the prevalence of obesity and obesity-related metabolic syndrome,such as insulin resistance in recent years,it is urgent to explore effective interventions to prevent the progression of obesity-related metabolic *** acid is a monounsaturated fatty acid that is available from dietary sources,mainly derived from marine products.P almitoleic acid plays a positive role in maintaining glucose homeostasis and reducing ***,it is still unknow the mechanism of palmitoleic acid in ameliorating insulin ***,we investigated the effects of palmitoleic acid on chow diet(CD)-fed and high-fat diet(HFD)-fed mice,which were fed CD or HFD for 12 weeks before *** administrated mice with BSA(control),oleic acid,or palmitoleic acid for 6 weeks on top of CD or HFD *** found that palmitoleic acid only improved glucose homeostasis in HFD-fed obese mice by increasing glucose clearance and reducing *** study explored that palmitoleic acid changed the composition of gut microbiota by decreasing Firmicutes population and increasing Bacteroidetes *** colon,palmitoleic acid increased intestinal tight junction integrity and reduced ***,palmitoleic acid decreased macrophage infiltration in liver and adipose tissue and increase glucose uptake in adipose ***(DAG)in tissue(for example,liver)is found to positively correlated with *** enhanced the levels of DAGs in liver but not in adipose tissue in this *** acid did not reverse the high DAG levels induced by HFD in ***,in HFD-fed mice,palmitoleic acid reduced insulin resistance by an independent-manner of *** might be associated with the beneficial effects of palmitoleic acid on altering the gut microbiota composition,improving of intestinal barrier function,and downregulating the inflammation in colon,liver,and adipose tissue.

关键词： Palmitoleic acid High fat diet Insulin resistance Gut microbiota

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Microbial community dynamics during composting of animal manures contaminated with arsenic,copper,and oxytetracycline

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Journal of Integrative Agriculture 2021年第6期20卷 1649-1659页

作者： Ebrahim SHEHATA CHENG Deng-miao MA Qian-qian LI Yan-li LIU Yuan-wang FENG Yao JI Zhen-yu LI Zhao-jun Key Laboratory of plant nutrition and Fertilizer Ministry of Agriculture and Rural Affairs/China-New Zealand Joint Laboratory for Soil Molecular EcologyInstitute of Agricultural Resources and Regional PlanningChinese Academy of Agricultural SciencesBeijing 100081P.R.China department of Natural Resources and Agricultural Engineering College of AgricultureDamanhour UniversityDamanhour 22511Egypt Research Center for Eco-Environmental Engineering Dongguan University of TechnologyDongguan 523808P.R.China

Effects of the heavy metal copper(Cu), the metalloid arsenic(As), and the antibiotic oxytetracycline(OTC) on bacterial community structure and diversity during cow and pig manure composting were investigated. Eight treatments were applied, four to each manure type, namely cow manure with:(1) no additives(control),(2) addition of heavy metal and metalloid,(3) addition of OTC and(4) addition of OTC with heavy metal and metalloid;and pig manure with:(5) no additives(control),(6) addition of heavy metal and metalloid,(7) addition of OTC and(8) addition of OTC with heavy metal and metalloid. After 35 days of composting, according to the alpha diversity indices, the combination treatment(OTC with heavy metal and metalloid) in pig manure was less harmful to microbial diversity than the control or heavy metal and metalloid treatments. In cow manure, the treatment with heavy metal and metalloid was the most harmful to the microbial community, followed by the combination and OTC treatments. The OTC and combination treatments had negative effects on the relative abundance of microbes in cow manure composts. The dominant phyla in both manure composts included Actinobacteria, Bacteroidetes, Firmicutes, and Proteobacteria. The microbial diversity relative abundance transformation was dependent on the composting time. Redundancy analysis(RDA) revealed that environmental parameters had the most influence on the bacterial communities. In conclusion, the composting process is the most sustainable technology for reducing heavy metal and metalloid impacts and antibiotic contamination in cow and pig manure. The physicochemical property variations in the manures had a significant effect on the microbial community during the composting process. This study provides an improved understanding of bacterial community composition and its changes during the composting process.

关键词： composting heavy metal and metalloid oxytetracycline microbial community principle component analysis redundancy analysis

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Effects of the substitution of cow’s milk with soymilk on the micronutrients,microbial,and sensory qualities of yoghurt

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Food Production, Processing and nutrition 2022年第1期4卷 162-171页

作者： Dupe T.Otolowo Omolola M.Omosebi Kudirat T.Araoye Temiloluwa E.Ernest Oluwatooyin F.Osundahunsi department of Food Science and technology Mountain Top UniversityPrayer CityNigeria department of Food Science and technology Wesley University OndoOndoNigeria department of Food Science and technology Federal University of Oye-EkitiOye-EkitiNigeria department of Food Science and technology Federal University of TechnologyAkureNigeria

The consumption of imported dairy products is high especially in developing countries including Nigeria where little or no milk is produced locally which makes the products expensive,out of reach to common consumers and also inconvenient for lactose intolerance and ***,as plant-based milk was substituted for cow’s milk in parts and in whole for the production of yoghurt and the effect of substitution was evaluated on the minerals,vitamins,microbial,and sensory properties of the products using the established *** differences(pproducts for *** showed the positive effect of substituting soymilk for cow’s milk at all the levels used,thus,the lactose intolerance and vegans can find alternative to dairy yoghurt in the 100%soymilk substitution and enjoy the functional health benefits of ***,the total dependence on importation of dairy milk and cost of production of composited milk yoghurt could be reduced to improve the nation’s economy and make the product economically accessible to common man.

关键词： Cow’s milk Soymilk Yoghurt Mineral and vitamin contents Microbial quality Sensory acceptability

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Chemical Quality Indexes of Mullet (<i>Mugil platanus</i>) Stored on Ice

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Food and nutrition Sciences 2014年第11期5卷 1030-1039页

作者： Sabrina da Costa Silva Andrade Eliane Teixeira Mársico Ronoel Luiz de Oliveira Godoy Sidney Pacheco Robson Maia Franco Sérgio Borges Mano Carlos Adam Conte-Junior department of Food technology UFF Niterói Brazil Embrapa Food Agroindustry Rio de Janeiro Brazil Graduation Program in Veterinary hygiene and Technological Process of products of Animal Origin Fluminense Federal University Niterói Brazil

The present study was conducted aiming at establishing chemical quality parameters to assess ice stored mullet (0℃ ± 1℃) through the evaluation of nucleotide (adenosine monophosphate [AMP], inosine [HxR] and hypoxanthine [Hx]) degradation, biogenic amine (histamine [HI], putrescine [PU], cadaverine [CA] and tyramine [TI]) quantification and mesophilic and psychrotrophic bacteria count monitoring. The microbial load of 7 log CFU·g–1 established as maximum acceptable limit was attained after the 20th day of ice storage. IMP concentration declined during the storage period to levels below the detection limit. HxR content increased only up to time T3 and then declined. Hx level increased during all the storage period. CA and HI content increase was not observed, on the other hand, PU and TI contents significantly increased (p < 0.05) at time T5. We concluded that IMP and Hx concentrations can be adequate parameters to assess mullet quality under the study conditions. HxR proved to be adequate to evaluate the freshness of mullet in the first days of storage while the amines, PU and TI, can be used to assess loss of quality. Mullet obtained in conditions similar to those of the present study and maintained at 0℃ ± 1℃ can be consumed up to the 20th storage day.

关键词： Quality Parameters Biogenic Amines Nucleotides Hypoxanthine Mugilidae

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Ginsenoside compound-K attenuates OVX-induced osteoporosis via the suppression of RANKL-induced osteoclastogenesis and oxidative stress

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Natural products and Bioprospecting 2023年第1期13卷 159-170页

作者： Lingli Ding Zhao Gao Siluo Wu Chen Chen Yamei Liu Min Wang Yage Zhang Ling Li Hong Zou Guoping Zhao Shengnan Qin Liangliang Xu Key Laboratory of Orthopaedics and Traumatology Lingnan Medical Research CenterThe First Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou University of Chinese MedicineGuangzhouChina Er Sha Sports Training Center of Guangdong Province GuangzhouChina School of Basic Medical Science Guangzhou University of Chinese MedicineGuangzhouChina Engineering Laboratory for nutrition Shanghai Institute of Nutrition and HealthChinese Academy of SciencesShanghaiChina Master Lab for Innovative Application of Nature products National Center of Technology Innovation for Synthetic BiologyTianjin Institute of Industrial BiotechnologyChinese Academy of SciencesTianjinChina CAS Key Laboratory of Quantitative Engineering Biology Shenzhen Institute of Synthetic BiologyShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhenChina CAS-Key Laboratory of Synthetic Biology CAS Center for Excellence in Molecular Plant SciencesShanghai Institute of Plant Physiology and EcologyChinese Academy of SciencesShanghaiChina Bio-Med Big Data Center Shanghai Institute of Nutrition and HealthChinese Academy of SciencesShanghaiChina State Key Laboratory of Genetic Engineering Department of Microbiology and ImmunologySchool of Life SciencesFudan UniversityShanghaiChina department of Microbiology The Chinese University of Hong KongHong KongChina department of Orthopaedics Guangzhou Institute of Traumatic SurgeryGuangzhou Red Cross HospitalMedical CollegeJinan UniversityGuangzhouChina

Osteoporosis(OP),a systemic and chronic bone disease,is distinguished by low bone mass and destruction of bone *** Compound-K(CK),one of the metabolites of ginsenoside Rb1,has anti-aging,anti-inflammatory,anti-cancer,and hypolipidemic *** have demonstrated CK could promote osteogenesis and fracture healing in our previous ***,the contribution of CK to osteoporosis has not been *** the present study,we investigated the effect of CK on osteoclastogenesis and ovariectomy(OVX)-induced *** results showed that CK inhibited receptor activator for nuclear factor-κB ligand(RANKL)-mediated osteoclast differentiation and reactive oxygen species(ROS)activity by inhibiting the phosphorylation of NF-κB p65 and oxidative stress in RAW264.7 *** addition,we also demonstrated that CK could inhibit bone resorption using bone marrow-derived ***,we demonstrated that CK attenuated bone loss by suppressing the activity of osteoclast and alleviating oxidative stress in *** together,these results showed CK could inhibit osteoclastogenesis and prevent OVX-induced bone loss by inhibiting NF-κB signaling pathway.

关键词： Ginsenoside CK NF-κB signaling pathway Osteoporosis Oxidative stress

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