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Journal of Energy Chemistry 2025年第1期100卷 509-521页

作者： Xinyuan Wang Fan Zhang Xingyu Zhou Qian Wang Changyu Liu Yangyang Liu Hui Wang Xiaojie Liu Key Laboratory of Synthetic and natural Functional Molecule of the Ministry of Education College of Chemistry & Materials Science Northwest University

Na3V2（PO4）2O2F （VP） is recognized as a promising cathode material for sodium-ion batteries due to its stable structural framework and high specific *** functional theory （DFT） and finite element simulations show that incorporating SO42-into VP decreases its band gap,lowers the migration energy barrier,and ensures a uniform Na+concentration gradient and stress distribution during charge and discharge ***,the average Na+diffusion coefficient of Na3V2（PO4）1.95（SO4）0.05O2F（VPS-1） is roughly double that of VP,leading to enhanced rate capability (80 C,75.5 mAh g-1) and cycling stability (111.0 mAh g-1capacity after 1000 cycles at 10 C current density) for ***-1 exhibits outstanding fast-charging capabilities,achieving an 80%state of charge in just 8.1 *** assembled VPS-1//SbSn/NPC full cell demonstrated stable cycling over 200 cycles at a high 5 C current,maintaining an average coulombic efficiency of 95.35%.

关键词： Anionic group modulation Polarization behavior Fast-charging Sodium-ion battery Fluorophosphate Cathode

Delonix regia： historic perspectives and modern phytochemical and pharmacological researches

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Chinese Journal of natural Medicines 2016年第1期14卷 31-39页

作者： Anuj Modi Vijay Mishra Ajita Bhatt Aviral Jain Mohd. Hashim Mansoori Ekta Gurnany Vimal Kumar department of Pharmacognosy ADINA Institute of Pharmaceutical Sciences Sagar 470001 India ADINA Institute of Pharmaceutical Sciences Sagar 470001 India department of phytopharmaceutical and natural product Institute of Pharmacy Nirma University Ahemdabad 382481 India

Delonix regia （Bojer ex Hook） Raffin （Fabaceae）, also known as flame of forest, is a semi-deciduous tree, distributed throughout Madagascar, India, Africa, and Northern Australia. Various parts of the plant are traditionally used for the treatment of different ailments such as inflammation, rheumatism, bronchitis, diabetes, anemia, fever, gynecological disorders, and pneumonia. The plant possess antioxidant, hepatoprotective, gastroprotective, wound healing, antiarthritic, larvicidal, antimalarial, antiemefic, antibacterial, antifungal, antiinflammatory, analgesic, antidiarrhoeal, antiheamolytic, diuretic, and anthelmintic activities. This review is an up-to-date compilation on its traditional uses in context to phytochemical and pharmacological perspectives.

关键词： Delonix regia Fabaceae Phytochemistry Pharmacology

Targeting harmful effects of non-excitatory amino acids as an alternative therapeutic strategy to reduce ischemic damage

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Neural Regeneration Research 2025年第9期20卷 2454-2463页

作者： Victoria Jiménez Carretero IrisÁlvarez-Merz Jorge Hernández-Campano Sergei A.Kirov Jesús M.Hernández-Guijo department of Pharmacology and Therapeutic School of MedicineUniv.Autónoma de MadridMadridSpain Ramón y Cajal Institute for Health Research(IRYCIS) Neurobiology-Research ServiceHospital Ramón y CajalMadridSpain Institute of Neurobiology Faculty of Mathematics and Natural SciencesHeinrich Heine University DüsseldorfDüsseldorfGermany department of Neuroscience and Regenerative Medicine&department of Neurosurgery Medical College of Georgia at Augusta UniversityAugustaGAUSA

The involvement of the excitatory amino acids glutamate and aspartate in ce rebral ischemia and excitotoxicity is ***,the role of non-excitatory amino acids in brain damage following a stroke or brain trauma remains largely *** release of amino acids by necrotic cells in the ischemic core may contribute to the expansion of the *** findings indicated that the reversible loss of field excitato ry postsynaptic potentials caused by transient hypoxia became irreversible when exposed to a mixture of just four non-excitatory amino acids(L-alanine,glycine,L-glutamine,and L-serine)at their plasma *** amino acids induce swelling in the somas of neurons and astrocytes during hypoxia,along with permanent dendritic damage mediated by N-methyl-D-aspartate *** N-methyl-D-aspartate receptors prevented neuronal damage in the presence of these amino acids during *** is likely that astroglial swelling caused by the accumulation of these amino acids via the alanine-serine-cysteine transporter 2 exchanger and system N transporters activates volume-regulated anion channels,leading to the release of excitotoxins and subsequent neuronal damage through N-methyl-D-aspartate receptor ***,previously unrecognized mechanisms involving non-excitatory amino acids may contribute to the progression and expansion of brain injury in neurological emergencies such as stroke and traumatic brain *** these pathways co uld highlight new therapeutic targets to mitigate brain injury.

关键词： cell swelling N-methyl-D-aspartate receptor non-excitatory amino acids stroke synaptic transmission

利用激发态分子内质子转移的烯醇式/酮式发射:开发机械变色,多通道成像和检测化学战剂模拟物的材料（英文）

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Science China Materials 2025年

作者：王康敏张敏杨丹妮万立秋张守鑫颜亮杨科李必进 Chongqing Key Laboratory of natural product Synthesis and Drug Research School of Pharmaceutical Sciences & Department of Medical LaboratoryShapingba Hospital Affiliated to Chongqing University Chongqing University State Key Laboratory of NBC Protection for Civilian Jiangsu Key Laboratory of Advanced Catalytic Materials & Technology School of Petrochemical Engineering Changzhou University

本文首次发展了只有烯醇式发射三苯胺单取代的2-(2′-羟基苯基)唑类机械变色材料;获得了压致变色中对应初始状态、中间状态和研磨后状态的三种不同的单晶.合成的双三苯胺取代的2-(2′-羟基苯基)唑具有烯醇式/酮式双发射的特性,可用于多...

本文首次发展了只有烯醇式发射三苯胺单取代的2-(2′-羟基苯基)唑类机械变色材料;获得了压致变色中对应初始状态、中间状态和研磨后状态的三种不同的单晶.合成的双三苯胺取代的2-(2′-羟基苯基)唑具有烯醇式/酮式双发射的特性,可用于多通道成像,可选择性的富集于活细胞的线粒体.此外,我们开发了可用于化学战剂模拟物氯磷酸二乙酯(DCP)检测的具有烯醇式发射或双发射的激发态分子内质子转移(ESIPT)材料;该类材料在检测中表现出良好的选择性、高灵敏度和快速响应性.

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Diverse Ring-seco Limonoids from Munronia unifoliolata and Their Biological Activities

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Chinese Journal of Chemistry 2022年第1期40卷 123-136页

作者： Yunpeng Sun Qiurong Li Letian Cui Pengfei Tang Yongyi Li Lingyi Kong Jun Luo Jiangsu Key Laboratory of Bioactive natural product Research State Key Laboratory of Natural MedicinesDepartment of Natural Medicinal ChemistryChina Pharmaceutical UniversityNanjingJiangsu 210009China

Twenty-two new limonoids,mufolinoids A—V(1—22),including six rings A,B-seco limonoids(1—6),twelve ring A-seco limonoids(7—18),four ring-intact limonoids(19—22),together with thirteen known compounds(23—35)were isolated from Munronia *** structures including absolute configurations were elucidated by combination of NMR,HR-MS,single-crystal X-ray diffraction and calculations of ECD and NMR *** 24,25,33,34 could be significantly reversed the multidrug resistance of MCF-7/doxorubicin(DOX)cells,and the reversal fold(RF)was much higher than that of positive drug *** 24,28,and 29 exhibited significant anti-inflammatory activity with the IC50 values in the range of 17.7—39.4μmol/***,compound 29 could markedly inhibit the release of IL-1βby inhibiting the initiation and assembly of NLRP3 inflammasome,which demonstrates the great potential of limonoids as an anti-inflammatory agent.

关键词： Munronia unifoliolata Limonoids Structure elucidation Inflammatory natural products

Novel and efficient supramolecular synthesis of pyrroles in the presence of β-cyclodextrin in water

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Chinese Chemical Letters 2012年第12期23卷 1331-1334页

作者： K.Ramesh K.Karnakar G.Satish Y.V.D.Nageswar CSIR-natural product Chemistry Indian Institute of Chemical Technology

A simple and efficient synthesis of highly substituted pyrroles was achieved in water medium via multi-component strategy, using amine, DMAD/DEAD as well as phenacyl bromide catalyzed by β-CD. Utilizing this protocol... 详细信息

关键词： Amine DMAD/DEAD Phenacyl bromide Water Recyclability β-Cyclodextrin

Two natural molecules preferentially inhibit azole-resistant Candida albicans with MDR1 hyperactivation

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Chinese Journal of natural Medicines 2019年第3期17卷 209-217页

作者： SHI Hong-Zhuo CHANG Wen-Qiang ZHANG Ming LOU Hong-Xiang department of natural product Chemistry Key Laboratory of Chemical Biology of Ministry of Education School of Pharmaceutical Sciences Shandong University

Antifungal drug resistance is a significant clinical problem, and antifungal agents that can evade resistance are urgently needed. In infective niches, resistant organisms often co-existed with sensitive ones, or a subpopulation of antibiotic-susceptible organisms may evolve into resistant ones during antibiotic treatment and eventually dominate the whole population. In this study, we established a co-culture assay in which an azole-resistant Candida albicans strain was mixed with a susceptible strain labeled with green fluorescent protein to mimic in vivo conditions and screen for antifungal drugs. Fluconazole was used as a positive control to verify the validity of this co-culture assay. Five natural molecules exhibited antifungal activity against both susceptible and resistant C. albicans. Two of these compounds, retigeric acid B(RAB) and riccardin D(RD), preferentially inhibited C. albicans strains in which the efflux pump MDR1 was activated. This selectivity was attributed to greater intracellular accumulation of the drugs in the resistant strains. Changes in sterol and lipid compositions were observed in the resistant strains compared to the susceptible strain, and might increase cell permeability to RAB and RD. In addition, RAB and RD interfered with the sterol pathway, further aggregating the decrease in ergosterol in the sterol synthesis pathway in the MDR1-activated strains. Our findings here provide an alternative for combating resistant pathogenic fungi.

关键词： Candida albicans MDR1 Azole resistance Co-culture

Effect of La,Ce on Taxus Cuspidata Cell Growth,Biosynthesis and Release of Taxol

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Journal of Rare Earths 1998年第4期16卷 61-67页

作者：元英进胡国武王传贵景莹申泮文 department of Chemical Engineering and natural product Institute of Biochemical Engineering Tianjin University Tianjin 300072 China department of Chemistry Nankai University Tianjin 300071 China

The effect of La, Ce was firstly tested on growth of the Taxus(T.) cuspidata cell suspensions, biosynthesis and release of taxol. The results indicate that the growth pattern of *** cells is altered significantly by adding high concentration of rare earth in the medium. The lag and exponential phases of cell growth are shortened, the stationary phase disappears and the biomass fluctuates periodically during the decline phase. The rare earth compounds added in the exponential phase obviously increase the taxol biosyntheis and release yields of *** cells, and the supplement of carbon source in the medium containing rare earth is also favorable to taxol biosynthesis.

关键词： Rare earths Lathanum Cerium Taxol Cell suspension culture Taxus cuspidata

Endless exploration for natural products: dedicated to the 80th birthday of Prof. SUN Han-Dong

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Chinese Journal of natural Medicines 2019年第12期17卷 881-882页

作者： KONG Ling-Yi Chinese Journal of natural Medicines Jiangsu Key Laboratory of Bioactive natural product Research and State Key Laboratory of natural Medicines Department of Natural Medicinal Chemistry China Pharmaceutical University

natural products always exhibit more intellectual bioactivities and atom economy,and it’s also an important source of innovative *** Han-Dong,Academician of Chinese Academy of Sciences from Kunming Institute of Botany,has made outstanding contributions to natural product chemistry,andsetagoodexamplefor *** occasion ofProfSun’s 80th birthday,I’d like to express my deep respect to him,and wish *** a happy birthday and good health.

关键词： Academician birthday drugs

Design and synthesis of antiviral pseudo-natural products through effective one-step acylmethylation macrocyclization

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Chinese Journal of natural Medicines 2023年第10期21卷 721-722页

作者： LI Shang WANG Xiaobing Jiangsu Key Laboratory of Bioactive natural product Research Department of Natural Medicinal ChemistryChina Pharmaceutical UniversityNanjing 210009China

Influenza virus poses a significant threat to global public health,causing serious repercussions on human life and social *** the past decades,various antiviral drugs targeting either the virus itself or its host were ***,the emergence of drug-resistant influenza virus strains has posed a critical challenge to the effectiveness of these existing anti-influenza agents .Consequently,there is an urgent need to develop novel molecules with new chemical *** natural products serve as a crucial resource for validating targets and discovering lead ***,the number of naturlly crring macrocyclic natural products is limited due to inherent biosynthetic pathways,which restricts the development of macrocyclic *** contrast,artificially synthesized pseudonatural products show enhanced availability and greater structural diversity,while possessing similar biological functions[5]and have attracted significant interest from medicinal ***,it is valuable to develop effective synthetic methods to expedite the discovery of macrocyclic lead compounds.

关键词： natural products C-H activation Macrocyclization H1N1 inhibitors