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Strengths,weaknesses,opportunities,and threats analysis of combination therapy for inflammatory bowel disease

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World Journal of Gastroenterology 2025年第9期31卷 176-182页

作者： Jia-Wang Yan Mei Nie Hang Zhang Yan-Miao Liu Fu-Shan Tang department of Clinical Pharmacy Zunyi Medical UniversityZunyi 563006Guizhou ProvinceChina Key Laboratory of Basic Pharmacology of Ministry of Education and Joint International Research Laboratory of Ethnomedicine of Ministry of Education Zunyi Medical UniversityZunyi 563006Guizhou ProvinceChina Key Laboratory of Basic Pharmacology of guizhou Province and School of Pharmacy Zunyi Medical UniversityZunyi 563006Guizhou ProvinceChina The First Clinical Institute Zunyi Medical UniversityZunyi 563006Guizhou ProvinceChina

Inflammatory bowel disease(IBD),encompassing Crohn’s disease and ulcerative colitis,manifests as a chronic,recurrent,and refractory intestinal inflammatory condition significantly impacting patients’quality of *** ongoing research,its etiology and pathogenesis remain incompletely *** advancements in medical research highlight the critical role of drug combination therapies in managing *** paper employs the strengths,weaknesses,opportunities,and threats framework to evaluate the four strategic elements(strengths,weaknesses,opportunities,and threats)pertaining to combination therapies for *** the strengths,the paper underscores the efficacy of multi-targeted strategies,the advancement of personalized medicine,and the mitigation of drug ***,the analysis identifies significant weaknesses,including the prohibitive cost of treatment,issues with patient compliance,and the necessity for comprehensive long-term safety *** paper also delineates opportunities to augment therapeutic success through the incorporation of biomarkers,the application of artificial intelligence,and extensive international collaborative *** contrast,the paper does not shy away from addressing the threats,which include the potential for therapeutic resistance and the logistical challenges inherent in global therapy *** initiatives aim to refine future therapeutic practices,fostering safer,more effective,and personalized treatment paradigms for IBD patients.

关键词： Inflammatory bowel disease Ulcerative colitis Crohn’s disease Combination therapy Strengths,weaknesses,opportunities,threats analysis

Holographic thermodynamics of a charged AdS black hole with a global monopole

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Communications in Theoretical physics 2025年第2期77卷 148-160页

作者： Hebin Zheng Yunxian Chen Jian Tang School of physics and Astronomy China West Normal University department of physics and Electronic Science Aba Teachers College

By regarding the Newton constant GNand cosmological constant Λ as variables, in this paper we study the thermodynamics and phase transition of the Reissner-Nordstr o m anti-de Sitter(RN-Ad S) black hole with a global monopole within the framework of Ad S/CFT correspondence. We find interesting critical phenomena and phase behavior in the(grand)canonical ensembles of fixed( Q,V,C),( Φ,V,C) and( Q,V,μ). When the other parameters are fixed, the free energy decreases with the global monopole increases. In the( Q,V,C) ensemble,the range of the unstable region decreases with the increase of the global monopole. In the( Φ,V,C) ensemble, when Φ < Φc, the free energy appears as two branches, where the upper and lower branches correspond to low and high entropy, respectively. When( Q,V,μ) is fixed, a new zero-order phase transition occurs in the high-entropy phase and the low-entropy phase at certainμ-dependent temperatures. When μ increases to a certain value, this zero-order phase transition disappears. This certain value is negatively related to the magnitude of the global ***, we find that p-V criticality does not appear with the change of global ***, it is important to note that the CFT states of charged black holes with global monopoles do not correspond to van der Waals fluids. Finally, we find that charged black holes with global monopoles can better reflect thermodynamic phase transitions and critical phenomena under the Ad S/CFT correspondence. By adjusting the change of the global monopole, the thermodynamic phase transition will also change.

关键词： black holes AdS-CFT correspondence global monopole

CMOS direct conversion X-ray detector coupled with fluorinated liquid

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Nuclear Science and Techniques 2025年第1期36卷 59-68页

作者： Shi-Hua Liu Chao-Song Gao Xin Zhang Xiang-Ming Sun Meng Wu Zhi-Hui Han Tong Wan Yong-Shuai Ge Key Laboratory of Quark&Lepton physics(MOE) Central China Normal UniversityWuhan 430079China guizhou Education university Guiyang 550018China Research Center for Medical Artificial Intelligence Chinese Academy of SciencesShenzhen Institutes of Advanced TechnologyShenzhen 518055China

X-ray detectors show potential applications in medical imaging,materials science,and nuclear *** achieve high detection efficiency and spatial resolution,many conventional semiconductor materials,such as amorphous selenium,cadmium telluride zinc,and perovskites,have been utilized in direct conversion X-ray ***,these semiconductor materials are susceptible to temperature-induced performance degradation,crystallization,delamination,uneven lattice growth,radiation damage,and high dark *** study explores a new approach by coupling an FC40 electronic fluorinated liquid with a specialized high-resolution and high-readout-speed complementary metal-oxide-semiconductor(CMOS)pixel array,specifically the Topmetal II−chip,to fabricate a direct conversion X-ray *** fluorinated liquid FC40(molecular formula:C_(21)F_(48)N_(2))is an electronic medium that is minimally affected by temperature and displays no issues with uniform *** exhibits a low dark current and minimal radiation damage and enables customizable thickness in X-ray *** addresses the limitations inherent in conventional semiconductor-based *** this study,simple X-ray detector imaging tests were conducted,demonstrating the excellent coupling capability between FC40 electronic fluorinated liquid and CMOS chips by the X-ray detector.A spatial resolution of 4.0 lp/mm was measured using a striped line par card,and a relatively clear image of a cockroach was displayed in the digital radiography imaging *** test results indicated the feasibility of fabricating an X-ray detector by combining FC40 electronic fluorinated liquid and CMOS *** to the absence of issues related to chip-material coupling,a high spatial resolution could be achieved by reducing the chip pixel *** method presents a new avenue for studies on novel liquid-based direct conversion X-ray detectors.

关键词： FC40 electronic fluorinated liquid CMOS pixel chip X-ray detector Spatial resolution

New Taub-NUT black holes with massive spin-2 hair

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Science China(physics,Mechanics & Astronomy) 2025年第2期68卷 51-58页

作者： Yu-Qi Chen Hai-Shan Liu Center for Joint Quantum Studies and department of physics School of ScienceTianjin UniversityTianjin 300350China

We consider Einstein gravity extended with quadratic curvature invariants,within which the well-known Ricci-flat Taub-NUT black hole remains a *** analysis of the unstable Lichnerowicz modes in the Taub-NUT background enables us to identify the mass and NUT parameters(m,n)where new Taub-NUT black holes can *** then adopt numerical techniques to construct these new Taub-NUT black holes,which bifurcate away from the Ricci-flat *** the Ricci-flat Taub-NUT,there can exist two new black holes for an appropriate given temperature,making it a total of three if we include the Ricci-flat one.

关键词： higher derivative gravity black hole solution Taub-NUT spacetime

Synergistic effects of constituents in rare earth-based composites:Enhanced structural,electrical and magnetic properties for water splitting applications

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Journal of Rare Earths 2025年第1期43卷 105-114,I0005页

作者： Chitralekha S.Shankar A.P.Singh Functional Materials Research Laboratory Department of PhysicsARSD CollegeUniversity of Delhi1021India department of physics Multanimal Modi CollegeCh.Charan Singh UniversityMeerutU.PIndia

Rare earth-based Bi_(0.85)La_(0.15)FeO_(3)(BLFO)and NdMnO_(3)(NMO)particles were synthesised using the solidstate route,and their roles affecting structural,electrical,magnetic properties along with hydroelectric application in different concentrations i.e.,(1-x)BLFO:xNMO(where x=0,0.10,0.20,0.30 and 1.0)ceramics composites were investigated.X-ray diffraction analyses confirm the pure-phase formation of BLFO:NMO composites,featuring micrometer-scale crystallite *** transform infrared(FT-IR)spectra of BLFO:NMO composites reveal peak shifts with rising NMO content,indicating composite *** composites exhibit robust Maxwell-Wagner polarization and a pronounced composition-dependent *** addition of NMO to BLFO results in a rise in dielectric permittivity at lower frequencies,confirming relaxor behavior and indicating success in achieving the transition *** spectroscopy facilitates a clearer understanding of how charge carriers contribute to these composites and the impact of grain/grain *** saturation magnetization maximum value(i.e.,0.807 emu/g)was attained in *** coercivity decreases with the addition of NMO in *** results suggest the composite's enhanced suitability for microelectronics and hydropower cells,showing improved hydroelectric cell performance with increased NMO in BLFO,highlighting a notable ion diffusion mechanism.

关键词： Composites X-ray diffraction Relative permittivity Hydroelectric cell Rare earths

Investigation and study on the epidemiology of gestational diabetes mellitus in guizhou

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World Journal of Diabetes 2025年第2期16卷 55-70页

作者： Lin Dong Wei Zhong Tian Qiao Zhuo Wang Yi Liang Dan-Qing Zhao department of Obstetrics and Gynecology Guizhou Medical UniversityGuiyang 550000Guizhou ProvinceChina department of Clinical Nutrition Guizhou Medical UniversityGuiyang 550000Guizhou ProvinceChina

BACKGROUND Gestational diabetes mellitus(GDM)is a growing public health concern,particularly in regions with diverse ethnic *** the incidence and risk factors of GDM is crucial for early prevention and management,especially in underrepresented areas like guizhou Province,China,where geographic and ethnic diversity may influence the disease’s prevalence and risk *** To investigate the incidence of GDM and identify its associated risk and protective factors among different ethnic groups in guizhou Province,providing essential data for early prevention *** A multi-center retrospective study was conducted,dividing participants into GDM and non-GDM groups according to standardized diagnostic *** were collected from 103629 deliveries across 40 hospitals in *** demographic,clinical,and laboratory parameters were analyzed using logistic regression to identify risk and protective factors for *** Among the 103629 deliveries,18957 cases of GDM were identified,with an incidence of approximately 18.3%.The risk of GDM was higher in the Han ethnic group compared to minority ethnic *** Dong ethnic group had the lowest incidence among the *** risk factors identified included older age(especially>35 years),higher pre-pregnancy body mass index(BMI),light physical activity,gravidity,family history of diabetes,hemoglobin,aspartate aminotransferase,alanine aminotransferase,and direct *** factors included higher education level,total protein,and *** were also differences based on blood type,with type A associated with higher *** The incidence rate in guizhou is 18.3%.Older age(especially>35 years),Han ethnicity,lower education level,higher pre-pregnancy BMI,light physical activity,and higher gravidity are the main risk factors for *** findings indicate that higher hemoglobin,higher liver function parameters(alanine aminotransferase,aspartate amino

关键词： guizhou Province Gestational diabetes mellitus Epidemiological investigation Risk factors Public health intervention

Octupole correlations in stable nucleus ^(153)Eu within reflection-asymmetric particle rotor model

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Chinese physics C 2025年第1期49卷 216-222页

作者： Yuanyuan Wang Shuangquan Zhang Mathematics and physics department North China Electric Power UniversityBeijing 102206China Hebei Key Laboratory of physics and Energy Technology North China Electric Power UniversityBaoding 071000China State Key Laboratory of Nuclear physics and Technology School of PhysicsPeking UniversityBeijing 100871China

The observed low-lying K=5/2^(±) positive-and negative-parity bands in the stable nucleus ^(153)Eu are investigated using the reflection-asymmetric triaxial particle rotor *** experimental energy spectra,energy staggering parameters,and intraband E2 and M1 transition probabilities are well *** calculated interband B(E1)values are found to depend sensitively on the octupole deformation parameter β_(30),although the energy spectra and intraband E2 and M1 transitions can be reproduced without the octupole degree of *** observed enhanced E1 transition probabilities can be reproduced with β_(30)=*** detailed analysis of the intrinsic wave functions shows these nearly degenerate positive-and negative-parity bands are built on two individual proton configurations,i.e.,dominated by πg_(7/2)[Ω=5/2]and πh_(11/2)[Ω=5/2],respectively,which differs from the parity doublet bands built on a single parity-mixed configuration.

关键词： octupole correlations parity doublet bands electromagnetic transitions reflection-asymmetric triaxial particle rotor model

Effective spin dynamics of spin-orbit coupled matter-wave solitons in optical lattices

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Communications in Theoretical physics 2025年第1期77卷 172-178页

作者： Kajal Krishna Dey Golam Ali Sekh department of physics Banwarilal Bhalotia CollegeAsansol-713303West BengalIndia department of physics Kazi Nazrul UniversityAsansol-713340West BengalIndia

We consider matter-wave solitons in spin-orbit coupled Bose-Einstein condensates embedded in an optical lattice and study the dynamics of the soliton within the framework of Gross-Pitaevskii *** express spin components of the soliton pair in terms of nonlinear Bloch equations and investigate the effective spin *** is seen that the effective magnetic field that appears in the Bloch equation is affected by optical lattices,and thus the optical lattice influences the precessional frequency of the spin *** make use of numerical approaches to investigate the dynamical behavior of density profiles and center-of-mass of the soliton pair in the presence of the optical *** is shown that the spin density is periodically varying due to flipping of spinors between the two *** amplitude of spin-flipping oscillation increases with lattice *** find that the system can also exhibit interesting nonlinear behavior for chosen values of *** present a fixed point analysis to study the effects of optical lattices on the nonlinear dynamics of the spin *** is seen that the optical lattice can act as a control parameter to change the dynamical behavior of the spin components from periodic to chaotic.

关键词： spin-orbit coupled Bose-Einstein condensates effective spin dynamics regular and chaotic dynamics

Production of ψ(4040),ψ(4160),and ψ(4415) mesons in strong interactions

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Chinese physics C 2025年第02期 121-140页

作者：徐胜男许晓明 department of physics Shanghai University

Using the inelastic scattering of charmed strange mesons by open-charm mesons in hadronic matter produced in Pb-Pb collisions at the Large Hadron Collider,we study the production of ψ(4040),ψ(4160),and ψ(4415)*** rate equations are established for inelastic *** scattering is caused by quark interchange in association with color interactions between all constituent pairs in different *** consider fifty-one reactions between charmed strange and open-charm *** cross sections for the reactions are obtained from a temperature-dependent interquark *** temperature dependence of the cross sections causes the contributions of the reactions to the production of ψ(4040),ψ(4160),and ψ(4415) to change with decreasing temperature during the evolution of hadronic *** central Pb-Pb collisions at ■=5.02 TeV,the master rate equations reveal that the number density of ψ(4040) is larger than that of ψ(4160),whose number density is larger than that of ψ(4415).

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