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A new interpretation and quantitative method for diplopia test： 304 cases of ocular motor nerve palsy for clinical test and verify

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International Journal of Ophthalmology(English edition) 2017年第11期10卷 1768-1770页

作者： Ling-Yun Zhou Tie-Juan Liu Xue-Mei Li Chang Su Xiao-Jie Ji Ming Zhao Ocular Motility Disorder treatment & rehabilitation Center Acupuncture Department the First Affiliated Hospital of Harbin Medical University Harbin 150001 HeilongjiangProvince China

We introduce a new interpretation and quantitative method for computerized diplopia test. By comparing this new method to the Hess screen test, we validate its applicability among 304 patients with ocular motor nerve palsy. This new method shows great assistant value as the Hess screen test in making accurate diagnosis and quantitative evaluation the severity of diplopia. Furthermore, it is more convenient and suitable for daily clinical use.

关键词： diplopia test interpreting and scoring method Hess charts ocular motor nerve palsy max angle of diplopia

Exogenous neural stem cell transplantation for cerebral ischemia

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Neural Regeneration Research 2019年第7期14卷 1129-1137页

作者： Ling-Yi Liao Benson Wui-Man Lau Dalinda Isabel Sánchez-Vidana Qiang Gao department of rehabilitation Medicine West China HospitalSichuan University department of rehabilitation Sciences The Hong Kong Polytechnic University

Cerebral ischemic injury is the main manifestation of stroke,and its incidence in stroke patients is 70–80%.Although ischemic stroke can be treated with tissue-type plasminogen activator,its time window of effectiveness is ***,the incidence of paralysis,hypoesthesia,aphasia,dysphagia,and cognitive impairment caused by cerebral ischemia is *** tissue regeneration can promote the recovery of the aforementioned *** stem cells can participate in the reconstruction of the damaged nervous system and promote the recovery of nervous function during self-repair of damaged brain *** stem cell transplantation for ischemic stroke has been a hot topic for more than 10 *** review discusses the treatment of ischemic stroke with neural stem cells,as well as the mechanisms of their involvement in stroke treatment.

关键词： nerve regeneration stem cell therapy neural stem cells cell transplantation ischemic stroke cerebral ischemia neuroplasticity functional recovery neural regeneration

Electro-acupuncture at Zusanli(ST 36) to improve lower extremity motor function in sensory disturbance patients with cerebral stroke A randomized controlled study of 240 cases

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Neural Regeneration Research 2009年第11期4卷 935-940页

作者： Weijun Gong Tong Zhang Lihua Cui YuqiYang Xinting Sun department of Neurological rehabilitation Beijing Boai Hospital China Rehabilitation Research Centre School of Rehabilitation MedicineCapital Medical University Beijing 100068 China

BACKGROUND： Studies have shown that sensory transduction is a way to introduce needle sensation. OBJECTIVE： To observe the influence of electro-acupuncture at the ＂Zusanll＂（ST 36） point on lower extremity motor function in various sensory disturbance patients with cerebral stroke. DESIGN, TIME AND SETTING： A randomized, controlled, clinical study was performed at the department of Neurological rehabilitation, China rehabilitation Research Centre from September 2006 to June 2008. PARTICIPANTS： Patients with first-time cerebral infarction or hemorrhage, or with a stroke history, but no neurodysfunction （single damage）, were selected for this study. The subjects were right-handed and disease state was stable. A total of 240 inpatients were randomly assigned to the following groups： electro-acupuncture （n = 124） and control （n = 116）. The two groups were further assigned into sub-groups： no sensory disturbance, superficial sensory disturbance, deep sensory disturbance, and deep and superficial sensory disturbance. METHODS： On the basis of routine limb function training, the acupoint Zusanliwas utilized in all patients from the electro-acupuncture group. Perpendicular acupuncture was 3.0-4.0 cm deep. An electric acupuncture instrument was connected when patients developed the needle sensation, deqi. A stimulation pattern consisting of distant and dense waves of 50 Hz was used to elicit slight dorsal foot extension. Acupuncture was administered 5 times per week, 30 minutes per session, for 6 weeks in total. MAIN OUTCOME MEASURES： FugI-Meyer assessment （FMA） was used to evaluate lower extremity motor function; Ver.1.0 gait analysis to estimate gait （step frequency, step speed, and step scope）; lower extremity Composite Spasticity Scale （CSS） to estimate muscle spastic degree. RESULTS： Following treatment, motor function improved in both groups. Compared with the control group, FMA score, step speed, step frequency, and step scope were increased in the electro-acupuncture

关键词： electro-acupuncture Zusanli (ST 36) sensory disturbance motor function sensory input

Environmental enrichment combined with fasudil treatment inhibits neuronal death in the hippocampal CA1 region and ameliorates memory deficits

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Neural Regeneration Research 2021年第8期16卷 1460-1466页

作者： Gao-Jing Xu Qun Zhang Si-Yue Li Yi-Tong Zhu Ke-Wei Yu Chuan-Jie Wang Hong-Yu Xie Yi Wu department of rehabilitation Medicine Huashan HospitalFudan UniversityShanghaiChina department of rehabilitation Medicine Jinshan Hospital of Fudan UniversityShanghaiChina

Currently, no specific treatment exists to promote recovery from cognitive impairment after a stroke. Dysfunction of the actin cytoskeleton correlates well with poststroke cognitive declines, and its reorganization requires proper regulation of Rho-associated kinase(ROCK) proteins. Fasudil downregulates ROCK activation and protects neurons against cytoskeleton collapse in the acute phase after stroke. An enriched environment can reduce poststroke cognitive impairment. However, the efficacy of environmental enrichment combined with fasudil treatment remains poorly understood. A photothrombotic stroke model was established in 6-week-old male C57 BL/6 mice. Twenty-four hours after modeling, these animals were intraperitoneally administered fasudil(10 mg/kg) once daily for 14 successive days and/or provided with environmental enrichment for 21 successive days. After exposure to environmental enrichment combined with fasudil treatment, the number of neurons in the hippocampal CA1 region increased significantly, the expression and proportion of p-cofilin in the hippocampus decreased, and the distribution of F-actin in the hippocampal CA1 region increased significantly. Furthermore, the performance of mouse stroke models in the tail suspension test and step-through passive avoidance test improved significantly. These findings suggest that environmental enrichment combined with fasudil treatment can ameliorate memory dysfunction through inhibition of the hippocampal ROCK/cofilin pathway, alteration of the dynamic distribution of F-actin, and inhibition of neuronal death in the hippocampal CA1 region. The efficacy of environmental enrichment combined with fasudil treatment was superior to that of fasudil treatment alone. This study was approved by the Animal Ethics Committee of Fudan University of China(approval No. 2019-Huashan Hospital JS-139) on February 20, 2019.

关键词： cognitive environment hippocampus injury neuroprotection pathway repair stroke

Effects of Repetitive Transcranial Magnetic Stimulation on Astrocytes Proliferation and nNOS Expression in Neuropathic Pain Rats

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Current Medical Science 2018年第3期38卷 482-490页

作者： Lu YANG Sai-hua WANG Yan HU Yan-fang SUI Tao PENG Tie-cheng GUO department of rehabilitation Medicine Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan 430030 China department of rehabilitation Medicine Hankou Hospital Wuhan 430014 China department of rehabilitation Medicine Wuhan FirstHospital Wuhan 430022 China department of rehabilitation Medicine Zhongnan Hospital of Wuhan University Wuhan 430071 China department of rehabilitation Medicine Haikou Hospital Haikou 570208 China

This study investigated the effects of different frequencies of repetitive transcranial magnetic stimulation （rTMS） on chronic neuropathic pain in rats. The behavior of rats with experimental chronic neuropathic pain was observed, and the expression of neuronal nitric oxide synthase （nNOS） in the ipsilateral dorsal root ganglions （DRGs） and the activation and proliferation of astrocytes in the ipsilateral spinal dorsal horn were detected. Thirty-two male Sprague-Dawley rats were randomly divided into four groups： sham-operated group, sham-rTMS group, 1 Hz group and 20 Hz group （8 rats in each group）. Chronic constriction nerve injury induced by sciatic nerve ligation was made to establish the models of the chronic neuropathic pain in rats except those in the sham-operated group. Then we applied different frequencies of rTMS to the primary motor cortex （M1） contralateral to the pain side once daily for 10 consecutive days. Pain behavior scores were observed before and after treatment. Western blot analysis was used to detect the expression of nNOS in ipsilateral L4-6 DRGs. Double immunofluorescent labeling for glial fibrillary acidic protein （GFAP） and 5-bromo-2- deoxyuridine （BrdU） was employed to observe the activation and proliferation of astrocytes in the ipsilateral L4-6 spinal dorsal horn. After rTMS treatment, the spontaneous pain behavior scores were significantly lower in the 20 Hz group than those in the sham-rTMS group （P〈0.05）. Moreover, the brush-evoked pain behavior scores were significantly lower in the 20 Hz group than those in the sham-rTMS and 1 Hz group （P〈0.05）, suggesting that the spontaneous pain and brush-evoked pain in the 20 Hz group were significantly alleviated. Western blot analysis revealed that the expression of nNOS in ipsilateral L4-6 DRGs was significantly decreased in the 20 Hz group as compared with the sham-rTMS group and the 1 Hz group （P〈0.01） after rTMS treatment. Double immunofluorescence suggested that the expression of GFAP a

关键词： neuropathic pain repetitive transcranial magnetic stimulation neuronal nitric oxide synthase astrocyte glial fibrillary acidic protein 5-bromo-2-deoxyuridine

Significant improvement after sensory tricks and trunk strength training for Parkinson’s disease with antecollis and camptocormia:A case report

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World Journal of Clinical Cases 2024年第2期12卷 443-450页

作者： Jia-Ren Wang Yue Hu department of Neurology and Neurological rehabilitation Shanghai Yangzhi Rehabilitation Hospital(Shanghai Sunshine Rehabilitation Center)Shanghai 201619China

BACKGROUND Patients with Parkinson's disease(PD)exhibit symptoms such as antecollis(AC)and camptocormia(CC).The pathology of these two conditions is ***,standard treatment methods have not been *** article reports the case of a 65-year-old female patient with AC and CC who was treated with central and peripheral interventions to alleviate *** SUMMARY We present the case of a 65-year-old female PD patient with AC and *** course of the disease was 5 *** was treated with rehabilitation strategies such as sensory tricks and trunk strength *** the inpatient period,we compared and analyzed the patient's gait,rehabilitation assessment scale score,and angles of her abnormal trunk posture in the first week,the third week,and the fifth *** patient's stride length increased,indicating that the patient's walking ability was *** Unified Parkinson's Disease Scale Part Three score and CC severity score ***,the score of the other scale *** addition,the patient showed significant improvements in AC,upper CC,and lower CC *** This case study suggested that sensory tricks and trunk strength training are beneficial and safe for patients with AC and CC.

关键词： Antecollis Camptocormia Parkinson's disease Sensory tricks Trunk strength training Case report

Traditional Chinese Medicine comprehensive therapy for the improvement of motor function in spinal cord injury patients

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Journal of Traditional Chinese Medicine 2016年第5期36卷 618-624页

作者： Wang Yuanhui Zhang Lei Pan Guodong Liu Jing Zhang Hongrui Song Xu Wang Qiang Clinical Medical School Jining Medical University department of rehabilitation Medicine the Affiliated Hospital of Jining Medical University department of rehabilitation Medicine the Affiliated Hospital of Qingdao University

OBJECTIVE: To study the effect of early comprehensive therapy of Traditional Chinese Medicine(TCM) on motor function of in patients with spinal cord ***: Fifty-one standard spinal cord injury patients with paraplegia were randomly assigned to an experimental or control group. The experimental group received TCM comprehensive therapy, and the control group received modern Western Medicine(WM) treatment for 4 weeks. The motor score(MS), Barthel Index(BI) and American Spinal Injury Association(ASIA) grading were measured in both groups before and after ***: After treatment, the MS and BI scores of the TCM comprehensive therapy group improved significantly(P 0.05). The differences between the experimental and control groups after treatment were not significant(P > 0.05).CONCLUSION: Early TCM comprehensive therapy is an effective method for improving motor function in patients with spinal cord injury.

关键词： Spinal cord injuries Medicine Chinese traditional treatment outcome

Increased activation of the caudate nucleus and parahippocampal gyrus in Parkinson's disease patients with dysphagia after repetitive transcranial magnetic stimulation:a case-control study

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Neural Regeneration Research 2022年第5期17卷 1051-1058页

作者： Pei-Ling Huang Song-Jian Wang Rui-Feng Sun Zi-Man Zhu Xiao-Ling Li Wen-Shan Li Meng-Yue Wang Meng Lin Wei-Jun Gong department of Neurological rehabilitation Beijing Rehabilitation Hospital of Capital Medical UniversityBeijingChina Beijing Key Laboratory of Fundamental Research on Biomechanics in Clinical Application School of Biomedical EngineeringCapital Medical UniversityBeijingChina department of Neurological rehabilitation Beijing Rehabilitation Medicine AcademyCapital Medical UniversityBeijingChina

Repetitive transcranial magnetic stimulation(r TMS)has been shown to effectively improve impaired swallowing in Parkinson's disease(PD)patients with ***,little is known about how r TMS affects the corresponding brain regions in this patient *** this casecontrol study,we examined data from 38 PD patients with dysphagia who received treatment at Beijing rehabilitation Medicine Academy,Capital Medical *** patients received high-frequency r TMS of the motor cortex once per day for 10 successive *** in brain activation were compared via functional magnetic resonance imaging in PD patients with dysphagia and healthy *** results revealed that before treatment,PD patients with dysphagia showed greater activation in the precentral gyrus,supplementary motor area,and cerebellum compared with healthy controls,and this enhanced activation was weakened after ***,before treatment,PD patients with dysphagia exhibited decreased activation in the parahippocampal gyrus,caudate nucleus,and left thalamus compared with healthy controls,and this activation increased after *** addition,PD patients with dysphagia reported improved subjective swallowing sensations after r *** findings suggest that swallowing function in PD patients with dysphagia improved after r TMS of the motor *** may have been due to enhanced activation of the caudate nucleus and parahippocampal *** study protocol was approved by the Ethics Committee of Beijing rehabilitation Hospital of Capital Medical University(approval No.2018 bkky017)on March 6,2018 and was registered with Chinese Clinical Trial Registry(registration *** CTR 1800017207)on July 18,2018.

关键词： brain regions caudate clinical trial dysphagia functional magnetic resonance imaging parahippocampal gyrus Parkinson's disease precentral gyrus repetitive transcranial magnetic stimulation saliva swallowing task

rehabilitation of anterior pituitary dysfunction combined with extrapontine myelinolysis: A case report

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World Journal of Clinical Cases 2019年第24期7卷 4420-4425页

作者： Ming-Xuan Yang Xue-Nong Chen department of rehabilitation Affiliated Hospital of Zunyi Medical University

BACKGROUND Extramedullary myelinolysis is a rare demyelinating disease, often caused by rapid increases in serum sodium concentration in patients with *** manifestations are neuropsychiatric symptoms, limb weakness, and dysarthria. Because of its poor prognosis and high disability rate, it poses a huge burden on the global economy, societies, and families. This article reports rehabilitation in a patient with pituitary dysfunction combined with extramedullary *** SUMMARY A 27-year-old Chinese man developed anorexia, vomiting, and limb weakness and was diagnosed with pituitary insufficiency. He had low serum sodium, slow movement, muscle weakness, and muscle tone abnormalities after sodium supplementation, involuntary limb shaking, ataxia, and dysarthria. According to the symptoms and signs and imaging reports, he was diagnosed with extramedullary myelinolysis. After treatment with hormone therapy and neurotrophic drugs, motor and speech function did not improve, so he was treated in the rehabilitation department for 4 wk. The patient's physical status was improved substantially during his stay at the rehabilitation *** Patients with extramedullary myelinolysis who actively participate in rehabilitation intervention can significantly improve their activities of daily living.

关键词： Anterior pituitary dysfunction Extrapontine myelinolysis rehabilitation Motor function Speech function Case report