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Comparison of p38 MAPK, soluble endoglin and endothelin-1 level in severe preeclampsia and HELLP syndrome patients

Asian pacific Journal of Reproduction 2019年第2期8卷 83-87页

作者： Efendi Lukas Maisuri T Chalid Upik A Miskad Syakib Bakri department of Obstetrics and Gynecology Faculty of MedicineHasanuddin University of MakassarIndonesia department of phatology Faculty of MedicineHasanuddin University of MakassarIndonesia Departement of Internal Medicine Faculty of MedicineHasanuddin University of MakassarIndonesia

Objective: To compare the levels of p38 mitogen-activated protein kinase (MAPK), soluble endoglin and endothelin-1 in the serum of patients with severe preeclampsia, hemolysis, elevated liver enzymes, and low platelets (HELLP) syndrome and normal pregnancies. Methods: This study was an observational analytic cross-sectional study performed at Wahidin Sudirohusodo Hospital, Makassar, Indonesia, in the period of 5th February 2016 to 20th January 2017. P38 MAPK, soluble endoglin and endothelin-1 levels of patients with normal pregnancies, severe preeclampsia and HELLP syndrome were measured by enzyme-linked immunoabsorbentassay technique, using kits of human soluble endoglin, endothelin-1 and p38 MAPK, Quantikine immunoassay: R&D System Inc. Results: Level of serum p38 MAPK in HELLP syndrome group was higher than in severe preeclampsia and normal pregnancy groups. Soluble endoglin and endothelin-1 levels in pregnancies with severe preeclampsia and HELLP syndrome were higher than normal pregnancy but there was no significant difference between these two groups (P>0.05). Levels of p38 MAPK, soluble endoglin and endothelin-1 also had a positive linear correlation with systolic and diastolic blood pressures (P<0.05). Conclusions: P38 MAPK in serum may be a marker for evidence of the severe hypoxia and its application may be considered for the diagnosis of HELLP syndrome.

关键词： Preeclampsia HELLP syndrome p38 MAPK Soluble endoglin Endothelin-1

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Orbital lesions,an exceedingly rare site of neuroendocrine tumor metastasis

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Journal of Cancer Metastasis and Treatment 2016年第1期2卷 341-344页

作者： Sara Pusceddu Massimo Milione Silvia Ortolani Alessio Pellegrinelli Marco Brugia Filippo de Braud Lorenzo Antonuzzo department of Medical Oncology Fondazione IRCCS“Istituto Nazionale dei Tumori”20133 MilanItaly department of phatology Fondazione IRCCS“Istituto Nazionale dei Tumori”20133 MilanItaly department of Medical Oncology Azienda Ospedaliera Universitaria IntegrataUniversity of Verona37134 VeronaItaly department of Medical Oncology Azienda Ospedaliera Universitaria Careggi50134 FirenzeItaly Medical Genetics University of Siena53100 SienaItaly

Neuroendocrine tumors are rare neoplasms arising primarily in the gastrointestinal tract and lung.The liver is the most common site of metastases,but these tumors can rarely metastasize to atypical sites.Surgery is the only curative approach while the optimal medical treatment is debated.From this perspective,a multidisciplinary approach for each single case becomes very important.In this report we describe the case of a male affected by a single intraorbital metastasis from a midgut well differentiated neuroendocrine tumor.The patient refused surgical removal and therefore he was at first treated with stereotactic radiotherapy and systemic treatment with a somatostatin analog(SSA).After achieving a stable disease for four months he underwent primary tumor resection.Six years after the initial diagnosis,the patient is currently stable and receiving SSA at standard dose.

关键词： Neuroendocrine tumors orbital metastases somatostatin analogues

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