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Role of copper chelating agents: between old applications and new perspectives in neuroscience

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Neural Regeneration Research 2025年第3期20卷 751-762页

作者： Rosalba Leuci Leonardo Brunetti Vincenzo Tufarelli Marco Cerini Marco Paparella Nikola Puvača Luca Piemontese department of Pharmacy-pharmaceutical Science University of Bari Aldo MoroBariItaly department of Precision and Regenerative Medicine and Jonian Area(DiMePRe-J) Section of Veterinary Science and Animal ProductionUniversity of Bari Aldo MoroBariItaly department of engineering Management in Biotechnology Faculty of Economics and Engineering Management in Novi SadUniversity Business Academy in Novi SadNovi SadSerbia

The role of copper element has been an increasingly relevant topic in recent years in the fields of human and animal health, for both the study of new drugs and innovative food and feed supplements. This metal plays an important role in the central nervous system, where it is associated with glutamatergic signaling, and it is widely involved in inflammatory processes. Thus, diseases involving copper(Ⅱ) dyshomeostasis often have neurological symptoms, as exemplified by Alzheimer's and other diseases(such as Parkinson's and Wilson's diseases). Moreover, imbalanced copper ion concentrations have also been associated with diabetes and certain types of cancer, including glioma. In this paper, we propose a comprehensive overview of recent results that show the importance of these metal ions in several pathologies, mainly Alzheimer's disease, through the lens of the development and use of copper chelators as research compounds and potential therapeutics if included in multi-target hybrid drugs. Seeing how copper homeostasis is important for the well-being of animals as well as humans, we shortly describe the state of the art regarding the effects of copper and its chelators in agriculture, livestock rearing, and aquaculture, as ingredients for the formulation of feed supplements as well as to prevent the effects of pollution on animal productions.

关键词： agriculture Alzheimer's disease chelators copper feed supplements multi-target

Fabrication and adsorption property of novel adsorbent for potential application to wastewater with Fe(Ⅲ) ions

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Journal of Central South University 2014年第7期21卷 2832-2836页

作者：朱卫霞宋航贾春梅姚舜 department of pharmaceutical and biological engineering Sichuan University

The spherical macroporous cellulose(SMC) was fabricated using medical absorbent cotton as raw material and nano CaCO3 as porogenic *** then,the phenylglycine was grafted onto the SMC to obtain the novel spherical macroporous cellulose derivative adsorbent(PSMC).FT-IR and scanning electron microscope(SEM) were employed to characterize the adsorbents and Fe3+ ions served as model solute to evaluate the adsorption property of the *** experimental results show that the amount of porogenic agents and the value of pH have obvious influence on adsorption capacity of the *** data of adsorption kinetic and isotherm display that the adsorbents possess excellent equilibrium adsorption capacity(348.94 mg/g) and have a bright prospect and considerable potential in the treatment of Fe3+ ions in wastewater.

关键词： cellulose modified with phenylglycine adsorption Fe(Ⅲ) ions porogenic agent kinetic and isotherm

Required catalytic properties for alkane production from carboxylic acids: Hydrodeoxygenation of acetic acid

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Journal of Energy Chemistry 2013年第6期22卷 883-894页

作者： Zhong He Xianqin Wang department of Chemical Biological and Pharmaceutical Engineering New Jersey Institute of Technology

The supported Pt catalysts(1 wt%)were prepared by the incipient impregnation method and analyzed using synchrotron-based X-ray diffraction,BET surface area,oxygen adsorption,CO pulse chemisorption,temperature-programmed desorption(TPD)of acetic acid,H2-TPD,NH3-TPD,O2-TPD,and *** reactivity of Pt-based catalysts was studied using a fixed bed reactor at 300 C and 4 MPa for hydrodeoxygenation of acetic acid,where Pt/TiO2 was very selective for ethane *** experiments revealed that several conditions must be satisfied to achieve this high selectivity to ethane from acetic acid,such as Pt sites,moderate acidity,and medium metal-oxygen bond strength in the oxide *** work provides insights in developing novel catalytic materials for hydrocarbon productions from various organics including bio-fuels.

关键词： hydrodeoxygenation ethane acetic acid bio-oil Pt/TiO2 acidity metal-oxygen interaction

Passive activity enhances residual control ability in patients with complete spinal cord injury

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Neural Regeneration Research 2025年第8期20卷 2337-2347页

作者： Yanqing Xiao Mingming Gao Zejia He Jia Zheng Hongming Bai Jia-Sheng Rao Guiyun Song Wei Song Xiaoguang Li Beijing Key Laboratory for Biomaterials and Neural Regeneration Beijing Advanced Innovation Center for Biomedical EngineeringSchool of Biological Science and Medical EngineeringBeihang UniversityBeijingChina department of Rehabilitation Evaluation China Rehabilitation Research CenterBeijingChina Cardiac Center Beijing Children’s HospitalCapital Medical UniversityBeijingChina The State Key Laboratory of Virtual Reality Technology and Systems Beihang UniversityBeijingChina department of Rehabilitation engineering China Rehabilitation Science InstituteBeijingChina

Patients with complete spinal cord injury retain the potential for volitional muscle activity in muscles located below the spinal injury ***,because of prolonged inactivity,initial attempts to activate these muscles may not effectively engage any of the remaining neurons in the descending pathway.A previous study unexpectedly found that a brief clinical round of passive activity significantly increased volitional muscle activation,as measured by surface *** this study,we further explored the effect of passive activity on surface electromyographic signals during volitional control tasks among individuals with complete spinal cord *** patients with chronic complete thoracic spinal cord injury were *** electromyography data from eight major leg muscles were acquired and compared before and after the passive activity *** results indicated that the passive activity led to an increased number of activated volitional muscles and an increased frequency of *** the cumulative root mean square of surface electromyography amplitude for volitional control of movement showed a slight increase after passive activity,the difference was not statistically *** findings suggest that brief passive activity may enhance the ability to initiate volitional muscle activity during surface electromyography tasks and underscore the potential of passive activity for improving residual motor control among patients with motor complete spinal cord injury.

关键词： complete spinal cord injury cycle training epidural electrical stimulation motor training passive activity physiological state spinal cord circuit surface electromyography volitional control task

An efficient approach for the treatment of radioactive waste perfluoropolyether lubricants via a synergistic effect of thermal catalysis and immobilization

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Journal of Environmental Sciences 2024年第2期136卷 512-522页

作者： Xinhang Du Wenhua Tong Xinyu Zhou Jia Luo Yuqiu Liu Yabo Wang Panyu Li Yongkui Zhang department of pharmaceutical&biological engineering School of Chemical EngineeringSichuan UniversityChengdu 610065China

Perfluoropolyether(PFPE)lubricants are a kind of high-molecular polymer with many excellent ***,the use of PFPEs in the nuclear industry can lead to partial decomposition and carrying radionuclides,resulting in a large amount of radioactive waste PFPE lubricants ***,radioactive waste PFPE lubricants are difficult to be effectively treated due to their high stability,the risk of possible leakage of radionuclides,and hypertoxic fluorine-containing *** this study,without any precedent,a strategy of Mn O_(2)-catalyzed decomposition and Na_(2)CO_(3)-immobilized conversion was proposed for PFPE lubricant decomposition and fluorine immobilization simultaneously based on the Lewis acid-base and oxygen vacancies concept.A high fluorine conversion efficiency of 95.4%was ***,the mechanism of decomposition suggested that Mn O_(2)mainly provided Lewis acid sites and attacked the(basic)fluorine or oxygen atoms in PFPE *** decomposition of PFPE chains was proceed down and volatile fluorine-containing gas was released by partial electron transfer,intramolecular disproportionation reaction,and unzipping ***,gas by-products could be further oxidized and then immobilized into fluoride salts by carbonate solid ***,this study provides a simple,safe,and potentially practical strategy for the harmless conversion of refractory fluorinated organic wastes,especially perfluoropolymers.

关键词： Perfluoropolyether lubricants Catalyzed decomposition Fluorine-containing gas Immobilized conversion Fluoride

Fabrication and characterization of hierarchical porous Ni2+doped hydroxyapatite microspheres and their enhanced protein adsorption capacity

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Chinese Journal of Chemical engineering 2022年第5期35卷 238-247页

作者： Yaling Li Hao Ai Liangzhi Qiao Yinghong Wang Kaifeng Du department of pharmaceutical&biological engineering School of Chemical EngineeringSichuan UniversityChengdu 610065China

Hydroxyapatite(HAP)is a common bio-adsorbent,which performance depends heavily upon its morphology and microporous *** this study,a novel synthesis strategy was proposed for hierarchical porous HAP microspheres by a simple"one-pot"hydrothermal *** the strategy,L-glutamic acid serves as soft template to modulate the morphology and inner crystalline of *** evaluate the application potential,doping Ni^(2+) on hierarchical porous HAP microspheres gives metal chelated affinity *** prepared adsorbents show a perfect spherical shape,particles size of 96.6μm,relatively specific surface area of 48.5 m^(2)·g^(-1) and hierarchical pores(mesopores:4 nm and macropores:53 nm).By the adsorption evaluation,it reveals that the Ni^(2+)-HAP adsorbents have high adsorption capacities of275.11 and 97.55 m^(2)·g^(-1) for hemoglobin and bovine serum albumin,respectively,which is comparable to other similar ***,this work provides a promising method for high-efficiency hydroxyapatite microspheres for proteins purification.

关键词： Hierarchical porous hydroxyapatite microspheres Templates Metal doping Proteins adsorption

Fabrication and characterization of novel tentacle-type adsorbent for resolution of chiral drugs

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Chinese Science Bulletin 2013年第27期58卷 3390-3397页

作者： ZHU WeiXia WANG QuanYi DU KaiFeng YAO Shun SONG Hang department of pharmaceutical & biological engineering School of Chemical Engineering Sichuan University

Novel tentacle-type chiral adsorbent based on silica gels modified with β-cyclodextrin (β-CD) and polyvinyl alcohol(PVA) is synthesized by surface grafting technique. The adsorption behavior of chiral pharmaceuticals using the resulting adsorbents is investigated. In the study, FT-IR and thermogravimetric analysis (TGA) are employed to characterize the chemical and physical properties of the adsorbent; mandelic acid (MA) serves as model solute to evaluate the sorption capacity and selectivity of the adsorbent. The experimental results show that the novel tentacle-type adsorbent is possessed of larger equilibrium adsorption capacity and better selectivity over the conventional one and could be as potential chiral stationary phase (CSPs).

关键词：手性药物吸附剂手型表征小说制备拆分表面接枝技术

Crystal Structure,Photoluminescence and Theoretical Studies of Diethyl 4,5-di(thienyl)-3,6-bis(trimethylsilyl)phthalate

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Chinese Journal of Structural Chemistry 2013年第10期32卷 1560-1566页

作者：唐建可牛心蕙蒋丽丽曲红梅 Key Laboratory of Systems Bioengineering Ministry of EducationTianjin Key Laboratory of Biological and Pharmaceutical EngineeringDepartment of Pharmaceutical Engineering School of Chemical Engineering and TechnologyTianjin University

The crystal structure of the title compound, diethyl 4,5-di（thienyl）-3,6-bis（trime- thylsilyl）phthalate （C26H3404S2Si2, Mr = 530.83）, has been determined by single-crystal X-ray diffraction. The crystal belongs to the orthorhombic system, space group Pccn with a = 43.008（5）, b = 10.9000（12）, c = 11.9357（14） A, V= 5595.3（11） A3, Z = 8, F（000） = 2256, Dc= 1.260 mg/m3, p = 0.305 mm-1, T = 113（2） K, S = 1.090, R = 0.0413 and wR = 0.0969 for 5952 observed reflections with 1 〉 2o（/）. The benzene ring system is planar and makes dihedral angles of 63.7（2） and 72.5（4） with the two thienyl rings A （C（23）-C（26）, S（2）） and B （C（19）-C（22）, S（1））, respectively. The UV-vis absorption and fluorescence of the title compound were discussed. The molecular structure of the title compound has been optimized using DFT method at the B3LYP/6-31G（d） level. The computational results showed that the optimized geometer parameters are consistent well with the experiment data. The vertical ionization potential, vertical electron affinity and frontier orbitals were also discussed.

关键词： crystal structure benzene derivatives orthorhombic system,photoluminescence B3LYP/6-31G(d)

Zirconium-mediated Synthesis and Crystal Structure of 3,6-Diiodo-4,5-dialkyl-phthalic Acid Dimethyl Ester

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Chinese Journal of Structural Chemistry 2015年第9期34卷 1347-1356页

作者：李旭东王会李君秋门奕灿曲红梅 Key Laboratory of Systems Bioengineering Ministry of EducationTianjin Key Laboratory of Biological and Pharmaceutical EngineeringDepartment of Pharmaceutical EngineeringSchool of Chemical Engineering and TechnologyTianjin University

A novel series of para-diiodobenzene derivatives, 3,6-diiodo-4,5-dialkyl-phthalic acid dimethyl esters, were prepared via cycloaddition of two TMS-substituted alkynes and dimethyl acetylenedicarboxylate, which was mediated by zirconocene. After iodination, three new compounds of 3,6-diiodo-4,5-dimethyl（dipropyl, dibutyl）-phthalic acid dimethyl esters （3a, 3b, 3c） were synthesized in high region-selectivity and yields, and characterized by NMR. The crystal structures were determined by single-crystal X-ray diffraction. The crystal of 3a （C12H121204, Mr = 474.02） belongs to the triclinic system, space group Pi with a = 7.6238（10）, b = 9.4571（12）, c = 10.8221（14） A, a = 66.611（10）, fl = 88.511（12）, 7 ： 77.604（11）% V= 697.93（16） A3, Z= 2, F（000） = 444, Dc = 2.256 mg/m3, g = 4.509 mm-1, T=133（2） K, S = 1.014, R = 0.0229 and wR = 0.0547 for 2644 observed reflections with I 〉 20（/）; the crystal of 3b （C16H201204, Mr - 530.12） is of triclinic system, space group Pi with a = 9.4122（19）, b = 10.626（2）, c = 11.353（2） A, a = 97.90（3）, fl = 113.83（3）, y = 110.22（3）°, V= 922.6（3） A3, Z- 2, F（000） = 508, Dc - 1.908 mg/m3, g = 3.422 mm-1, T = 113（2） K, S = 1.115, R = 0.0428 and wR = 0.1072 for 3971 observed reflections with I〉 20（/）; the crystal of 3c （ClsH241204, Mr = 558.17） belongs to the monoclinic system, space group P21/c with a = 26.396（2）, b = 8.7560（8）, c = 25.7970（18） A, fl = 91.721（4）o, V= 5959.6（8） A3, Z = 12, F（000） = 3240, Dc = 1.866 mg/m3,/z = 3.184 mm-l, T= 113（2） K, S = 1.154, R = 0.0424 and wR = 0.0766 for 13056 observed reflections with I 〉 20（/）.

关键词： zirconocene 3,6-diiodo-4,5-dialkyl-phthalic acid dimethyl ester,para-diiodobenzene derivative crystal structure X-ray diffraction NMR