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Induction chemotherapy with docetaxel,cisplatin and fluorouracil followed by concurrent chemoradiotherapy for unresectable sinonasal undifferentiated carcinoma: Two cases of report

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World Journal of Clinical Cases 2019年第6期7卷 765-772页

作者： Sho Watanabe Yoshitaka Honma Naoya Murakami Hiroshi Igaki Taisuke Mori Hidekazu Hirano Natsuko Okita Hirokazu Shoji Satoru Iwasa Atsuo Takashima Ken Kato Kenya Kobayashi Fumihiko Matsumoto Seiichi Yoshimoto Jun Itami Narikazu Boku department of Head and Neck Medical Oncology National Cancer Center Hospital department of Radiation Oncology National Cancer Center Hospital department of Pathology and Clinical Laboratories National Cancer Center Hospital department of Gastrointestinal Medical Oncology National Cancer Center Hospital department of Head and Neck Surgery National Cancer Center Hospital

BACKGROUND Sinonasal undifferentiated carcinoma(SNUC) is a rare aggressive tumor that is often unresectable. Optimal treatment for patients with unresectable,locally advanced SNUC(LA-SNUC) has not been established,and the patient outcome remains poor. We report two cases of unresectable LA-SNUC in which induction chemotherapy with docetaxel,cisplatin and fluorouracil(TPF) followed by radiotherapy with concurrent cisplatin(CCRT),a standard treatment option for locally advanced head and neck cancer,demonstrated promising *** SUMMARY A 39-year-old man presented with tearing and pain in the right eye. A biopsy of the tumor invading the sinonasal cavities,right orbit and cranial base confirmed the diagnosis of LA-SNUC. Induction TPF chemotherapy induced remarkable tumor shrinkage and rapidly improved the symptoms. He subsequently received CCRT and achieved complete remission of the disease. The other case is a 21-year-old man who presented with worsening vision. The unresectable tumor involving the nasal septum and cranial base was pathologically diagnosed as SNUC. TPF chemotherapy followed by CCRT yielded complete remission of the disease with preserved visual function. Both patients have been disease-free for44 *** Induction TPF chemotherapy followed by CCRT may remarkably improve the outcomes in LA-SNUC patients.

关键词： Sinonasal undifferentiated carcinoma Chemotherapy with docetaxel, cisplatin and fluorouracil chemotherapy Docetaxel Cisplatin Fluorouracil Intensity-modulated radiotherapy Chemoradiotherapy Case report

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Liver cancer: challenge and prospect

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cancer Biology & Medicine 2016年第4期13卷 405-406页

作者： Qiang Li department of Hepatobiliary cancer Tianjin Medical University Cancer Institute and Hospital National Clinical ResearchCenter for Cancer Tianjin Key Laboratory of Cancer Prevention and Therapy Tianjin Clinical Research Center for Cancer

According to GLOBOCAN 2012,liver cancer is the sixth most common cancer in the *** were 782,000 new cases diagnosed in 2012,with 50%in China *** cancer is the second most common cause of cancer death worldwide and its prognosis is very *** World Health Organization(WHO)declared 745,517 deaths caused by liver cancer in 2012,with more than half from China^1.

关键词：肝癌展望世界卫生组织死亡原因世界范围癌症 WHO

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Inflammation and tumor progression:signaling pathways and targeted intervention

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Signal Transduction and Targeted Therapy 2021年第8期6卷 2426-2471页

作者： Huakan Zhao Lei Wu Guifang Yan Yu Chen Mingyue Zhou Yongzhong Wu Yongsheng Li department of Medical Oncology Chongqing University Cancer HospitalChongqingChina department of Radiotherapy Chongqing University Cancer HospitalChongqingChina

cancer development and its response to therapy are regulated by inflammation,which either promotes or suppresses tumor progression,potentially displaying opposing effects on therapeutic *** inflammation facilitates tumor progression and treatment resistance,whereas induction of acute inflammatory reactions often stimulates the maturation of dendritic cells(DCs)and antigen presentation,leading to anti-tumor immune *** addition,multiple signaling pathways,such as nuclear factor kappa B(NF-kB),Janus kinase/signal transducers and activators of transcription(JAK-STAT),toll-like receptor(TLR)pathways,cGAS/STING,and mitogen-activated protein kinase(MAPK);inflammatory factors,including cytokines(e.g.,interleukin(IL),interferon(IFN),and tumor necrosis factor(TNF)-a),chemokines(e.g.,C-C motif chemokine ligands(CCLs)and C-X-C motif chemokine ligands(CXCLs)),growth factors(e.g.,vascular endothelial growth factor(VEGF),transforming growth factor(TGF)-P),and inflammasome;as well as inflammatory metabolites including prostaglandins,leukotrienes,thromboxane,and specialized proresolving mediators(SPM),have been identified as pivotal regulators of the initiation and resolution of ***,local irradiation,recombinant cytokines,neutralizing antibodies,small-molecule inhibitors,DC vaccines,oncolytic viruses,TLR agonists,and SPM have been developed to specifically modulate inflammation in cancer therapy,with some of these factors already undergoing clinical ***,we discuss the initiation and resolution of inflammation,the crosstalk between tumor development and inflammatory *** also highlight potential targets for harnessing inflammation in the treatment of cancer.

关键词： inflammation interferon acute

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Correlation of radiotherapy with prognosis of elderly patients with hormone receptor-positive breast cancer according to immunohistochemical subtyping

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Chinese Journal of cancer Research 2019年第3期31卷 471-480页

作者： Xiangcheng Zhi Xiaonan Yang Teng Pan Jingjing Liu Xiao Chen Liping Lou Zhendong Shi Jin Zhang department of Breast cancer Tianjin Medical University Cancer Institute & Hospital National Clinical Research Center of Cancer Key Laboratory of Cancer Prevention and Therapy Tianjin’s Clinical Research Cancer for Cancer

Objective: The present study examined the effect of radiotherapy on recurrence and survival in elderly patients with hormone receptor-positive early breast ***: A retrospective analysis of 327 patients aged ≥65 years, with stage I-II, hormone receptor-positive breast cancer who underwent breast-conserving surgery and received endocrine therapy(ET) or radiotherapy plus endocrine therapy(ET+RT) was performed. Both groups were divided into luminal A type and luminal B type subgroups. Evaluation criteria were 5-year disease-free survival(DFS), local relapse rate(LRR), overall survival(OS), and distant metastasis rate(DMR).Results: There were significant differences in 5-year DFS [hazard ratio(HR)=1.59, 95% confidence interval(95% CI), 1.15-2.19;P=0.005] and LRR(HR=3.33, 95% CI, 1.51-7.34;P=0.003), whereas there were no significant differences in OS and DMR between ET group and ET+RT group. In luminal A type, there was no significant difference in 5-year DFS, LRR, OS and DMR between ET group and ET+RT group. In luminal B type,there were statistically significant differences in 5-year DFS(HR=2.19, 95% CI, 1.37-3.49;P=0.001), LRR(HR=5.45, 95% CI, 1.65-17.98;P=0.005), and OS(HR=1.75, 95% CI, 1.01-3.05;P=0.048) between ET group and ET+RT group. In the ET group, there were significant differences between luminal A type and luminal B type in5-year DFS(HR=1.84, 95% CI, 1.23-2.75;P=0.003) and OS(HR=1.76, 95% CI, 1.07-2.91;P=0.026).Conclusions: After breast-conserving surgery, radiotherapy can reduce the LRR and improve the DFS and OS of luminal B type elderly patients, whereas luminal A type elderly patients do not benefit from *** radiotherapy, luminal A type patients have better DFS and OS than luminal B type patients.

关键词： Breast-conserving surgery disease-free survival endocrine therapy hormone receptor-positive overall survival radiotherapy

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Bioinformatics analysis of breast cancer bone metastasis related geneCXCR4

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Asian Pacific Journal of Tropical Medicine 2013年第9期6卷 732-738页

作者： Heng-Wei Zhang Xian-Fu Sun Ya-Ning He Jun-Tao Li Xu-Hui Guo Hui Liu department of Breast Henan Cancer Hospital Affiliated cancer Hospital of Zhengzhou University

Objective:To analyze breast cancer bone metastasis related ***:This research screened breast cancer bone metastasis related genes by high-flux gene ***:It was found that the expressions of 396 genes were different including 165 up-regulations and 231 *** expression of chemokine receptor CXCR4 was obviously upregulated in the tissue with breast cancer bone *** with the tissue without hone metastasis,there was significant difference,which indicated that CXCR4 played a vital role in breast cancer bone ***:The hioinformatics analysis of CXCR4 can provide a certain basis for the occurrence and diagnosis of breast cancer bone metastasis,target gene therapy and evaluation of prognosis.

关键词： Breast cancer bone metastasis CXCR4 Bioinformatics analysis

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Sparing lung tissue with virtual block method in VMAT planning for locally advanced non-small cell lung cancer

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Nuclear Science and Techniques 2022年第4期33卷 136-150页

作者： Jia-Yun Chen Da-Quan Wang Xiao-Dong Zhang Qi Fu Xue-Na Yan Kuo Men Jian-Rong Dai Nan Bi department of Radiation Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China department of Radiation Oncology State Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineSun Yat-Sen University Cancer CenterGuangzhou 510060China department of Radiation Physics The University of Texas MD Anderson Cancer CenterHoustonTXUSA

This study aimed to exploit a new virtual block method to spare normal lung tissue in VMAT planning for patients with locally advanced non-small cell lung cancer(LA-NSCLC).The previous method was used to manually restrict the angle of the beam passing through,which ignored the location and shape of large targets that varied between different slices and did not block the beamlets *** the previous method,this new virtual block method was used to block the beamlets when necessary by closing the multi-leaf collimator(MLC)at prerequisite *** algorithm for closing the MLC depended on the thickness of the beamlets passing through the lungs and avoided only the entrance radiation ***,this block can be automatically contoured.A retrospective study was performed to compare the VMAT plans with and without the virtual block method for 17 LANSCLC patients,named the block plan(B-plan)/non-block plan(N-plan).All cases were selected in this study because of the large tumor size and unmet dose constraints of the *** addition to the maximum dose constraint for the virtual block,B-plans adopted identical optimization parameters to N-plans for each *** two types of plans were compared in terms of dosimetric indices and plan *** results were statistically analyzed using the Wilcoxon nonparametric signed-rank test.B-plans have advantages in the following dosimetric metrics that have statistical significance(p<0.05):(1)lower V_(5)/V_(10)/D_(mean)/normal tissue complication probability(NTCP)of total lungs;(2)reductions in V_(5)/V_(10)for the contralateral lung;(3)decrease in Dmean/V_(40)of the heart;(4)decrease in esophagus V_(40);(5)reductions in Dmean,V_(5)/V_(10) of normal tissue.B-plans(82.51±7.07)achieved higher-quality scores than N-plans(80.74±7.22).The new virtual block spared the lungs as well as other normal structures in VMAT planning for ***,the block method may decrease the risk of radiation-related toxicity in p

关键词： Virtual block VMAT Normal tissue sparing Lung cancer

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The Nobel Prize in Chemistry 2015:Exciting discoveries in DNA repair by Aziz Sancar

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Science China(Life Sciences) 2016年第1期59卷 97-102页

作者： David K.Orren department of Toxicology and cancer Biology University of Kentucky College of Medicine and Markey Cancer Center University of Kentucky

INTRODUCTIONOn October 7, 2015, the Nobel Prize in Chemistry for 2015 was awarded to three deserving scientists for their pioneer- ing research on DNA repair. Tomas Lindahl was recognized for studies that uncovered the inherent instability of DNA as well as the mechanism of the base excision repair pathway, Paul Modrich for characterization of the mismatch repair pathway, and Aziz Sancar for mechanistic elucidation of the nucleotide excision repair （NER） pathway. For me, the an- nouncement of these awards in my area of research was extremely gratifying, particularly so because Aziz was my mentor during my Ph.D. studies that examined the steps of prokaryotic NER. Memorably, I trained in the Sancar labor- atory at a time where groundbreaking discoveries were be- ing made in the burgeoning field of DNA repair, and can personally attest to his dedication and keen intellect.

关键词：诺贝尔化学奖 DNA修复兴奋桑

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Morphine-3-glucuronide upregulates PD-L1 expression via TLR4 and promotes the immune escape of non-small cell lung cancer

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cancer Biology & Medicine 2021年第1期18卷 155-171页

作者： Kaiyuan Wang Jian Wang Ting Liu Wenwen Yu Nan Dong Chen Zhang Wenbin Xia Feng Wei Lili Yang Xiubao Ren department of Anesthesiology Tianjin Medical University Cancer Institute and HospitalNational Clinical Research Center for CancerKey Laboratory of Cancer Prevention and TherapyTianjinTianjin’s Clinical Research Center for CancerKey Laboratory of Cancer Immunology and BiotherapyTianjin 300060China department of Immunology Tianjin Medical University Cancer Institute and HospitalNational Clinical Research Center for CancerKey Laboratory of Cancer Prevention and TherapyTianjinTianjin’s Clinical Research Center for CancerKey Laboratory of Cancer Immunology and BiotherapyTianjin 300060China department of cancer Biobank Tianjin Medical University Cancer Institute and HospitalNational Clinical Research Center for CancerKey Laboratory of Cancer Prevention and TherapyTianjinTianjin’s Clinical Research Center for CancerKey Laboratory of Cancer Immunology and BiotherapyTianjin 300060China department of Biotherapy Tianjin Medical University Cancer Institute and HospitalNational Clinical Research Center for CancerKey Laboratory of Cancer Prevention and TherapyTianjinTianjin’s Clinical Research Center for CancerKey Laboratory of Cancer Immunology and BiotherapyTianjin 300060China

Objective:Patients with cancer pain are highly dependent on morphine analgesia,but studies have shown a negative correlation between morphine demand and patient *** long-term use of morphine may result in abnormally elevated serum morphine-3-glucuronide(M3G)***,the effects of M3G on tumor progression are worth ***:The effects of M3G on PD-L1 expressions in human non-small cell lung cancer(NSCLC)cell lines were first *** of TLR4 downstream pathways after M3G treatment was then determined by Western *** effects of M3G on human cytotoxic T lymphocytes(CTL)cytotoxicity and INF-γrelease was also ***,the LLC murine lung adenocarcinoma cell line were used to establish a murine lung cancer model,and the effects of M3G on tumor growth and metastasis were ***:M3G promoted the expressions of PD-L1 in the A549 and H1299 cell lines in a TLR4-dependent manner(P<0.05).M3G activated the PI3 K and the NFκB signaling pathways,and this effect was antagonized by a TLR4 pathway inhibitor.A PI3 K pathway inhibitor reversed the M3G-mediated PD-L1 upregulation.M3G inhibited the cytotoxicity of CTL on A549 cells and decreased the level of INF-γ.Repeated M3G intraperitoneal injections promoted LLC tumor growth and lung metastasis through the upregulation of tumor expressed PD-L1 and the reduction of CTL in the tumor ***:M3G specifically activated TLR4 in NSCLC cells and upregulated PD-L1 expression through the PI3 K signaling pathway,thereby inhibiting CTL cytotoxicity and finally promoting tumor immune escape.

关键词： Non-small cell lung cancer TLR4 PD-L1 morphine-3-glucuronide immune escape

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Global, regional, and national burden of early-onset gastric cancer

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cancer Biology & Medicine 2024年第8期21卷 667-678页

作者： Nuopei Tan Hongliang Wu Maomao Cao Fan Yang Xinxin Yan Siyi He Mengdi Cao Shaoli Zhang Yi Teng Qianru Li Jiachen Wang Changfa Xia Wanqing Chen department of cancer Screening National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China department of Anesthesiology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China

Objective: The burden of gastric cancer(GC) across different age groups needs updating. We determined the GC global, regional, and national burden profiles and changes in incidence for 3 sequential 5-year intervals from 2003 to ***: The latest incidence and mortality estimates of GC from 185 countries and regions were extracted from the GLOBOCAN 2022 database. The 5-year interval age-standardised incidence rates(ASIRs) were evaluated using cancer registry data from volumes X±XII of the cancer Incidence in Five Continents(CI5). Correlation analysis was used to evaluate the relationship between ASIR or the age-standardised mortality rate(ASMR) and the Human Development Index(HDI).Results: There was an estimated global 968,000 new GC cases and 660,000 deaths in 2022, with male predominance. GC ASIRs and ASMRs were 9.2 and 6.1 per 100,000 persons, respectively. East Asia had the highest burden, with 53.8% of cases and 48.2% of deaths among all geographic regions. There was a significant correlation between ASIR and HDI. Over three 5-year intervals from 2003 to 2017, the incidence of GC notably decreased in most countries but peaked at 2008±2012 in New Zealand, Turkey, and South Africa. Several countries in Europe, Oceania, and America suggest an increasingly concerning trend among younger individuals, especially ***: GC is a significant health issue, especially among males and in geographic regions with an HDI, such as eastern Asia. While the incidence of GC is decreasing in many countries due to prevention efforts and improved treatments, a rising trend persists among younger individuals. Comprehensive prevention strategies tailored to different age patterns are clearly needed.

关键词： Gastric cancer cancer burden GLOBOCAN incidence mortality

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Clinical impact of atypical endoscopic features in rectal neuroendocrine tumors

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World Journal of Gastroenterology 2015年第47期21卷 13302-13308页

作者： Jong Hee Hyun Seong Dae Lee Eui Gon Youk Jae Bum Lee Enu-Jung Lee Hee Jin Chang Dae Kyung Sohn Center for Colorectal cancer National Cancer Center department of Surgery Daehang Hospital

AIM: To validate the association between atypical endoscopic features and lymph node metastasis(LNM).METHODS: A total of 247 patients with rectal neuroendocrine tumors(NETs) were analyzed. Endoscopic images were reviewed independently by two endoscopists, each of whom classified tumors by sized and endoscopic features, such as shape, color, and surface change(kappa coefficient 0.76 for inter-observer agreement). All of patients underwent computed tomography scans of abdomen and pelvis for evaluation of LNM. Univariate and multivariate analyses were performed to identify the factors associated with LNM. Additionally, the association between endoscopic atypical features and immunohistochemical staining of tumors was ***: Of 247 patients, 156(63.2%) were male and 15(6.1%) were showed positive for LNM. On univariate analysis, tumor size(P < 0.001), shape(P < 0.001), color(P < 0.001) and surface changes(P < 0.001) were significantly associated with LNM. On multivariate analysis, tumor size(OR = 11.53, 95%CI: 2.51-52.93, P = 0.002) and atypical surface(OR = 27.44, 95%CI: 5.96-126.34, P < 0.001) changes were independent risk factors for LNM. The likelihood of atypical endoscopic features increased as tumor size increased. Atypical endoscopic features were associated with LNM in rectal NETs < 10 mm(P = 0.005) and 10-19 mm(P = 0.041) in diameter. Immunohistochemical staining showed that the rate of atypical endoscopic features was higher in non L-cell ***: Atypical endoscopic features as well as tumor size are predictive factors of LNM in patients with rectal NETs.

关键词： Rectal neuroendocrine tumor Colonoscopy Lymph node metastasis

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