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Congenital Heart Disease 2024年第1期19卷 65-68页

作者： Michael A.Rebolledo Jane S.Yao Jason N.Johnson Umar S.Boston Benjamin R.Waller III Division of pediatric Cardiology Department of PediatricsThe University of Tennessee Health Science CenterThe Heart InstituteLe Bonheur Children’s HospitalMemphisUSA College of Medicine The University of Tennessee Health ScienceMemphisUSA Division of pediatric Cardiothoracic Surgery Department of SurgeryThe University of Tennessee Health Science CenterHeart InstituteLe Bonheur Children’s HospitalMemphisUSA

We describe a 63-year-old male who appears to have undergone an early form of the arterial switch operation for D-transposition of the great arteries performed in the *** review the clinical and imaging data that support our *** had a diagnostic cardiac catheterization which demonstrated severe pulmonary hypertension responsive to epoprostenol and *** case may represent one example of the experimental surgical work done prior to *** Jatene’s description of theﬁrst successful arterial switch performed in 1975.

关键词： Adult congenital heart disease arterial switch operation great vessel anomaly imaging(all modalities)

Unroofed coronary sinus,left-sided superior vena cava and mitral insufficiency:A case report and review of the literature

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World Journal of Cardiology 2024年第10期16卷 595-603页

作者： Fouad Bitar Ziad Bulbul Yehya Jassar Rana Zareef Jennifer Abboud Mariam Arabi Fadi Fouad Bitar department of pediatric and Adolescent American University of Beirut Medical CenterBeirut 1103Lebanon department of Surgery American University of Beirut Medical CenterBeirut 1103Lebanon

BACKGROUND Unroofed coronary sinus(UCS)is a rare subtype of atrial septal *** is frequently associated with a persistent left superior vena cava and is often part of a more intricate cardiac *** SUMMARY This report describes a rare case of an adolescent patient with UCS featuring atrial situs solitus,absence of the right superior vena cava and a persistent left superior vena cava draining into the left atrium consistent with total unroofing of the coronary *** was associated with concurrent severe mitral insufficiency secondary to redundant and prolapsing leaflets,and a substantial left-to-right shunt across the coronary sinus orifice.A comprehensive examination of the existing literature is included,shedding light on the diagnostic challenges of UCS and describing the available surgical options within the context of mitral valve *** UCS is a complex condition requiring careful consideration of associated anomalies and a tailored surgical approach.

关键词： Unroofed coronary sinus Mitral insufficiency Single left superior vena cava Surgical options Absent right superior vena cava Case report

SARS-CoV-2 variants are associated with different clinical courses in children with MIS-C

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World Journal of pediatrics 2024年第2期20卷 143-152页

作者： Andres F.Moreno Rojas Emelia Bainto Helen Harvey Adriana H.Tremoulet Jane C.Burns Kirsten B.Dummer department of pediatrics Division of Pediatric CardiologyUniversity of California San Diegoand Rady Children’s Hospital3020 Children’s Way MC 5004San DiegoCA 92123USA Kawasaki Disease Research Center La JollaCAUSA department of pediatrics Division of Pediatric Critical CareUniversity of California San Diegoand Rady Children’s HospitalSan DiegoCAUSA department of pediatrics University of California San Diegoand Rady Children’s HospitalSan DiegoCAUSA

Background Recent infection with SARS‑CoV-2 in children has been associated with multisystem inflammatory syndrome in children(MIS-C).SARS‑CoV-2 has undergone different *** publications exist about specific variants and their correlation with the severity of *** This was a single-center,retrospective study including all patients admitted with MIS-C at Rady Children’s Hospital-San Diego between May 2020 and March *** epidemiologic data,including viral genomic information,were obtained from public ***,clinical presentation,laboratory values,and outcomes were obtained from electronic medical *** The analysis included 104 pediatric *** MIS-C waves were *** variants in San Diego during the first wave included clades 20A to *** the second wave,there were variants from clades 20A to C,20G,21C(Epsilon),20I(Alpha),and 20J(Gamma).The third wave had Delta strains(clades 21A,21I,and 21J),and the fourth had Omicron variants(clades 21K,21L,and 22C).MIS-C presented with similar symptoms and laboratory findings across all *** patients were admitted to the pediatric intensive care unit(PICU)(74%)and required inotropic support(63%)during the second *** of the patients required mechanical circulatory support,and only two required invasive ventilatory *** was no *** The various strains of SARS-CoV-2 triggered MIS-C with differing severities,with the second wave having a more severe clinical *** the differences in disease severity across variants were due to changes in the virus or other factors remains unknown.

关键词： Complications COVID-19 MIS-C SARS-CoV-2 variants

Poor oral health was associated with higher risk of gastric cancer: Evidence from 1431677 participants

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World Journal of Gastrointestinal Surgery 2024年第2期16卷 585-595页

作者： Fei Liu Shi-Jun Tang Zi-Wei Li Xu-Rui Liu Quan Lv Wei Zhang Dong Peng department of Gastrointestinal Surgery The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China department of pediatric Dentistry Stomatological Hospital of Guizhou Medical UniversityGuizhou 550000Guizhou ProvinceChina

BACKGROUND In recent years,the association between oral health and the risk of gastric cancer(GC)has gradually attracted increased ***,in terms of GC incidence,the association between oral health and GC incidence remains *** is reported to increase the risk of ***,some studies have shown that periodontitis has no effect on the risk of ***,the present study aimed to assess whether there is a relationship between oral health and the risk of *** To assess whether there was a relationship between oral health and the risk of *** Five databases were searched to find eligible studies from inception to April 10,***-Ottawa Scale score was used to assess the quality of included *** quality of cohort studies and case-control studies were evaluated separately in this *** of GC were described by odds ratio(OR)and 95%confidence interval(CI).Funnel plot was used to represent the publication bias of included *** performed the data analysis by StataSE *** A total of 1431677 patients from twelve included studies were enrolled for data analysis in this *** to our analysis,we found that the poor oral health was associated with higher risk of GC(OR=1.15,95%CI:1.02-1.29;I2=59.47%,P=0.000.01),gingivitis(OR=1.19,95%CI:0.71-1.67;I2=0.00%,P>0.01),dentures(OR=1.27,95%CI:0.63-1.19;I2=68.79%,P>0.01),or tooth brushing(OR=1.25,95%CI:0.78-1.71;I2=88.87%,P>0.01)had no influence on the risk of ***,patients with periodontitis(OR=1.13,95%CI:1.04-1.23;I2=0.00%,P<0.01)had a higher risk of *** Patients with poor oral health,especially periodontitis,had a higher risk of *** should be concerned about their oral *** oral health might reduce the risk of GC.

关键词： Oral health Tooth loss Periodontitis Gastric cancer Risk factor

ccdc141 is required for left-right axis development by regulating cilia formation in the Kupffer's vesicle of zebrafish

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Journal of Genetics and Genomics 2024年第9期51卷 934-946页

作者： Pengcheng Wang Wenxiang Shi Sijie Liu Yunjing Shi Xuechao Jiang Fen Li Sun Chen Kun Sun Rang Xu department of pediatric Cardiology Xinhua HospitalShanghai Jiao Tong University School of MedicineShanghai 200092China department of Cardiovascular Medicine Heart Failure CenterRuijin HospitalRuijin Hospital Lu Wan BranchShanghai Jiao Tong University School of MedicineShanghai 200025China Scientific Research Center Xinhua HospitalShanghai Jiao Tong University School of MedicineShanghai 200092China department of pediatric Cardiology Shanghai Children's Medical CenterShanghai Jiao Tong University School of MedicineShanghai 200127China

Laterality is a crucial physiological process intricately linked to the cilium-centrosome complex during embryo *** in the process can result in severe organ ***-coil domain containing 141(CCDC141)has been previously known as a centrosome-related gene,but its role in left-right(LR)asymmetry has not been *** this study,we utilize the zebrafish model and human exome analysis to elucidate the function of ccdc141 in laterality *** knockdown of ccdc141 in zebrafish disrupts early LR signaling pathways,cilia function,and Kupffer's vesicle *** ccdc141-knockdown embryos exhibiting aberrant LR patterns,ccdc141-null mutants show no apparent abnormality,suggesting a genetic compensation response *** parallel,we observe a marked reduction inα-tubulin acetylation levels in the ccdc141 *** treatment with histone deacetylase(HDAC)inhibitors,particularly the HDAC6 inhibitor,rescues the ccdc141 crispant ***,exome analysis of 70 patients with laterality defects reveals an increased burden of CCDC141 mutations,with in-vivo studies verifying the pathogenicity of the patient mutation *** findings highlight the critical role of ccdc141 in ciliogenesis and demonstrate that CCDC141 mutations lead to abnormal LR patterns,identifying it as a candidate gene for laterality defects.

关键词： Left-right axis Cilia WES Laterality defects Zebrafish CCDC141

Witness for resolution: post-conflict quadratic affiliation in semi-free ranging pigs

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Current Zoology 2024年第2期70卷 233-243页

作者： Ivan Norscia Edoardo Collarini Carlo Robino Elena Chierto Giada Cordoni department of Life Sciences and Systems Biology University of TorinoVia Accademia Albertina 1310123 TorinoItaly department of Public Health Sciences and pediatric s University of TorinoC.So Galileo Galilei 2210126 TorinoItaly

In social mammals,post-conflict resolution can involve the reunion of former opponents(reconciliation),spontaneous/solicited post-conflict affliation of a third party with either opponent(triadic contacts),and affiliation between other individuals(hereafter bystanders;quadratic contacts).Quadratic contacts-possibly informing complex cognitive abilities-have been neglected in post-conflict *** investi-gated quadratic affliation in semi-free ranging pigs Sus scrofa,at the ethical farm Parva-Domus(Cavagnolo,Italy).Kinship was *** collected behavioral data on adult pigs(n=104)via video recordings(43 h)followed by video *** and anxiety behaviors between bystanders were collected under post-conflict(PC;following a conflict between non-bystanders)and matched-control(MC;no conflict)*** affiliation was present in pigs,as bystanders affliated more in PC than MC,and such affiliation was followed by a decrease in the anxiety behaviors of both the interacting ***,quadratic contacts may be partly aimed at reducing one's own anxiety(intrinsic regulation).Quadratic affiliation was highest between closely related bystanders,which suggests that such affiliation may be most effective when close kin is *** affiliation was lowest after reconciliation and spontaneous triadic *** suggests that direct peacemaking between opponents and spontaneous triadic contacts with close kin may most likely replace quadratic ***,pigs can be influenced by the negative events that affect other pigs-but not themselves-and their response may be modulated by social *** non-random quadratic affiliation may point toward the presence of elements of social appraisal abilities inpigs.

关键词： anxiety reduction emotional regulation reconciliation social appraisal triadic contacts.

Visible light cross-linking and bioactive peptides loaded integrated hydrogel with sequential release to accelerate wound healing complicated by bacterial infection

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Nano Research 2024年第3期17卷 1737-1747页

作者： Guiyan Wang Ning Yuan Jun Zhang Man Qin Suwei Dong Yuguang Wang department of pediatric Dentistry Peking University School and Hospital of StomatologyBeijing 100081China State Key Laboratory of Natural and Biomimetic Drugs Chemical Biology Centerand School of Pharmaceutical SciencesPeking UniversityBeijing 100191China department of Prosthodontics Peking University School and Hospital of StomatologyBeijing 100081China

The effective management of bacterial infections that are resistant to multiple drugs remains a substantial clinical *** eradication of drug-resistant bacteria and subsequent promotion of angiogenesis are imperative for the regeneration of the infected ***,a novel and facile peptide containing injectable hydrogel with sustained antibacterial and angiogenic capabilities is *** antibacterial peptide that consists of 11 residues(CM11,WKLFKKILKVL)is loaded onto acrylate-modified gelatin through charge interactions.A vascular endothelial growth factor mimetic peptide KLT(KLTWQELYQLKYKGI)with a GCG(Gly-Cys-Gly)modification at the N-terminal is covalently coupled through a visible light-induced thiol-ene *** this reaction,the acrylate gelatin undergoes cross-linkage within *** on the physical/chemical double crosslinking strategy,the bioactive peptides achieve sustained and sequential *** results show that the hydrogel significantly inhibits methicillin-resistant Staphylococcus aureus(MRSA)growth through the rapid release of CM11 peptides at early stage;it forms obvious growth inhibition zones against pathogenic bacterial ***,cell counting kit-8 assay and scratch test confirm that the CM11/KLT-functionalized hydrogels promote cell proliferation and migration through the later release of KLT *** a mouse skin wound infected with self-luminous MRSA,the CM11/KLT-functionalized hydrogels enhance wound healing,with rapidly bacterial infection reduction,lower expression of inflammatory factors,and neovascularization *** results suggest that the rationally designed,sustained and sequential release CM11/KLT-functionalized hydrogels have huge potential in promoting the healing of multi-drug resistant bacterial infected wounds.

关键词： antimicrobial peptide vascular endothelial growth factor(VEGF)mimetic peptide sequential release visible-light crosslinking hydrogel wound therapy

pediatric stricturing Crohn's disease

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World Journal of Gastroenterology 2024年第12期30卷 1651-1654页

作者： Alessandro Boscarelli Matteo Bramuzzo department of pediatric Surgery and Urology Institute for Maternal and Child Health-IRCCS“Burlo Garofolo”Trieste 34137Italy department of Gastrointestinal Endoscopy and Nutrition Institute for Maternal and Child Health-IRCCS"Burlo Garofolo"Trieste 34137Italy

Crohn’s disease(CD)is a chronic inflammatory disease of the digestive *** incidence of pediatric CD is increasing and is currently 2.5-11.4 per 100000 ***,approximately 25%of children with CD develop stricturing CD(SCD)that requires *** stricturing diseases refractory to pharmacological management frequently require non-pharmacological ***-pharmacological therapeutic strategies include endoscopic balloon dilatation,stricturoplasty,and surgical resection of the strictured ***,strictures tend to recur postoperatively regardless of treatment *** lifetime risk of surgery in patients with childhood SCD remains at 50%-90%.Thus,new and emerging strategies,advanced diagnostic tools,and minimally invasive approaches are under investigation to improve the outcomes and overall quality of life of pediatric patients with SCD.

关键词： Stricturing Crohn’s disease pediatrics Insights Future perspectives

Evolving strategies: Enhancements in managing eosinophilic esophagitis in pediatric patients

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World Journal of Clinical pediatrics 2024年第1期13卷 14-22页

作者： Ahmed Elghoudi Doaa Zourob Eman Al Atrash Fatima Alshamsi Manal Alkatheeri Hassib Narchi Rana Bitar department of pediatric Sheikh Khalifa Medical CityAbu DhabiUnited Arab Emirates Division of pediatric Gastroenterology Sheikh Khalifa Medical CityAbu DhabiUnited Arab Emirates pediatric Residency Program Sheikh Khalifa Medical CityAbu DhabiUnited Arab Emirates College of Medicine and Health Sciences United Arab Emirates UniversityAlainAbu DhabiUnited Arab Emirates

Eosinophilic esophagitis is a newly recognized disease first described about 50 years *** definition,diagnosis,and management have evolved with new published consensus guidelines and newly approved treatment available to pediatricians,enabling a better understanding of this disease and more targeted treatment for *** describe the definition,presentation,and diagnosis of eosinophilic esophagitis including management,challenges,and future directions in *** definition,diagnosis,and management of eosinophilic esophagitis have evolved over the last 50 *** guidelines and newly approved biologic treatment have enabled pediatricians to better understand this disease and allow for more targeted treatment for *** describe the definition,presentation,diagnosis,management,and treatment in addition to the challenges and future directions of eosinophilic esophagitis management in children.

关键词： Eosinophilic esophagitis Esophagitis Gastroesophageal reflux disease Food allergy Dysphagia

Late chordee correction after tubularized incised plate repair for proximal hypospadias:An underreported problem

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UroPrecision 2024年第2期2卷 51-57页

作者： Amr Abdelhamid Abouzeid Mohammad Seada Mohamed Waly department of pediatric Surgery Ain Shams University Faculty of MedicineCairoEgypt department of pediatric Surgery Benha Specialized Children HospitalBenhaEgypt

Background:Repair of proximal hypospadias remains a challenge with no consensus on the best surgical *** reports have shown recurrence of chordee after plate-preserving *** this report,we present our experience in managing cases who presented with persistent/recurrence of chordee after tubularized incised plate(TIP)repair for proximal ***:Between 2015 and 2023,the study included eight patients who presented with ventral penile curvature after previous hypospadias repair in infancy(TIP urethroplasty).Reoperation to correct persistent ventral curvature was performed several years after the primary TIP repair(3-15 years;mean 7.9 years;median 7.5 years).The reoperation was a two-stage procedure:the first stage comprised transection of the urethra and grafting(lower lip mucosal graft);the second stage(6 months later)was a Thiersch-Duplay ***:Complications included poor taking of the graft after the first stage in one case(12.5%),which was regrafted using buccal(cheek)*** after second stage included urethro-cutaneous fistulae in five(62.5%)that were successfully surgically treated at a later ***-up after second stage ranged between 6 months and 7 years(mean 2.4 years;median 1 year).Satisfaction with reoperation to correct penile curvature was noted by parents as well as older children(adolescents)who appreciated better cosmesis by increasing ventral penile length and improved ***:Preservation of the urethral plate in proximal hypospadias may result in shortened penile length,mostly on the ventral aspect.A two-stage reoperation to increase the length of the penile urethra can successfully reverse this complication.

关键词： complications hypospadias proximal severe ventral curvature