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Obstructive jaundice leads to accumulation of oxidized low density lipoprotein in human liver tissue

World Journal of Gastroenterology 2006年第31期12卷 5094-5095页

作者： Mustafa Comert Yucel Ustundag Ishak Ozel Tekin Banu Dogan Gun Figen Barut department of SurgerySchool of medicine Zonguldak Karaelmas UniversityTurkey department of GastroenterologySchool of medicine Zonguldak Karaelmas UniversityKozlu-ZonguldakTurkey department of ImmunologySchool of medicine Zonguldak Karaelmas UniversityKozlu-ZonguldakTurkey department of pathologyschool of medicine Zonguldak Karaelmas UniversityKozlu-ZonguldakTurkey

Oxidized low density lipoprotein （ox-LDL） molecule is one of the most important modified lipoproteins produced during the oxidative stress. Modified lipoproteins have been defined as being part of the immune inflammatory mechanisms in association with oxidant stress. We have reported the accumulation of ox-LDL in Balb/c mice liver after bile duct ligation previously. Here, we investigated this finding in human beings with obstructive jaundice. Our study demonstrates that obstructive jaundice results in tremendous accumulation of ox-LDL in the liver tissue of patients.

关键词： Obstructive jaundice Liver Oxidative stress Oxidized low density lipoprotein

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Relation between common polymorphisms in genes related to inflammatory response and colorectal cancer

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World Journal of Gastroenterology 2006年第31期12卷 5037-5043页

作者： George Theodoropoulos Ioannis Papaconstantinou Evangelos Felekouras Nikolaos Nikiteas Petros Karakitsos Dimitris Panoussopoulos Andreas Ch Lazaris Efstratios Patsouris John Bramis Maria Gazouli 1st Propaideutic Surgical departmentHippocration University Hospital School of MedicineUniversity of AthensGreece 1st Surgical departmentLaikon University Hospital University of AthensGreece department of pathologyschool of medicine University of AthensGreece 2nd Propaideutic Surgical departmentLaikon University Hospital University of AthensGreece department of CytopathologyUniversity General Hospital "Artikon" University of AthensGreece department of BiologySchool of medicine University of AthensGreece

AIM： To investigate the association between common single nucleotide polymorphisms （SNPs） in inflammatory response-related genes such as interleukin （IL）-6, IL-8, tumor necrosis factor α （TNFα）, peroxisome proliferators-activated receptor γ （PPARγ）, intercellular adhesion molecule-1 （ICAM-1） and the risk of colorectal cancer （CRC） in a group of Greek patients. METHODS： The study group consisted of 222 CRC patients and 200 healthy controls. Genotyping was performed using allele-specific PCR of PRC-RFLP and the results were confirmed by sequencing. We studied the association of SNPs in the IL-6 （-174G 〉 C）, IL-8 （-251T 〉 A）, TNFα （-308G 〉 A）, ICAM-1 （R241G and K469E）, and PPARγ （Pro12Ala） genes and the risk of CRC. RESULTS： The IL-6 -174G, R241 and K469 alleles of ICAM-1 were associated with increased risk of CRC （OR = 1.77, 95% CI： 1.34-2.34; OR = 1.83, 95% CI： 1.23-2.72; and OR = 1.35, 95% CI： 1.03-1.77 respectively）. The IL-8 and TNFα polymorphisms had no effect. Whereas the PPARγ Pro12 genotype was associated with increased risk of disease （OR = 1.78, 95% CI： 1.25-2.49）. CONCLUSION： The association between common SNPs in immunologic response-related genes and CRC is reported in the present study. Apart from shedding light on the mechanisms of malignancy initiation and progression, SNPs may improve appropriate screening for sub-populations at risk.

关键词： Colorectal cancer Inflammation Single nucleotide polymorphisms

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