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Disparate outcomes in Hispanic patients with metabolic dysfunctionassociated steatotic liver disease/steatohepatitis and type 2 diabetes: Large cohort study

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World Journal of Diabetes 2024年第5期15卷 886-897页

作者： Joseph Matthew Gosnell George Golovko Esteban Arroyave Akshata Moghe Michael L Kueht Omar AbdulSaldarriaga Kevin H McKinney Heather L Stevenson Monique R Ferguson department of pathology University of Texas Medical BranchGalvestonTX 77555United States department of Pharmacology&Toxicology University of Texas Medical BranchGalvestonTX 77555United States department of Medicine University of Texas Health Science Center at HoustonHoustonTX 77030United States department of Surgery University of Texas Medical BranchGalvestonTX 77555United States Center for Tropical Diseases Department of Internal MedicineUniversity of Texas Medical BranchGalvestonTX 77555United States department of Internal Medicine University of Texas Medical BranchGalvestonTX 77555United States

BACKGROUND Metabolic dysfunction-associated steatotic liver disease(MASLD)and metabolic dysfunction-associated steatohepatitis(MASH)are a growing health burden across a significant portion of the global patient ***,these conditions seem to have disparate rates and outcomes between different ethnic *** combination of MASLD/MASH and type 2 diabetes increases the risk of hepatocellular carcinoma(HCC),and Hispanic patients experience the greatest burden,particularly those in South *** To compare outcomes between Hispanic and non-Hispanic patients in the United States,while further focusing on the Hispanic population within Southeast texas to determine whether the documented disparity in outcomes is a function of geographical circumstance or if there is a more widespread reason that all clinicians must account for in prognostic *** This cohort analysis was conducted with data obtained from TriNetX,LLC(“TriNetX”),a global federated health research network that provides access to deidentified medical records from healthcare organizations *** cohort networks were used:university of texas medical branch(UTMB)hospital and the United States national database collective to determine whether disparities were related to geographic regions,like Southeast *** This study findings revealed Hispanics/Latinos have a statistically significant higher occurrence of HCC,type 2 diabetes mellitus,and liver fibrosis/cirrhosis in both the United States and the UTMB Hispanic/Latino *** mortality in Hispanics/Latinos was lower within the United States group and not statistically elevated in the UTMB *** This would appear to support that Hispanic patients in Southeast texas are not uniquely affected compared to the national Hispanic population.

关键词： Metabolic dysfunction-associated steatotic liver disease Metabolic dysfunction-associated steatohepatitis Hispanic Diabetes mellitus TriNetX Non-alcoholic fatty liver disease Non-alcoholic steatohepatitis Steatotic liver disease Hepatocellular carcinoma

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Outcomes of endoscopic submucosal dissection in cirrhotic patients: First American cohort

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World Journal of Hepatology 2024年第5期16卷 784-790页

作者： Robert Luke Pecha Fares Ayoub Ankur Patel Abdullah Muftah Michael W Wright Mai A Khalaf Mohamed O Othman department of Gastroenterology and Hepatology UC DavisSacramentoCA 95817United States department of Gastroenterology and Hepatology Baylor College of MedicineHoustonTX 77030United States Internal Medicine Baylor College of MedicineHoustonTX 77030United States department of Gastroenterology and Hepatology University of Texas Medical Branch at GalvestonGalvestonTX 77550United States medical School Baylor College of MedicineHoustonTX 77030United States department of Tropical Medicine Tanta UniversityTanta 31527Egypt

BACKGROUND Among patients with cirrhosis and pre-malignant or early malignant mucosal lesions,surgical intervention carries a much higher bleeding *** such lesions are discovered,endoscopic submucosal dissection(ESD)may offer curative therapy with lower risks than surgery and improved outcomes compared to traditional endoscopic *** To evaluate the outcomes of ESD in patients with *** Patients with cirrhosis undergoing ESD between July 2015 and August 2022 were retrospectively matched in 1:2 fashion to controls based on lesion location,size,and anticoagulation *** outcomes were compared between *** A total of 64 Lesions from 59 patients were included(16 cirrhosis,43 control).There were no differences in patient or lesion characteristics between *** bloc and curative resection was achieved in 84.21%,78.94%of the cirrhosis group and 88.89%,68.89%of controls,respectively,with no significant *** patients had significantly higher rates of intra-procedural coagulation grasper use for control of bleeding(47.37%vs 20%;P=0.02).There were otherwise no significant differences in adverse event *** the 29 patients with follow up,we found higher rates of recurrence in the cirrhosis group compared to controls(40%vs 5.26%;P=0.019),however this effect did not persist on multivariable analysis controlling for known *** ESD may be safe and effective in patients with *** procedure related outcomes were not significantly different between ***-procedural bleeding requiring use of the coagulation grasper use was expectedly higher in the cirrhosis group given the known effects of liver disease on hemostasis.

关键词： Endoscopic aubmucosal dissection Cirrhosis Advanced polypectomy Intraprocedural bleeding Colon cancer

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A case of Sjogren's syndrome evolving into multicentric reticulohistiocytosis

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Rheumatology & Autoimmunity 2023年第3期3卷 179-184页

作者： Daniel Gonzalez Vinh Lu Madeline Bonnet Rachelle Gietzen Anthony Linfante Enrique Medina Vijaya Murthy Division of Rheumatology University of Texas Medical BranchGalvestonTexasUSA department of Internal Medicine University of Texas Medical BranchGalvestonTexasUSA university of texas medical branch(UTMB)John Sealy School of Medicine GalvestonTexasUSA department of pathology University of Texas Medical BranchGalvestonTexasUSA department of Dermatology University of Texas Medical BranchGalvestonTexasUSA

Introduction:Multicentric reticulohistiocytosis(MRH)is a rare disease that is known to affect the skin and joints,*** is considered a rare form of non-Langerhans cell histiocytosis(Group C)that can cause destructive inflammatory arthritis involving both the small and large *** eruptions of periungual,“coral beads”and nodules appearing over the distal fingers are considered pathognomonic clues for identifying this *** evaluation of the cutaneous papules typically shows infiltrative histiocytes and multinucleated giant *** no well-established therapies exist to date,a variety of immunosuppressants have been used with varying degrees of *** Description:A 53-year-old Caucasian female patient with a family history of rheumatoid arthritis and a personal history of Sjogren's syndrome presented to the rheumatology clinic complaining of pain in her bilateral hands and *** were several small,papulo-nodular lesions ranging from 1 to 2mm in size noted at the base of her nails.A 4mm punch biopsy of one of the papules from the neck showed dermal infiltration of eosinophilic mononucleated and multinucleated giant cells with“ground glass”appearing cytoplasm consistent with MRH.X-ray of her hands showed periarticular demineralization and erosions surrounding several bilateral proximal and distal interphalangeal joints,and thus tofacitinib in addition to methotrexate,hydroxychloroquine,and dexamethasone(dosed weekly)was started to help control any further articular ***:Our aim is to further support the relation of MRH with autoimmune diseases,including Sjogren's *** diseases have been reported in association with MRH,although a clear association has yet to be made.

关键词： erosive arthritis multicentric reticulohistiocytosis Sjogren's syndrome

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Advancing spinal cord injury research with optical clearing,light sheet microscopy,and artificial intelligence-based image analysis

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Neural Regeneration Research 2023年第12期18卷 2661-2662页

作者： Qiang Li Alfredo Sandoval Jr Bo Chen department of Neurobiology University of Texas Medical BranchGalvestonTXUSA

From the days of Ramon y Cajal's first sketches,neuroscientists have recognized the importance of visualizing the complex architecture of the central nervous *** the past century,we have come to appreciate how the rich structural and functional complementarity of axons and cell types in the spinal cord make it uniquely suited for information transfer between the periphery and the brain.

关键词： artificial image sketch

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Cross-neutralization and cross-protection among SARS-CoV-2 viruses bearing different variant spikes

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Signal Transduction and Targeted Therapy 2022年第9期7卷 3202-3205页

作者： Yang Liu Jianying Liu Jing Zou Birte Kalveram Rafael R.G.Machado Ping Ren Sina Tureli Derek J.Smith Scott C.Weaver Xuping Xie Pei-Yong Shi department of Biochemistry and Molecular Biology University of Texas Medical BranchGalvestonTXUSA Institute of Infectious Diseases Shenzhen Bay LaboratoryShenzhenChina department of Microbiology and Immunology University of Texas Medical BranchGalvestonTXUSA department of pathology University of Texas Medical BranchGalvestonTXUSA Center for Pathogen Evolution Department of ZoologyUniversity of CambridgeCambridgeUK Sealy Institute for Drug Discovery University of Texas Medical BranchGalvestonTXUSA Sealy Center for Structural Biology&Molecular Biophysics University of Texas Medical BranchGalvestonTXUSA

Dear Editor The rapid evolution of SARS-CoV-2 mandates a better under-standing of cross-neutralization and cross-protection among *** information is essential to guide vaccine strategy and public *** examine the cross-protection among different variant spikes,we initially prepared four chimeric SARS-CoV-2 viruses(Fig.1a),each bearing the spike gene from Alpha,Beta,Gamma,or Epsilon in the backbone of USA-WA1/2020[isolated in January 2020 and defned as wild-type(WT)].

关键词： vaccine cross backbone

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Small duct primary sclerosing cholangitis: A discrete variant or a bridge to large duct disease, a practical review

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World Journal of Hepatology 2022年第3期14卷 495-503页

作者： Christopher M Nguyen Kevin T Kline Heather L Stevenson Kashif Khan Sreeram Parupudi department of Internal Medicine The University of Texas Medical BranchGalvestonTX 77555United States department of Gastroenterology and Hepatology The University of Texas Medical BranchGalvestonTX 77555United States department of pathology University of Texas Medical BranchGalvestonTX 77555United States

The natural history,associations with inflammatory bowel disease(IBD),and long-term outcomes of large duct primary sclerosing cholangitis(ldPSC)have been well *** duct primary sclerosing cholangitis(sdPSC)is a much less common and relatively more benign *** natural history of sdPSC has been difficult to characterize given the limited number of studies in the literature especially with regards to the subset of patients who progress to large duct *** has been unclear whether sdPSC represented a subset of ldPSC,an earlier staging of ldPSC,or a completely separate and distinct entity of its *** associations between sdPSC and IBD have been established with suspicion that concurrent sdPSC-IBD may be a key prognostic factor in determining which patients are at risk of progression to *** is known regarding the discrete circumstances that predisposes some patients with sdPSC to progress to *** has been suspected that progression to large biliary duct involvement subjects this subset of patients to potentially developing lifethreatening *** the authors conducted a thorough review of the published sdPSC literature using Pubmed searches and cross-referencing to compile all accessible studies regarding cohorts of sdPSC patients in order better characterize the subset of sdPSC patients who progress to ldPSC and the associated outcomes.

关键词： Small duct primary sclerosing cholangitis Inflammatory bowel disease Progression Primary sclerosing cholangitis Outcomes

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Amyloid goiter secondary to familial Mediterranean fever with E148Q mutation:A unique case

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慢性疾病与转化医学:英文版 2023年第3期9卷 266-268页

作者： Juan C.A.Moreno Eduardo Eyzaguirre Suimin Qiu department of pathology The University of Texas Medical BranchGalvestonTexasUSA

Dear Editor,Goiter is defined as the enlargement of the thyroid *** is currently divided into diffuse and nodular and subdivided into toxic(associated with hyperthyroidism)or nontoxic(associated with normal thyroid stimulating hormone[TSH]levels).1 The most common cause of goiter is iodine deficiency,2 and other causes are increased levels of TSH,natural goitrogens,iron and vitamin A deficiency,genetic factors(DICER1 syndrome and PTEN hamartoma tumor syndrome),and hereditary(Plummer syndrome)factors.

关键词： vitamin stimulating fever

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Transperineal laser ablation of the prostate as a treatment for benign prostatic hyperplasia and prostate cancer: The results of a Delphi consensus project

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Asian Journal of Urology 2024年第2期11卷 271-279页

作者： Andrea Cocci Marta Pezzoli Fernando Bianco Franco Blefari Pierluigi Bove Francois Cornud Gaetano De Rienzo Paolo Destefanis Danilo Di Trapani Alessandro Giacobbe Luca Giovanessi Antonino Laganà Giovanni Lughezzani Guglielmo Manenti Gianluca Muto Gianluigi Patelli Novello Pinzi Stefano Regusci Giorgio I.Russo Juan I.M.Salamanca Matteo Salvi Luigi Silvestri Fabrizio Verweij Eric Walser Riccardo GBertolo Valerio Iacovelli Alessandro Bertaccini Debora Marchiori Hugo Davila Pasquale Ditonno Paolo Gontero Gennaro Iapicca Theo M De Reijke Vito Ricapito Pierluca Pellegrini Andrea Minervini Sergio Serni Francesco Sessa department of Urology Careggi HospitalUniversity of FlorenceFlorenceItaly Urology Section University of FlorenceFlorenceItaly Urological Research Network MiamiFLUSA Urology Section Prato HospitalPratoItaly Torvergata Oncoscience Research Centre of Excellence TORDepartment of Experimental MedicineUniversity of Rome Tor VergataRomeItaly department of Urology San Carlo di Nancy HospitalRomeItaly department of Radiology Hôpital CochinParis Descartes UniversityParisFrance Urology and Andrology Unit II Department of Emergency and Organ TransplantationUniversity of BariBariItaly Unit of Urology Cittàdella Salute e della Scienza HospitalUniversity of TurinTurinItaly Urology Unit Buccheri La Ferla Fatebenefratelli HospitalPalermoItaly department of Urology Humanitas Gradenigo HospitalTurinItaly Urology Unit Surgical DepartmentFondazione Poliambulanza Istituto OspedalieroBresciaItaly Departement of Urology “S.Giovanni Evangelista”HospitalTivoliItaly Humanitas Clinical and Research CentereIRCCS Department of UrologyRozzanoItaly department of Biomedical Sciences Humanitas UniversityPieve EmanueleItaly department of Biomedicine and Prevention University of Rome“Tor Vergata”RomeItaly department of Diagnostic Imaging and Interventional Radiology University of Rome“Tor Vergata”RomeItaly department of Interventional Radiology Pesenti-Fenaroli Hospital-ASST Bergamo EstAlzano LombardoItaly department of Urology University of SienaSienaItaly Swiss International Prostate Center GenevaSwitzerland Clinique Générale Beaulieu GenevaSwitzerland department of Urology University of CataniaItaly department of Urology Puerta de Hierro-Majadahonda University HospitalMadridSpain Lyx Institute of Urology Universidad Francisco de VitoriaMadridSpain department of Medico-Surgical Sciences and Biotechnologies Sapienza University of RomeFaculty of Pharmacy and MedicineUrology Unit ICOTLatinaItaly department of Urology European Institute of Oncology(IEO)IRCCSMilanItaly department of Radiology D

Objective: To evaluate transperineal laser ablation (TPLA) with Echolaser® (Echolaser® TPLA, Elesta S.p.A., Calenzano, Italy) as a treatment for benign prostatic hyperplasia (BPH) and prostate cancer (PCa) using the Delphi consensus ***: Italian and international experts on BPH and PCa participated in a collaborative consensus project. During two rounds, they expressed their opinions on Echolaser® TPLA for the treatment of BPH and PCa answering online questionnaires on indications, methodology, and potential complications of this technology. Level of agreement or disagreement to reach consensus was set at 75%. If the consensus was not achieved, questions were modified after each round. A final round was performed during an online meeting, in which results were discussed and ***: Thirty-two out of forty invited experts participated and consensus was reached on all topics. Agreement was achieved on recommending Echolaser® TPLA as a treatment of BPH in patients with ample range of prostate volume, from 80 mL (80%), comorbidities (100%), antiplatelet or anticoagulant treatment (96%), indwelling catheter (77%), and strong will of preserving ejaculatory function (100%). Majority of respondents agreed that Echolaser® TPLA is a potential option for the treatment of localized PCa (78%) and recommended it for low-risk PCa (90%). During the final round, experts concluded that it can be used for intermediate-risk PCa and it should be proposed as an effective alternative to radical prostatectomy for patients with strong will of avoiding urinary incontinence and sexual dysfunction. Almost all participants agreed that the transperineal approach of this organ-sparing technique is safer than transrectal and transurethral approaches typical of other techniques (97% of agreement among experts). Pre-procedural assessment, technical aspects, post-procedural catheterization, pharmacological therapy, and expected outcomes were discussed, leading t

关键词： Transperineal laser ablation Prostatecancer Benignprostatic hyperplasia Delphi consensus

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The disruption of intestinal homeostasis when foods are colored red

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Cellular & Molecular Immunology 2022年第7期19卷 855-857页

作者： Wenjing Yang Yingzi Cong department of Microbiology and Immunology The University of Texas Medical BranchGalvestonTX 77555USA

Food colorant Red 40 has been shown to induce colitis in the context of dysregulated ***,the mechanism involved is still not fully understood.A study by Chen et *** this issue of Cellular Molecular Immunology[1]demonstrates that under dysregulated IL-23 production from myeloid cells,Red 40 induces IFNγ^(+)cytotoxic CD4^(+)T cells to promote colitis.

关键词： homeostasis Immunology

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Survival differences of low-grade versus high-grade head and neck pleomorphic dermal sarcomas and a review of a scalp case

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World Journal of Otorhinolaryngology-Head and Neck Surgery 2023年第1期9卷 74-78页

作者： Tyler A.Janz Barry D.Long Rohan R.Joshi Orly M.Coblens department of Otolaryngology-Head and Neck Surgery University of Texas Medical BranchGalvestonTexasUSA

Objective:To examine survival by tumor grade of pleomorphic dermal sarcomas(PDS)of the head and neck(H&N)and review a scalp PDS ***:Patients in the Surveillance,Epidemiology,and End Results(SEER)database were included from 1980 to 2016 based on a diagnosis of H&N *** estimates were performed using Kaplan–Meier ***,a case of a grade III H&N PDS is ***:Two hundred-seventy cases of PDS were *** mean age at diagnosis was 75.1 years(SD:13.5).Two hundred-thirty-four(86.7%)patients were ***-seven percent of patients received surgery as a part of their *** 5-year overall survival rates for grades I,II,III,and IV PDSs were 69%,60%,50%,and 42%,respectively(P=0.03).Conclusions:H&N PDS occurs most commonly in older-age *** management is frequently a part of H&N PDS *** rates significantly decline based on tumor grade.

关键词： head and neck cancer pleomorphic dermal sarcoma

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