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Endothelial dysfunction in the kidney transplant population:Current evidence and management strategies

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World Journal of Transplantation 2025年第1期15卷 24-43页

作者： Arun Prabhahar Akshey Batta Juniali Hatwal Vivek Kumar Raja Ramachandran Akash Batta department of Telemedicine(Internal medicine and Nephrology) Post Graduate Institute of Medical Education and ResearchChandigarh 160012India department of Urology and Renal Transplant Neelam HospitalRajpura 140401PunjabIndia department of Internal medicine Post Graduate Institute of Medical Education and ResearchChandigarh 160012India department of Nephrology Post Graduate Institute of Medical Education and ResearchChandigarh 160012India department of Cardiology Dayanand Medical College and HospitalLudhiana 141001PunjabIndia

The endothelium modulates vascular homeostasis owing to a variety of vasoconstrictors and *** dysfunction(ED),characterized by impaired vasodilation,inflammation,and thrombosis,triggers future cardiovascular(CV)*** kidney disease,a state of chronic inflammation caused by oxidative stress,metabolic abnormalities,infection,and uremic toxins damages the *** is also associated with a decline in estimated glomerular filtration *** kidney transplantation,endothelial functions undergo immediate but partial restoration,promising graft longevity and enhanced CV ***,the anticipated CV outcomes do not happen due to various transplant-related and unrelated risk factors for ED,culminating in poor CV health and graft *** in kidney transplant recipients is an underrecognized and poorly studied *** diseases are the leading cause of death among kidney transplant candidates with functioning *** contributes to the pathogenesis of many of the CV *** biomarkers and vasoreactivity tests are available to study endothelial *** an increasing number of transplants happening every year,and improved graft rejection rates due to the availability of effective immunosuppressants,the focus has now shifted to endothelial protection for the prevention,early recognition,and treatment of CV diseases.

关键词： Endothelial dysfunction Endothelium Cardiovascular disease Kidney transplantation Chronic kidney disease Nitric oxide Flow-mediated dilatation Nitro-glycerine-mediated dilatation Biomarkers

Infestation and pathological lesions of some lymph nodes induced by Linguatula serrata nymphs in sheep slaughtered in Shahrekord Area(Southwest Iran)

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Asian Pacific Journal of Tropical Biomedicine 2015年第7期5卷 566-570页

作者： Hamidreza Azizi Hossein Nourani Abdollah Moradi department of pathobiology School of Veterinary Medicine Shahrekord University School of Veterinary medicine Shahrekord University

Objective: To determine the infection rates of mesenteric and mediastinal lymph nodes in relation to Linguatula serrata(L. serrata) nymphs. Methods: In the present study, mesenteric and mediastinal lymph nodes of 200 sheep with different sex and age that were slaughtered in a Shahrekord slaughterhouse were collected. The lymph nodes were examined macroscopically and for histopathological examination, tissue samples were taken from the gross lesions processed routinely by paraffin method and stained with hematoxylin and eosin. Results: Out of 200 examined sheep, the mesenteric lymph nodes in 18 sheep(9%) and the mediastinal lymph nodes of 9 sheep(4.5%) were infected by L. serrata nymphs. The infection rate increased with age, but no significant difference was observed between males and females or the two types of lymph nodes(P > 0.01). Different nonspecific gross and macroscopic lesions were seen in infected lymph nodes. L. serrata nymph sections were observed in some histopathological slides. Conclusions: It is concluded that the sheep may play an important role in linguatulosis of final hosts and human beings in this region.

关键词： Linguatula serrata Lymph nodes Histopathological examination Pathology Sheep

Study on small ruminant lungworms and associated risk factors in northeastern Iran

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Asian Pacific Journal of Tropical medicine 2012年第11期5卷 853-856页

作者： Hassan Borji Mohammad Azizzadeh Mansour Ebrahimi Mohammad Asadpour department of pathobiology School of Veterinary MedicineFerdowsi University of MashhadMashhadIran department of clinical science School of Veterinary MedicineFerdowsi University of MashhadMashhadIran

Objective:To determine the prevalence,identify the species involved and assess possible risk factors of lungwonn infection in small ruminant slaughtered in abattoir of Mashhad in the northeast of Iran from October 2010 -August ***:Faecal and post mortem examination were conducted on 350 and 2 500 animals,***:The overall prevalence of lungwonn infection was 10.85%and 3.80%in coproscopic and post mortem examination respectively,and this difference was found to be *** prevalence of lungwonn infection was recorded in post mortem examination in sheep(4.1%) than in goats (0.5%)(P<0.05).The proportion of infection with Dictyocaulus filaria,Protostrongylus rufescens and mixed infection were 3.7%,0.1%and 0.2%in sheep while in goats,the infection was reported with Dictyocaulus filaria(0.5%) *** seasonal dynamics of lungwonn infection showed that prevalence was highest in winter(7.8%) with a remarkable decline during the dry time(summer) (0.8%) which the difference was significant(P<0.001).The animals of less than one year old showed greater infection in post mortem examination than older animals significantly(P<0.001). Also,the infection rate between male and female animals showed significant difference(P<0.05) with prevalence rate of 4.6%and 2.0%,***:Due to its impact on production, emphasis should be given for the control and prevention of lungworm infection in this area.

关键词： Dictyocaulus filaria Protostrongylus rufescens Lungworms Small ruminant Iran

Long-Term Patterns of Meningitis Mortality:A Continual Downward Trend and a Vulnerable Infant population—China,1987–2021

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China CDC weekly 2023年第34期5卷 745-750页

作者： Yu Wu Huiyun Fan Binbin Su Chao Guo Luzhao Feng department of population Health and Aging Science School of Population Medicine and Public HealthChinese Academy of Medical Sciences/Peking Union Medical CollegeBeijingChina APEC Health Science Academy(HeSAY) Peking UniversityBeijingChina Institute of population Research Peking UniversityBeijingChina department of Infectious Diseases School of Population Medicine and Public HealthChinese Academy of Medical Sciences/Peking Union Medical CollegeBeijingChina.

Summary What is already known about this topic?Meningitis,a life-threatening disease,presents a significant public health *** rate of progress in burden reduction notably lags behind other diseases that can be prevented through *** is added by this report?This research explored the changes in the mortality rate of meningitis in China over a span of 35 *** study further identified the effects of age,period,and cohort on the mortality trends.

关键词： mortality diseases vaccination

Activities of Daily Living-Related Functional Impairment Among population Aged 65 and Older—China,2011–2050

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China CDC weekly 2023年第27期5卷 593-598页

作者： Binbin Su Panliang Zhong Chen Chen Yu Wu Xiaoying Zheng School of population medicine and Public Health Chinese Academy of Medical Sciences/Peking Union Medical CollegeBeijingChina department of population Health and Aging Science School of Population Medicine and Public HealthChinese Academy of Medical Sciences/Peking Union Medical CollegeBeijingChina

Summary What is already known about this topic?The elevated prevalence of functional impairment among elderly individuals in China contributes to an increased burden of *** is added by this report?This report presents a comprehensive evaluation of trends in functional impairment related to activities of daily living(ADL)among the elderly population in ***,it offers insights for future projections of these trends in this demographic *** are the implications for public health practice?Addressing the care needs and functional impairment issues among the aging population in China necessitates interdepartmental collaboration.

关键词： population demographic elderly

Resveratrol downregulates TGF-β1 and Smad3 expression and attenuates oxidative stress in CCl_4-induced kidney damage in rats

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Asian Pacific Journal of Tropical Biomedicine 2020年第9期10卷 397-402页

作者： Saeed Mohammadi Jamshid Karimi Heidar Tavilani Iraj Khodadadi Roohollah Mohseni Mohammad Hashemnia department of Clinical biochemistry.Hamadan University of Medical Sciences HamadanIran Nutrition Health Research Center Hamadan University of Medical SciencesHamadanIran Clinical biochemistry Research center Basic Health Sciences InstituteShahrekord University of Medical SciencesShahrekordIran department of pathobiology Veterinary Medicine Faculty Razi UniversityKermanshahIran

Objective:To evaluate the effect of resveratrol against CCl4-induced ***:Forty-two male Wistar rats were divided into seven groups *** six weeks,kidney weight,body weight,blood urea,serum creatinine,oxidative stress markers,and gene expression of renal transforming growth factor-beta1(TGF-β1),TGF-βreceptor type 1(TGF-βR1)and Smad3 were *** addition,the protein level of TGF-β1 in the tissue lysate was ***:Resveratrol had a protective role in renal tissue by the improvement of antioxidant balance and reduction of renal parameters such as creatinine and urea(P<0.001).In addition,the renal m RNA level of TGF-β1,TGF-βR1,Smad3,as well as the protein level of TGF-β1 were decreased in rats treated with resveratrol(P<0.001),compared to the CCl4 ***:Overall,resveratrol shows a protective effect against nephrotoxicity in CCl4 treated rats by reducing oxidative stress status and modulating the TGF-βsignaling.

关键词： Nephrotoxicity Transforming growth factor beta1 Resveratrol Carbon tetrachloride

Mending the broken in amyotrophic lateral sclerosis: DNA damage and repair in motor neuron degeneration

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Neural Regeneration Research 2021年第1期16卷 104-105页

作者： Byung Woo Kim Lee J.Martin department of Pathology Division of Neuropathologythe Pathobiology Graduate Training ProgramJohns Hopkins University School of MedicineBaltimoreMDUSA department of Neuroscience Johns Hopkins University School of MedicineBaltimoreMDUSA

Amyotrophic lateral sclerosis(ALS)is a fatal neurodegenerative disease that causes paralysis and respiratory failure(Petrov et al.,2017).The driving mechanisms are unknown,and there are no effective treatments(Petrov et al.,2017).Aging and a few gene mutations,a common one being missense mutations in superoxide dismutase-1(SOD1),are risk factors for ALS(Figure 1).The recent Food and Drug Administration approval of edaravone for the treatment of ALS putatively supports a role for oxidative and nitrative stresses in the disease processes(Figure 1A).DNA damage,abnormalities in DNA repair,and other nuclear abnormalities are implicated also in the pathogenesis of human ALS(Bradley and Krasin,1982;Kim et al.,2020).

关键词： al. damage degeneration

Structure and function of aggrecan

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Cell Research 2002年第1期12卷 19-32页

作者： CHRIS KIANI, LIWEN CHEN, YAO JIONG WU, ALBERT J YEE, BURTON B YANG, Sunnybrook and Women’s College Health Sciences Centre and department of Laboratory medicine and Patobiology, 2 department of Surgeny, Faculty of medicine, University of Toronto, Canada Sunnybrook and Women' s College Health Sciences Centre and department of Laboratory medicine and pathobiology University of Toronto Canada Sunnybrook and Women' s College Health Sciences Centre and department of Surgeny Faculty of Medicine University of Toronto Canada

Aggrecan is the major proteoglycan in the articular cartilage. This molecule is important in the proper functioning of articular cartilage because it provides a hydrated gel structure (via its interaction with hyaluronan and link protein) that endows the cartilage with load-bearing properties. It is also crucial in chondroskeletal morphogenesis during development. Aggrecan is a multimodular molecule expressed by chondrocytes. Its core protein is composed of three globular domains (G1, G2, and G3) and a large extended region (CS) between G2 and G3 for glycosaminoglycan chain attachment. G1 comprises the amino terminus of the core protein. This domain has the same structural motif as link protein. Functionally, the G1 domain interacts with hyaluronan acid and link protein, forming stable ternary complexes in the extracellular matrix. G2 is homologous to the tandem repeats of G1 and of link protein and is involved in product processing. G3 makes up the carboxyl terminus of the core protein. It enhances glycosaminoglycan modification and product secretion. Aggrecan plays an important role in mediating chondrocyte-chondrocyte and chondrocyte-matrix interactions through its ability to bind hyaluronan.

关键词： Proteoglycan chondroitin sulfate glycosaminoglycan G1 domain G3 domain.

Larvicidal activities of chinaberry,neem and Bacillus thuringiensis israelensis(Bti) to an insecticide resistant population of Anopheles arabiensis from Tolay,Southwest Ethiopia

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Asian Pacific Journal of Tropical Biomedicine 2016年第7期6卷 554-561页

作者： Assalif Demissew Meshesha Balkew Melaku Girma department of medicine College of Medicine and Health SciencesAmbo University Aklilu Lemma Institute of pathobiology Addis Ababa University Human Health Malaria Control DepartmentInternational Center of Insect Physiology and Ecology

Objective:To elucidate the larvicidal potency of neem, chinaberry and Bacillus thuringiensis israelensis(Bti) to larvae of Anopheles arabiensis under semi-field condition and adult susceptibility/resistance to the conventionally used insecticides in Tolay,Southwestern ***: Wild collected 3rd and 4th stage larvae were exposed to neem, and chinaberry seed powder dissolved in water and Bti in artificial containers at three treatment levels:0.2, 0.1 and 0.05 g/m^2 and controls were free of treatments. Larval and pupal mortalities were monitored daily and residual activities were determined. The experiments were replicated three times. The World Health Organization tube test for all classes of insecticides was conducted on adult Anopheles arabiensis reared from field collected larvae and pupae. Data were analyzed using STATA software version ***: In the first application, neem powder caused 88.9%, 87.9% and 79.4% larval and pupal mortality at 0.2, 0.1 and 0.05 g/m^2 after 4.3, 6.0 and 5.7 days, respectively. The corresponding killing effect of chinaberry was 80.3%, 62.1% and 30.3% after 7.0, 7.7 and 8.3days respectively. Bti at all treatments killed 100% after 24 h except 2.7 days for 0.05 g/m^*** mosquitoes were susceptible only for fenitrothion and pirimiphos-methyl with 100%mortality while resistant to deltamethrin, alpha-cypermethrin, etofenprox and dichlorodiphenyl-tricgloroethane with only 9.0%, 3.0%, 5.1% and 2.0% mortalities ***: Neem, chinaberry and Bti showed potent larvicidal and pupicidal activities. However, in the area, high level of mosquito resistance to pyrethroids and dichlorodiphenyl-tricgloroethane was seen which will pose serious challenge to vector control in the future. Therefore, using integrated approach including these botanical larvicides is warranted to manage insecticide resistance.

关键词： Larvicide Anopheles arabiensis Tolay Insecticide Resistance Botanical Bio-efficacy