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Acute phase reactants, challenge in the near future of animal production and veterinary medicine

Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2005年第10期6卷 941-947页

作者： GRUYS E. ,TOUSSAINT M.J.M. ,UPRAGARIN N. ,VAN EDEREN A.M. ,ADEWUYI A.A. ,CANDIANI D. ,NGUYEN T.K.A. ,SABECKIENE (BALCIUTE) J. department of pathobiology Faculty of Veterinary medicine Utrecht University Utrecht the Netherlands department of pathobiology Faculty of Veterinary medicine Utrecht University Utrecht the Netherlands department of pathobiology Faculty of Veterinary medicine Utrecht University Utrecht the Netherlands department of pathobiology Faculty of Veterinary medicine Utrecht University Utrecht the Netherlands department of pathobiology Faculty of Veterinary medicine Utrecht University Utrecht the Netherlands department of pathobiology Faculty of Veterinary medicine Utrecht University Utrecht the Netherlands department of pathobiology Faculty of Veterinary medicine Utrecht University Utrecht the Netherlands department of pathobiology Faculty of Veterinary medicine Utrecht University Utrecht the Netherlands department of Farm Resources and Production medicine Faculty of Veterinary medicine Kasetsart University Nakhon Pathom Thailand department of Veterinary Morphophysiology University of Torino Italy department of Embryo Transfer and Reproduction the National Institute of Animal Husbandry Hanoi Vietnam department of Infectious Diseases Lithuanian Veterinary Academy Kaunas Lithuania)

The future of acute phase proteins (APPs) in science is discussed in this paper. Many functions and associated pathological processes of APPs are unknown. Extrahepatic formation in local tissues needs attention. Local serum amyloid A (SAA) formation may be involved in deposition of AA-amyloid induced by conformational change of SAA resulting in amyloid formation, having tremendous food safety implications. Amyloidogenesis is enhanced in mouse fed beta pleated sheet-rich pro- teins. The local amyloid in joints of chicken and mammary corpora amylacea is discussed. Differences in glycosylation of glycoproteins among the APPs, as has been shown for α1-acid glycoprotein, have to be considered. More knowledge on the reactivity patterns may lead to implication of APPs in the diagnostics and staging of a disease. Calculation of an index from values of several acute phase variables increases the power of APPs in monitoring unhealthy individuals in animal populations. Vaccinations, just as infections in eliciting acute phase response seem to limit the profitability of vaccines because acute phase reactions are contraproductive in view of muscle anabolism. Interest is focused on amino acid patterns and vitamins in view of dietary nutrition effect on sick and convalescing animals. When inexpensive methodology such as liquid phase methods (nephelometry, turbidimetry) or protein array technology for rapid APPs measurement is available, APPs have a future in routine diagnostics. Specific groups of patients may be screened or populations monitored by using APPs.

关键词： Acute phase protein Amino acid Joint Mammary gland Mastitis Serum amyloid A (SAA) Vitamin A

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Apolipoprotein A-I binding protein-mediated neuroprotection in glaucomatous neuroinflammation and neurodegeneration

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Neural Regeneration Research 2025年第5期20卷 1414-1415页

作者： Sinwoo Hwang Seunghwan Choi Soo-Ho Choi Keun-Young Kim Yury I.Miller Won-Kyu Ju Hamilton Glaucoma Center and Shiley Eye Institute The Viterbi Family Department of OphthalmologyUniversity of California San DiegoLa JollaCAUSA department of medicine University of California San DiegoLa JollaCAUSA National Center for Microscopy and Imaging Research Department of NeurosciencesUniversity of California San DiegoLa JollaCAUSA

Glaucoma is a multifactorial eye disorder that can cause vision loss and irreversible blindness,affecting individ uals aged 40 to 80 yea rs *** to the aging population,it is expected that the number of people affected by glaucoma will surpass 111 million by 2040 as the disease becomes more *** primarily contributes to optic nerve axon loss and the progressive degeneration of retinal ganglion cells (RGCs),subsequently leading to vision impairment.

关键词： irreversible pass primarily

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Dihydroartemisinin increased the abundance of Akkermansia muciniphila by YAP1 depression that sensitizes hepatocellular carcinoma to anti-PD-1 immunotherapy

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Frontiers of medicine 2023年第4期17卷 729-746页

作者： Zhiqin Zhang Xinli Shi Jingmin Ji Yinglin Guo Qing Peng Liyuan Hao Yu Xue Yiwei Liu Caige Li Junlan Lu Kun Yu department of pathobiology and Immunology Hebei University of Chinese MedicineShijiazhuang 050200China

The effect of anti-programmed cell death 1(anti-PD-1)immunotherapy is limited in patients with hepatocellular carcinoma(HCC).Yes-associated protein 1(YAP1)expression increased in liver tumor cells in early HCC,and Akkermansia muciniphila abundance decreased in the *** response to anti-PD-1 treatment is associated with *** abundance in many ***,the interaction between *** abundance and YAP1 expression remains unclear in ***,anti-PD-1 treatment decreased *** abundance in the colon,but increased YAP1 expression in the tumor cells by mice with liver tumors in ***,hepatocyte-specific Yap1 knockout(Yap1^(LKO))maintained bile acid homeostasis in the liver,resulting in an increased abundance of *** in the ***1 knockout enhanced anti-PD-1 ***,YAP1 inhibition is a potential target for increasing *** abundance to promote anti-PD-1 efficacy in liver ***(DHA),acting as YAP1 inhibitor,increased *** abundance to sensitize anti-PD-1 *** by gavage increased the number and activation of CD8^(+)T cells in liver tumor niches during DHA treatment or combination with *** findings suggested that the combination anti-PD-1 with DHA is an effective strategy for liver tumor treatment.

关键词： hepatocellular carcinoma YAP1 Akkermansia muciniphila anti-PD-1 dihydroartemisinin bile acid

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Within-host model of respiratory virus shedding and antibody response to H9N2 avian influenza virus vaccination and infection in chickens

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Infectious Disease Modelling 2021年第1期6卷 490-502页

作者： Xiao-Ting Xie Alexander Yitbarek Jake Astill Shirene Singh Salah Uddin Khan Shayan Sharif Zvonimir Poljak Amy L.Greer department of population medicine University of GuelphONCanada department of pathobiology University of GuelphONCanada School of Veterinary medicine University of the West IndiesSt.AugustineTrinidad and Tobago

Avian influenza virus(AIV)H9N2 subtype is an infectious pathogen that can affect both the respiratory and gastrointestinal systems in chickens and continues to have an important economic impact on the poultry *** the host innate immune response provides control of virus replication in early infection,the adaptive immune response aids to clear infections and prevent future *** virus-innate immune response pathways can improve our understanding of early infection dynamics and help to guide our understanding of virus shedding dynamics that could lead to reduced transmission between *** some countries use vaccines for the prevention of H9N2 AIV in poultry,the virus continues to be endemic in regions of Eurasia and Africa,indicating a need for improved vaccine efficacy or vaccination *** we explored how three type-I interferon(IFN)pathways affect respiratory virus shedding patterns in infected chickens using a within-host ***,prime and boost vaccination strategies for a candidate H9N2 AIV vaccine are assessed for the ability to elicit seroprotective antibody *** model demonstrates that inclusion of virus sensitivity to intracellular type-I IFN pathways results in a shedding pattern most consistent with virus titres observed in infected chickens,and the inclusion of a cellular latent period does not improve model ***,early administration of a booster dose two weeks after the initial vaccine is administered results in seroprotective titres for the greatest length of time for both broilers and *** results demonstrate that type-I IFN intracellular mechanisms are required in a model of respiratory virus shedding in H9N2 AIV infected chickens,and also highlights the need for improved vaccination strategies for laying hens.

关键词： Avian influenza Disease modelling Innate immunity Adaptive immunity Poultry

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The health benefits of selenium in food animals:a review

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Journal of Animal Science and Biotechnology 2022年第6期13卷 1623-1633页

作者： Brittany M.Pecoraro Diego F.Leal Alba Frias-De-Diego Matthew Browning Jack Odle Elisa Crisci College of Veterinary medicine Department of Population Health and PathobiologyNorth Carolina State UniversityRaleighNorth CarolinaUSA Laboratory of Developmental Nutrition Department of Animal ScienceNorth Carolina State UniversityRaleighNorth CarolinaUSA

Selenium is an essential trace mineral important for the maintenance of homeostasis in animals and *** evinces a strong antioxidant,anti-inflammatory and potential antimicrobial *** biological function is primarily achieved by its presence in selenoproteins as a form of *** deficiency may result in an array of health disorders,affecting many organs and systems;to prevent this,dietary supplementation,mainly in the forms of organic(i.e.,selenomethionine and selenocysteine)inorganic(i.e.,selenate and selenite)sources is *** pigs as well as other food animals,dietary selenium supplementation has been used for improving growth performance,immune function,and meat quality.A substantial body of knowledge demonstrates that dietary selenium supplementation is positively associated with overall animal health especially due to its immunomodulatory activity and protection from oxidative *** also possesses potential antiviral activity and this is achieved by protecting immune cells against oxidative damage and decreasing viral *** this review we endeavor to combine established and novel knowledge on the beneficial effects of dietary selenium supplementation,its antioxidant and immunomodulatory actions,and the putative antimicrobial effect ***,our review demonstrates the gaps in knowledge pertaining to the use of selenium as an antiviral,underscoring the need for further in vivo and in vitro studies,particularly in pigs.

关键词： Antimicrobial Antioxidant Food animals Immunomodulation Pig Selenium

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Serodiagnosis of human hydatidosis with an ELISA developed based on antigens derived from sheep hydatid cysts and comparison with a commercial human ELISA kit

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Asian Pacific Journal of Tropical medicine 2013年第9期6卷 723-727页

作者： Fotoohi S Hashemi Tabar G.R Borji H department of pathobiology Faculty of Veterinary MedicineFerdowsi University of Mashhad

Objective:To explore the serodiagnosis of hydatid cyst in human using different antigens of sheep(hydatid fluid,somatic and Lxcretory/secretory antigens of protoscolexi by ELISA and compares this result with commercial human ELISA ***:one hundred blood samples from patients with history of severe abdominal pain and cosinophilia were *** serum samples were obtained from surgically and pathologically confirmed cystic echinococcosis patients from Mashhad university hospital as positive control and 5 serum samples from infant under one year old as negative *** samples were centrifuged at 3000xg at 20℃for 15 min and sera were stored at-20℃.First,these samples were tested for the presence of antibody by commercial human *** was developed on microplates coated with hydatid fluid,Somatic and Excretory/secretory antigens of protoscolex of ***:The results of this study as analyzed by Kappa test showed that,hydatid fluid antigen could be used as a precise source of detection in indirect ELISA ***:Hydatid fluid in comparison with Excretory-secretory and somatic antigens showed more compatibility agreement in kappa test which can be used for further studies in development of any ELISA test for diagnosis of human hydatidosis.

关键词： Hydatidosis Human Hydatid fluid Protoscolex Sheep

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Duplication and diversification of insulin genes in ray-finned fish

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Zoological Research 2019年第3期40卷 185-197页

作者： David M.Irwin department of Laboratory medicine and pathobiology University of Toronto Banting and Best Diabetes Centre University of Toronto

Insulin is a key hormone for the regulation of metabolism in *** is produced by pancreatic islet cells in response to elevated glucose levels and leads to the uptake of glucose by tissues such as liver and adipose tissue to store *** also has additional functions in regulating *** work has shown that the proglucagon gene,which encodes hormones counter regulating insulin,is duplicated in teleost fish,and that the peptide hormones encoded by these genes have diversified in function.I sought to determine whether similar processes have occurred to insulin genes in these *** of fish genomes revealed an unexpected diversity of insulin genes.A triplication of the insulin gene occurred at the origin of teleost fish,however one of these three genes,insc,has been lost in most teleost fish *** two other insulin genes,insa and insb,have been retained but show differing levels of selective constraint suggesting that they might have diversified in ***,a duplicate copy of the insa gene,which I named insab,is found in many *** coding sequenee encoded by insab genes is under weak selective constraint,with its predicted protein sequences losing their potential to be processed into a two-peptide ***,these sequences have retained perfectly conserved cystine residues,suggesting that they maintain insulin's three-dimensional structure and therefore might modulate the processing and secretion of insulin produced by the other genes.

关键词： Insulin Teleost fish Gene duplicati on Adaptive evolution Gene loss

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Poultry gut health and beyond

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Animal Nutrition 2023年第2期13卷 240-248页

作者： Richard Ducatelle Evy Goossens Venessa Eeckhaut Filip Van Immerseel Livestock Gut Health Team Department of PathobiologyPharmacology and Zoological MedicineFaculty of Veterinary MedicineGhent UniversityBelgium

Intestinal health is critically important for the digestion and absorption of nutrients and thus is a key factor in determining *** health issues are very common in high performing poultry lines due to the high feed intake,which puts pressure on the physiology of the digestive *** nutrients which are not digested and absorbed in the small intestine may trigger dysbiosis,i.e.a shift in the microbiota composition in the intestinal *** as well as other stressors elicit an inflammatory response and loss of integrity of the tight junctions between the epithelial cells,leading to gut *** this paper,key factors determining intestinal health and the most important nutritional tools which are available to support intestinal health are reviewed.

关键词： Poultry Intestinal health Inflammation Gut leakage Microbiota Feed additive

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Gut-associated lymphoid tissue or so-called “dome” carcinoma of the colon: Review

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World Journal of Gastrointestinal Oncology 2019年第1期11卷 59-70页

作者： Aoife J McCarthy Runjan Chetty department of Anatomical Pathology Laboratory Medicine Program University Health Network department of Laboratory medicine and pathobiology Faculty of Medicine University of Toronto

AIM To present a comprehensive review of the etiology, clinical features, macroscopic and pathological findings, and clinical significance of Gut-associated lymphoid tissue or "dome" carcinoma of the *** The English language medical literature on gut-or gastrointestinal-associated lymphoid tissue(GALT) or "dome" carcinoma of the colon was searched and *** GALT/dome-type carcinomas of the colon are thought to arise from the M-cells of the lymphoglandular complex of the intestine. They are typically asymptomatic and have a characteristic endoscopic plaque-or "dome"-like appearance. Although the histology of GALT/dome-type carcinomas displays some variability, they are characterized by submucosal localization, a prominent lymphoid infiltrate with germinal center formation, tumor-infiltrating lymphocytes, absence of desmoplasia, and dilated glands lined by columnar epithelial cells with bland nuclear features and cytoplasmic eosinophilia. None of the patients reported in the literature with follow-up have developed metastatic disease or local *** Increased awareness amongst histopathologists of this variant of colorectal adenocarcinoma is likely to lead to the recognition of more cases.

关键词： Dome-type carcinoma Gastrointestinal-associated lymphoid tissue carcinoma Gut-associated lymphoid tissue Lymphoglandular complex Colorectal cancer

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Gender disparities and woman-specific trends in Barrett’s esophagus in the United States:An 11-year nationwide populationbased study

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World Journal of Methodology 2025年第1期15卷 60-71页

作者： Karina Fatakhova Faisal Inayat Hassam Ali Pratik Patel Attiq Ur Rehman Arslan Afzal Muhammad Sarfraz Shiza Sarfraz Gul Nawaz Ahtshamullah Chaudhry Rubaid Dhillon Arthur Dilibe Benjamin Glazebnik Lindsey Jones Emily Glazer Division of Gastroenterology and Hepatology Mather Hospital and Zucker School of Medicine at Hofstra UniversityPort JeffersonNY 11777United States department of Internal medicine Allama Iqbal Medical CollegeLahorePunjab 54550Pakistan Division of Gastroenterology and Hepatology East Carolina University Brody School of MedicineGreenvilleNC 27834United States Division of Gastroenterology and Hepatology Geisinger Wyoming Valley Medical CenterWilkes-BarrePA 18711United States department of Internal medicine East Carolina University Brody School of MedicineGreenvilleNC 27834United States department of Internal medicine St.Dominic's HospitalJacksonMS 39216United States department of Gastroenterology Hepatologyand NutritionCleveland Clinic FoundationClevelandOH 44195United States department of Internal medicine Mather Hospital and Hofstra University ZuckerSchool of MedicinePort JeffersonNY 11777United States

BACKGROUND Barrett's esophagus(BE)is a known premalignant precursor to esophageal adenocarcinoma(EAC).The prevalence rates continue to rise in the United States,but many patients who are at risk of EAC are not *** practice guidelines include male gender as a predisposing factor for BE and *** population-based clinical evidence regarding female gender remains *** To study comparative trends of gender disparities in patients with BE in the United *** A nationwide retrospective study was conducted using the 2009-2019 National Inpatient Sample(NIS)*** with a primary or secondary diagnosis code of BE were *** major outcome of interest was determining the gender disparities in patients with *** analysis for respective outcomes for females was also reported to ascertain any time-based *** We identified 1204190 patients with BE for the study *** the included patients,717439(59.6%)were men and 486751(40.4%)were *** mean age was higher in women than in men(67.1±0.4 vs 66.6±0.3 years,P<0.001).The rate of BE per 100000 total NIS hospitalizations for males increased from 144.6 in 2009 to 213.4 in 2019(P<0.001).The rate for females increased from 96.8 in 2009 to 148.7 in 2019(P<0.001).There was a higher frequency of obesity among women compared to men(17.4%vs 12.6%,P<0.001).Obesity prevalence among females increased from 12.3%in 2009 to 21.9%in 2019(P<0.001).A lower prevalence of smoking was noted in women than in men(20.8%vs 35.7%,P<0.001).However,trend analysis showed an increasing prevalence of smoking among women,from 12.9%in 2009 to 30.7%in 2019(P<0.001).Additionally,there was a lower prevalence of alcohol abuse,Helicobacter pylori(***),and diabetes mellitus among females than males(P<0.001).Trend analysis showed an increasing prevalence of alcohol use disorder and a decreasing prevalence of *** and diabetes mellitus among women(P<0.001).CONCLUSION The prevalence of BE among

关键词： Barrett’s esophagus Gender disparity Epidemiological trends Esophageal adenocarcinoma Screening endoscopy Female gender Risk factors

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