检索结果-南通市图书馆

Preoperative evaluation of pancreatic ductal adenocarcinoma with synchronous liver metastasis: Diagnosis and assessment of unresectability

引用

World Journal of Gastroenterology 2016年第45期22卷 10024-10037页

作者： Hao-Jun Shi Chen Jin De-Liang Fu department of pancreatic Surgery Pancreatic Disease Institute Huashan Hospital Fudan University

AIM To identify predictors for synchronous liver metastasis from resectable pancreatic ductal adenocarcinoma(PDAC) and assess unresectability of synchronous liver *** Retrospective records of PDAC patients with synchronous liver metastasis who underwent simultaneous resections of primary PDAC and synchronous liver metastasis, or palliative surgical bypass, were collected from 2007 to 2015. A series of pre-operative clinical parameters, including tumor markers and inflammation-based indices, were analyzed by logistic regression to figure out predictive factors and assess unresectability of synchronous liver metastasis. Cox regression was used to identify prognostic factors in liver-metastasized PDAC patients after surgery, with intention to validate their conformance to the indications of simultaneous resections and palliative surgical bypass. Survival of patients from different groups were analyzed by the Kaplan-Meier method. Intra- and post-operative courses were compared, including complications. PDAC patients with no distant metastases who underwent curative resection served as the control *** CA125 > 38 U/mL(OR = 12.397, 95%CI: 5.468-28.105, P 62 U/mL(OR = 5.181, 95%CI: 1.612-16.665, P = 0.006) and age > 62 years(OR = 3.921, 95%CI: 1.217-12.632, P = 0.022) correlated with unresectability of synchronous liver metastasis, both of which also indicated a worse long-term outcome of liver-metastasized PDAC patients after surgery. After the simultaneous resections, patients with postoperatively elevated serum CA125 levels had shorter survival than those with post-operatively reduced serum CA125 levels(7.7 mo vs 16.3 mo, P = 0.013). The survival of liver-metastasized PDAC patients who underwent the simultaneous resections was similar to that of non-metastasized PDAC patients who underwent cu

关键词： CA125 pancreatic ductal adenocarcinoma Liver metastasis Unresectability Prognosis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Is routine drainage necessary after pancreaticoduodenectomy?

引用

World Journal of Gastroenterology 2014年第25期20卷 8110-8118页

作者： Qiang Wang Yong-Jian Jiang Ji Li Feng Yang Yang Di Lie Yao Chen Jin De-Liang Fu department of pancreatic Surgery Pancreatic Disease InstituteHuashan Hospital Affiliated with Fudan University

With the development of imaging technology and surgical techniques, pancreatic resections to treat pancreatic tumors, ampulla tumors, and other pancreatic diseases have increased. pancreaticoduodenectomy, one type of pancreatic resection, is a complex surgery with the loss of pancreatic integrity and various anastomoses. Complications after pancreaticoduodenectomy such as pancreatic fistulas and anastomosis leakage are common and significantly associated with patient outcomes. pancreatic fistula is one of the most important postoperative complications; this condition can cause intraperitoneal hemorrhage, septic shock, or even death. An effective way has not yet been found to avoid the occurrence of pancreatic fistula. In most medical centers, the frequency of pancreatic fistula has remained between 9% and 13%. The early detection and routine drainage of anastomotic fistulas, pancreatic fistulas, bleeding, or other intra-abdominal fluid collections after pancreatic resections are considered as important and effective ways to reduce postoperative complications and the mortality rate. However, many recent studies have argued that routine drainage after abdominal operations, including pancreaticoduodenectomies, does not affect the incidence of postoperative complications. Although inserting drains after pancreatic resectionscontinues to be a routine procedure, its necessity remains controversial. This article reviews studies of the advantages and disadvantages of routine drainage after pancreaticoduodenectomy and discusses the necessity of this procedure.

关键词： pancreaticoduodenectomy Drainage Suction Fistula Postoperative complications Intra-abdominal infections

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Current status and progress of pancreatic cancer in China

引用

World Journal of Gastroenterology 2015年第26期21卷 7988-8003页

作者： Quan-Jun Lin Feng Yang Chen Jin De-Liang Fu department of pancreatic Surgery Pancreatic Disease InstituteHuashan HospitalShanghai Medical CollegeFudan University

Cancer is currently one of the most important public health problems in the *** cancer is a fatal disease with poor *** in most other countries,the health burden of pancreatic cancer in China is increasing,with annual mortality rates almost equal to incidence *** increasing trend of pancreatic cancer incidence is more significant in the rural areas than in the urban *** diagnoses and deaths of pancreatic cancer in China are now beyond the number of cases in the United *** 2012 estimates that cases in China account for 19.45%(65727/337872) of all newly diagnosed pancreatic cancer and 19.27%(63662/330391) of all deaths from pancreatic cancer *** population's growing socioeconomic status contributes to the rapid increase of China's proportional contribution to global ***,we present an overview of control programs for pancreatic cancer in China focusing on prevention,early diagnosis and *** addition,we describe key epidemiological,demographic,and socioeconomic differences between China and developed *** including no nationwide screening program for pancreatic cancer,delay in early detection resulting in a late stage at presentation,lack of awareness of pancreatic cancer in the Chinese population,and low investment compared with other cancer types by government have led to backwardness in China's pancreatic cancer diagnosis and ***,we suggest measures to improve health outcomes of pancreatic cancer patients in China.

关键词： pancreatic cancer Incidence Diagnosis Treatment

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Accuracy of routine multidetector computed tomography to identify arterial variants in patients scheduled for pancreaticoduodenectomy

引用

World Journal of Gastroenterology 2015年第3期21卷 969-976页

作者： Feng Yang Yang Di Ji Li Xiao-Yi Wang Lie Yao Si-Jie Hao Yong-Jian Jiang Chen Jin De-Liang Fu department of pancreatic Surgery Pancreatic Disease InstituteHuashan HospitalShanghai Medical CollegeFudan University

AIM:To assess the efficacy of cross-sectional multidetector computed tomography(MDCT) imaging without arterialreconstruction to identify aberrant right hepatic artery(RHA) and celiac artery stenosis(CAS) in patients scheduled for ***:Patients with peri-ampullary and pancreatic head tumors who underwent routine preoperative MDCT and subsequent computed tomography(CT) angiography(CTA),conventional angiography or pancreaticoduodenectomy between September 2007 and August 2013 were *** analysis of imaging data was undertaken using CTA,conventional angiographic and surgical findings as the reference *** accuracy,sensitivity,specificity,positive predictive value(PPV) and negative predictive value(NPV) of MDCT in evaluation of aberrant RHA and CAS were ***:A group of 458 patients met the inclusion criteria of this study to detect aberrant RHA,and 181 cases were included to identify ***-four(11.8%) patients were confirmed to have aberrant RHA,while 12(6.6%) patients with CAS were *** yielded an accuracy of 98.5%,sensitivity of 96.3% and specificity of 98.8% in the detection of aberrant *** sensitivity,specificity,PPV and NPV of MDCT for detecting CAS were 58.3%,98.2%,70% and 97.1%,***:Routine MDCT is recommended such that surgeons and radiologists be alerted to the importance of arterial variants on preoperative CT scans in patients scheduled for pancreaticoduodenectomy.

关键词： pancreaticoduodenectomy Aberrant hepatic artery Ce

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Erythrocyte-derived drug delivery systems in cancer therapy

引用

Chinese Chemical Letters 2021年第3期32卷 990-998页

作者： Yishen Mao Caifeng Zou Yongjian Jiang Deliang Fu department of pancreatic Surgery Pancreatic Disease InstituteHuashan HospitalShanghai Medical CollegeFudan UniversityShanghai 200040China

As natural blood components,erythrocytes were good candidates for being used as drug delive ry systems to improve the pharmacokinetics,biocompatibility and many other aspects of different *** advantages brought by erythrocytes making erythrocyte-derived drug delivery systems,also known as erythrocyte carriers,suitable for various anti-cancer agents,especially newly invented agents like nanoparticles,which were characterized by their undesired systematic toxicity,anaphylactic reactions and poor *** researches on erythrocyte carriers in ca ncer therapy showed inspiring results in four major aspects:cancer enzyme therapy,delivering chemotherapeutic agents,combining with nanoparticles,and several other anti-cancer agents for gene or immune *** novel delivering system was now undergoing the translation process from laboratory to clinical *** carriers for cancer enzyme therapy have entered the stage of clinical trial and have showed promising outcomes,and others were still at pre-clinical *** summary,erythrocyte-derived drug delivery system might play an indispensable role in the management of cancer in the future.

关键词： Erythrocytes Drug delivery Cancer therapy Nanoparticles Chemotherapy

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Impact of postoperative glycemic control and nutritional status on clinical outcomes after total pancreatectomy

引用

World Journal of Gastroenterology 2017年第2期23卷 265-274页

作者： Hao-Jun Shi Chen Jin De-Liang Fu department of pancreatic Surgery Pancreatic Disease InstituteHuashan HospitalFudan UniversityShanghai 200040China

AIM To evaluate the impact of glycemic control and nutritional status after total pancreatectomy(TP) on complications, tumor recurrence and overall *** Retrospective records of 52 patients with pancreatic tumors who underwent TP were collected from 2007 to 2015. A series of clinical parameters collected before and after surgery, and during the follow-up were evaluated. The associations of glycemic control and nutritional status with complications, tumor recurrence and long-term survival were determined. Risk factors for postoperative glycemic control and nutritional status were *** High early postoperative fasting blood glucose(FBG) levels(OR = 4.074, 95%CI: 1.188-13.965, P = 0.025) and low early postoperative prealbumin levels(OR = 3.816, 95%CI: 1.110-13.122, P = 0.034) were significantly associated with complications after TP. Postoperative Hb A1 c levels over 7%(HR = 2.655, 95%CI: 1.299-5.425, P = 0.007) were identified as one of the independent risk factors for tumor recurrence. Patients with postoperative Hb A1 c levels over 7% had much poorer overall survival than those with Hb A1 c levels less than 7%(9.3 mo vs 27.6 mo, HR = 3.212, 95%CI: 1.147-8.999, P = 0.026). Patients with long-term diabetes mellitus(HR = 15.019, 95%CI: 1.278-176.211, P= 0.031) and alcohol history(B = 1.985, SE = 0.860, P = 0.025) tended to have poor glycemic control and lower body mass index levels after TP, *** At least 3 mo are required after TP to adapt to diabetes and recover nutritional status. Glycemic control appears to have more influence over nutritional status on longterm outcomes after TP. Improvement in glycemic control and nutritional status after TP is important to prevent early complications and tumor recurrence, and improve survival.

关键词： Total pancreatectomy Glycemic control Nutritional status Complication Tumor recurrence Prognosis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Unraveling the enigma:A comprehensive review of solid pseudopapillary tumor of the pancreas

引用

World Journal of Gastrointestinal Oncology 2024年第3期16卷 614-629页

作者： Ye-Cheng Xu De-Liang Fu Feng Yang department of pancreatic Surgery Pancreatic Disease InstituteHuashan HospitalFudan UniversityShanghai 200040China

Solid pseudopapillary tumor of the pancreas(SPTP)is a rare neoplasm predom-inantly observed in young ***,CTNNB1 mutations,β-catenin nuclear accumulation,and subsequent Wnt-signaling pathway activation are the leading molecular *** preoperative diagnosis often relies on imaging techniques and endoscopic *** resection remains the mainstay *** models,such as the Fudan Prognostic Index,show promise as predictive tools for assessing the prognosis of *** three types of metachronous liver metastasis can be beneficial in tailoring individu-alized treatment and follow-up *** advancements,challenges persist in understanding its etiology,establishing standardized treatments for unresectable or metastatic diseases,and developing a widely recognized grading *** comprehensive review aims to elucidate the enigma by consolidating current knowledge on the epidemiology,clinical presentation,pathology,molecular characteristics,diagnostic methods,treatment options,and prognostic factors.

关键词： Pancreas Solid pseudopapillary tumor β-catenin Endoscopic ultrasound Surgery Recurrence Liver metastasis Prognostic prediction

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Clinical significance of variant hepatic artery in pancreatic resection:A comprehensive review

引用

World Journal of Gastroenterology 2022年第19期28卷 2057-2075页

作者： Ye-Cheng Xu Feng Yang De-Liang Fu department of pancreatic Surgery Huashan HospitalShanghai 200040China department of pancreatic Surgery Pancreatic Disease InstituteHuashan HospitalShanghai 200040China

The anatomical structure of the pancreaticoduodenal region is complex and closely related to the surrounding vessels.A variant of the hepatic artery,which is not a rare finding during pancreatic surgery,is prone to intraoperative *** injury to the hepatic artery may affect liver perfusion,resulting in necrosis,liver abscess,and even liver *** preoperative identification of hepatic artery variations,detailed planning of the surgical approach,careful intraoperative dissection,and proper management of the damaged artery are important for preventing hepatic ***,despite the potential risks,planned artery resection has become acceptable in carefully selected *** reconstruction is sometimes essential to prevent postoperative ischemic complications and can be performed using various *** complexity of procedures such as pancreatectomy with en bloc celiac axis resection may be mitigated by the presence of an aberrant right hepatic artery or a common hepatic artery originating from the superior mesenteric ***,we comprehensively reviewed the anatomical basis of hepatic artery variation,its incidence,and its effect on the surgical and oncological outcomes after pancreatic *** addition,we provide recommendations for the prevention and management of hepatic artery injury and liver ***,the hepatic artery variant may not worsen surgical and oncological outcomes if it is accurately identified pre-operatively and appropriately managed intraoperatively.

关键词： Hepatic artery Pancreatectomy pancreaticoduodenectomy Arterial reconstruction Celiac axis resection Outcome Prognosis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Prediction of malignancy and adverse outcome of solid pseudopapillary tumor of the pancreas

引用

World Journal of Gastrointestinal Oncology 2018年第7期10卷 184-193页

作者： Li You Feng Yang De--Liang Fu department of pancreatic Surgery Pancreatic Disease InstituteHuashan HospitalShanghai Medical CollegeFudan University

Since solid pseudopapillary tumor of the pancreas(SP-TP) was officially classified by the World Health Org-anization in 1996,SPTP has recently received special attention in the *** have shown that SPTP is a heterogeneous tumor,with a small percentage of patients harboring aggressive ***,cri-teria for malignancy grade in SPTP have not been well *** prognosis of SPTP is generally good,with cases having a chance for long-term survival even with recurrence and/or metastasis after surgical *** current American Joint Committee on Cancer/Union for International Cancer Control tumor,node,metastasis staging system is not specific to *** lack of a pre-dictive staging classification that accurately describes the heterogeneity of this disease hinders meaningful research into optimal individualized *** we summarize and discuss the associated factors proposed for appraisal of the malignant potential and adverse outcome of SPTP.

关键词： Pancreas Recurrence Solid pseudopapillary tumor Malignancy Metastasis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Utility of PET/CT in diagnosis, staging, assessment of resectability and metabolic response of pancreatic cancer

引用

World Journal of Gastroenterology 2014年第42期20卷 15580-15589页

作者： Xiao-Yi Wang Feng Yang Chen Jin De-Liang Fu pancreatic disease Institute Department of Pancreatic Surgery Huashan Hospital Fudan University department of Surgery Shanghai Medical College Fudan University

pancreatic cancer is one of the most common gastrointestinal tumors, with its incidence staying at a high level in both the United States and China. However, the overall 5-year survival rate of pancreatic cancer is still extremely low. Surgery remains the only potential chance for long-term survival. Early diagnosis and precise staging are crucial to make proper clinical decision for surgery candidates. Despite advances in diagnostictechnology such as computed tomography(CT)and endoscopic ultrasound,diagnosis,staging and monitoring of the metabolic response remain a challenge for this devastating *** emission tomography/CT(PET/CT),a relatively novel modality,combines metabolic detection with anatomic *** has been widely used in oncology and achieves good results in breast cancer,lung cancer and *** utilization in pancreatic cancer has also been widely ***,the value of PET/CT in pancreatic disease is still *** PET/CT change the treatment strategy for potential surgery candidates?What kind of patients benefits most from this exam?In this review,we focus on the utility of PET/CT in diagnosis,staging,and assessment of resectability of pancreatic *** addition,its ability to monitor metabolic response and recurrence after treatment will be emphasis of *** hope to provide answers to the questions above,which clinicians care most about.

关键词： Position emission tomography/computed tomography pancreatic cancer Diagnosis Staging Metabolic response

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：