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Moxibustion of Zusanli(ST36)and Shenshu(BL23)alleviates the inflammation of rheumatoid arthritis in rats through regulating macrophage migration inhibitory factor/glucocorticoids signaling

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Journal of Traditional Chinese Medicine 2024年第2期44卷 353-361页

作者： ZHANG Linlin ZHONG Yumei LU Wenting SHANG Yanan GUO Yanding LUO Xiaochao CHEN Yang LUO Kun HU Danhui YU Huiling ZHOU Haiyan Acupuncture and Moxibustion College Chengdu University of Traditional Chinese MedicineChengdu 610075China department of painology First People's Hospital of ChengduChengdu 610095China Chinese Evidence-Based Medicine Centre West China HospitalSichuan UniversityChengdu 610044China Traditional Chinese Medicine College Chongqing Medical UniversityChongqing 400016China External treatment center First People's Hospital of ChengduChengdu 610095China

OBJECTIVE:To test the hypothesis that moxibustion may inhibit rheumatoid arthritis(RA)synovial inflammation by regulating the expression of macrophage migration inhibitory factor(MIF)/glucocorticoids(GCs).METHODS:Fifty male Sprague-Dawley rats were randomly divided into five groups(n=10 each):blank Control(CON)group,RA Model(RA)group,Moxibustion(MOX)group,MIF inhibitor(S,R)-3-(4-hydroxyphenyl)-4,5-dihydro-5-isoxazole acetic acid methyl ester(ISO-1)group,and Moxibustion+MIF inhibitor ISO-1(MOX+ISO-1)group.Rats in the ISO-1 group and ISO-1+MOX group were intraperitoneally injected with the inhibitor ISO-1.The rats in the RA group,ISO-1 group,MOX group,and ISO-1+MOX group were injected with Freund's complete adjuvant(FCA)in the right hind footpad to establish an experimental RA rat model.In the MOX group and MOX+ISO-1 group,rats were treated with Moxa.The thickness of the footpads of the rats in each group was measured at three-time points before,after modeling and after moxibustion treatment.The contents of serum MIF,corticosterone(CORT),tumor necrosis factor-α(TNF-α)and interleukin-1β(IL-1β)were detected by enzyme-linked immunosorbent assay;and the contents of synovial MIF were detected by Western blot.Hematoxylin-eosin(HE)staining method was used to observe the pathological changes of synovial tissue under a section light microscope,and pathological scoring was performed according to the grading standard of the degree of synovial tissue disease.RESULTS:Moxibustion was found to reduce the level of MIF and alleviate inflammation in RA rats in this study.In addition,after inhibiting the expression of MIF,the level of CORT increased,and the level of TNF-α decreased.Treating RA rats with inhibited MIF by moxibustion,the level of CORT was almost unchanged,but the level of TNF-α further decreased.The correlation analysis data suggested that MIF was positively related to the expression of TNF-α and negatively correlated with the expression of CORT.CONCLUSION:Reducing MIF to increase CORT and decrease TNF-α by moxibustion

关键词： rheumatoid arthritis macrophage migration inhibitory factor moxibustion corticosterone glucocorticoids

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The significance of painology in the English name of Chinese Journal of painology

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中华疼痛学杂志 2022年第1期18卷 144-144页

作者：刘小立 Editorial department of Chinese Journal of painology Fourth Hospital of Hebei Medical UniversityShijiazhuang CityHebei Province 050011China

Chinese Journal of painology is the English name of this Journal to publish from the first issue of 2020. This will begin the new era of this journal, in which the new word of painology is the first created English professional term in China, corresponding to Chinese meaning of "painology". There is no proper professional term for "pain as a discipline" in the existing English vocabulary. Algology and Dolorology used to be the word to describe the pain, since these two words are uncommon and often muddled in meanings, so cannot be understood popularly. China is the earliest country to establish independent pain discipline in the world. It is necessary to have a special term for the burgeoning discipline. Therefore we decided to create a new English professional term "painology" for this new discipline and this journal.

关键词： journal word discipline

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The significance of painology in the English name of Chinese Journal of painology

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中华疼痛学杂志 2020年第1期16卷 F0003-F0003页

作者：刘小立 Editorial department of Chinese Journal of painology Fourth Hospital of Hebei Medical UniversityShijiazhuang CityHebei Province 050011China

Chinese Journal of painology is the English name of this Journal to publish from the first issue of 2020.This will begin the new era of this journal,in which the new word of painology is the first created English professional term in China,corresponding to Chinese meaning of"painology".There is no proper professional term for"pain as a disceipline"in the existing English vocabulary.Algology and Dolorology used to be the word to describe the pain,since these two words are uncommon and often muddled in meanings,so cannot be understood popularly.China is the earliest country to establish independent pain discipline in the world.It is necessary to have a special term for the burgeoning discipline.Therefore we decided to create a new English professional term"Painoldgy"for this new discipline and this jourmal.

关键词： word journal discipline

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