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Ki-67 Change in Anthracyline-containing Neoadjuvant Chemotherapy Response in Breast Cancer

Current Medical Science 2024年第1期44卷 156-167页

作者： Zi-guo YANG Le-hao REN Feng WANG Pi-lin WANG Wen-yan WANG Shu-ye LIN department of General surgery Beijing Tiantan HospitalCapital Medical UniversityBeijing 100070China department of Critical Care Medicine Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Cancer Research Center Beijing Chest HospitalCapital Medical University/Beijing Tuberculosis and Thoracic Tumor Research InstituteBeijing 101149China

Objective Anthracycline-containing regimens are irreplaceable in neoadjuvant chemotherapy(NAC)for breast cancer(BC)at ***,30% of early breast cancer(EBC)patients are resistant to anthracycline-containing chemotherapy,leading to poor prognosis and higher ***-67 is associated with the prognosis and response to therapy,and it changes after *** A total of 105 BC patients who received anthracycline-containing NAC were ***,the optimal model of Ki-67 was selected,and its predictive efficacy was ***(IHC)was used to determine the estrogen receptor(ER),progesterone receptor(PR),and human epidermal growth factor receptor 2(HER-2)status and Ki-67 *** in situ hybridization(FISH)was used to verify the HER-2 when the IHC score was 2+.Results The post-NAC Ki67 level after treatment with anthracycline drugs was lower than pre-NAC Ki-67(19.6%±23.3%vs.45.6%±23.1%,P<0.001).Furthermore,patients with the Ki-67 decrease had a border line higher pathological complete response(pCR)rate(17.2%vs.0.0%,P=0.068),and a higher overall response rate(ORR)(73.6%vs.27.8%,P<0.001),when compared to patients without the Ki-67 *** ΔKi-67 and ΔKi-67%were valuable markers for the prediction of both the pCR rate and *** area under the curve(AUC)for ΔKi-67 on pCR and ORR was 0.809(0.698-0.921)and 0.755(0.655-0.855),respectively,while the AUC for ΔKi-67% on pCR and ORR was 0.857(0.742-0.972)and 0.720(0.618-0.822),*** logistic regression model 1 revealed thatΔKi-67 was an independent predictor for both pCR[odds ratio(OR)=61.030,95% confidence interval(CI)=4.709-790.965;P=0.002]and ORR(OR=10.001,95%CI:3.044-32.858;P<0.001).Multivariate logistic regression model 2 revealed thatΔKi-67%was also an independent predictor for both pCR(OR=408.922,95%CI=8.908-18771.224;P=0.002)and ORR(OR=5.419,95%CI=1.842-15.943;P=0.002).Conclusions The present study results suggest thatΔKi67 andΔKi67%are candidate predictor

关键词： breast cancer change in Ki-67 neoadjuvant chemotherapy anthracycline,response

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thoracic Ganglioneuroma: A Rare Neural Tumor (Case Report and Literature Review)

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Open Journal of thoracic surgery 2024年第2期14卷 46-53页

作者： Addas Ramzi Abughararah Tariq Abualnasr Mazen Kahtani Fatamah thoracic surgery department King Abdulaziz Medical City National Guard Hospital Jeddah Saudi Arabia General surgery department King Abdulaziz Medical City National Guard Hospital Jeddah Saudi Arabia

Ganglioneuroma is an extremely rare tumor that is derived from neural crest. Many ganglioneuroma cases are detected incidentally unless they are large enough to cause compressive symptoms. We report an 18-year-old patient with posterior mediastinal ganglioneuroma which was abutting the descending aorta. The patient underwent successful resection by thoracoscopic approach and was followed up for one year with no complications. In summary, a detailed review with experts in both radiology and pathology is mandated to diagnose these tumors. Informed consent was obtained from the patient.

关键词： Neural Cell Tumors Ganglioneuroma Mediastinal Mass

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Advancements in nutritional diagnosis and support strategies during the perioperative period for patients with liver cancer

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World Journal of Gastrointestinal surgery 2024年第8期16卷 2409-2425页

作者： Xiao-Qin Li Yun Liang Chen-Feng Huang Sui-Ning Li Lei Cheng Chuan You Yao-Xia Liu Tao Wang department of Hepatobiliary surgery The Affiliated Hospital of North Sichuan Medical CollegeNanchong 637000Sichuan ProvinceChina department of paediatric surgery The Affiliated Hospital of North Sichuan Medical CollegeNanchong 637000Sichuan ProvinceChina department of Cardiovascular surgery The First Affiliated HospitalJinan UniversityGuangzhou 510632Guangdong ProvinceChina department of Geriatric Endocrinology Sichuan Provincial People's HospitalUniversity of Electronic Science and Technology of ChinaChengdu 610072Sichuan ProvinceChina department of Pediatric Cardiology West China Second University HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina department of Pediatrics Key Laboratory of Birth Defects and Related Diseases of Women and Children(Sichuan University)Ministry of EducationChengdu 610041Sichuan ProvinceChina

Liver cancer represents a grave hepatic condition and constitutes a significant global health *** resection remains the principal therapeutic modality for liver ***,perioperative malnutrition exerts a notable impact on patients with liver cancer,emerging as an independent risk factor for disease mortality and adverse ***,precise nutritional diagnosis and timely nutritional support hold the potential to enhance therapeutic efficacy and quality of life for liver cancer *** study represents a meticulous foray into the literature,extracting data from PubMed,Web of Science,and EMBASE databases,with a focus on the past 5 *** scrutinizes the impact of malnutrition on patients undergoing liver cancer surgery,the etiological underpinnings of malnutrition within this patient cohort,the critical assessment of perioperative nutritional status,and the strategic approaches to nutritional *** rigorous inclusion and exclusion criteria,the amassed scholarly works are meticulously synthesized,methodically organized,and categorically elaborated ***,the authors propose the incorporation of a multidisciplinary nutrition management team during the perioperative period,comprising nutritionists,pharmacists,physicians,nurses,psychologists,and rehabilitation therapists,among other specialized ***,they collaborate to devise and implement personalized nutritional support plans,monitor patients’nutritional status,and make necessary adjustments as *** comprehensive management and intervention,improvements in the nutritional status of liver cancer patients can be achieved,thereby enhancing surgical success rates and facilitating postoperative *** is believed that this manuscript will offer valuable insights to advance the nutritional management during the perioperative phase of liver cancer,aiding in ameliorating patients'nutritional status and treatment outcomes.

关键词： Liver cancer Nutritional diagnosis Nutritional support Perioperative period Genetic testing Immunonutrition Probiotics and gut microbiota

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Fourier-domain-compressed optical time-stretch quantitative phase imaging flow cytometry

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Photonics Research 2024年第8期12卷 1627-1639页

作者： RUBING LI YUEYUN WENG SHUBIN WEI SIYUAN LIN JIN HUANG CONGKUAN SONG HUI SHEN JINXUAN HOU YU XU LIYE MEI DU WANG YUJIE ZOU TAILANG YIN FULING ZHOU QING GENG SHENG LIU CHENG LEI Institute of Technological Sciences Wuhan UniversityWuhan 430072China School of Power and Mechanical Engineering Wuhan UniversityWuhan 430072China department of thoracic surgery Renmin HospitalWuhan UniversityWuhan 430060China department of Hematology Zhongnan HospitalWuhan UniversityWuhan 430071China department of Thyroid and Breast surgery Zhongnan HospitalWuhan UniversityWuhan 430071China department of Radiation and Medical Oncology Zhongnan HospitalWuhan UniversityWuhan 430071China School of Computer Science Hubei University of TechnologyWuhan 430068China Reproductive Medical Center Renmin HospitalWuhan UniversityWuhan 430060China Suzhou Institute of Wuhan University Suzhou 215000China Shenzhen Institute of Wuhan University Shenzhen 518057China

Optical time-stretch(OTS)imaging flow cytometry offers a promising solution for high-throughput and highprecision cell analysis due to its capabilities of high-speed,high-quality,and continuous *** sensing(CS)makes it practically applicable by significantly reducing the data volume while maintaining its highspeed and high-quality imaging *** enrich the information of the images acquired with CS-equipped OTS imaging flow cytometry,in this work we propose and experimentally demonstrate Fourier-domaincompressed OTS quantitative phase imaging flow *** is capable of acquiring intensity and quantitative phase images of cells simultaneously from the compressed *** evaluate the performance of our method,static microparticles and a corn root cross section are experimentally measured under various compression ***,to show how our method can be applied in practice,we utilize it in the drug response analysis of breast cancer *** results show that our method can acquire high-quality intensity and quantitative phase images of flowing cells at a flowing speed of 1 m/s and a compression ratio of 30%.Combined with machine-learning-based image analysis,it can distinguish drug-treated and drug-untreated cells with an accuracy of over 95%.We believe our method can facilitate cell analysis in both scientific research and clinical settings where both high-throughput and high-content cell analysis is required.

关键词： flow stretch phase

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Adjuvant chemotherapy for isolated resectable colorectal lung metastasis: A retrospective study using inverse probability treatment weighting propensity analysis

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World Journal of Gastrointestinal surgery 2024年第10期16卷 3171-3184页

作者： Zhao Gao Shi-Kai Wu Shi-Jie Zhang Xin Wang Ying-Chao Wu Xuan Jin department of Medical Oncology Peking University First HospitalBeijing 100034China department of thoracic surgery Peking University First HospitalBeijing 100034China department of Gastrointestinal surgery Peking University First HospitalBeijing 100034China

BACKGROUND The benefit of adjuvant chemotherapy(ACT)for patients with no evidence of disease after pulmonary metastasis resection(PM)from colorectal cancer(CRC)remains *** To assess the efficacy of ACT in patients after PM resection for *** This study included 96 patients who underwent pulmonary metastasectomy for CRC at a single institution between April 2008 and July *** primary end-point was overall survival(OS);secondary endpoints included cancer-specific survival(CSS)and disease-free survival(DFS).An inverse probability of treat-ment-weighting(IPTW)analysis was conducted to address indication ***-vival outcomes compared using Kaplan-Meier curves,log-rank test,Cox regre-ssion and confirmed by propensity score-matching(PSM).RESULTS With a median follow-up of 27.5 months(range,18.3-50.4 months),the 5-year OS,CSS and DFS were 72.0%,74.4%and 51.3%,*** had no significant effect on OS after PM resection from CRC[original cohort:P=0.08;IPTW:P=0.15].No differences were observed for CSS(P=0.12)and DFS(P=0.68)between the ACT and non-ACT *** analysis showed no association of ACT with better survival,while sublobar resection(HR=0.45;95%CI:0.20-1.00,P=0.049)and longer disease-free interval(HR=0.45;95%CI:0.20-0.98,P=0.044)were associated with improved *** ACT does not improve survival after PM resection for *** well-designed randomized controlled trials are needed to determine the optimal ACT regimen and duration.

关键词： Colorectal cancer Resection of pulmonary metastasis Adjuvant chemotherapy Inverse probability treatment weighting Prognosis

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Neonatal Intestinal Obstruction in Acute Renal Failure in Premature Infant: A Case Report

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Open Journal of Pediatrics 2024年第2期14卷 338-343页

作者： Ondima Lucienne Irène Patricia Okiemy Niendet Cardinale Princilia Gandzali-Ngabe Pierre Eric Caryne Mboutol-Mandavo Bosseba Missengui Rhodia Hélène Akobande Nuptia Erica department of paediatric surgery CHU Brazzaville Brazzaville Congo Faculty of Health Sciences Marien Ngouabi University Brazzaville Congo department of Nephrology and Dialysis Brazzaville University Hospital Brazzaville Congo

Introduction: Intestinal obstruction is a common cause of abdominal surgery in the neonate. Diagnosis is straightforward using standard radiology, and surgical technique depends on the underlying anatomical lesion. Peritoneal dialysis (PD) is an effective, albeit invasive, therapy for neonatal renal failure. We report a case of neonatal obstruction with severe renal failure treated by PD to highlight our hospital practice and possible remedies in a context of limited resources. Case Presentation: This was a female neonate of moderate prematurity admitted on day 4 of life for management of a flat neonatal obstruction. Radiological diagnosis suggested small bowel atresia. Biological tests revealed severe renal failure with creatinine levels of 416 micromoles per liter and blood urea of 27.1 micromoles per liter. Management consisted of preoperative peritoneal dialysis for 48 hours followed by laparotomy. The intraoperative diagnosis was GROSFELD type IIIa digestive atresia. The postoperative course was favourable, transit was resumed on day 5 and the patient returned home on day 12. Progress at 3 months was satisfactory. Conclusion: Neonatal intestinal obstruction with renal failure in premature infants is associated with a poor prognosis, even more so if there is a delay in treatment. Peritoneal dialysis seems to be a suitable alternative for this management in our working conditions with limited resources.

关键词： Neonate Occlusion Peritoneal Dialysis Case Report

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Subxyphoid Pericardial Drainage for Tuberculous Pericardial Effusion in Antananarivo

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World Journal of Cardiovascular surgery 2024年第2期14卷 21-31页

作者： Tsirimalala Rajaobelison Zakarimanana Lucas Randimbinirina Maharo Ramifehiarivo Manoahasina Ranaliarinosy Rabarison Toky Mamin’ny Aina Rajaonanahary Andriamihaja Jean-Claude Rakotoarisoa department of Cardiovascular surgery Faculty of Medicine of Antananarivo University of Antananarivo Antananarivo Madagascar department of Pathology Faculty of Medicine of Antananarivo University of Antananarivo Antananarivo Madagascar department of Vascular surgery Faculty of Medicine of Antananarivo University of Antananarivo Antananarivo Madagascar department of thoracic surgery Faculty of Medicine of Antananarivo University of Antananarivo Antananarivo Madagascar

Introduction: Tuberculosis is the leading cause of pericardial effusion in sub-Saharan African countries. The aim of this study was to describe the diagnosis and the surgical management of tuberculous pericardial effusion in low-income country. Methods: This was a retrospective and descriptive study performed at Vascular surgery Unit for 10 years-period (from January 2012 to December 2021), including all cases of drainage of pericardial effusion due to tuberculosis. Results: Sixty-seven cases were recorded, including 38 males (56.71%) and 29 women (43.28%). The average age was 35.47 years old. Patients lived in urban areas in 67.16% of cases. Thirteen patients (13.43%) had a previous history of pulmonary tuberculosis. The most common risk factors for tuberculosis infection were malnourishment (80.59%), indoor air pollution (77.61%) and close contact with tuberculosis patient (40.29%). The commonest symptom were dyspnea, (95.52%), chest pain (89.55%), fever (67.16%), tachycardia (95.52%) and cough (80.59%). Twenty-seven patients (39.02%) presented clinical signs of cardiac tamponade. Electrocardiogram showed sinus tachycardia (97.53%) with microvoltage (39.02%). Chest-X-ray showed cardiomegaly (100%) and pleural effusion (56.71%). Echocardiography showed moderate (43.28%) and large (56.71%) pericardial effusion. All patients underwent subxiphoid pericardial drainage. Mycobacterium tuberculosis detection via GeneXpert test of pericardial effusion were positive in 38.80% of patients. Pericardial biopsies confirmed the diagnosis of tuberculosis in 41.79%. The mortality rate was 8.95%. Conclusion: Subxiphoid pericardial drainage reduced thr risk of cardiac tamponade in patients with massive pericardial effusion. Histopathology of pericardial biopsies made a definitive diagnosis for tuberculosis.

关键词： Tuberculosis Echocardiography Pericardial Effusion surgery Cardiac Tamponade

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Amlodipine inhibits the proliferation and migration of esophageal carcinoma cells through the induction of endoplasmic reticulum stress

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World Journal of Gastroenterology 2024年第4期30卷 367-380页

作者： Yan-Min Chen Wen-Qian Yang Cheng-Wei Gu Ying-Ying Fan Yu-Zhen Liu Bao-Sheng Zhao department of thoracic surgery The First Affiliated Hospital of Xinxiang Medical UniversityWeihui 453100Henan ProvinceChina department of Oncology The Affiliated HospitalHenan Polytechnic UniversityJiaozuo 454000Henan ProvinceChina Life Science Research Center The First Affiliated Hospital of Xinxiang Medical UniversityWeihui 453100Henan ProvinceChina department of Gastroenterology The First Affiliated Hospital of Xinxiang Medical UniversityWeihui 453100Henan ProvinceChina

BACKGROUND L-type calcium channels are the only protein channels sensitive to calcium channel blockers,and are expressed in various cancer *** Cancer Genome Atlas database shows that the mRNA levels of multiple L-type calcium channel subunits in esophageal squamous cell carcinoma tumor tissue are significantly higher than those in normal esophageal epithelial ***,we hypothesized that amlodipine,a long-acting dihydropyridine L-type calcium channel blocker,may inhibit the occurrence and development of esophageal cancer(EC).AIM To investigate the inhibitory effects of amlodipine on EC through endoplasmic reticulum(ER)*** Cav1.3 protein expression levels in 50 pairs of EC tissues and corresponding paracancerous tissues were ***,the inhibitory effects of amlodipine on proliferation and migration of EC cells in vitro were detected using 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2-H-tetrazolium bromide and Transwell *** vivo experiments were performed using murine xenograft *** elucidate the underlying mechanisms,in vitro cell studies were performed to confirm that ER stress plays a role in inhibition proliferation and migration of EC cells treated with *** The expression level of Cav1.3 in esophageal carcinoma was 1.6 times higher than that in paracancerous *** treatment decreased the viability of esophageal carcinoma cells in a dose-and time-dependent *** vivo animal experiments also clearly indicated that amlodipine inhibited the growth of EC tumors in ***,amlodipine reduces the migration of tumor cells by inhibiting epithelial-mesenchymal transition(EMT).Mechanistic studies have demonstrated that amlodipine induces ER stress-mediated apoptosis and suppresses ***,amlodipine-induced autophagy was characterized by an increase in autophagy lysosomes and the accumulation of light chain 3B *** combination of amlodipine with the ER stress inhibitor 4-p

关键词： L-type calcium channel Amlodipine Esophageal cancer Autophagy Endoplasmic reticulum stress

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The state-of-the-art of atmospheric pressure plasma for transdermal drug delivery

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Plasma Science and Technology 2024年第4期26卷 9-26页

作者：聂兰兰刘大伟程鹤赵峰卢新培 State key laboratory of advanced electromagnetic engineering and technology School of Electrical and Electronic EngineeringHuazhong University of Science and TechnologyWuhan 430074People’s Republic of China School of Chemistry and Chemical Engineering Nanjing University of Science and TechnologyNanjing 210094People’s Republic of China department of thoracic surgery Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022People’s Republic of China

Plasma-enhanced transdermal drug delivery(TDD) presents advantages over traditional methods,including painless application, minimal skin damage, and rapid recovery of permeability. To harness its clinical potential, factors related to plasma’s unique properties, such as reactive species and electric fields, must be carefully *** review provides a concise summary of conventional TDD methods and subsequently offers a comprehensive examination of the current state-of-the-art in plasma-enhanced TDD. This includes an analysis of the impact of plasma on HaCaT human keratinocyte cells, ex vivo/in vivo studies, and clinical research on plasma-assisted TDD. Moreover, the review explores the effects of plasma on skin physical characteristics such as microhole formation, transepidermal water loss(TEWL), molecular structure of the stratum corneum(SC), and skin resistance. Additionally, it discusses the involvement of various reactive agents in plasma-enhanced TDD, encompassing electric fields,charged particles, UV/VUV radiation, heat, and reactive species. Lastly, the review briefly addresses the temporal behavior of the skin after plasma treatment, safety considerations, and potential risks associated with plasma-enhanced TDD.

关键词： plasma transdermal drug delivery skin physical characteristics reactive agents

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A multicenter prospective study on the management of hepatoblastoma in children:a report from the Chinese Children's Cancer Group

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World Journal of Pediatrics 2024年第6期20卷 590-601页

作者： Meng-Jie Tang Xiao-Li Ma Xiang-Ling He Wei-Hua Pan Xiao-Hong Zhang Sha-Yi Jiang Ju Gao Fu Li Wei Yao Song Gu Wei-Ling Zhang Qiang Zhao Shi-Hao Huang Yong-Jun Fang Wei Liu Hui-Zhong Niu Chun-Mei Wang Li-Rong Sun Hui Gao Yun-Peng Dai Shun-Gen Huang Zhi-Yong Zhong Xi-Ge Wang Zhong-Rong Li Liang-Chun Yang Ye-Ming Wu Huan-Min Wang Xin Sun Xiao-Jun Yuan department of Pediatric Hematology/Oncology Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of MedicineNo.1665Kongjiang RoadYangpu DistrictShanghai 200092China Medical Oncology department Pediatric Oncology CenterBeijing Children's HospitalCapital Medical UniversityNational Center for Children's HealthBeijing 100045China department of Hematology/Oncology Children's Medical CenterHunan Provincial People's HospitalThe First Affiliated Hospital of Hunan Normal UniversityChangsha 41005China department of Pediatric surgery Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200092China department of Hematology/Oncology Guangzhou Women and Children's Medical CenterNational Children's Medical Center for South Central RegionGuangzhou 510623China department of Hematology Shanghai Children's HospitalShanghai Jiao Tong UniversityShanghai 200062China department of Pediatrics West China Second University HospitalSichuan UniversityChengdu 610041China department of Hematology/Oncology Qilu Children's Hospital of Shandong UniversityJinan 250022China department of Pediatric surgery Children's Hospital of Fudan UniversityShanghai 201102China department of General surgery Shanghai Children's Medical Center(National Children's Medical Center-Shanghai)Shanghai Jiao Tong University School of MedicineShanghai 200127China department of Pediatrics Beijing Tongren HospitalCapital Medical UniversityBeijing 100730China department of Pediatric Oncology Tianjin Medical University Cancer Institute and HospitalTianjin 300060China department of Hematology/Oncology Children's Hospital of Nanjing Medical UniversityNanjing 210008China department of Hematology/Oncology Henan Children's HospitalZhengzhou 450018China department of Pediatric General surgery Hebei Children's Hospital of Hebei Medical UniversityShijiazhuang City 050031China Children's Hospital the First Affliated Hospital of Zhengzhou UniversityZhengzhou 450052China department of paediatric

Background This study aimed to identify survival risk factors in Chinese children with hepatoblastoma(HB)and assess the effectiveness of the new treatment protocol proposed by the Chinese Children's Cancer Group(CCCG)in *** A multicenter,prospective study that included 399 patients with HB from January 2015 to June 2020 was *** demographics,treatment protocols,and other related information were *** regression models and Kaplan-Meier curve methods were *** The 4-year event-free survival(EFS)and overall survival(OS)were 76.9 and 93.5%,*** 4-year EFS rates for the very-low-risk,low-risk,intermediate-risk,and high-risk groups were 100%,91.6%,81.7%,and 51.0%,*** 4-year 0S was 100%,97.3%,94.4%,and 86.8%,*** regression analysis found that age,tumor rupture(R+),and extrahepatic tumor extension(E+)were independent prognostic factors.A total of 299 patients had complete remission,and 19 *** with declining alpha-fetoprotein(AFP)>75%after the first two cycles of neoadjuvant chemotherapy had a better EFS and OS than those≤75%.Conclusions The survival outcome of HB children has dramatically improved since the implementation of CCCG-HB-2016 ***≥8 years,R+,and E+were independent risk factors for *** with a declining AFP>75%after the first two cycles of neoadjuvant chemotherapy had better EFS and OS.

关键词： Alpha-fetoprotein Hepatoblastoma Multicenter Prospective study Survival

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