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Elevated peripheral levels of receptor-interacting protein kinase 1(RIpK1)and IL-8 as biomarkers of human amyotrophic lateral sclerosis

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Signal Transduction and Targeted Therapy 2024年第1期9卷 271-278页

作者： Jun Wei Min Li Zhi Ye Xinqian Hu Xiaoyan He Jia Wang gaofeng Chen Chengyu Zou Daichao Xu Hongbing Zhang Junying Yuan Yunhong Zha Institute of Neural Regeneration and Repair and department of Neurology The First College of Clinical Medical ScienceYichang Central HospitalCollege of Basic Medical ScienceChina Three Gorges UniversityHubei Province Clinical Medical Research Center for Rare Diseases of Nervous SystemYichang 443000China Interdisciplinary research Center on Biology and chemistry Shanghai Institute of Organic ChemistryChinese Academy of SciencesShanghai Key Laboratory of Aging StudiesShanghai 201210China State Key Laboratory of Common Mechanism research for Major Diseases Haihe Laboratory of Cell EcosystemDepartment of PhysiologyInstitute of Basic Medical Sciences and School of Basic MedicineChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina

Amyotrophic lateral sclerosis(ALS)is a devastating fatal neurodegenerative disease with no ***-interacting protein kinase 1(RIpK1)has been proposed to mediate pathogenesis of *** has been identified as an old drug that can also inhibit RIpK1 *** conducted a drug-repurposing biomarker study of primidone as a RIpK1 inhibitor using SOD1g93A mice and ALS ***1g93A mice treated with primidone showed significant delay of symptomatic onset and improved motor ***-hundred-sixty-two ALS participants dosed daily with primidone(62.5 mg)completed 24-week follow-up.A significant reduction was showed in serum levels of RIpK1 and IL-8,which were significantly higher in ALS patients than that of healthy controls(ppK1 levels were correlated positively with the severity of bulbar symptoms(pggests that serum levels of RIpK1 and IL-8 in peripheral can be used as clinical biomarkers for the activation of RIpK1 in central nervous system in human ALS *** primidone may provide a promising therapeutic strategy for *** effect of primidone for the treatment of other inflammatory diseases may also be considered,since the activation of RIpK1 has been implicated in mediating a variety of inflammatory diseases including COVID-19-associated cytokine release syndrome(CRS).(ChiCTR2200060149).

关键词： RIpK1 diseases Serum

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Manipulating photogenerated electron flow in nickel single‐atom catalysts for photocatalytic CO_(2)reduction into tunable syngas

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Carbon Energy 2024年第8期6卷 205-213页

作者： Yida Zhang Qingyu Wang Lihui Wu Haibin pan Chengyuan Liu Yue Lin gongming Wang Xusheng Zheng National Synchrotron Radiation Laboratory University of Science and Technology of ChinaHefeiAnhuiChina College of chemistry and Materials Science University of Science and Technology of ChinaHefeiAnhuiChina department of chemistry Hefei National Research Center for Physical Sciences at the MicroscaleUniversity of Science and Technology of ChinaHefeiAnhuiChina

The key to designing photocatalysts is to orient the migration of photogenerated electrons to the target active sites rather than dissipate at inert ***,we demonstrate that the doping of phosphorus(p)significantly enriches photogenerated electrons at Ni active sites and enhances the performance for CO_(2)reduction into *** photocatalytic CO_(2)reduction,Ni single‐atom‐anchored p‐modulated carbon nitride showed an impressive syngas yield rate of 85μmol gcat^(−1)h^(−1)and continuously adjustable CO/H_(2)ratios ranging from 5:1 to 1:2,which exceeded those of most of the reported carbon nitride‐based single‐atom *** studies reveal that p doping improves the conductivity of catalysts,which promotes photogenerated electron transfer to the Ni active sites rather than dissipate randomly at low‐activity nonmetallic sites,facilitating the CO_(2)‐to‐syngas photoreduction process.

关键词： carbon nitride CO_(2)photoreduction electron flow Ni single atoms syngas

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Detecting Malicious Uniform Resource Locators Using an Applied Intelligence Framework

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Computers, Materials & Continua 2024年第6期79卷 3827-3853页

作者： Simona-Vasilica Oprea Adela Bara department of Economic Informatics and Cybernetics Bucharest University of Economic StudiesBucharest010572Romania

The potential of text analytics is revealed by Machine Learning(ML)and Natural Language processing(NLp)*** this paper,we propose an NLp framework that is applied to multiple datasets to detect malicious Uniform Resource Locators(URLs).Three categories of features,both ML and Deep Learning(DL)algorithms and a ranking schema are included in the proposed *** apply frequency and prediction-based embeddings,such as hash vectorizer,Term Frequency-Inverse Dense Frequency(TF-IDF)and predictors,word to vector-word2vec(continuous bag of words,skip.gram)from google,to extract features from ***,we apply more state-of-the-art methods to create vectorized features,such as ***,feature engineering that is specific to URL structure is deployed to detect scams and other *** framework assessment,four ranking indicators are weighted:computational time and performance as accuracy,F1 score and type error *** the computational time,we propose a new metric-Feature Building Time(FBT)as the cutting-edge feature builders(like doc2vec or gloVe)require more *** applying the proposed assessment step,the skip.gram algorithm of word2vec surpasses other feature builders in ***,eXtreme gradient Boost(XgB)outperforms other *** this setup,we attain an accuracy of 99.5%and an F1 score of 0.99.

关键词： Detecting malicious URL classifiers text to feature deep learning ranking algorithms feature building time

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A new approach to pedestal differentiation for soil loss estimation-a case study from a burnt area in north-central portugal

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Journal of Forestry research 2024年第3期35卷 45-54页

作者： Frank g.A.Verheijen Martinho A.S.Martins Sergio A.prats Jan J.Keizer Centre for Environmental and Marine studies(CESAM) Department Environment and PlanningUniversity of Aveiro3810-193 AveiroPortugal Mediterranean Institute for Agriculture Environment and Development(MED-CHANGE)Institute for Advanced Studies and ResearchUniversity of EvoraPolo da MitraAp.947006-554 EvoraPortugal geoBiociencias Geotecnologias E Geoengenharias(GEOBIOTEC)Department Environment and PlanningUniversity of Aveiro3810-193 AveiroPortugal

Soil pedestals have long been used as qualitative indicators of soil splash *** rangelands,plant-capped pedestals,generally grass tussocks,have also been used to quantitatively estimate soil loss since the first half of the twentieth *** agricultural lands,forests,and bad-lands,stone-capped pedestals have been used as qualitative and semi-quantitative indicators of active,'extreme'*** work has been reported on using capstone pedestal data for quantifying soil *** postulate that three distinct capstone pedestal types may be present in any given location and that a detailed analysis of a pedestal height histogram may be used to recognize their *** analysis can subsequently inform if soil loss can be reliably estimated and if so,which of the existing methods using pedestal height data will provide more accurate *** three proposed capstone pedestal types are:(1)neo-pedestals formed underneath surface stones exposed by(partial)removal of the soil surface cover;(2)endo-pedestals formed underneath stones that were buried in the soil but have been exposed by erosion;and(3)phoenix-pedestals formed underneath stones from collapsed *** the pedestal height histogram of any given location,a skew to smaller heights may indicate the existence of endo-and/or phoenix-pedestals,which may be revealed as a bi-(or tri)modal distribution when using a smaller bin *** concept was applied to a case study where soil loss had been monitored for control plots and mulched plots during a 5-year period following wildfire in a eucalypt *** measured pedestal heights and used methods to quantitatively assess soil loss from soil pedestal data in the available *** pedestal data at the end of the 5-year period under or overestimated soil loss in the control treatment,with results ranging from 60 to 115%of measured soil loss,depending on the *** is postulated that phoenix-and endo-pedestals may be a driving fact

关键词： Soil pedestals Mulch Wildfire Soil erosion Char

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A facile access for the synthesis of some C-2 substituted imidazopyrazines by utilizing the palladium catalyzed Suzuki cross-coupling reaction under microwave irradiation

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Chinese Chemical Letters 2016年第1期27卷 31-36页

作者： M.Nibin Joy Bhaskaran Savitha Ayyiliyath M.Sajith Yadav D.Bodke Talavara Venkatesh K.K.Abdul Khader M.Syed Ali padusha A.Muralidharan department of p.g studies and research in industrial chemistry Kuvempu University post graduate and research department of chemistry Jamal Mohamed College Bharathidasan University Organic chemistry Division School of Chemical Sciences Kasaragod Govt.College Kannur University

A rapid, efficient, and facile synthesis of an assortment of C-2 substituted imidazopyrazines has been achieved by utilizing the palladium catalyzed Suzuki cross-coupling of 2-bromo-1H-imidazo[4,5-b]pyrazine with various boronic acids under microwave irradiation. The utilization of（A-^（ta）phos）_2pdCl_2 as a catalyst in combination with Cs F as base and DME-H_2O（4：1） as the solvent system at 100℃ procured the diaryls in acceptable to excellent yields. prominent features of this developed methodology include short reaction times, fewer side products, and exceptional tolerance to a wide variety of functional groups.

关键词： Imidazopyrazine Boronic acid Suzuki coupling Microwave

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Boosting the Activity and Stability of the photoreduction of Diluted CO_(2) by Copper Oxide Decorated CeO_(2) Hetero-shells

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Chemical research in Chinese Universities 2024年第3期40卷 513-520页

作者： XIAO Mingjiao LI Di WEI Yanze HE Yilei WANg Zumin YU Ranbo department of physical chemistry School of Metallurgical and Ecological EngineeringUniversity of Science&Technology BejingBeijing 100083P.R.China State Key Laboratory of Biochemical Engineering Institute of Process EngineeringChinese Academy of SciencesBeijing 100190P.R.China Key Laboratory of Biopharmaceutical preparation and Delivery Chinese Academy of SciencesBeijing 100190P.R.China

Inspired by the natural photosynthesis systems,the integrated harnessing and conversion of CO_(2) present a promising solution for addressing the ever-rising global atmospheric concentration of CO_(2).Hollow multi-shelled structured(HoMS)photocatalysts,featuring alternating shells and cavities,have recently gained recognition as efficient nano-reactors for capturing CO_(2) molecules and facilitating effective photoreduction within these hierarchical structures,leveraging the preeminent enrichment *** this work,to augment the photocatalytic efficacy of HoMS in CO_(2) treatment,highly dispersed Cu_(x)O nanoparticles(Nps)were incorporated on the CeO2 shells through a polymer-assisted impregnation method to create more active sites and strengthen the interaction between the hetero-shells and CO_(2) *** photoreduction of the CO_(2)-to-CO rate under a diluted CO_(2)(15%,volume fraction)atmosphere is improved by the introduction of Cu_(x)O Nps,with the highest CO yielding rate reaching 120µmol·h^(−1)·g^(−1) without any sacrificial *** comparison experiments and theoretical calculations reveal that the Cu_(x)O Nps promote the adsorption of CO_(2) molecules in HoMS,accelerate the charge transfer efficiency,and stabilize the surface oxygen vacancies(Ovs)during the photoreduction CO_(2) conversion *** hope these easy-to-prepare HoMS nanoreactors can contribute to the effective enrichment and valorization of CO_(2) in industrial exhaust gases.

关键词： photoreduction CO_(2) Cu_(x)O/CeO_(2)hollow multi-shell structure(HoMS) Hetero-shell

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Development of Modified glasses by Transparent, Functional Hybrid Sol-gel Nano-Ceramic Coatings, a Comparative Study

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World Journal of Engineering and Technology 2024年第1期12卷 170-184页

作者： Md. Barkat Ullah Yeasmin Akter Khodeja Afrin Md. Saiful Quddus department of Applied chemistry and Chemical Engineering Noakhali Science and Technology University Noakhali Bangladesh Bangladesh Council of Scientific and industrial research (BCSIR) Dhaka Bangladesh

This paper concentrates on the development of glasses with self-cleaning surfaces exhibiting high water contact angles. In this study, we prepared super-hydrophobic nano-ceramic coated glass based on titania & silica using simple sol-gel & dip coating methods and studied the best composition of the coatings by altering ratios of titanium tetraisopropoxide (TTIp)/tetraethyl orthosilicate (TEOS) with different homogenizing agents. We characterized the coatings by surface roughness measurement, percentage of optical transmission, static contact angle, near-infrared (NIR) transmission, and diffuse reflectance. The fabrication of coatings on glass substrates played an important role in increasing the water contact angle of about 95° and visible & NIR transmission of about 90%. We compared our modified glass substrate with commercial low emissivity (Low E) glass using X-ray diffraction (XRD) analysis, which showed pure amorphous surface claiming excellent wettability and thus the prepared glass substrate could have a variety of applications in different fields.

关键词： Sol-gel Nano-Ceramic Coatings Self-Cleaning glass Water Contact Angle Optical Transmission

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Exploring the thermophysical properties of natural deep eutectic solvents for gas capture applications: a comprehensive review

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green Chemical Engineering 2024年第3期5卷 307-338页

作者： Ahmad Al-Bodour Noor Alomari Alberto guti errez Santiago Aparicio Mert Atilhan department of Chemical and paper Engineering Western Michigan University department of chemistry University of Burgos Faculty of Sciences

With the intensifying challenge of global warming driven largely by anthrop.genic activities, effective greenhouse gas capture techniques are critical. This paper focuses on the role of deep eutectic solvents(DES) as promising agents for such capture at the source. We review the key DES-based methods for greenhouse gas capture, drawing conclusions from a thorough analysis of the existing literature. In particular, we examine the effect of DES structure on gas solubilities and explore the mechanism of gas solubility in DES through molecular simulation. We present a synthesis of state-of-the-art results in this area, assessing the potential of DES as an alternative to current industrial gas capture methods. Furthermore, we propose future research directions for the design of novel DES tailored to more specific applications.

关键词： global warming Climate change Deep eutectic solvents gas capture gas separation

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MOF-derived Cu embedded into N-doped mesoporous carbon as a robust support of pdAu nanocatalysts for ethanol electrooxidation

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Rare Metals 2024年第3期43卷 1083-1094页

作者： Yu-Fu Huang peng Wu Jun-ping Tang Jian Yang Jing Li Shuai Chen Xue-Ling Zhao ChengChen Bin-Wei Zhang Yan-Yun Ma Wei-Heng Shi Dong-Hai Lin Shi-gang Sun School of Energy and Materials Shanghai Engineering Research Center of Advanced Thermal Functional MaterialsShanghai Key Laboratory of Engineering Materials Application and EvaluationShanghai Polytechnic UniversityShanghai201209China State Key Laboratory of physical chemistry of Solid Surfaces Department of ChemistryCollege of Chemistry and Chemical EngineeringXiamen UniversityXiamen361005China School of chemistry and Chemical Engineering Chongqing UniversityChongqing401331China Center of Advanced Energy Technology and Electrochemistry Institute of Advanced Interdisciplinary StudiesChongqing UniversityChongqing400044China Institute of Functional Nano&Soft Materials(FUNSOM) Jiangsu Key Laboratory for Carbon-Based Functional Materials&DevicesSoochow UniversitySuzhou215123China department of Materials Science and Engineering Drexel UniversityPhiladelphiaPA19104USA

Metal-organic frameworks(MOFs)h ave attracted widespread attention due to their large surface area and porous *** designing the nanostructures of MOFs to promote their application in ethanol electrooxidation is still a ***,a novel Cu-NCNs(Cu-nitrogen-doped carbon nanotubes)support was synthesized by pyrolysis of melamine(MEL)and Cu-ZIF-8 together,and then,pd-Au nanoalloys were loaded by sodium borohydride reduction method to prepare pdAu@Cu-NCNs *** generating mesoporous carbon with high specific surface area and favorable electron and mass transport can be used as a potential excellent carrier for pdAu *** addition,the balance of catalyst composition and surface structure was tuned by controlling the content of pd and ***,the best-performed pd_(2)Au_(2)@Cu-NCN-1000-2(where 1000 means the carrier calcination temperature,and 2 means the calcination constant temperature time)catalyst exhibits better long-term stability and electrochemical activity for ethanol oxidation in alkaline media(4.80 A·mg^(-1)),which is 5.05 times higher than that of commercial pd/C(0.95 A·mg^(-1)).Therefore,this work is beneficial to further promoting the application of MOFs in direct ethanol fuel cells(DEFCs)and can be used as inspiration for the design of more efficient catalyst support structures.

关键词： Metal-organic frameworks(MOFs) N-doped Mesoporous carbon pdAu Ethanol electrooxidation

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Oxygen vacancy engineering for tuning the catalytic activity of LaCoO_(3) perovskite

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Journal of Rare Earths 2024年第3期42卷 506-514,I0003页

作者： Jeong Hyun Cho Minjae Kim Inchan Yang Kyung Tae park Chang Houn Rhee Hai Woong park Ji Chul Jung department of Chemical Engineering Myongji UniversityYongin 17058Republic of Korea Institute of Advanced Composite Materials Korea Institute of Science and TechnologyWanju-gunJeollabuk-do 55324Republic of Korea Iron&Steel process Engineering research group POSCOPohang 37859Republic of Korea Hydrogen research Center Research Institute of Industrial Science&Technology(RIST)Pohang 37673Republic of Korea

Herein, we attempted to engineer oxygen vacancies on the surface of LaCoO_(3) perovskite through simple post-treatments(acid or reductive thermal treatments). Acid treatment induces oxygen vacancies through the selective etching of the La cations, whereas thermal treatment in a reducing atmosphere generates oxygen vacancies by directly removing lattice oxygen. The characterization results confirm that the number of surface oxygen vacancies, which are crucial in various catalytic oxidation reactions,considerably increases in the LaCoO_(3) catalysts treated with acid or reducing gas. Acid treatment enriches the oxygen vacancies while maintaining the structure of the LaCoO_(3) catalysts, which can not be achieved through reductive thermal treatment. Therefore, the acid treatment is considered a promising technique for oxygen vacancy engineering of perovskite catalysts for tuning their catalytic activities. Furthermore,the catalytic activities of the posttreated LaCoO_(3) catalysts for CO oxidation were evaluated and are noted to be considerably better than those of the pristine LaCoO_(3) catalyst due to their abundant oxygen vacancies. Consequently, we conclude that the oxygen vacancies of perovskite catalysts can be effectively engineered via two simple methods and play a significant role in CO oxidation.

关键词： LaCoO_(3)perovskite Acid treatment Reductive thermal treatment Oxygen vacancy CO oxidation Rare earths

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