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Spousal Involvement in the Workplace of Doctors: What Is Defined as Appropriate or Inappropriate

health 2024年第3期16卷 187-203页

作者： Uchenna Onubogu Boma Oyan Martha Okorie department of paediatrics & child health Rivers State University Teaching Hospital Port Harcourt Nigeria

Background: Workers spend a significant amount of time in the workspace. Involvement of a spouse in a doctor’s workplace can take different forms and come with different intentions. Objectives: The survey aimed to determine the prevalence and extent of spousal involvement in physicians’ workplaces as well as the outcome of such involvement on doctor’ swell-being, productivity, and relationship with colleagues. Methods: This cross-sectional online survey on spousal involvement in the workplace of doctors was conducted among 83 responding doctors from July to August 2023. Results: Among the respondents, 60 (72.3%) had witnessed a doctor’s spouse being involved in the workplace. The most common reason for spousal involvement in the workplace was to protect the spouse from what they perceived as a threat 34 (54.0%). Spouse’s ignorance of boundaries in the workplace (OR: 6.09 (95% CI: 1.70, 21.79) p: 0.003) and exertion of control by the spouse (OR: 11.2 (95% CI: 2.26, 56.41) p: 0.002) were significantly associated with higher odds of inappropriate spousal involvement in the workplace, while expression of love for spouse with acts of kindness was significantly associated with a lowered odd of inappropriate spousal involvement (OR: 0.11 (95% CI: 0.03, 0.36) p: 0.0001). Conclusion: Spousal involvement in the workplace is relatively common. Ignorance of the boundaries of the workplace and exertion of control by the spouse were significant enablers of inappropriate spousal involvement in the workplace of doctors. The establishment of workplace policies that define the limits of spousal involvement in the doctor’s workplace can foster a healthy workspace environment, enhance doctors’ well-being, and improve patient care.

关键词： Spouse Workplace Involvement Hospital healthcare Workers Conflicts Appropriate

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Early embryonic failure caused by a novel mutation in the TUBB8 gene:A case report

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World Journal of Clinical Cases 2024年第12期12卷 2092-2098页

作者： Xiao-Yu Zhang Xing-Xing Zhang Lei Wang department of Reproductive Center Zaozhuang Maternal and Child Healthcare HospitalZaozhuang 277000Shandong ProvinceChina

BACKGROUND This study aimed to explore the relationship between gene mutations and early embryonic development arrest and to provide more possibilities for the diagnosis and treatment of repeated implantation *** SUMMARY Here,we collected and described the clinical data of a patient with early embryonic development stagnation after repeated in vitro fertilization attempts for primary infertility at the department Reproductive Center of Zaozhuang Maternal and child healthcare *** also detected the whole-exon gene of the patient's spouse and parents,and conducted bioinformatics analysis to determine the pathogenesis of the *** A novel mutant of the TUBB8 gene[c.602G>T(p.C201F)]was identified,and this mutant provided new data on the genotype-phenotype relationships of related diseases.

关键词： Genes Mutation Embryonic development Fertilization in vitro Intracytoplasmic sperm injection Case report

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Aberrant protamination in sperm correlates to anomalous nuclear and cytoplasmic architectures in infertile males with sperm dysmorphology

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Asian Journal of Andrology 2024年第2期26卷 183-188页

作者： Huan Jiang Chu-Jie Huang department of Reproductive Endocrinology Longgang District Maternity&Child Healthcare Hospital of Shenzhen City(Longgang Maternity and Child Institute of Shantou University Medical College)Shenzhen 518172China Institute of Reproductive Immunology College of Life Science and TechnologyJinan UniversityGuangzhou 510632China

Aberrant sperm protamination is linked to sperm dysmorphology and nuclear chromatin ***,its effects on sperm cytoplasmic maturation remain largely *** relationships of protamines,sperm morphology,DNA damage,and cytoplasmic remodeling were illustrated in this study to provide fresh perspectives on the mechanisms of male infertility.A total of 205 infertile males were allocated into 5 groups according to the percentage of spermatozoa exhibiting abnormal morphology within their *** concentration,motility,abnormal sperm morphology,cytoplasmic droplets(CDs),and excess residual cytoplasm(ERC)were analyzed according to the World health Organization manual(2010).Sperm nuclear vacuoles(NVs)were determined by propidium iodide(pI)*** protamine expressions(p1 and p2)were detected by western *** damage was measured by acridine orange test(AOT)to calculate the proportion of sperm with single-strand DNA breaks(SSBs).Our data showed that sperm concentration and motility in infertile males significantly decreased with the severity of abnormal sperm morphology(both pp1 level,p1/p2 ratio,and SSB rate increased with the severity of sperm dysmorphology,whilst the p2 level decreased(all pperm dysmorphology and positively correlated with the SSB rate(all pps between the SSB rate and the p1/p2 ratio were also significant(pprotamination may cause sperm dysmorphology and compromise male fertility by impairing sperm's nucleus and cytoplasm maturation,with the p1/p2 ratio potentially serving as a valuable indicator of sperm quality and male fertility.

关键词： abnormal sperm morphology excess residual cytoplasm male infertility protamines sperm DNA damage sperm nuclear vacuoles

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proteomic profiling of cerebrospinal fluid in pediatric myelin oligodendrocyte glycoprotein antibody-associated disease

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World Journal of pediatrics 2024年第3期20卷 259-271页

作者： Yi-Long Wang Meng-Ying Zhu Zhe-Feng Yuan Xiao-Yan Ren Xiao-Tong Guo Yi Hua Lu Xu Cong-Ying Zhao Li-Hua Jiang Xin Zhang Guo-Xia Sheng pei-Fang Jiang Zheng-Yan Zhao Feng Gao department of Neurology Children's HospitalZhejiang University School of MedicineHangzhou 310052China children's Hospital Zhejiang University School of MedicineHangzhou 310052China children's Hospital National Clinical Research Center for Child HealthZhejiang University School of MedicineHangzhou 310052China

Background Myelin oligodendrocyte glycoprotein(MOG)antibody-associated disease(MOGAD)is an autoimmune demy-elinating disorder of the central nervous *** Extracted proteins from 34 cerebrospinal fluid(CSF)samples[patients with MOGAD(MOG group,n=12);healthy controls(HC group,n=12);patients with MOG seronegative and metagenomics next-generation sequencing-negative inflammatory neurological diseases(IND group,n=10)]were processed and subjected to label-free quantitative *** partial least squares-discriminant analysis(pLS-DA)and orthogonal pLS-DA(O-pLS-DA)models were also performed based on proteomics *** analysis of differentially expressed proteins(DEps)was performed using Gene Ontology,Interpro,and Kyoto Encyclopedia Genes and *** enzyme-linked immunosorbent assay was used to determine the complement levels in serum from patients with *** Four hundred and twenty-nine DEps(149 upregulated and 280 downregulated proteins)were identified in the MOG group compared to the HC group according to the p value and fold change(FC).Using the O-pLS-DA model,872 differentially abundant proteins were identified with variable importance projection(VIp)scores>*** proteins(gamma-glutamyl hydrolase,cathepsin F,interalpha-trypsin inhibitor heavy chain 5,latent transforming growth factor beta-binding protein 4 and leukocyte-associated immunoglobulin-like receptor 1)overlapping between the top 30 DEps with top-ranked p value and FC and top 30 proteins in pLS-DA VIp lists were *** analysis revealed that the dysregulated proteins in the MOG group were primarily involved in complement and coagulation cascades,cell adhesion,axon guidance,and glycosphingolipid biosynthesis compared to the HC *** The proteomic alterations in CSF samples from children with MOGAD identified in the current study might provide opportunities for developing novel biomarker candidates.

关键词： Acute disseminated encephalomyelitis Cerebrospinal fluid Complement cascades Myelin oligodendrocyte glycoprotein-associated disease proteomics

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The miR-9-5p/CXCL11 pathway is a key target of hydrogen sulfide-mediated inhibition of neuroinflammation in hypoxic ischemic brain injury

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Neural Regeneration Research 2024年第5期19卷 1084-1091页

作者： Yijing Zhao Tong Li Zige Jiang Chengcheng Gai Shuwen Yu Danqing Xin Tingting Li Dexiang Liu Zhen Wang department of physiology School of Basic Medical SciencesCheeloo College of MedicineShandong UniversityJinanShandong ProvinceChina department of Neurosurgery Qingdao Municipal HospitalQingdaoShandong ProvinceChina department of Medical psychology and Ethics School of Basic Medicine SciencesCheeloo College of MedicineShandong UniversityJinanShandong ProvinceChina Key Laboratory of Birth Regulation and Control Technology of National health Commission of China Maternal and Child Health Care Hospital of Shandong Province Affiliated to Qingdao UniversityJinanShandong ProvinceChina

We previously showed that hydrogen sulfide(H2S)has a neuroprotective effect in the context of hypoxic ischemic brain injury in neonatal ***,the precise mechanism underlying the role of H2S in this situation remains *** this study,we used a neonatal mouse model of hypoxic ischemic brain injury and a lipopolysaccharide-stimulated BV2 cell model and found that treatment with L-cysteine,a H2S precursor,attenuated the cerebral infarction and cerebral atrophy induced by hypoxia and ischemia and increased the expression of miR-9-5p and cystathionineβsynthase(a major H2S synthetase in the brain)in the prefrontal *** also found that an miR-9-5p inhibitor blocked the expression of cystathionineβsynthase in the prefrontal cortex in mice with brain injury caused by hypoxia and ***,miR-9-5p overexpression increased cystathionine-β-synthase and H2S expression in the injured prefrontal cortex of mice with hypoxic ischemic brain injury.L-cysteine decreased the expression of CXCL11,an miR-9-5p target gene,in the prefrontal cortex of the mouse model and in lipopolysaccharide-stimulated BV-2 cells and increased the levels of proinflammatory cytokines BNIp3,FSTL1,SOCS2 and SOCS5,while treatment with an miR-9-5p inhibitor reversed these *** findings suggest that H2S can reduce neuroinflammation in a neonatal mouse model of hypoxic ischemic brain injury through regulating the miR-9-5p/CXCL11 axis and restoringβ-synthase expression,thereby playing a role in reducing neuroinflammation in hypoxic ischemic brain injury.

关键词： chemokine(C-X-C motif)ligand 11 cystathionineβsynthase H2S hypoxic ischemic brain injury inflammation L-cysteine lipopolysaccharide microglia miR-9-5p neuroprotection

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BMp9 induces osteogenic differentiation through up-regulating LGR4 via the mTORC1/ Stat3 pathway in mesenchymal stem cells

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Genes & Diseases 2024年第3期11卷 468-483页

作者： Jie Zhang Jinhai Jiang Hang Liu Shiyu Wang Kaixin Ke Siyuan Liu Yue Jiang Lu Liu Xiang Gao Baicheng He Yuxi Su department of pharmacology School of PharmacyChongqing Medical UniversityChongqing 400016China Key Laboratory of Biochemistry and Molecular pharmacology of Chongqing Chongqing Medical UniversityChongqing 400016China department of Orthopedics Second Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China orthopedics department Children's Hospital of Chongqing Medical UniversityChongqing 400014China China International Science and Technology Cooperation Base of child Development and Critical Disorders Jiangxi Hospital Affiliated Children's Hospital of Chongqing Medical UniversityJiangxi 330000China National Clinical Research Center for child health and Disorders China

Bone defects and non-union are prevalent in clinical orthopedy,and the outcomes of current treatments are often *** tissue engineering offers a promising approach to treating these conditions *** morphogenetic protein 9(BMp9)can commit mesenchymal stem cells to osteogenic lineage,and a knowledge of the underlying mechanisms may help advance the field of bone tissue ***-rich repeats con-taining G protein-coupled receptor 4(LGR4),a member of G protein-coupled receptors,is essential for modulating bone *** study is aimed at investigating the impact of LGR4 on BMp9-induced osteogenesis in mesenchymal stem cells as well as the underlying *** marrow stromal cells from BMp9-knockout mice exhibited diminished LGR4 expression,and exogenous LGR4 clearly restored the impaired osteogenic potency of the bone marrow stromal ***,LGR4 expression was increased by BMp9 in C3H10T1/2 ***4 augmented the benefits of BMp9-induced osteogenic markers and bone formation,whereas LGR4 inhibition restricted these ***,the BMp9-induced li-pogenic markers were increased by LGR4 *** protein levels of Raptor and p-Stat3 were elevated by *** knockdown or p-Stat3 suppression attenuated the osteoblastic markers and LGR4 expression brought on by ***4 significantly reversed the blocking ef-fect of Raptor knockdown or p-Stat3 suppression on the BMp9-induced osteoblastic *** interacts with p-Stat3,and p-Stat3 activates the LGR4 promoter *** conclusion,LGR4 boosts BMp9 osteoblastic potency in mesenchymal stem cells,and BMp9 may up-regulate LGR4 via the mTORC1/Stat3 signal activation.

关键词： BMp9 LGR4 mTORC1 Osteogenic differentiation Stat3

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Ursolic acid inhibiting excessive reticulophagic flux contributes to alleviate ochratoxin A-induced endoplasmic reticulum stress- and mitochondrial-mediated apoptosis

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Food Science and Human Wellness 2024年

作者： Huiqiong Deng Wenying Chen Lingyun Han Boyang Zhang Xun Luo Song Yao Hongwei Wang Yao Zhou Shuangchao Liu Xiao Li Shen School of public health Zunyi Medical University Chongqing Fuling District Center for Disease Control and prevention Key Laboratory of Maternal & child health and Exposure Science of Guizhou Higher Education Institutes Research and Development department Allife Medicine Inc.

Foods and animal feeds frequently become contaminated with the nephrotoxic ochratoxin A (OTA). Our prior research has indicated that ursolic acid (UA)， which is widely present in fruits and medicinal plants， has the potential to alleviate nephrotoxicity triggered by OTA. Additionally， excessive induction of endoplasmic reticulum (ER)-phagy exacerbates OTA-induced apoptosis. Therefore， further investigation is essential to comprehend whether UA can mitigate OTA-induced apoptosis by influencing ER-phagy. This objective is accomplished through a series of experiments involving assessments of cell viability， apoptosis， fluorescence microscopy， and western blot analysis. The outcomes of these experiments reveal that pre-treatment with 4 μmol/L UA for 2 h can markedly reverse the elevated apoptotic rate， the co-localization of ER and lysosomes， and the protein expressions of GRp78， p-eIF2α， Chop， Bax， and Bak， as well as the reduced cell viability and the protein expressions of Lonp1， Trap1， p62， Tex264， FAM134B， Bcl-2， and Bcl-xl， all caused by exposure to 1 μmol/L OTA for 24 h in human proximal tubule epithelial-originated kidney-2 (HK-2) cells (p pression of LC3B-II induced by OTA is further amplified by UA pre-treatment (p p between ER stress (ERS) and excessive ER-phagy， thereby further promoting ERS- and mitochondrial-mediated apoptosis in vitro. However， this effect is significantly mitigated by UA through the inhibition of autophagosome-lysosome fusion， consequently blocking the excessive ER-phagic flux.

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Value of combining targeted emergency nursing with psychological nursing in children with febrile convulsions

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World Journal of Clinical Cases 2024年第21期12卷 4518-4526页

作者： Qing Han Feng-Ru Wu Yun Hong Li-Li Gu Yu Zhu department of Emergency Nantong Maternal and Child Heath Care HospitalAffiliated Maternity and Child Health Care Hospital of Nantong UniversityNantong 226000Jiangsu ProvinceChina

BACKGROUND Febrile convulsions are a common pediatric emergency that imposes significant psychological stress on children and their *** emergency care and psychological nursing are widely applied in clinical practice,but their value and impact on the management of pediatric febrile convulsions are *** To determine the impact of targeted emergency nursing combined with psychological nursing on satisfaction in children with febrile *** Data from 111 children with febrile convulsions who received treatment at Nantong Maternal and child health Care Hospital between June 2021 and October 2022 were *** control group consisted of 44 children who received conventional nursing care and the research group consisted of 67 children who received targeted emergency and psychological *** time to fever resolution,time to resolution of convulsions,length of hospital stays,pittsburgh Sleep Quality Index,patient compliance,nursing satisfaction of the parents,occurrence of complications during the nursing process,and parental anxiety and depression were compared between the control and research *** anxiety and depression were assessed using the Hamilton Rating Scale for Depression(HAMD)and the Hamilton Rating Scale for Anxiety(HAMA).RESULTS The fever resolution,convulsion disappearance,and hospitalization times were longer in the control group compared with the research group(pp,sleep time,sleep quality,sleep disturbance,sleep efficiency,and daytime status scores were significantly better in the research group compared with the control group(pparents of children in the research group were lower than the scores in the control group after nursing(ppliance with treatment of children in the research group was higher than in the control group(pparental satisfaction with nursing in the research group was higher than in the control group(p

关键词： Targeted emergency nursing psychological nursing children with febrile convulsions Satisfaction Treatment compliance

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Association of psychological stress with wives’hypertension across over 10 million Chinese married female population aged 20-49 years

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Chinese Medical Journal 2024年第13期137卷 1583-1591页

作者： Zhenyan Zhao Jiajing Jia Xinyi Lyu Lihua Zhang Yuanyuan Wang Yuan He Zuoqi peng Ya Zhang Hongguang Zhang Qiaomei Wang Haiping Shen Yiping Zhang Donghai Yan Xu Ma Ying Yang State Key Laboratory of Cardiovascular Disease Department of CardiologyFuwai HospitalNational Center for Cardiovascular DiseaseChinese Academy of Medical Science and Peking Union Medical CollegeBeijing 100037China National Research Institute for Family planning Beijing 100081China National Human Genetic Resources Center Beijing 102206China Graduate School of peking Union Medical College Beijing 100730China department of Maternal and child health National Health and Family Planning Commission of the PRCBeijing 100044China

Background:psychological stress has been reported to be a potential risk factor for hypertension among females,but it remains unclear whether spousal chronic stress levels alter the risk of hypertension among *** examined the associations between stress within the family and hypertension among married ***:Reproductive-aged women who were planning for pregnancy and their husbands were recruited from the National Free pre-pregnancy Checkup projects(NFpCp)across 31 provinces in China in 2016 and *** stress of wives or husbands was measured with a 5-point Likert-type scale,and assessed from three domains:work/life-related stress,economic stress,and overall ***-adjusted logistic regression models were used to assess the associations between stress status and the prevalence of ***:Of 10,027,644 couples,261,098(2.60%)women had *** results showed that higher stress levels among themselves or their husbands were associated with a higher prevalence of hypertension in women(p_(for trend)pared with non-stressed participants,female participants with the highest stress themselves were at a greater risk of hypertension,with adjusted odds ratio(OR)of 1.31(95%confidence interval[CI]:1.25-1.37);and compared with participants whose husbands had no stress,those whose husbands had the highest stress level were at a higher risk of hypertension with adjusted OR of 1.24(95%CI:1.20-1.29).Moreover,compared with non-stressed status for both couples,only-wife-stressed,only-husband-stressed,and both-stressed couples were found to be significantly associated with increased risks of wives’hypertension,with adjusted ORs of 1.28(95%CI:1.25-1.31),1.19(95%CI:1.17-1.21),and 1.28(95%CI:1.26-1.31),***:Moderate to severe stress in both spouses might be associated with female hypertension prevalence,which highlights the importance of paying attention to the psychological stresses of couples within the f

关键词： psychological stress Hypertension Occupational stress Life stress Financial stress

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Comparative study on emotional behavior and parental job stress of only-child and non-only-child preschool children

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World Journal of Clinical Cases 2024年第21期12卷 4642-4651页

作者： Zhi-Wei Fu Kai-Li Wang Ning-Yu Du Yue-Jing Li Jing-Jing Duan Sheng-Xia Zhao department of children's health Shijiazhuang Maternity and Child Healthcare HospitalShijiazhuang 050000Hebei ProvinceChina

BACKGROUND Studies have revealed that children's psychological,behavioral,and emotional problems are easily influenced by the family *** recent years,the family structure in China has undergone significant changes,with more families having two or three *** To explore the relationship between emotional behavior and parental job stress in only preschool and non-only preschool *** children aged 3-6 in kindergartens in four main urban areas of Shijiazhuang were selected by stratified sampling for a questionnaire and divided into only and nononly child *** emotional behaviors and parental pressure were *** and non-only children were paired in a 1:1 ratio by class and age(difference less than or equal to 6 months),and the matched data were *** relationship between children's emotional behavior and parents'job stress before and after matching was *** Before matching,the mother's occupation,children's personality characteristics,and children's rearing patterns differed between the groups(ppairs,differences in the children's parenting styles *** were significant differences in children's gender and parents'attitudes toward children between the two *** Strengths and Difficulties Questionnaire(SDQ)scores of children in the only child group and the parenting Stress Index-Short Form(pSI-SF)scores of parents were significantly lower than those in the non-only child group(ppearson’s correlation analysis showed that after matching,there was a positive correlation between children's parenting style and parents'attitudes toward their children(r=0.096,ppSI-SF score was positively correlated with children's gender,parents'attitudes toward their children,and SDQ scores(r=0.077,0.193,0.172,0.222).CONCLUSION preschool children's emotional behavior and parental pressure were significantly higher in multi-child *** pressure in differently

关键词： Only child Family structure children's emotional behavior parental stress Tendency score

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