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Molecule‑Level Multiscale Design of Nonflammable Gel Polymer Electrolyte to Build Stable SEI/CEI for Lithium Metal Battery

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Nano-Micro Letters 2025年第1期17卷 404-423页

作者： Qiqi Sun Zelong Gong Tao Zhang Jiafeng Li Xianli Zhu Ruixiao Zhu Lingxu Wang Leyuan Ma Xuehui Li Miaofa Yuan Zhiwei Zhang Luyuan Zhang Zhao Qian Longwei Yin Rajeev Ahuja Chengxiang Wang Key laboratory for Liquid‑Solid Structural Evolution and Processing of Materials(Ministry of Education) School of Materials Science and EngineeringShandong UniversityJinan 250061People’s Republic of China Condensed Matter Theory Department of Physics and AstronomyUppsala UniversityUppsala 75120Sweden

The risk of flammability is an unavoidable issue for gel polymer electrolytes(GPEs).Usually,flameretardant solvents are necessary to be used,but most of them would react with anode/cathode easily and cause serious interfacial instability,which is a big challenge for design and application of nonflammable ***,a nonflammable GPE(SGPE)is developed by in situ polymerizing trifluoroethyl methacrylate(TFMA)monomers with flame-retardant triethyl phosphate(TEP)solvents and LiTFSI–LiDFOB dual lithium *** is strongly anchored to PTFMA matrix via polarity interaction between-P=O and-CH_(2)CF_(3).It reduces free TEP molecules,which obviously mitigates interfacial reactions,and enhances flame-retardant performance of TEP *** TEP molecules are also inhibited in solvation of Li^(+),leading to anion-dominated solvation sheath,which creates inorganic-rich solid electrolyte interface/cathode electrolyte interface *** coordination structure changes Li^(+)transport from sluggish vehicular to fast structural transport,raising ionic conductivity to 1.03 mS cm^(-1) and transfer number to 0.41 at 30℃.The Li|SGPE|Li cell presents highly reversible Li stripping/plating performance for over 1000 h at 0.1 mA cm^(−2),and 4.2 V LiCoO_(2)|SGPE|Li battery delivers high average specific capacity>120 mAh g^(−1) over 200 *** study paves a new way to make nonflammable GPE that is compatible with Li metal anode.

关键词： Anchoring effect Nonflammable gel electrolyte In situ cross-linked Electrode-electrolyte interface Li metal battery

Human Papillomavirus as an Independent Predictor in oral Squamous Cell Cancer

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International Journal of oral Science 2009年第3期1卷 119-125页

作者： Dan Zhao Qin-gan Xu Xin-ming Chen Ming-wen Fan Key laboratory for oral biomedical engineering of Ministry of Education Wuhan University Wuhan China department of Pathology School ＆ Hospital of Stomatology Wuhan University Wuhan China

Aim There is an increasing evidence for the role of high risk human papillomavirus （HPV） in the pathogenesis of oral squamous cell carcinoma （OSCC）. The purpose of this study is to evaluate the relevance of HPV infection to the survival and prognosis of OSCC. Methodology Fifty-two patients with OSCC were followed from 4 to 88 months with a median of 50.7 months. HPV DNA was identified in formalin-fixed, paraffin-embedded tumor specimens by nested PCR with MY09/MY11 and GP5^＋/GP6^＋ primer pairs and the HPV genotype was determined by direct DNA sequencing. Association between the HPV status and risk factors for cancer as well as tumor-host characteristics were *** curves were calculated by the Kaplan-Meier method and analyzed using the log-rank test. Results HPV was found in 40.4% of the tumors with HPV16 accounting for 63.5%, HPV18 for 30.8%, HPV6 for 3.9% and HPVll for 1.8%. No infection with more than one HPV genotype was detected. HPV infection was significantly associated with poor histological grade, TNM stage Ⅰ -Ⅱ, alcohol usage and no smoking status. Multivariate analysis showed that HPV had an independent prognostic effect on the overall survival after adjusting other confounding factors such as histological grade, TNM stage and tobacco usage. The presence of HPV was significantly correlated with a better survival in patients with OSCC. Conclusion HPV infection can act as an independent predictor for the survival and prognosis of OSCC.

关键词： human papillomavirus (HPV) oral squamous cell carcinoma (OSCC) survival analysis

NEW FOCUSED ULTRASOUND TRANSDUCER FOR FAT CELL DISRUPTION

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Journal of Innovative Optical Health Sciences 2012年第1期5卷 85-90页

作者： YANG CUI JUE PENG HU TANG TIANFU WANG SIPING CHEN department of biomedical engineering School of Medicine Shenzhen Key Laboratory of Biomedical Engineering Shenzhen UniversityShenzhen 518060 GuangdongChina

Being an emerging body-shaping technology of fat cell disruption,high-intensity focused ultrasound has been investigated intensively in recent years for its favorable natures such as painlessness,safety and *** of the major problems for the technology,however,is the overheating of *** this study,we modified the transducer design in order to solve the overheating *** simulated the performance of the modified design by finite element analysis and fabricated the newly designed *** measuring the actual performance data,we proved that the new design can effectively reduce temperature rise while keeping the acoustic intensity field unaffected.

关键词： Focused ultrasound transducer fat disruption acoustic field overheating

A novel method for evaluating tissue inhomogeneity in elastography

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Progress in Natural Science:Materials International 2006年第5期16卷 474-479页

作者： BAI Peirui, WAN Mingxi, WANG Supin, ZHANG Dachun and DANG Jun (department of biomedical engineering, Xi’an Jiaotong University, Key laboratory of biomedical Information engineering of Ministry of Education, Xi’an 710049, China) department of biomedical engineering Xi' an Jiaotong University Key Laboratory of Biomedical Information Engineering of Ministry of Education Xi'an 710049 China

Based on the detection of differential Renyi information (DRI) of segmented pre- and post-compression radio-frequency (RF) echo signals, a novel method for evaluating tissue inhornogeneity in elastography prior to the cross-correlation operation is proposed. In vitro experiments were carried out to corroborate the performance of the DRI method. Experimental results illustrate that valuable insights into local tissue inhomogeneity can be obtained through analyzing the DRI curves of the echo segments, which can provide information to aid the study of strain estimation algorithm in elastography.

关键词： ultrasound elastography tissue compression tissue inhomogeneity time-frequency analysis Renyi information.

pH and lipase-responsive nanocarrier-mediated dual drug delivery system to treat periodontitis in diabetic rats

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Bioactive Materials 2022年第12期7卷 254-266页

作者： Lu Wang Yuzhou Li Mingxing Ren Xu Wang Lingjie Li Fengyi Liu Yiqing Lan Sheng Yang Jinlin Song College of Stomatology Chongqing Medical UniversityChongqingChina Chongqing Key laboratory of oral Diseases and biomedical Sciences ChongqingChina Chongqing Municipal Key laboratory of oral biomedical engineering of Higher Education ChongqingChina

Precise and controlled drug delivery to treat periodontitis in patients with diabetes remains a significant clinical ***-based drug delivery systems offer a potential therapeutic strategy;however,the low loading efficiency,non-responsiveness,and single effect of conventional nanoparticles hinder their clinical *** this study,we designed a novel self-assembled,dual responsive,and dual drug-loading nanocarrier system,which comprised two parts:the hydrophobic lipid core formed by 1,2-Distearoyl-sn-glycero-3-phosphoethanolamine-Poly(ethylene glycol)(DSPE-PEG)loaded with alpha-lipoic acid(ALA);and a hydrophilic shell comprising a poly(amidoamine)dendrimer(PAMAM)that electrostatically adsorbed minocycline hydrochloride(Mino).This unique design allows the controlled release of antioxidant/ALA under lipase stimulation from periodontal pathogens and antimicrobial/Mino under the low pH of the inflammatory *** vivo and in vitro studies confirmed that this dual nanocarrier could inhibit the formation of subgingival microbial colonies while promoting osteogenic differentiation of cells under diabetic pathological conditions,and ameliorated periodontal bone *** effective and versatile drug-delivery strategy has good potential applications to inhibit diabetes-associated periodontal bone loss.

关键词： Diabetes mellitus Periodontitis Bone loss PAMAM Drug delivery

Electrospun naringin-loaded microsphere/sucrose acetate isobutyrate system promotes macrophage polarization toward M2 and facilitates osteoporotic bone defect repair

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Regenerative Biomaterials 2023年第1期10卷 470-485页

作者： Jihong Li Jinlin Song Di Meng Yin Yi Ting Zhang Yu Shu Xiaohong Wu Stomatological Hospital of Chongqing Medical University No.426 Songshibei RoadYubei DistrictChongqing 401147China Chongqing Key laboratory of oral Diseases and biomedical Sciences Chongqing 401147China Chongqing Municipal Key laboratory of oral biomedical engineering of Higher Education Chongqing 401147China

Repairing osteoporotic bone defects is still a major clinical *** studies have revealed that immune response is also essential in *** intrinsic inflammatory response of the host,especially the M1/M2 polarization status and inflammatory secretory function of macrophages,can directly affect osteogenic ***,in this study,an electrospun naringin-loaded microspheres/sucrose acetate isobutyrate(Ng-m-SAIB)system was constructed to investigate its effect on the polarization of macrophage and osteoporotic bone *** results of both in vitro and in vivo experiments showed that Ng-m-SAIB had good biocompatibility and could promote the polarization of macrophage toward M2,thereby forming a favorable microenvironment for *** animal experiments also showed that Ng-m-SAIB could promote the osteogenesis of critical size defects in the skull of the osteoporotic model mouse(the senescence-accelerated mouse-strain P6).Together,these results collectively suggested that Ng-m-SAIB might be a promising biomaterial to treat osteoporotic bone defects with favorable osteo-immunomodulatory effects.

关键词： electrospun microspheres macrophage polarization Ng-m-SAIB osteoporotic bone defects

Beta-nerve growth factor promotes neurogenesis and angiogenesis during the repair of bone defects

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Neural Regeneration Research 2015年第7期10卷 1159-1165页

作者： Wei-hui Chen Chuan-qing Mao Li-li Zhuo Joo L.Ong department of oral Surgery Union Hospital Fujian Medical University department of biomedical engineering University of Texas at San Antonio

We previously showed that the repair of bone defects is regulated by neural and vascular signals. In the present study, we examined the effect of topically applied β-nerve growth factor（β-NGF） on neurogenesis and angiogenesis in critical-sized bone defects filled with collagen bone substitute. We created two symmetrical defects, 2.5 mm in diameter, on either side of the parietal bone of the skull, and filled them with bone substitute. Subcutaneously implanted osmotic pumps were used to infuse 10 μgβ-NGF in PBS（β-NGF ＋ PBS） into the right-hand side defect, and PBS into the left（control） defect, over the 7 days following surgery. Immunohistochemical staining and hematoxylin-eosin staining were carried out at 3, 7, 14, 21 and 28 days postoperatively. On day 7, expression of β III-tubulin was lower on the β-NGF ＋ PBS side than on the control side, and that of neurofilament 160 was greater. On day 14, β III-tubulin and protein gene product 9.5 were greater on the β-NGF ＋ PBS side than on the control side. Vascular endothelial growth factor expression was greater on the experimental side than the control side at 7 days, and vascular endothelial growth factor receptor 2 expression was elevated on days 14 and 21, but lower than control levels on day 28. However, no difference in the number of blood vessels was observed between sides. Our results indicate that topical application of β-NGF promoted neurogenesis, and may modulate angiogenesis by promoting nerve regeneration in collagen bone substitute-filled defects.

关键词： nerve regeneration β-nerve growth factor collagen angiogenesis protein gene product 9.5 vascular endothelial growth factor β III-tubulin neural regeneration

Spin-glass behavior in the competing CoCrGaO_(4)cubic spinel system

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Nano Research 2025年第1期18卷 501-507页

作者： Jiyu Hu Jiangli Ni Zhenfa Zi Chaocheng Liu School of Physics and Materials engineering Hefei Normal UniversityHefei 230009China National Synchrotron Radiation laboratory University of Science and Technology of ChinaHefei 230026China

Spin glasses(SGs),generally defined as disordered systems with randomized competing interactions,are widely investigated complex *** the ground states of spin glasses is crucial for understanding the nature of disordered magnets and many other physical manifestations,while also helping to solve some hard combinatorial optimization problems across multiple ***,the intrinsic cause of SG has always been elusive,especially in spinel oxide ***,we report the SG behavior observed in the cubic spinel oxides CoCrGaO_(4),and provide a comprehensive understanding of its intrinsic *** results indicate a frustrated state under multi-magnetic competition,and the features of SG are confirmed by susceptibility *** fitting parameters ofτ0,T0,and zv of isothermal remanent magnetization further reveal the relaxation behavior and strong spin ***,the varying exchange coupling under different temperatures and magnetic fields is unveiled,which should be responsible for the disordered *** studies unravel the underlying mechanism responsible for doping-induced magnetic frustration and introduce CoCrGaO_(4)as a potential platform for investigating spin glass behavior,thereby advancing fundamental research on frustrated magnetism within the spinel system.

关键词： spin glass(SG) magnetic frustration magnetic competition spinel ferrites

THE STUDY ON NOVEL MICROELECTRODE ARRAY CHIPS FOR THE DETECTION OF HEAVY METALS IN WATER POLLUTION

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Journal of Innovative Optical Health Sciences 2012年第1期5卷 11-17页

作者： HUI-XIN ZHAO WEI CAI DA HA HAO WAN PING WANG Biosensor National Special laboratory Key laboratory for biomedical engineering of Education Ministry department of biomedical engineering Zhejiang University Hangzhou 310027P.R.China

Qualitative and quantitative analysis of trace heavy metals in aqueous environment are rapidly assuming significance along with the rapid development of *** this paper,gold microelectrode array(MEA)plated with mercury film was used for simultaneous voltammetric detection of zinc,cadmium,lead and copper ions in *** electrochemical behavior and the actual surface area of the MEA were investigated by cyclic voltammetry in K_(3)[Fe(CN)_(6)].Electrochemical impedance spectrum(EIS)was utilized to examine the deposition of mercury on the electrode *** on anodic stripping voltammetry,mercury filmAu MEA was applied to the detection of heavy metals in artificial analyte,where good calibrate linearity was obtained for cadmium,lead and copper ions,but with zinc exhibiting poor linearity.

关键词： Microelectrode array(MEA)chip heavy metals detection water pollution