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Chemical characterization of fine and ultrafine PM, direct and indirect genotoxicity of PM and their organic extracts on pulmonary cells

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Journal of Environmental Sciences 2018年第9期30卷 168-178页

作者： Sylvain Billet Yann Landkocz Perrine J. Martin Anthony Verdin Frederic Ledoux Capucine Lepers Veronique Andre Fabrice Cazier Francois Sichel Pirouz Shirali Pierre Gosset Dominique Courcot University of the Littoral Opal Coast Unit of Environmental Chmistry and Interactions with Liuing Organisms UCEIV EA4492 SFR Condorcet FR CNRS 3417 Dunkerque France Normandy Uniu UNICAEN ABTE EA4651 Caen France University of the Littoral Opal Coast Common Centre of Measurements CCM Dunkerque France Centre Francois Baclesse Caen France department of Anatomy and Pathological Cytologly Saint-Vincent Hospital Catholic Hospital Lille France

Particulate matter in ambient air constitutes a complex mixture of fine and ultrafine particles composed of various chemical compounds including metals, ions, and organics. A multidisciplinary approach was developed by studying physico-chemical characteristics and mechanisms involved in the toxicity of particulate atmospheric pollution. PM0.3-2.s and PM2.5 including ultrafine particles were sampled in Dunkerque, a French industrialized seaside city. PM samples were characterized from a chemical and toxicological point of view. Physico-chemical characterization evidenced that PM2.5 comes from several sources： natural ones, such as soil resuspension and marine sea-salt emissions, as well as anthropogenic ones, such as shipping traffic, road traffic, and industrial activities. Human BEAS-2B tung cells were exposed to PM0.3-2.5, or to the Extractable Organic Matter （EOM） of PM0.3-2.5 and PM2.s. These exposures induced several mechanisms of action implied in the genotoxicity, such as oxidative DNA adducts and DNA Damage Response. The toxicity of PM-EOM was higher for the sample including the ultrafine fraction （PM2.5） containing also higher concentrations of polycyclic aromatic hydrocarbons. These results evidenced the major role of organic compounds in the toxicity of PM.

关键词： Air pollution particulate matter PM2.5 Ultrafine particles Physico-chemical characterization Biotransformation Genotoxicity

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Biodegradable,strong,and clear wood package for plastic alternative

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Nano Research 2024年第9期17卷 8531-8541页

作者： Jianfu Tang Xueqin Fan Haozhou Huang Xiaofei Dong Xueqi Li Peiru Wang Ran Yin Yanjun Xie Jian Li Gang Tan Zhenqian Pang Wentao Gan Key Laboratory of Bio-based Material Science&Technology(Ministry of Education) Northeast Forestry UniversityHarbin 150040China department of Architecture College of Civil Engineering and ArchitectureZhejiang UniversityHangzhou 310027China Smart Materials for Architecture Research Lab Innovation Center of Yangtze River DeltaZhejiang UniversityJiaxing 314100China Heilongjiang Key Laboratory of Complex Traits and Protein Machines in organisms Northeast Forestry UniversityHarbin 150040China

Using biodegradable material derived from renewable resources as petroleum-based plastics replacement is a promising way towards sustainable ***,the insufficient mechanical properties and complex manufacturing process of bioplastics still need to be improved for high-quality food ***,we report a top-down strategy to transform natural wood into a clear wood packaging film through scalable delignification and polyvinyl alcohol(PVA)*** wood packaging film demonstrates a laminated structure with completely collapsed cell walls and PVA intertwined together after energy-saving air drying,resulting in high light transmittance with low haze,good mechanical performance,and high barrier performance for oxygen and water *** dynamics simulations reveal the underlying fracture mechanism between cellulose and PVA,which effectively enhances the Young’s modulus and strength of the wood packaging *** findings contribute to the development of biodegradable and strong packaging materials,as well as other food-related applications,using sustainable wood.

关键词： wood food package mechanical enhancement plastic replacement biodegradability

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Effects of Dracaena arborea(Dracaenaceae) on sexual dysfunction in 4 weeks hyperglycemic male rats

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Asian Pacific Journal of Tropical Medicine 2014年第8期7卷 609-619页

作者： Wankeu-Nya M Watcho P Nguelefack TB Cairo-Juarez M Tapondjou L Kamanyi A Animal Physiology and Phytopharmacology Laboratory Department of Animal BiologyUnivcrsity of DschangP.O.BOX 67 Dschang-Cameroon Laboratory of Animal Biology and Physiology Department of Animal Organisms BiologyUniversity of DoualaP.O.BOX 24157Douala-Cameroon Laboratorio de Comportamiento Reproductive Escuela de Medicina Veterinaria y ZootecniaUniversidad Autnoma de Tlaxeala.TlaxealaC.P 90000Mexico Organic Chemistry Laboratory Department of chemistryUniversity of DschangP.O.BOX 67 Dschang-Cameroon

Objective:To investigate the effects of Dracaena arborea(***) on the sexual behavior parameters in experienced type-1 diabetic ***:Aqueous and ethanol(100 and 500mg/kg respectively)extracts of dried root barks of *** citrate(1.44 mg/kg),trimethylamine-N-oxide(TMAO,20 mg/kg)and distilled water(110 mL/*** orally administered to 4 weeks streptozolocin-induced diabetic *** latency and frequency(***),intromission latency and frequency(IL,IF) and post-ejaculatory interval(PEI) were measured by ejaculating series during 90 min once a week for 4 *** was determined at the beginning and at the end of the treatment Results:*** did not show any major antihvperglycemic *** to the control group,a significant(P<0.05-0.001)increase in MF and IF was noticed in rats treated with sildenafil citrate(89.71% and 90.07% respectively),aqueous(500 mg/kg.88.08%and 88.749;respectively) and ethanol(100 mg/kg;89.53%and 89.17respectively) extracts of *** after two weeks(series 1) of ***,IL and PEI were significantly(P<0.05-0.001) decreased after 4 weeks of daily treatment[sildenafil citrate(96.***.96.31%and 34.98%),and *** aqueous 500 mg/kg(94.***.94.33% and 66.609;i and ethanol extracts 100 mg/kg(96.***.97.089;and 64.26%)].Conclusions:These aphrodisiac potentials of *** in experienced diabetic rats could be due to the antioxidant and androgenic properties of phenols,*** and sterols revealed in the plant extracts.

关键词： Erectile dysfunction Streptozotocin Diabetes Dracaena arborea Aphrodisiac properties Rats

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PCR-based approaches for identification of multi-copy transgene integration sites in mouse genome

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Chinese Science Bulletin 2006年第18期51卷 2231-2235页

作者： ZHAO Xudong DANG Suying LIANG Bin LEI Xia CHEN Zheng WANG Long YAN Lanzhen SUN Hantang FU Jiliang FEI Jian WANG Zhugang Shanghai Research Center for Model organisms Shanghai 201203 China Laboratory of Genetic Engineering Department of Medical Genetics Institute of Health Science jointly-funded by Shanghai Institutes for Biological Sciences of Chinese Academy of Sciences and Shanghai Second Medical University Shanghai 200025 China State Key Laboratory of Medical Genomics Rui-Jin Hospital Affiliated to Shanghai Second Medical University Shanghai 200025 China

Generation of transgenic mice by DNA microinjection has become one of the most important technologies in studying gene function in vivo. Ran- dom integration of transgene often results in inser- tional mutation which may complicate phenotype analysis of transgenic mice and/or create a good opportunity to study the function of endogenous gene. However,the utilization of these potentially valuable resources is hampered due to lack of efficient ap- proaches for rapid identification of multi-copy trans- gene integration sites. Here we propose two PCR-based approaches to identifying trans- gene/genome junction sequences. The efficiency of these two strategies was tested in 9 independent transgenic mouse lines. Among them,the transgene in 8 mouse lines was clearly localized to certain chromosome regions. These rapid and efficient ap- proaches will greatly facilitate the study of insertional mutation due to transgene integration.

关键词：转基因结合部位插入突变 PCR

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A bHLH transcription activator regulates defense signaling by nucleo-cytosolic trafficking in rice

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Journal of Integrative Plant Biology 2020年第10期62卷 1552-1573页

作者： Fanwei Meng Chao Yang Jidong Cao Huan Chen Jinhuan Pang Qiqi Zhao Zongyi Wang Zheng Qing Fu Jun Liu State Key Laboratory of Plant Genomics Institute of MicrobiologyChinese Academy of SciencesBeijing 100101China CAS Center for Excellence in Biotic Interactions University of Chinese Academy of SciencesBeijing 100049China department of Biological Science University of South CarolinaColumbiaSC 29028USA School of Life Sciences University of Inner MongoliaHohhot 010021China Beijing Key Laboratory of Agricultural Product Detection and Control for Spoilage organisms and Pesticides Beijing University of AgricultureBeijing 102206China

Crosstalk between plant hormone signaling pathways is vital for controlling the immune response during pathogen *** acid(SA)and jas-monic acid(JA)often play important but antagonistic roles in the immune responses of higher ***,we identify a basic helix-loop-helix transcription acti-vator,OsbHLH6,which confers disease resistance in rice by regulating SA and JA signaling via nucleo-cytosolic trafficking in rice(Oryza sativa).OsbHLH6 expression was upregulated during Magnaporthe oryzae *** rice plants overexpressing OsbHLH6 display increased JA responsive gene expression and enhanced disease susceptibility to the ***-localized OsbHLH6 activates JA signaling and suppresses SA signaling;however,the SA regulator OsNPR1(Nonexpressor of PR genes 1)sequesters OsbHLH6 in the cytosol to alleviate its *** data suggest that OsbHLH6 controls disease re-sistance by dynamically regulating SA and JA signaling.

关键词： sativa) effect. bHLH

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On the origin of microbial magnetoreception

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National Science Review 2020年第2期7卷 472-479页

作者： Wei Lin Joseph L.Kirschvink Greig A.Paterson Dennis A.Bazylinski Yongxin Pan Key Laboratory of Earth and Planetary Physics Institute of Geology and Geophysics Chinese Academy of Sciences Institutions of Earth Science Chinese Academy of Sciences France-China Joint Laboratory for Evolution and Development of Magnetotactic Multicellular organisms Chinese Academy of Sciences Division of Geological & Planetary Sciences California Institute of Technology Earth-Life Science Institute Tokyo Institute of Technology department of Earth Ocean and Ecological Sciences University of Liverpool School of Life Sciences University of Nevada at Las Vegas College of Earth and Planetary Sciences University of Chinese Academy of Sciences

A broad range of organisms, from prokaryotes to higher animals, have the ability to sense and utilize Earth’s geomagnetic field—a behavior known as magnetoreception. Although our knowledge of the physiological mechanisms of magnetoreception has increased substantially over recent decades, the origin of this behavior remains a fundamental question in evolutionary biology. Despite this, there is growing evidence that magnetic iron mineral biosynthesis by prokaryotes may represent the earliest form of biogenic magnetic sensors on Earth. Here, we integrate new data from microbiology, geology and nanotechnology, and propose that initial biomineralization of intracellular iron nanoparticles in early life evolved as a mechanism for mitigating the toxicity of reactive oxygen species(ROS), as ultraviolet radiation and free-iron-generated ROS would have been a major environmental challenge for life on early Earth. This iron-based system could have later been co-opted as a magnetic sensor for magnetoreception in microorganisms, suggesting an origin of microbial magnetoreception as the result of the evolutionary process of exaptation.

关键词： magnetoreception biomineralization magnetotactic bacteria exaptation

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Molecular Cloning and cDNA Sequence Analysis of Two New Lepidopteran OR83b Orthologue Chemoreceptors

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Agricultural Sciences in China 2010年第8期9卷 1160-1166页

作者： XIU Wei-ming ZHANG Yi-fan YANG Dian-lin DONG Shuang-lin LIU Yu-sheng Agro-Environmental Protection Institute Ministry of Agriculture/Farmland Ecosystem Observation and Experiment Station of Genetically Modified Organisms in Wuqing Chinese Academy of Agricultural Sciences Tianjin 300191 P.R.China Key Laboratory of Monitoring and Management of Plant Diseases and Insects Ministry of Agriculture/Entomology Department Plant Protection College Nanjing Agricultural University Nanjing 210095 P.R. China Plant Protection College Shandong Agricultural University Tai ＇an 271018 P.R. China

The aim of this study was to isolate the full-length cDNA sequences of an unusually highly conserved olfactory receptor （orthologue to the Drosophila melanogaster DOR83b） from the antennae of Spodoptera exigua and S. litura by using reverse transcription-polymerase chain reaction （RT-PCR） and rapid amplification of cDNA ends （RACE） methods. Bioinformatics methods were used to further analyze the cDNA sequences and putative amino acid sequences. The two full-length cDNA sequences from olfactory receptor （OR） of male S. exigua and S. litura were named as SexiOR2 and SlitOR2, respectively. SexiOR2 and SlitOR2 consisted of nucleotide sequence of 1 906 and 2 483 bp, respectively, and both with deduced amino acid sequences of 473 residues. The sequence analysis indicated that the deduced amino acid sequences of the cDNA shared the high homologies with OR83b orthologue chemoreceptor sequences from previously reported moths, implying that the cDNA sequences were of OR83b orthologue chemoreceptor genes.

关键词： Spodoptera exigua Spodoptera litura olfactory receptor gene sequence analysis

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IDENTIFICATION OF INDIVIDUAL CLONORCHIS SINENSIS BY ANALYSIS OF TRANSPOSON

IDENTIFICATION OF INDIVIDUAL CLONORCHIS SINENSIS BY ANALYSIS...

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第十九届国际动物学大会

作者： D.H.Lai Z.R.Lun Center for Parasitic organisms School of Life Sciences Zhongshan （Sun Yat-Sen） University Guangzhou 510275 China Center for Parasitic organisms School of Life Sciences Zhongshan （Sun Yat-Sen） University Guangzhou 510275 China

＜正＞Genetic mobile elements （GMEs） are DNA sequences that have the ability to integrate into the genome at a new site. GMEs exist in all organisms from bacteria to mammals, and have driven genome evolution in diverse ways. LTR （long terminal repeat） retrotrans-posons as one of GMEs can increase copies in the genome through RNA proceed. Evidences show that analysis of GMEs is a useful tool for studying molecular epidemiology and genetic variation of organisms. By analysis of the sequences of LTR retrotransposon CsRnl, we amplified the blanking regions between

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Epidemiology of Male Sexual Dysfunction (MSD) in Patients Consulting in Some Health Services in the City of Douala, Cameroon

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Open Journal of Epidemiology 2023年第4期13卷 436-448页

作者： Paul V. Mboumwa Modeste Wankeu-Nya Théodore Sala Béyemé Zacharie Nde Emma F. Bend Frantz Ngalle Epoupa Brice L. Koloko Sylvin B. Ateba Marie I. Ngaha Njila Paul Moundipa Théophile Dimo Dieudonné Massoma Lembè department of Biology of Animal organisms Faculty of Science University of Douala Douala Cameroon department of Animal Production Faculty of Agronomy and Agricultural Sciences University of Dschang Dschang Cameroon department of Urology of Laquintinie Hospital of Douala Douala Cameroon department of Biology and Physiology Faculty of Science University of Yaounde I Yaounde Cameroon

Sexual dysfunction is a group of diseases, disorders or difficulties experienced by men or women during any stage of normal sexual activity. In Africa in general and Cameroon in particular, statistical data concerning the prevelance and the main causes of male sexual dysfunction are rare due to socio-cultural and religious burdens and sometimes self-medication. The objective of this work was to determine the prevalences, comorbidities and the risk factors of the main sexual dysfunction in some hospitals in city of Douala. Through a descriptive retrospective study carried out from Novembre 2019 to June 2021, sociodemographic parameter, reasons of consultation, risk factors and type of male sexual dysfunction (erectile dysfunction or erectile dysfunction (ED), ejaculation disorders (EjD), libido disorders (LD) and disorders of sexual activity with pain or painful sexual intercourse (PSI)) were collected in the medical files of patients who have made urological consultation between 2016 and 2020 at the Deido District hospital, Laquintinie Douala Hospital and Douala General hospital respectively. At the end of our data collection, out of a total of 24995 consultations, 2743 (10.98%) patients were suffering from at least one male sexual dysfunction. Moreover, sexual disorders were the 2nd reason of urological consultation (13.69%) after urinary disorders (33.85%). Among sexual disorders, erectile (76%) and ejaculatory (20%) disorders were the predominant pathologies recorded with the prevalences of 9.79 et 2.62% respectively, and were mostly represented in patients from [41 - 50] for erectile dysfunction, and [18 - 30] years old for ejaculative dysfunction. In addition, the number of patients with ejaculatory and erectile dysfunctions was more important in patients from [18 - 30] and [31 - 40] years old respectively. Among patients presenting sexual disorders, several risk factors or pathologies were associated with the dysfunction: benign prostatic hyperplasi

关键词： Male Sexual Dysfunction Patient Urologist Prevalence

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Post Debarking Response of Prunus africana (Hook. F) Kalkman (Rosaceae) Trees at Two Exploitation Sites in North Kivu (Eastern Democratic Republic of Congo)

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Open Journal of Forestry 2023年第2期13卷 161-181页

作者： Kambale Eloge Muhesi Musubao Moïse Kapiri Jean Lagarde Betti Ndongo Din department of Water and Forests Higher Institute of Agronomic Veterinary and Forestry Studies of Butembo Butembo Democratic Republic of Congo department of Water and Forests Catholic University of the Graben Butembo Democratic Republic of Congo Faculty of Sciences Department of Biology and Physiology of Plant Organisms University of Douala Douala Cameroon

Prunus africana is a species of great economic, medicinal and ecological importance. Due to its multiple uses, unsustainable exploitation methods and low regeneration capacity in tropical rainforests, this species is threatened with extinction. Present and exploited in the eastern part of DR Congo, knowledge of the dynamics of post-bark regeneration of Prunus africana remains fragmentary and poorly known. In North Kivu province, this species thrives in both afromontane forest and lowland tropical rainforest habitats. In order to contribute to the rational and sustainable exploitation of Prunus africana in this province, this paper was carried out with the objective of contributing to the knowledge of the dynamics of the regeneration of post-harvest bark of Prunus africana in two exploitation sites (low and high altitude). To achieve this objective, the inventory was conducted on 16 plots of 25 hectares each, with 8 plots per site. Dendrometric parameters (diameter at breast height (DBH), total tree height) and tree growth and regeneration parameters, i.e., stem bark thickness of the unharvested and harvested portions of the trees (bark reconstitution) were measured. A total of 716 barked stems of Prunus africana in 2016 in 25 hectares constituted the study sample. Results show that sites do not influence diameter at breast height of P. africana trees (p > 0.05) or total tree height. The bark diameter of harvested trees and the bark diameter of unharvested trees varied significantly by site (p 0.05). In contrast, the annual growth rate of bark differed with altitude;the highest rate was observed in trees growing at high altitude (2.97 ± 0.9 mm/yr) compared to 2.23 ± 0.74 mm/yr at low altitude. In view of these results, this study indicates that a half-rotation of 7 years could allow an effective reconstitution of the bark of Prunus africana at the second passage on the remaining side of the same stem.

关键词： Dendrometric Parameters Regeneration Capacity Tree Reconstitution Rate Debarking Prunus africana DR Congo

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