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世界核心医学期刊文摘(眼科学分册) 2006年第1期 6-7页

作者： Krebs I. Binder S. StolbaU. 杨秀梅 department of ophthalmology rudolf foundationclinic juchgasse 25 1030 vienna austria dr

PURPOSE: To examine whether the encouraging functional results one year after photodynamic therapy (PDT) can be maintained up to three years. DESIGN: Prospective interventional case series. METHODS: Highly myopic eyes that had been treated with PDT for subfoveal choroidal neovascularization and had been observed at least 36 months were included. Distance acuity (Early Treatment of Diabetic Retinopathy charts), reading acuity (Jaeger charts), 10-degree static threshold perimetry,fluorescein angiography,and optical coherence tomography were performed. The main outcome measures were the differences of the values among the baseline and the month 12 and themonth 36 examinations. RESULTS: Twenty eyes of 18 patients were included: 15 patients were female, and 3 patients were male. The average age was 64 years (range, 36 to 85 years). The mean distance acuity was 43 letters at baseline and 53 letters after 12 months and after 36 months. The mean reading acuity changed from mean J10.8 to mean J8.1 after 12 months and to mean J9.85 after 3 years. The mean defect decreased from mean 13.5 dB at baseline to mean 12.5 dB after 12 months and mean 11.2 dB after 36 months. The maximum retinal thickness decreased from mean 360 μ m at baseline to mean 259 μ m after one year and mean 238 μ m after 36 months. CONCLUSION: Distance acuity and central visual field showed stabilization after themonth 12 examination up to the month 36 examination. The reading acuity decreased between the month 12 and the month 36 examinations, which might be related to an increase of retinal atrophy.

关键词：光动力疗法远视力

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光学相干断层扫描引导光动力疗法的再次治疗

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世界核心医学期刊文摘（眼科学分册） 2005年第12期1卷 40-40页

作者： Krebs I Binder S StolbaU 王静波 department of ophthalmology Rudolf FoundationClinic Juchgasse 25 1030Vienna Austria.Dr

Aim: To evaluate the results of a retreatment modality of photodynamic therapy (PDT) based on optical coherence tomography (OCT) and fluorescein angiography (FA). To quantify the effect of PDT with the help of measurement of the retinal thickness. Methods: Eyes with predominantly classic subfoveal choroidal neovascularisation (CNV) due to age related macular degeneration were included. PDT was performed every three months, when needed. OCT, FA, and measures of distance acuity were performed at baseline, after 6 weeks, 3 months, and from then on every 3 months. A control group of a consecutive series of eyes that had been retreated based only on FA results was installed. Results: Forty eyes of 38 patients were included. The average age was 73 years. The maximum retinal thickness decreased from 404 μ m at baseline to 281.6 μ m at month 12. Furthermore there was a significant decrease of retinal thickness in both subgroups. The number of retreatments was reduced, when activity was diagnosed using OCT and FA. (2.4 v 4.0). The distance acuity correlated significantly with the maximum retinal thickness (p=0.0042). Conclusion: Information about the activity of a neovascular lesion can be obtained with the help of OCT. The retreatment modalities can be optimised by using OCT and FA and the number of retreatments can be reduced.

关键词：光动力疗法老年性黄斑变性中心凹视网膜厚度脉络膜新生血管远视力荧光素血管造影主型定量评价

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世界核心医学期刊文摘（眼科学分册） 2006年第5期2卷 20-20页

作者： Stolba U. Krebs I. Lamar P.D. 杨秀梅 department of ophthalmology Rudolf Foundation Hospital Juchgasse 25 1030 Vienna Austria Dr.

Aim: To evaluate long term results after transpupillary thermotherapy (TTT) in eyes with exudative age related macular degeneration. Methods: In a prospective clinical study eyes with occult or predominantly occult choroidal neovascularisation and no pretreatment were scheduled to have a TTT with a power of 630 mW. Visual acuity for far and near distances as well as contrast sensitivity were evaluated 6, 12, and 24 months postoperatively and statistically analysed. Results: 47 eyes fulfilled the inclusion criteria. Overall, 70%of the patients showed an improved (14%) or had unchanged (56%) ETdrS vision after 24 months. Reading vision was stabilised (51%) or better (5%) in 56%of the eyes at this time. However, the increasing number of eyes with severe deterioration resulted in a significant decrease of both parameters over time (p=0.0002 and p=0.0003, respectively). Contrast sensitivity could be maintained (70%) or improved (9%) in 79%. Statistical analyses indicated a trend but no significant decrease over time (p=0.056). Conclusion: Although in the majority of patients far and near distance acuity could be stabilised on average a significant decrease over time after TTT was observed. Statistical comparison of months 12 and 24 showed no further deterioration.

关键词：隐匿性脉络膜新生血管渗出性年龄相关性黄斑变性经瞳孔温热疗法远期疗效观察治疗试验研究前瞻性临床研究伴发对比敏感度统计学分析

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