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视盘小凹合并黄斑病变的青少年患者出现罕见的后极部透明条索:术中及组织病理学的发现

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世界核心医学期刊文摘（眼科学分册） 2005年第10期1卷 55-56页

作者： Hirakata A. Hida T. Wakabayashi T. Fukuda M. 陈立军 Department of Ophth almology Kyorin University School of Medicine 6-20-2 Shinkawa Mitaka Tokyo 181-8611 Japan

Background: The mechanism responsible for optic disc pit maculopathy is unclea r, but abnormal vitreous structures, including the anomalous Cloquet’s canal at the optic disc pit, have been suggested as important factors. Case: We report t he intraoperative and ultrastructual findings of an unusual posterior vitreous s trand in the eye of an 8-year-old girl with optic disc pit maculopathy. Observ ations: The patient presented with decreased vision in the left eye. Examination of the left eye revealed a best-corrected visual acuity (VA) of 0.08 and a mac ular detachment associated with an optic disc pit. Vitrectomy was performed with the adjunctive use of triamcinolone acetonide intraoperatively. The presence of an unusual posterior hyaloid strand tightly attached to the margin of the optic disc pit was noted. An unusual movement of this strand was observed during the surgery. The strand was excised, and fluid-gas exchange was performed using gas tamponade with 20%SF6. After 12 months, a complete macular reattachment was ob tained, with the VA improving to 1.2. Electron microscopic examination of the re moved strand revealed abundant thick collagen fibrils with a frame of fine fibri ls. Conclusion: The unusual posterior vitreous strand connected to the optic dis c pit may have contributed to the pathogenesis of maculopathy in this young chil d.

关键词：黄斑病变后极部组织病理学玻璃体切割术黄斑脱离玻璃体条索超微结构胶原纤维矫正视力左眼视力

用电解法治疗浅层变异型颗粒状角膜营养不良(Reis-Bucklers角膜营养不良)年轻患者的角膜浑浊

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世界核心医学期刊文摘（眼科学分册） 2005年第10期1卷 24-25页

作者： Kamoi M. Mashima Y. Kawashima M. Tsubota K. 吴琼 Department of Ophth almology Keio University School of Medicine 35 Shinanomachi Shinjuku-ku To kyo 160-8582 Japan Dr.

PURPOSE: To report the efficacy of electrolysis as a treatment of corneal opac ities in a young patient with the superficial variant of granular corneal dystro phy. DESIGN: Interventional case report. METHODS: An 11-year-old boy presented with subepithelial opacities in both eyes. His visual acuity was 0.2 in the lef t eye; he received corneal electrolysis under topical anesthesia. RESULTS: The e lectrolysis, which required only 5 minutes, resulted in the disappearance of the subepithelial opacities. His visual acuity improved to 0.4 on the next day and was 1.0 eight months later. The corneal curvature and thickness were not altered by the electrolysis. CONCLUSIONS: Corneal electrolysis proved to be an effectiv e treatment for subepithelial opacities, and we recommend electrolysis as an eff ective and simple treatment for young patients with SGCD.

关键词：角膜营养不良 Reis-Bucklers 角膜浑浊变异型电解术角膜上皮浅层角膜曲度左眼视力干预性

人工晶体植入术中用Zeiss IOLMaster进行生物测量时的参数优化

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世界核心医学期刊文摘（眼科学分册） 2005年第11期1卷 10-11页

作者： Madge S.N. Khong C.H. Lamont M. R.J. Antcliff 陈立军 Department of Ophth almology Royal UnitedHospital Combe Park Bath BA1 3NG United Kingdom Dr.

Purpose: To compare the accuracy of biometry using conventional A-scan ultras onography and partial coherence interferometry, and to improve the accuracy of b iometry by sequential audit of postoperative refractive error. Methods: The stud y was performed in three phases. In phase 1, 20 consecutive patients undergoing routine phacoemulsification underwent biometry using bothA-scan ultrasonography and the Zeiss IOLMaster (ZIOLM).Asingle experienced optometrist refracted all p atients 2 weeks after surgery. The errors between expected and achieved refracti on were calculated and compared between the two methods. In phases 2 and 3, a fu rther 22 and 20 patients, respectively, were recruited and only the ZIOLM was us ed for biometry. The manufacturer’s suggested A-constant was refined and the e rror between expected and achieved refraction was calculated. Results: In phase 1, the median unexpected error for the ZIOLM was +0.63 (interquartile range +0 .368 to +1.015) and for A-scan biometry was 0.24 (interqu artile range-1.335 to +0.802). In phase 1 65%of patients’- postoperative refractions were found to be within 1.0 D of emmetropia using th e ZIOLM (55%using A-scan biometry). Refinements to the A-constant improved th is to 95%by phase 3. Conclusion: An error was identified in IOL power estimatio n with the ZIOLM, when using the manufacturer’s recommended A-constant (recomm ended and previously optimized ultrasound A-constant 118.0; ZIOLMoptimized A-c onstant 118.6). Serial modifications to the A-constant were successful in reduc ing the unexpected error towellwithin the tolerance limits of published internat ional standards.

关键词：晶体植入 Zeiss 生物测量人工晶体屈光不正术后屈光度验光师正视眼预计值四分位数

利用小活检样本进行角膜缘上皮原代培养和自体移植成功治疗严重单侧眼表疾病

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世界核心医学期刊文摘（眼科学分册） 2005年第2期1卷 10-11页

作者： Nakamura T. Inatomi T. SotozonoC. 秦雪娇 Department of Ophth almology Kyoto Prefectural Univ. of Medicine Kawaramachi Hirokoji Kamigyo-ku Kyoto 602-0841 Japan Dr.

Background: Patients with severe unilateral ocular surface disease require rec onstruction of the damaged ocular surface. We succeeded in culturing primary cor neal limbal epithelial cells taken from minimal biopsy and,once grown, transplan ting them on denuded amniotic membrane (AM). Methods: Autologous corneal limbal epithelial cells from a 3 mm2 biopsy of the uninjured eye were grown for 3weeks on a denuded AM carrier. The resultant sheet was then transplanted onto the unil ateral severely chemically injured eye. Results: Minimal biopsy showed the autol ogous cultivated corneal epithelial cells to have 4-5 layers of sufficient stra tification and to be well differentiated. At 19 months post-transplantation, th e ocular surface epithelium was stable and there were no epithelial defects. Con clusion: We document that it is possible to produce sufficiently stratified, wel l differentiated, autologous cultivated corneal limbal epithelium on AM from a m inimal biopsy of the donor eye and to transplant it onto the injured eye.

关键词：单侧眼原代培养检样自体移植眼表重建化学烧伤角膜上皮细胞