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Torsion of the spermatic cord in adults:a multicenter experience in adults with surgical exploration for acute scrotal pain with suspected testicular torsion

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Asian Journal of Andrology 2022年第6期24卷 575-578页

作者： Van Thi Dang Benjamin Pradere Anne Mauger de Varennes Nadia Ali Benali Maxime Vallee William Berchiche Bastien Gondran-Tellier Gaelle Margue Clement Michiels Charles Gaillard Tristan Grevez Florian Bardet Maud Hulin Anthony Manuguerra Ugo Pinar Caroline Plassais Margeux Felber William Wandoren Kévin Kaulanjan Ines Dominique Marc Sbizerra Emilien Seizilles de Mazancourt Xavier Matillon Igor Duquesne Maxime Chabenes Victor Gallard Lucas Freton Francois Lannes Zine-Eddine Khene department of urology Toulouse University HospitalToulouse 31000France department of urology Medical University of ViennaVienna 1090Austria department of urology Rennes University HospitalRennes 35000France department of urology Poitiers University HospitalPoitiers 86000France department of urology Marseille North HospitalMarseille 13000France department of urology Bordeaux University HospitalBordeaux 33000France department of urology Tours University HospitalTours 37000France department of urology Dijon University HospitalDijon 21o00France department of urology Reims University HospitalReims 5i000France department of urology Nancy University HospitalNancy 54000France department of urology Hopitaux Universitaires Pitie-SalpetriereAP-HPParis 75013France department of urology Pointe a Pitre University HospitalGuadeloupe 97000France department of urology Lyon University HospitalLyon 69000France department of urology Cochin HospitalAP-HPParis 75000France department of urology Grenoble University HospitalGrenoble 38000France department of urology Strasbourg University HospitalStrasbourg 67000France

Acute scrotal pain(AsP)requiring surgical exploration is common in the pediatric population,but little has been reported on this subject with regard to the adult *** aim of this study was to investigate the demographic and clinical characteristics and outcomes of scrotal explorations performed on adult *** over 21 years of age who underwent surgical exploration for ASP with suspected testicular torsion(TT)at 14 French hospitals between January 2005 and December 2019 were included in this *** main outcome measures were demographic characteristics,pathology found during scrotal exploration,and perioperative *** regression was used to perform univariate and multivariate analyses to identify predictors of *** for 1329 men were *** median age was 30(interquartile range[IQR]:25-35;range:21-89)*** the clinical examination,867(65.2%)patients presented with an elevation of the testicle,613(46.1%)patients with scrotal edema or erythema,and 211(15.9%)patients with nausea or *** findings identified TT in only 684(51.5%)patients,epididymo-orchitis in 112(8.4%)patients,a tumor in 16(1.2%)patients,and no causes in 475(35.7%)*** for nonviable testes was required in 101(7.6%)*** multivariate analysis,an elevation of the testicle,erythema/swelling,and the presence of nausea/vomiting were found to be associated with the occurrence of *** torsion is not exclusive to children and adolescents,so must be considered in males of any age with acute scrotal ***,one-third of scrotal explorations in adults did not lead to a diagnosis.

关键词： adults diagnosis exploration scrotal emergencies spermatic cord torsion ultrasonography

Identification of senescence-related molecular subtypes and key genes for prostate cancer

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Asian Journal of Andrology 2023年第2期25卷 223-229页

作者： De-Chao Feng Wei-Zhen Zhu Xu Shi Qiao Xiong Jia You Qiang Wei Lu Yang department of urology Institute of UrologyWest China HospitalSichuan UniversityChengdu 610041China

We identified distinct senescence-related molecular subtypes and critical genes among prostate cancer(PCa)patients undergoing radical prostatectomy(RP)or radical radiotherapy(RT).We conducted all analyses using R software and its suitable *** genes,namely,secreted frizzled-related protein 4(SFRP4),DNA topoisomerase II alpha(TOP2A),pleiotrophin(PTN),family with sequence similarity 107 member A(FAM107A),C-X-C motif chemokine ligand 14(CXCL14),prostate androgen-regulated mucin-like protein 1(PARM1),leucine zipper protein 2(LUZP2),cluster of differentiation 38(CD38),cartilage oligomeric matrix protein(COMP),vestigial-like family member 3(VGLL3),apolipoprotein E(APOE),and aldehyde dehydrogenase 2 family member(ALDH2),were eventually used to subtype PCa patients from The Cancer Genome Atlas(TCGA)database and GSE116918,and the molecular subtypes showed good correlations with clinical *** terms of the tumor immune environment(TME)analysis,compared with cluster 1,cancer-associated fibroblasts(CAFs)scored significantly higher,while endothelial cells scored lower in cluster 2 in TCGA *** was a statistically significant correlation between both CAFs and endothelial cells with biochemical recurrence(BCR)-free survival for PCa patients undergoing *** the GSE116918 database,cluster 2 had significantly lower levels of CAFs and tumor purity and higher levels of stromal,immune,and Estimation of STromal and Immune cells in MAlignant Tumor tissues using Expression data(ESTIMATE)scores than cluster 1;in addition,patients with high levels of CAFs,stromal scores,immune scores,and ESTIMATE scores and low levels of tumor purity tended to suffer from *** on the median of differentially expressed checkpoints,high expression of CD96,hepatitis A virus cellular receptor 2(HAVCR2),and neuropilin 1(NRP1)in GSE116918 and high expression of CD160 and tumor necrosis factor(ligand)superfamily member 18(TNFSF18)in TCGA database were associated with a significantl

关键词： cellular senescence immune checkpoints molecular subtypes prostate cancer tumor immune environment

Use of a lyophilized bovine pericardium graft to repair tunical defect in patients with Peyronie＇s disease： experience in a clinical setting

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Asian Journal of Andrology 2017年第3期19卷 316-320页

作者： Javier Romero Otero Borja Garcia Gomez Jose Medina Polo Carlos Pascual Mateoe Silvia Garcia Barreras Eduard Garcia Cruz Javier de la Riva de la Vifia Alfredo Rodriguez Antolin 12 de Octubre University Hospital Department of Urology Madrid Spain Monteprincipe University Hospital Department of Urology Madrid Spain Clinic Hospital Department of Urology Barcelona Spain

Many different materials are available for grafting during surgery for Peyronie＇s disease （PD）. To study the outcomes associated with the use of a lyophilized bovine pericardium graft （Peri-Guard） to repair tunical defects in patients with PD, descriptive study of 43 patients with disabling penile curvature was performed. Curvature was measured before and after the intervention using a standardized procedure. Surgical technique was plaque excision and grafting of the tunical defect carried out by a single surgeon. A lyophilized bovine pericardium patch was used for grafting. We measured the change in penile curvature and length, the ability to perform successful sexual intercourse without further pharmacological or surgical treatment, and the satisfaction with treatment. Follow-up data were available for a total of 41 patients. Median age was 50 years （IQR 48-52）; mean follow-up time was 14 ± 6 months. Complete penile straightening was achieved in 33 patients （80.5%） and five patients （12.2%） had curvature under 20. Three months after surgery and stretching therapy, mean （s.d.） flaccid penile length increased from 11.2 ± 2.8 cm to 12.1 ± 2.9 cm （P = 0.062）. Seventy-five percentage of patients reported being able to achieve successful intercourse without further treatment. Eighty-five percentage of patients reported to be satisfied with the treatment. There was no evidence of tissue rejection or infection, and only four patients suffered an adverse event. Plaque excision and grafting of the tunical defect with lyophilized bovine pericardium seems to be a safe and effective treatment for patients with PD.

关键词： penile curvature pericardium patch Peyronie's disease surgical treatment

Aldosterone induces inflammatory cytokines in penile corpus cavernosum by activating the NF-κB pathway

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Asian Journal of Andrology 2018年第1期20卷 24-29页

作者： Fei Wu Zu-Quan Xiong Shan-Hua Mao Ji-Meng Hu Jian-Qing Wang Hao-Wen Jiang Qiang Ding department of urology Fudan Institute of Urology Huashan Hospital Fudan University Shanghai 200040 China

Emerging evidence indicates that aldosterone and mineralocorticoid receptors （MRs） are associated with the pathogenesis of erectile dysfunction. However, the molecular mechanisms remain largely unknown. In this study, freshly isolated penile corpus cavernosum tissue from rats was treated with aldosterone, with or without MRs inhibitors. Nuclear factor （NF）-kappa B （NF-κB） activity was evaluated by real-time quantitative PCR, luciferase assay, and immunoblot. The results demonstrated that mRNA levels of the NF-κB target genes, including inhibitor of NF-κB alpha （IκB-α, NF-κB1, tumor necrosis factor-alpha （TNF-α, and interleukin 6 （IL-6）, were higher after aldosterone treatment. Accordingly, phosphorylation of p65/RelA, IκB-α, and inhibitor of NF-κB kinase-β was markedly increased by aldosterone. Furthermore, knockdown of MRs prevented activation of the NF-κB canonical pathway by aldosterone. Consistent with this finding, ectopic overexpression of MRs enhanced the transcriptional activation of NF-κB by aldosterone. More importantly, the MRs antagonist, spironolactone blocked aldosterone-mediated activation of the canonical NF-κB pathway. In conclusion, aldosterone has an inflammatory effect in the corpus cavernosum penis, inducing NF-κB activation via an MRs-dependent pathway, which may be prevented by selective MRs antagonists. These data reveal the possible role of aldosterone in erectile dysfunction as well as its potential as a novel pharmacologic target for treatment.

关键词： aldosterone erectile dysfunction NF-κB receptors

Circadian rhythm in prostate cancer: time to take notice of the clock

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Asian Journal of Andrology 2023年第2期25卷 184-191页

作者： Wei-Zhen Zhu Qi-Ying He De-Chao Feng Qiang Wei Lu Yang department of urology Institute of UrologyWest China HospitalSichuan UniversityChengdu 610041China

The circadian clock is an evolutionary molecular product that is associated with better adaptation to changes in the external *** of the circadian rhythm plays a critical role in tumorigenesis of many kinds of cancers,including prostate cancer(PCa).Integrating circadian rhythm into PCa research not only brings a closer understanding of the mechanisms of PCa but also provides new and effective options for the precise treatment of patients with *** review begins with patterns of the circadian clock,highlights the role of the disruption of circadian rhythms in PCa at the epidemiological and molecular levels,and discusses possible new approaches to PCa therapy that target the circadian clock.

关键词： chronotherapy circadian clock circadian rhythm prostate cancer

Regional location of lymph node metastases predicts survival in patients with de novo metastatic prostate cancer

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Asian Journal of Andrology 2023年第4期25卷 462-467页

作者： Zhi-Peng Wang Jun-Ru Chen Jin-Ge Zhao Sha Zhu Xing-Ming Zhang Jia-Yu Liang Ben He Yu-Chao Ni Guang-Xi Sun Peng-Fei Shen Hao Zeng department of urology Institute of UrologyWest China HospitalSichuan UniversityChengdu 610041China department of urology The Third People’s Hospital of ChengduChengdu 610031China

To report the regional locations of metastases and to estimate the prognostic value of the pattern of regional metastases inmen with metastatic hormone-sensitive prostate cancer (mHSPC), we retrospectively analyzed 870 mHSPC patients betweenNovember 28, 2009, and February 4, 2021, from West China Hospital in Chengdu, China. The patients were initially classifiedinto 5 subgroups according to metastatic patterns as follows: simple bone metastases (G1), concomitant bone and regional lymphnode (LN) metastases (G2), concomitant bone and nonregional LN (NRLN) metastases (G3), lung metastases (G4), and livermetastases (G5). In addition, patients in the G3 group were subclassified as G3a and G3b based on the LN metastatic plane(below or above the diaphragm, respectively). The associations of different metastatic patterns with castration-resistant prostatecancer-free survival (CFS) and overall survival (OS) were analyzed by univariate and multivariate analyses. The results showedthat patients in G1 and G2 had relatively favorable clinical outcomes, patients in G3a and G4 had intermediate prognoses, andpatients in G3b and G5 had the worst survival outcomes. We observed that patients in G3b had outcomes comparable to those inG5 but had a significantly worse prognosis than patients in G3a (median CFS: 8.2 months vs 14.3 months, P = 0.015;medianOS: 38.1 months vs 45.8 months, P = 0.038). In conclusion, metastatic site can predict the prognosis of patients with mHSPC,and the presence of concomitant bone and NRLN metastases is a valuable prognostic factor. Furthermore, our findings indicatethat the farther the NRLNs are located, the more aggressive the disease is.

关键词： lymph node metastases metastatic hormone-sensitive prostate cancer metastatic pattern metastatic site nonregional lymph node metastases staging

Real-world effectiveness and safety of goserelin 10.8-mg depot in Chinese patients with localized or locally advanced prostate cancer

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Cancer Biology & Medicine 2023年第12期20卷 1047-1059页

作者： Nanhui Chen Zengjun Wang Ming Chen Qi Ma Yi He Yujie Wang Xin Li Mingxing Qiu Lei Shi Shaoxing Zhu Qun Xie Xiuheng Liu Benkang Shi Guowen Lin Weizhong Yang Yongbin Liao Haibin Zhang Shusheng Wang Jiexian Li Shaogang Wang Lijun Dong Hui Chen Jiaju Lu YongyiCheng Xiaoping Zhang Lulin Ma Liqun Zhou He Wang Shen Li Dingwei Ye department of urology Meizhou People’s HospitalMeizhou 514089China department of urology Jiangsu Province HospitalNanjing 210029China department of urology Zhongda Hospital Southeast UniversityNanjing 210009China Translational Research Laboratory for urology Ningbo First HospitalNingbo 315016China department of urology First Affiliated Hospital of JiaxingJiaxing 314050China department of urology The First Affiliated Hospital of Xinjiang Medical UniversityUrumqi 830091China department of urology Baotou Cancer HospitalBaotou 014016China department of urology The People’s Hospital of Sichuan ProvinceChengdu 610032China department of urology Yantai Yuhuangding HospitalYantai 264008China department of urology Cancer Hospital of The University of Chinese Academy of SciencesHangzhou 310022China department of urology Zhuhai Hospital Affiliated with Jinan UniversityZhuhai 519000China department of urology Tongji HospitalTongji Medical CollegeHUSTWuhan 430032China department of urology Qilu Hospital of Shandong UniversityJinan 250012China department of urology Fudan University Shanghai Cancer CenterShanghai 200032China department of urology Huizhou Third People’s HospitalHuizhou 516002China department of urology Jiangmen Central HospitalJiangmen 529030China department of urology Foshan First People’s HospitalFoshan 528041China department of urology Guangzhou Province Traditional Chinese Medical HospitalGuangzhou 510120China department of urology Guangzhou Panyu Central HospitalGuangzhou 511489China department of urology Renmin Hospital of Wuhan UniversityWuhan 430064China department of urology Hebei Petro China Central Hospital(China National Petroleum Corporation Central Hospital)Langfang 065099China department of urology Harbin Medical University Cancer HospitalHarbin 150086China department of urology Shandong Provincial HospitalJinan 250014China department of urology Shaanxi Provincial People’s HospitalXi’an 710021China department of urology Union Hospital Tongji Medical

Objective:Real-word data on long-acting luteinizing hormone-releasing hormone(LHRH)agonists in Chinese patients with prostate cancer are *** study aimed to determine the real-world effectiveness and safety of the LHRH agonist,goserelin,particularly the long-acting 10.8-mg depot formulation,and the follow-up patterns among Chinese prostate cancer ***:This was a multicenter,prospective,observational study in hormone treatment-na?ve patients with localized or locally advanced prostate cancer who were prescribed goserelin 10.8-mg depot every 12 weeks or 3.6-mg depot every 4 weeks with or without an *** patients had follow-up evaluations for 26 *** primary outcome was the effectiveness of goserelin in reducing serum testosterone and prostate-specific antigen(PSA)*** secondary outcomes included testosterone and PSA levels,attainment of chemical castration(serum testosterone<50 ng/d L),and goserelin *** exploratory outcome was the monitoring pattern for serum testosterone and *** analyses were ***:Between September 2017 and December 2019,a total of 294 eligible patients received≥1 dose of goserelin;287 patients(97.6%)were treated with goserelin 10.8-mg *** week 24±2,the changes from baseline[standard deviation(95%confidence interval)]in serum testosterone(n=99)and PSA(n=131)were-401.0 ng/d L[308.4 ng/d L(-462.5,-339.5 ng/d L)]and-35.4 ng/m L[104.4 ng/m L(-53.5,-17.4 ng/m L)],*** 112 evaluable patients,100(90.2%)achieved a serum testosterone level<50 ng/d ***-emergent adverse events(TEAEs)and severe TEAEs occurred in 37.1%and 10.2%of patients,*** mean testing frequency(standard deviation)was 1.6(1.5)for testosterone and 2.2(1.6)for ***:Goserelin 10.8-mg depot effectively achieved and maintained castration and was well-tolerated in Chinese patients with localized and locally advanced prostate cancer.

关键词： Goserelin hormone-sensitive luteinizing hormone-releasing hormone prostate cancer China real-world

Upgrading and upstaging of low-risk prostate cancer among Korean patients： a multicenter study

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Asian Journal of Andrology 2015年第5期17卷 811-814,I0009页

作者： Insang Hwang Donghoon Lim Young Beom Jeong Seung Chol Park Jun Hwa Noh Dong Deuk Kwon Taek Won Kang department of urology Chonnam National University Medical School Gwangju Korea department of urology Chosun University Medical School Gwangju Korea department of urology Chonbuk National University Medical School Jeonju Korea department of urology Wonkwang University School of Medicine Iksan Korea department of urology Kwangju Christian Hospital Gwangju Korea

Only 54% of prostate cancer cases in Korea are localized compared with 82% of cases in the US. Furthermore, half of Korean patients are upgraded after radical prostatectomy （41.6%-50.6%）. We investigated the risk factors for upgrading and/or upstaging of low-risk prostate cancer after radical prostatectomy. We retrospectively reviewed the medical records of 1159 patients who underwent radical prostatectomy at five hospitals in Honam Province. Preoperative data on standard clinicopathological parameters were collected. The radical prostatectomy specimens were graded and staged and we defined a ＂worsening prognosis＂ as a Gleason score ≥ 7 or upstaging to ≥ pT3. Multivariate logistic regression models were used to assess factors associated with postoperative pathological upstaging. Among the 1159 patients, 324 were classified into the clinically low-risk group, and 154 （47.5%） patients were either upgraded or upstaged. The multivariable analysis revealed that the preoperative serum prostate-specific antigen level （odds ratio [OR], 1.131; 95% confidence interval [CI], 1.007-1.271; P = 0.037）, percent positive biopsy core （OR： 1.018; 95% CI： 1.002-1.035; P = 0.032）, and small prostate volume （≤30 ml）（OR： 2.280; 95% CI： 1.351-3.848; P = 0.002） were predictive of a worsening prognosis. Overall, 47.5% of patients with low-risk disease were upstaged postoperatively. The current risk stratification criteria may be too relaxed for our study cohort.

关键词： prostate cancer prostatectomy risk factors

Pretreatment elevated fibrinogen level predicts worse oncologic outcomes in upper tract urothelial carcinoma

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Asian Journal of Andrology 2020年第2期22卷 177-183页

作者： Hang Xu Jian-Zhong Ai Ping Tan Tian-Hai Lin Xi Jin Li-Na Gong Hao-Ran Lei Lu Yang Qiang Wei department of urology and Institute of urology West China HospitalSichuan UniversityChengdu 610041China

This study aimed to further validate the prognostic role of fibrinogen in upper tract urothelial carcinoma(UTUC)in a large Chinese cohort.A total of 703 patients who underwent radical nephroureterectomy were retrospectively *** levels of≥4.025 g l?1 were defined as *** regression analysis was performed to determine the association between fibrinogen and adverse pathological ***–Meier analysis and Cox regression models were used to assess the associations of fibrinogen with cancer-specific survival(CSS),disease recurrence-free survival(RFS),and overall survival(OS).Harrell c-index and decision curve analysis were used to assess the clinical utility of multivariate *** median follow-up duration was 42(range:1–168)*** regression analysis revealed that elevated fibrinogen was associated with higher tumor stage and grade,lymph node involvement,lymphovascular invasion,sessile carcinoma,concomitant variant histology,and positive surgical margins(all P<0.05).Multivariate Cox regression analysis demonstrated that elevated fibrinogen was independently associated with decreased CSS(hazard ratio[HR]:2.33;P<0.001),RFS(HR:2.09;P<0.001),and OS(HR:2.09;P<0.001).The predictive accuracies of the multivariate models were improved by 3.2%,2.0%,and 2.8%for CSS,RFS,and OS,respectively,when fibrinogen was *** curve analysis showed an added benefit for CSS prediction when fibrinogen was added to the *** fibrinogen may be a strong independent predictor of worse oncologic outcomes in UTUC;therefore,it may be valuable to apply this marker to the current risk stratification in UTUC.

关键词： fibrinogen prognosis radical nephroureterectomy upper tract urothelial carcinoma